T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer

Molecular Biology Reports

Volumn 39, Issue 11, 2012, Pages 9941-9946

  Tong, Danian ^a   Zhou, Yujia ^b   Chen, Wei ^a   Deng, Yang ^a   Li, Lei ^a   Jia, Zhenyi ^a   Qi, Dachuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Pancreatic cancer; Polymorphisms; T cell immunoglobulin and mucin domaincontaining molecule 3

Indexed keywords

MEMBRANE PROTEIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING MOLECULE 3; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CANCER INFILTRATION; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR; TIM3 GENE;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84869494310     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1862-y     Document Type: Article

References (24)

1. Shields MA, Dangi-Garimella S, Redig AJ, Munshi HG (2012) Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression. Biochem J 441: 541-552
2. Sun C, Rosendahl AH, Ansari D, Andersson R (2011) Proteomebased biomarkers in pancreatic cancer. World J Gastroenterol 17: 4845-4852
3. Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK (2011) Emerging TIM-3 functions in antimicrobial and tumor immunity. Trends Immunol 32: 9-345
4. Zhu C, Anderson AC, Kuchroo VK (2011) TIM-3 and its regulatory role in immune responses. Curr Top Microbiol Immunol 350: 1-15
5. Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH (2010) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235: 172-189
6. Pan HF, Zhang N, Li WX, Tao JH, Ye DQ (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep 37: 395-398
7. Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, Umetsu DT (2009) The costimulatory role of TIM molecules. Immunol Rev 229: 259-270
8. Su EW, Lin JY, Kane LP (2008) TIM-1 and TIM-3 proteins in immune regulation. Cytokine 44: 9-13
9. Anderson DE (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets 11: 1005-1009
10. Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, Lee YC, Chung HT (2004) Molecular variations in Th1-specific cell surface gene TIM-3. Exp Mol Med 36: 274-278
11. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK (2002) Th1-specific cell surface protein TIM-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541
12. Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB (2003) TIM-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 4: 1093-1101
13. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK (2003) Interaction of TIM-3 and TIM-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 4: 1102-1110
14. Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR, Fairweather D (2006) Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol 176: 6411-6415
15. Chae SC, Park YR, Shim SC, Yoon KS, Chung HT (2004) The polymorphisms of Th1 cell surface gene TIM-3 are associated in a Korean population with rheumatoid arthritis. Immunol Lett 95: 91-95
16. Chae SC, Park YR, Lee YC, Lee JH, Chung HT (2004) The association of TIM-3 gene polymorphism with atopic disease in Korean population. Hum Immunol 65: 1427-1431
17. Cao B, Zhu L, Zhu S, Li D, Zhang C, Xu C, Zhang S (2010) Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer. Cancer Immunol Immunother 59: 7-1851
18. Brück P, Ramos-Lopez E, Bartsch W, Böhme A, Badenhoop K (2008) TIM-3 polymorphisms in type 1 diabetes families. J Hum Genet 53: 559-564
19. Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC (2007) T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9- independent ligand-binding surface. Immunity 26: 311-321
20. Hu WK, Lu XX, Yang S, Xu GP, Lan F, Chen SX, Ni W, Xiong WN, Xiong SD (2010) Expression of the Th1-specific cell-surface protein TIM-3 increases in a murine model of atopic asthma. J Asthma 46: 872-877
21. Wu FH, Yuan Y, Li D, Lei Z, Song CW, Liu YY, Li B, Huang B, Feng ZH, Zhang GM (2010) Endothelial cell-expressed TIM-3 facilitatesmetastasis ofmelanoma cells by activating theNF-kappaB pathway. Oncol Rep 24: 693-699
22. Dorfman DM, Hornick JL, Shahsafaei A, Freeman GJ (2010) The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. Hum Pathol 41: 1486-1494
23. Su EW, Bi S, Kane LP (2011) Galectin-9 regulates T helper cell function independently of TIM-3. Glycobiology 21: 1258-1265
24. Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K (2010) TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell 7: 708-717