Inflammation and thrombosis: New insights

Frontiers in Bioscience - Scholar

Volumn 4 S, Issue 2, 2012, Pages 620-638

  Lester, Patrick A ^a,b   Diaz, Jose A ^b   Shuster, Katherine A ^a,b   Henke, Peter K ^b   Wakefield, Thomas W ^b   Myers, Daniel D ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adhesion molecules; Biomarkers; Inflammation; Inflammatory mediators; Microparticles; Murine models; Neutrophil extracellular traps; Review; Thrombogenesis; Thrombosis; Tissue factor; Vascular disease

Indexed keywords

ANTICOAGULANT AGENT; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; CYTOKINE; ENOXAPARIN; FIBRINOLYTIC AGENT; LOW MOLECULAR WEIGHT HEPARIN; PADGEM PROTEIN INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROCOAGULANT; PROTEIN INHIBITOR; SELECTIN; THROMBOPLASTIN; TIPLASININ; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; WARFARIN;

ARTERY THROMBOSIS; ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; BLOOD VESSEL WALL; DEEP VEIN THROMBOSIS; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL MODEL; HUMAN; INFLAMMATION; LOW DRUG DOSE; MEDIATOR; NEUTROPHIL; NONHUMAN; THROMBOSIS; VASCULAR THROMBOSIS; VEIN THROMBOSIS; VENOUS CIRCULATION; ANIMAL; BLOOD; PATHOLOGY; REVIEW;

MURINAE;

ANIMALS; HUMANS; INFLAMMATION; THROMBOSIS;

EID: 84869476666     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (160)

