IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 67, Issue 12, 2012, Pages 1538-1546

  Hong, X ^a   Caruso, D ^a   Kumar, R ^b   Liu, R ^c   Liu, X ^c   Wang, G ^a   Pongracic, J A ^b   Wang, X ^a,c  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Ara h 2; component resolved diagnostics; diagnostic performance; peanut allergy; peanut anaphylaxis

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4;

ANAPHYLAXIS; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PEANUT ALLERGY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SENSITIZATION; SOYBEAN;

2S ALBUMINS, PLANT; ADOLESCENT; ALLERGENS; ANTIBODY SPECIFICITY; ANTIGENS, PLANT; CHILD; CHILD, PRESCHOOL; CROSS REACTIONS; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE; PEANUT HYPERSENSITIVITY; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY;

EID: 84869499864     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12047     Document Type: Article

References (40)

1. Taylor SL, Hefle SL, Bindslev-Jensen C, Bock SA, Burks AW Jr, Christie L, et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J Allergy Clin Immunol 2002; 109: 24-30.
2. Sicherer SH, Sampson HA,. Food allergy. J Allergy Clin Immunol 2010; 125 (Suppl 2): S116-S125.
3. Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA,. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol 2010; 125: 1322-1326.
4. Bock SA, Munoz-Furlong A, Sampson HA,. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107: 191-193.
5. Bock SA, Munoz-Furlong A, Sampson HA,. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007; 119: 1016-1018.
6. Sampson HA, Mendelson L, Rosen JP,. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992; 327: 380-384.
7. Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC,. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2005; 116: 377-383.
8. Sporik R, Hill DJ, Hosking CS,. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy 2000; 30: 1540-1546.
9. Sampson HA,. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001; 107: 891-896.
10. Roberts G, Lack G,. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol 2005; 115: 1291-1296.
11. Beyer K, Morrow E, Li XM, Bardina L, Bannon GA, Burks AW, et al. Effects of cooking methods on peanut allergenicity. J Allergy Clin Immunol 2001; 107: 1077-1081.
12. Maleki SJ, Viquez O, Jacks T, Dodo H, Champagne ET, Chung SY, et al. The major peanut allergen, Ara h 2, functions as a trypsin inhibitor, and roasting enhances this function. J Allergy Clin Immunol 2003; 112: 190-195.
13. Krause S, Reese G, Randow S, Zennaro D, Quaratino D, Palazzo P, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. J Allergy Clin Immunol 2009; 124: 771-778 e5.
14. Mittag D, Akkerdaas J, Ballmer-Weber BK, Vogel L, Wensing M, Becker WM, et al. Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J Allergy Clin Immunol 2004; 114: 1410-1417.
15. Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 2010; 125: 191-197 e1-13.
16. Nicolaou N, Murray C, Belgrave D, Poorafshar M, Simpson A, Custovic A,. Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol 2011; 127: 684-685.
17. Astier C, Morisset M, Roitel O, Codreanu F, Jacquenet S, Franck P, et al. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol 2006; 118: 250-256.
18. Codreanu F, Collignon O, Roitel O, Thouvenot B, Sauvage C, Vilain AC, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis. Int Arch Allergy Immunol 2011; 154: 216-226.
19. Asarnoj A, Moverare R, Ostblom E, Poorafshar M, Lilja G, Hedlin G, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy 2010; 65: 1189-1195.
20. Peeters KA, Koppelman SJ, van Hoffen E, van der Tas CW,. den Hartog Jager CF, Penninks AH, et al. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy 2007; 37: 108-115.
21. Lewis SA, Grimshaw KE, Warner JO, Hourihane JO,. The promiscuity of immunoglobulin E binding to peanut allergens, as determined by Western blotting, correlates with the severity of clinical symptoms. Clin Exp Allergy 2005; 35: 767-773.
22. Flinterman AE, van Hoffen E,. den Hartog Jager CF, Koppelman S, Pasmans SG, Hoekstra MO, et al. Children with peanut allergy recognize predominantly Ara h2 and Ara h6, which remains stable over time. Clin Exp Allergy 2007; 37: 1221-1228.
23. Vereda A, van Hage M, Ahlstedt S, Ibanez MD, Cuesta-Herranz J, van Odijk J, et al. Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol 2011; 127: 603-607.
24. van Neerven RJ, Knol EF, Ejrnaes A, Wurtzen PA,. IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int Arch Allergy Immunol 2006; 141: 119-129.
25. Savilahti EM, Rantanen V, Lin JS, Karinen S, Saarinen KM, Goldis M, et al. Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. J Allergy Clin Immunol 2010; 125: 1315-1321 e9.
26. Tomicic S, Norrman G, Falth-Magnusson K, Jenmalm MC, Devenney I, Bottcher MF,. High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life. Pediatr Allergy Immunol 2009; 20: 35-41.
27. Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009; 124: 292-300, 300.e1-97.
28. Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler W, et al. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol 2011; 127: 640-646 e1.
29. Tsai HJ, Kumar R, Pongracic J, Liu X, Story R, Yu Y, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy 2009; 39: 101-109.
30. Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF Jr, Bock SA, Branum A, et al. Second symposium on the definition and management of anaphylaxis: summary report-Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006; 117: 391-397.
31. Ebo DG, Hagendorens MM, De Knop KJ, Verweij MM, Bridts CH, De Clerck LS, et al. Component-resolved diagnosis from latex allergy by microarray. Clin Exp Allergy 2010; 40: 348-358.
32. Strobl C, Boulesteix AL, Zeileis A, Hothorn T,. Bias in random forest variable importance measures: illustrations, sources and a solution. BMC Bioinformatics 2007; 8: 25.
33. Kulis M, Chen X, Lew J, Wang Q, Patel OP, Zhuang Y, et al. The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice. Clin Exp Allergy 2012; 42: 326-336.
34. Lin J, Bruni FM, Fu Z, Maloney J, Bardina L, Boner AL, et al. A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay. J Allergy Clin Immunol 2012; 129: 1321-1328 e5.
35. Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE, et al. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J Allergy Clin Immunol 2012; 129: 1056-1063.
36. Tay SS, Clark AT, Deighton J, King Y, Ewan PW,. Patterns of immunoglobulin G responses to egg and peanut allergens are distinct: ovalbumin-specific immunoglobulin responses are ubiquitous, but peanut-specific immunoglobulin responses are up-regulated in peanut allergy. Clin Exp Allergy 2007; 37: 1512-1518.
37. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, et al. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol 2008; 121: 737-743 e10.
38. Starkl P, Krishnamurthy D, Szalai K, Felix F, Lukschal A, Oberthuer D, et al. Heating Affects Structure, Enterocyte Adsorption and Signalling, As Well as Immunogenicity of the Peanut Allergen Ara h 2. Open Allergy J 2011; 4: 24-34.
39. Vissers YM, Blanc F, Skov PS, Johnson PE, Rigby NM, Przybylski-Nicaise L, et al. Effect of heating and glycation on the allergenicity of 2S albumins (Ara h 2/6) from peanut. PLoS One 2011; 6: e23998.
40. Gadisseur R, Chapelle JP, Cavalier E,. A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP(c) 250 with the ImmunoCAP(c) ISAC. Clin Chem Lab Med 2011; 49: 277-280.