Fibronectin-Integrin Signaling Is Required for L-Glutamine's Protection against Gut Injury

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Niederlechner, Stefanie ^a   Klawitter, Jelena ^a   Baird, Christine ^a   Kallweit, Alyssa R ^a   Christians, Uwe ^a   Wischmeyer, Paul E ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; F ACTIN; FIBRONECTIN; GLUTAMINE; GLYCYLARGININYLGLYCYLASPARTYLSERYLPROLINE; GLYCYLARGININYLGLYCYLGLUTAMICYLSERYLPROLINE; HEAT SHOCK PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR 1; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DISRUPTION; CELL LEVEL; CELL PROTECTION; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HYPERTHERMIA; INTESTINE INJURY; INTRACELLULAR SIGNALING; MEMBRANE STABILIZATION; MOLECULAR MECHANICS; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; STOMACH PROTECTION; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; ENZYME INHIBITORS; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; GENE EXPRESSION REGULATION; GENE SILENCING; GLUTAMINE; HOT TEMPERATURE; HSP70 HEAT-SHOCK PROTEINS; INTEGRINS; INTESTINAL MUCOSA; POLY(ADP-RIBOSE) POLYMERASES; PROTEOLYSIS; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84869756382     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050185     Document Type: Article

References (50)

1. Larson SD, Li J, Chung DH, Evers BM, (2007) Molecular mechanisms contributing to glutamine-mediated intestinal cell survival. Am J Physiol Gastrointest Liver Physiol 293: G1262-1271.
2. Potten CS, Loeffler M, (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110: 1001-1020.
3. Lambert GP, Gisolfi CV, Berg DJ, Moseley PL, Oberley LW, et al. (2002) Selected contribution: Hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress. Journal of applied physiology 92: 1750-1761; discussion 1749.
4. Prosser C, Stelwagen K, Cummins R, Guerin P, Gill N, et al. (2004) Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. Journal of applied physiology 96: 650-654.
5. Rieder F, Brenmoehl J, Leeb S, Scholmerich J, Rogler G, (2007) Wound healing and fibrosis in intestinal disease. Gut 56: 130-139.
6. Han SW, Roman J, (2006) Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B. Oncogene. 25: 4341-4349.
7. Kolachala VL, Bajaj R, Wang L, Yan Y, Ritzenthaler JD, et al. (2007) Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. J Biol Chem 282: 32965-32973.
8. Ruoslahti E, (1996) RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol 12: 697-715.
9. Todorovic V, Chen CC, Hay N, Lau LF, (2005) The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol 171: 559-568.
10. Hynes RO, (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
11. Miranti CK, Brugge JS, (2002) Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 4: E83-90.
12. Fletcher DA, Mullins RD, (2010) Cell mechanics and the cytoskeleton. Nature 463: 485-492.
13. Keshavarzian A, Banan A, Farhadi A, Komanduri S, Mutlu E, et al. (2003) Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease. Gut 52: 720-728.
14. Brakebusch C, Fassler R, (2003) The integrin-actin connection, an eternal love affair. EMBO J 22: 2324-2333.
15. Yee KL, Weaver VM, Hammer DA, (2008) Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol 2: 8-15.
16. Gianotti L, Alexander JW, Gennari R, Pyles T, Babcock GF, (1995) Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN J Parenter Enteral Nutr 19: 69-74.
17. Klimberg VS, Salloum RM, Kasper M, Plumley DA, Dolson DJ, et al. (1990) Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg 125: 1040-1045.
18. Souba WW, (1991) Glutamine: a key substrate for the splanchnic bed. Annu Rev Nutr 11: 285-308.
19. Wischmeyer P, Pemberton JH, Phillips SF, (1993) Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clin Proc 68: 978-981.
20. Zapata-Sirvent RL, Hansbrough JF, Ohara MM, Rice-Asaro M, Nyhan WL, (1994) Bacterial translocation in burned mice after administration of various diets including fiber- and glutamine-enriched enteral formulas. Crit Care Med 22: 690-696.
21. Ziegler TR, Bazargan N, Leader LM, Martindale RG, (2000) Glutamine and the gastrointestinal tract. Curr Opin Clin Nutr Metab Care 3: 355-362.
22. Askanazi J, Carpentier YA, Michelsen CB, Elwyn DH, Furst P, et al. (1980) Muscle and plasma amino acids following injury. Influence of intercurrent infection. Annals of surgery 192: 78-85.