1. C. S. Kitchens: How I treat superficial venous thrombosis. Blood, 117(1), 39-44 (2011)
2. R. Virchow: Gessamelte Abhandlungen zur Wissenschaftlichen Medicin. A M Von Meidinger Sohn, Frankfurt (1856)
3. G. J. Stewart, W. G. Ritchie and P. R. Lynch: Venous endothelial damage produced by massive sticking and emigration of leukocytes. Am J Pathol, 74(3), 507-32 (1974)
4. H. Cai and D. G. Harrison: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res, 87(10), 840-4 (2000)
5. R. J. Bisoendial, M. Levi, P. P. Tak and E. S. Stroes: The prothrombotic state in rheumatoid arthritis: an additive risk factor for adverse cardiovascular events. Semin Thromb Hemost, 36(4), 452-7 (2010)
6. M. La Regina, A. Y. Gasparyan, F. Orlandini and D. Prisco: Behcet's Disease as a Model of Venous Thrombosis. Open Cardiovasc Med J, 4, 71-7 (2010)
7. M. A. Gimbrone, Jr.: Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol, 75(6), 67B-70B (1995)
8. R. Altman: Risk factors in coronary atherosclerosis athero-inflammation: the meeting point. Thromb J, 1(1), 4 (2003)
9. J. Bech-Laursen, M. Somers, S. Kurz, A. Warnholtz, L. McCxann, B. Freeman, M. Tarpley, T. Fukai and D. Harrison: Endothelial regulation of vasomotion in Apo (E) - deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation, 103(9), 1282-1288 (2001) (Pubitemid 32221353)
10. J. Loscalzo: Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res, 88(8), 756-62 (2001) (Pubitemid 32429970)
11. P. O. Bonetti, L. O. Lerman and A. Lerman: Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol, 23(2), 168-75 (2003) (Pubitemid 36231924)
12. M. Levi, E. de Jonge, T. van der Poll and H. ten Cate: Disseminated intravascular coagulation. Thromb Haemost, 82(2), 695-705 (1999)
13. P. R. Moreno, V. H. Bernardi, J. Lopez-Cuellar, A. M. Murcia, I. F. Palacios, H. K. Gold, R. Mehran, S. K. Sharma, Y. Nemerson, V. Fuster and J. T. Fallon: Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes. Circulation, 94(12), 3090-7 (1996) (Pubitemid 26427472)
14. A. N. De Maria: Relative risk of cardiovascular events in patients with rheumatoid arthritis. Am J Cardiol, 89(6A), 33D-38D (2002) (Pubitemid 34241486)
15. R. J. Shebuski and K. S. Kilgore: Role of inflammatory mediators in thrombogenesis. J Pharmacol Exp Ther, 300(3), 729-35 (2002) (Pubitemid 34164973)
16. J. A. Heit, A. T. Cohen, F. A. Anderson and V. T. E. I. A. G. on Behalf of the: Estimated Annual Number of Incident and Recurrent, Non-Fatal and Fatal Venous Thromboembolism (VTE) Events in the US. ASH Annual Meeting Abstracts, 106(11), 910-910 (2005)
17. J. A. Heit, T. M. Petterson, S. A. Farmer, K. R. Bailey and L. J. Melton: Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism: A 35-Year Population-Based Study. ASH Annual Meeting Abstracts, 108(11), 1488-1488 (2006)
18. W. W. Coon: Epidemiology of venous thromboembolism. Ann Surg, 186(2), 149-64 (1977) (Pubitemid 8152629)
19. F. A. Anderson, Jr., H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier and J. E. Dalen: A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med, 151(5), 933-8 (1991)
20. J. A. Heit, M. D. Silverstein, D. N. Mohr, T. M. Petterson, C. M. Lohse, W. M. O'Fallon and L. J. Melton, 3rd: The epidemiology of venous thromboembolism in the community. Thromb Haemost, 86(1), 452-63 (2001) (Pubitemid 32663974)
21. M. D. Silverstein, J. A. Heit, D. N. Mohr, T. M. Petterson, W. M. O'Fallon and L. J. Melton, 3rd: Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med, 158(6), 585-93 (1998) (Pubitemid 28144815)
22. M. C. Proctor and L. J. Greenfield: Pulmonary embolism: diagnosis, incidence and implications. Cardiovasc Surg, 5(1), 77-81 (1997) (Pubitemid 27219728)
23. R. D. Hull, G. F. Pineo and G. E. Raskob: The economic impact of treating deep vein thrombosis with low-molecular-weight heparin: outcome of therapy and health economy aspects. Haemostasis, 28 Suppl 3, 8-16 (1998) (Pubitemid 29049316)
24. E. Bernardi, P. Bagatella, M. Frulla, P. Simioni and P. Prandoni: Postthrombotic syndrome: incidence, prevention, and management. Seminars in Vascular Medicine, 1(1), 71-80 (2001)
25. P. K. Henke and A. J. Comerota: An update on etiology, prevention, and therapy of postthrombotic syndrome. Journal of Vascular Surgery: Official Publication, the Society for Vascular Surgery (and) International Society for Cardiovascular Surgery, North American Chapter, 53(2), 500-509 (2011)
26. T. W. Wakefield, R. M. Strieter, M. R. Prince, L. J. Downing and L. J. Greenfield: Pathogenesis of venous thrombosis: a new insight. Cardiovasc Surg, 5(1), 6-15 (1997) (Pubitemid 27219718)
27. D. R. Danilenko-Dixon, J. A. Heit, M. D. Silverstein, B. P. Yawn, T. M. Petterson, C. M. Lohse and L. J. Melton: Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum: a populationbased, case-control study. American Journal of Obstetrics and Gynecology, 184(2), 104-110 (2001) (Pubitemid 32141651)
28. C. M. Alvarado, J. A. Diaz, A. E. Hawley, S. K. Wrobleski, R. E. Sigler and D. D. Myers: Male mice have increased thrombotic potential: Sex differences in a mouse model of venous thrombosis. Thrombosis Research (2011)
29. M. D. Silverstein, J. A. Heit, D. N. Mohr, T. M. Petterson, W. M. O'Fallon and L. J. Melton: Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Archives of Internal Medicine, 158(6), 585-593 (1998) (Pubitemid 28144815)
