Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease

Gut

Volumn 52, Issue 5, 2003, Pages 720-728

  Keshavarzian, A ^a   Banan, A ^a   Farhadi, A ^a   Komanduri, S ^a   Mutlu, E ^a   Zhang, Y ^a   Fields, J Z ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; FREE RADICAL;

ADULT; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; COLON MUCOSA; ENTERITIS; EPITHELIUM CELL; FEMALE; HUMAN; INFLAMMATORY CELL; INTESTINE CELL; INTESTINE MUCOSA; MALE; MEDIATOR RELEASE; NITRATION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TISSUE INJURY;

ACTINS; ADULT; BLOTTING, WESTERN; CHEMILUMINESCENT MEASUREMENTS; COLITIS, ULCERATIVE; COLON; COLONIC DISEASES, FUNCTIONAL; CROHN DISEASE; CYTOSKELETAL PROTEINS; FEMALE; FREE RADICALS; HUMANS; IMMUNOBLOTTING; INTESTINAL MUCOSA; MALE; NITRIC OXIDE; OXIDATION-REDUCTION; TUBULIN; TYROSINE;

EID: 0013069021     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.5.720     Document Type: Article

References (45)

1. Simmonds NJ, Allen RE, Stevens TRJ, et al. Chemiluminescence assay of mucosal active oxygen metabolites in inflammatory bower disease. Gastroenterology 1989;103:186-96.
2. Keshavarzian A, Sedghi S, Kanofsky J, et al. Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe. Gastroenterology 1992;103:177-85.
3. Harris ML, Schiller HJ, Reilly PM, et al. Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon? Pharmacol Ther 1992;53:375-408.
4. McKenzie SJ, Baker MS, Buffinton GD, et al. Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease. J Clin Invest 1996;98:136-41.
5. Grisham MB, Yamada T. Neutrophils, nitrogen oxides and inflammatory bowel disease. Ann N Y Acad Sci 1992;664:103-15.
6. Hollander D. The intestinal permeability barrier: A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol 1992;27:721-6.
7. Gardiner KR, Anderson NH, Rowlands BJ. Colitis and colonic mucosal barrier dysfunction. Gut 1995;37:530-5.
8. Kimura H, Hokari R, Miura S, et al. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 1998;42:180-7
9. Ramchilewitz D, Stamler JS, Bachwich D, et al. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in Ulcerative colitis and Crohn's disease. Gut 1995;36:718-23.
10. Singer II, Kawka DW, Scott S, et al. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 1996;111:871-85.
11. Banan A, Fields JZ, Zhang Y, et al. iNOS upregulation mediates oxidant-induced disruption of F-Actin and the permeability barrier of intestinal monolayers. Am J Physiol 2001;280:1234-46.
12. Banan A, Fields JZ, Zhang Y, et al. Nitric oxide and its metabolites mediate ethanol- induced microtubule disruption. J Pharmacol Exper Therap 2000;294:997-1008.
13. Banan A, Zhang Y, Losurdo J, et al. Carbonylation and disassembly of the F-actin cytoskeleton in oxidant-induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor-α in a human intestinal cell line. Gut 2000;46:830-7.
14. Banan A, Choudhary S, Zhang Y, et al. Oxidant-induced intestinal barrier disruption and it's prevention by epidermal growth factor and transforming growth factor-α in a human colonic cell line:Role of the microtubule cytoskeleton. Free Radical Biol Med 2000;2B:727-38.
15. Banan A, Choudhary S, Zhang Y, et al. Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms. J Pharmacol Exp Ther 1999;291:1075-85.
16. Banan A, Fields JZ, Zhang Y, et al. The β1 isoform of protein kinase C mediates epidermal growth factor protection of the microtubules and barrier integrity of intestinal monolayers against oxidant damage. Am J Physiol Gastrointest Liver Physiol 2001;281:833-47.
17. Banan A, McCormack SA, Johnson LR. Polyamines are required for microtubule formation during mucosal ulcer healing. Am J Physiol Gasrointest Liver Physiol 1998;274:879-85.
18. Banan A, Wang J-Y, McCormack SA, et al. Relationship between polyamines, actin distribution, and gastric mucosal ulcer healing in rats. Am J Physiol Gastrointest Liver Physiol 1996;34:G893-903.