23. Oehler R, Roth E, (2004) Glutamine Metabolism. In: Boca Raton, Florida: CRC Press Cynober LA, editor. Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition. LLC: 169-180.
24. Häussinger D, Lang F, (1992) Cell volume and hormone action. Trends Pharmacol Sci 13: 371-373.
25. Huang LE, Caruccio L, Liu AY, Chen KY, (1995) Rapid activation of the heat shock transcription factor, HSF1, by hypo-osmotic stress in mammalian cells. Biochem J 307 (Pt 2): 347-352.
26. Lavoinne A, Meisse D, Quillard M, Husson A, Renouf S, et al. (1998) Glutamine and regulation of gene expression in rat hepatocytes: the role of cell swelling. Biochimie 80: 807-811.
27. Schliess F, Reinehr R, Haussinger D, (2007) Osmosensing and signaling in the regulation of mammalian cell function. FEBS J 274: 5799-5803.
28. Schliess F, Wiese S, Haussinger D, (1999) Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 13: 1557-1564.
29. Wischmeyer PE, (2002) Glutamine and heat shock protein expression. Nutrition 18: 225-228.
30. Wischmeyer PE, Lynch J, Liedel J, Wolfson R, Riehm J, et al. (2001) Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med 29: 2075-2080.
31. Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB, (1997) Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 272: G879-884.
32. Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB, (2009) Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology 136: 924-932.
33. Häussinger D, Graf D, Weiergraber OH (2001) Glutamine and cell signaling in liver. J Nutr 131: 2509S-2514S; discussion 2523S-2504S.
34. Häussinger D, Kubitz R, Reinehr R, Bode JG, Schliess F, (2004) Molecular aspects of medicine: from experimental to clinical hepatology. Mol Aspects Med 25: 221-360.
35. Hamiel CR, Pinto S, Hau A, Wischmeyer PE, (2009) Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. American Journal of Physiology-Cell Physiology 297: C1509-C1519.
36. Sen S, Ng WP, Kumar S, (2011) Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics. Annals of biomedical engineering 39: 1163-1173.
37. Valenick LV, Hsia HC, Schwarzbauer JE, (2005) Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Experimental cell research 309: 48-55.
38. Saleem S, Li J, Yee SP, Fellows GF, Goodyer CG, et al. (2009) beta1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival. The Journal of pathology 219: 182-192.
39. Yu J, Yin P, Yin J, Liu F, Zhu X, et al. (2010) Involvement of ERK1/2 signalling and growth-related molecules' expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells. Int J Hyperthermia 26: 538-555.
40. Morrison AL, Dinges M, Singleton KD, Odoms K, Wong HR, et al. (2006) Glutamine's protection against cellular injury is dependent on heat shock factor-1. Am J Physiol Cell Physiol 290: C1625-1632.
41. Keller JM, Escara-Wilke JF, Keller ET, (2008) Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells. Comp Biochem Physiol A Mol Integr Physiol 150: 307-314.
42. Hung JJ, Cheng TJ, Lai YK, Chang MD, (1998) Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells. J Biol Chem 273: 31924-31931.
43. Uehara K, Takahashi T, Fujii H, Shimizu H, Omori E, et al. (2005) The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury. Critical Care Medicine 33: 381-390.
44. Goke M, Zuk A, Podolsky DK, (1996) Regulation and function of extracellular matrix intestinal epithelial restitution in vitro. Am J Physiol 271: G729-740.
45. Quaroni A, Isselbacher KJ, Ruoslahti E, (1978) Fibronectin synthesis by epithelial crypt cells of rat small intestine. Proc Natl Acad Sci U S A 75: 5548-5552.
46. Gu J, Fujibayashi A, Yamada KM, Sekiguchi K, (2002) Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways. J Biol Chem 277: 19922-19928.
47. vom Dahl S, Schliess F, Reissmann R, Gorg B, Weiergraber O, et al. (2003) Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J Biol Chem 278: 27088-27095.
48. Bortner CD, Cidlowski JA, (2002) Apoptotic volume decrease and the incredible shrinking cell. Cell Death Differ 9: 1307-1310.
49. Kerr JF, Wyllie AH, Currie AR, (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
50. Oudemans-van Straaten HM, Bosman RJ, Treskes M, van der Spoel HJ, Zandstra DF, (2001) Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med 27: 84-90.