19. Breuer RI, Soergel KH, Lashner BA, et al. Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. Gut 1997;40:485-91.
20. Seo M, Okada M, Maeda K, et al. Correlation between endoscopic severity and the clinical activity index in ulcerative colitis. Am J Gastroenterol 1998;93:2124-9.
21. Best WR, Becktel JM, Singleton JW, et al. Deveropment of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 1976;70:439-44.
22. Robinson CE, Keshavarzian A, Pasco DS, et al. Determination of protein carbonyl groups by immunoblotting. Anal Biochem 1999;266:48-57.
23. Bradford MA. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding. Anal Biochem 1976;72:224-54.
24. Keshavarzian A, Doria M, Sedghi S, et al. Mitomycin-C induced colitis in rats - a new animal model of acute colonic inflammation implicating reactive oxygen species. J Lab Clin Med 1992;120:779-91.
25. Keshavarzian A, Morgan G, Sedghi S, et al. Role of oxygen free metabolites in experimental coritis. Gut 1990;31:786-90.
26. Choudhary S, Keshavarzian A, Yong S, et al. Novel antioxidants zorimid and AEOL11201 ameliorate colitis in rats. Dig Dis Sci 2001;46:2222-30.
27. Keshavarzian A, Haydek J, Zabihi R, et al. Agents capable of eliminating reactive oxygen species. Catarase, WR-2721, or Cu(11)2(3,5-DIPS)4 decrease experimental colitis. Dig Dis Sci 1992;37:1866-73.
28. Gionchetti P, Guarnieri C, Campieri M, et al. Scavenger effect of sulfosalazine, 5- aminosalicylic acid, and olsalazine on superoxide radical generation. Dig Dis Sci 1991;36:174-8.
29. Greenfield SM, Punchard NA, Thompson RP. Inhibition of red cell membrane lipid peroxidation by sulphasalazine and 5-aminosalicylic acid. Gut 1991;32:1156-9.
30. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;107:365-76.
31. Holmes EW, Yong SL, Eizenhamer D, et al. Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci 1998;43:1088-95.
32. Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction. Am J Physiol 1996;270:225-37.
33. Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. Am J Physiol 1992;262:1138-42.
34. Whittle BJR. Nitric oxide in gastrointestinal physiology and pathology. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven 1994:267-94.
35. Kubes P, McCafferty DM. Nitric oxide and intestinal inflammation. Am J Med 2000;109:150-8.
36. Chen K, Inoue M, Okada A. Expression of inducible nitric oxide synthase mRNA in rat digestive tissues after endotoxin and its role in intestinal mucosal injury. Biochem Biophys Res Comm 1996;224:703-8.
37. Oudkerk Pool M, Bouma G, Visser JJ, et al. Serum nitrate levels in ulcerative colitis and Crohn's disease. Scand J Gastroenterol 1995;30:784-8.
38. Roediger WE, Lawson MJ, Nance SH, et al. Detectable colonic nitrite levels in inflammatory bowel disease - mucosal or bacterial malfunction? Digestion 1986;35:199-204.
39. Sasajima K, Yoshida Y, Yamakado S, et al. Changes in urinary nitrate and nitrite during treatment of ulcerative colitis. Digestion 1996;57:170-3.
40. Lundberg JO, Herulf M, Olesen M, et al. Increased nitric oxide production in collagenous and lymphocytic colitis. Eur J Clin Invest 1997;27:869-71.
41. Kennedy M, Denenberg AG, Szabo C, et al. Poly (ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells. Gastroenterology 1998;114:510-18.
42. Unno N, Menconi MJ, Smith M, et al. Nitric oxide mediates interferon-gamma- induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 1995;23:1170-6.
43. Karczewski J, Groot J. Molecular physiology and pathophysiology of tight junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia. Am J Physiol 2000;279:G660-5.
44. Ferro TJ, Gertzberg N, Selden L, et al. Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide. Am J Physiol 1997;272:L979-8.
45. Menconi MJ, Salzman AL, Unno N, et al. Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol 1997;272:G1007-21.