30. J. A. Heit, M. D. Silverstein, D. N. Mohr, T. M. Petterson, W. M. O'Fallon and L. J. Melton: Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Archives of Internal Medicine, 160(6), 809-815 (2000) (Pubitemid 30165241)
31. J. A. Heit, W. M. O'Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr and L. J. Melton: Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Archives of Internal Medicine, 162(11), 1245-1248 (2002) (Pubitemid 34595030)
32. A. P. McDonald, T. R. Meier, A. E. Hawley, J. N. Thibert, D. M. Farris, S. K. Wrobleski, P. K. Henke, T. W. Wakefield and D. D. Myers, Jr.: Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis. Thromb Res, 125(1), 72-8 (2010)
33. H. Bjarnason, J. R. Kruse, D. A. Asinger, G. K. Nazarian, C. A. Dietz, M. D. Caldwell, N. S. Key, A. T. Hirsch and D. W. Hunter: Iliofemoral deep venous thrombosis: safety and efficacy outcome during 5 years of catheter-directed thrombolytic therapy. Journal of Vascular and Interventional Radiology: JVIR, 8(3), 405-418 (1997) (Pubitemid 27524134)
34. J. A. Heit, C. E. Kobbervig, A. H. James, T. M. Petterson, K. R. Bailey and L. J. Melton: Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Annals of Internal Medicine, 143(10), 697-706 (2005)
35. I. Hrachovinova, B. Cambien, A. Hafezi-Moghadam, J. Kappelmayer, R. T. Camphausen, A. Widom, L. Xia, H. H. Kazazian, Jr., R. G. Schaub, R. P. McEver and D. D. Wagner: Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med, 9(8), 1020-5 (2003) (Pubitemid 37021781)
36. D. Myers, Jr., D. Farris, A. Hawley, S. Wrobleski, A. Chapman, L. Stoolman, R. Knibbs, R. Strieter and T. Wakefield: Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res, 108(2), 212-21 (2002) (Pubitemid 36062701)
37. V. V. Sullivan, A. E. Hawley, D. M. Farris, B. S. Knipp, A. J. Varga, S. K. Wrobleski, P. Thanapron, M. J. Eagleton, D. D. Myers, J. B. Fowlkes and T. W. Wakefield: Decrease in fibrin content of venous thrombi in selectindeficient mice. J Surg Res, 109(1), 1-7 (2003) (Pubitemid 36263416)
38. V. Evangelista, Z. Pamuklar, A. Piccoli, S. Manarini, G. Dell'Elba, R. Pecce, N. Martelli, L. Federico, M. Rojas, G. Berton, C. A. Lowell, L. Totani and S. S. Smyth: Src family kinases mediate neutrophil adhesion to adherent platelets. Blood, 109(6), 2461-2469 (2007) (Pubitemid 46425889)
39. P. Andre, D. Hartwell, I. Hrachovinova, S. Saffaripour and D. D. Wagner: Pro-coagulant state resulting from high levels of soluble P-selectin in blood. Proc Natl Acad Sci U S A, 97(25), 13835-40 (2000)
40. K. J. Woollard: Soluble bio-markers in vascular disease: much more than gauges of disease? Clinical and Experimental Pharmacology and Physiology, 32(4), 233-240 (2005) (Pubitemid 40586055)
41. D. D. Myers, Jr., J. E. Rectenwald, P. W. Bedard, N. Kaila, G. D. Shaw, R. G. Schaub, D. M. Farris, A. E. Hawley, S. K. Wrobleski, P. K. Henke and T. W. Wakefield: Decreased venous thrombosis with an oral inhibitor of P selectin. J Vasc Surg, 42(2), 329-36 (2005) (Pubitemid 41139242)
42. D. D. Myers, Jr., P. K. Henke, P. W. Bedard, S. K. Wrobleski, N. Kaila, G. Shaw, T. R. Meier, A. E. Hawley, R. G. Schaub and T. W. Wakefield: Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg, 44(3), 625-32 (2006) (Pubitemid 44293198)
43. D. D. Myers, Jr., S. K. Wrobleski, C. Longo, P. W. Bedard, N. Kaila, G. D. Shaw, F. J. Londy, S. E. Rohrer, B. A. Fex, P. J. Zajkowski, T. R. Meier, A. E. Hawley, D. M. Farris, N. E. Ballard, P. K. Henke, R. G. Schaub and T. W. Wakefield: Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost, 97(3), 400-7 (2007) (Pubitemid 46437802)
44. T. R. Meier, D. D. Myers, Jr., S. K. Wrobleski, P. J. Zajkowski, A. E. Hawley, P. W. Bedard, N. E. Ballard, F. J. Londy, N. Kaila, G. P. Vlasuk, R. G. Schaub and T. W. Wakefield: Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation. Thromb Haemost, 99(2), 343-51 (2008) (Pubitemid 351230965)
45. A. D. Keefe and R. G. Schaub: Aptamers as candidate therapeutics for cardiovascular indications. Current Opinion in Pharmacology, 8(2), 147-152 (2008)
46. D. R. Gutsaeva, J. B. Parkerson, S. D. Yerigenahally, J. C. Kurz, R. G. Schaub, T. Ikuta and C. A. Head: Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood, 117(2), 727-735 (2011)
47. J. Chang, J. T. Patton, A. Sarkar, B. Ernst, J. L. Magnani and P. S. Frenette: GMI-1070, a novel panselectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood, 116(10), 1779-1786 (2010)
48. E. Ramacciotti, D. D. Myers, Jr., S. K. Wrobleski, K. B. Deatrick, F. J. Londy, J. E. Rectenwald, P. K. Henke, R. G. Schaub and T. W. Wakefield: P-selectin/PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis. Thromb Res, 125(4), e138-42 (2010)
49. H. I. Hassouna: Laboratory evaluation of hemostatic disorders. Hematology/Oncology Clinics of North America, 7(6), 1161-1249 (1993)
50. G. Palareti, B. Cosmi, C. Legnani, A. Tosetto, C. Brusi, A. Iorio, V. Pengo, A. Ghirarduzzi, C. Pattacini, S. Testa, A. W. A. Lensing and A. Tripodi: D-dimer testing to determine the duration of anticoagulation therapy. The New England Journal of Medicine, 355(17), 1780-1789 (2006) (Pubitemid 44631361)
51. F. Paganelli, M. C. Alessi, P. Morange, J. M. Maixent, S. Lévy and I. J. Vague: Relationship of plasminogen activator inhibitor-1 levels following thrombolytic therapy with rt-PA as compared to streptokinase and patency of infarct related coronary artery. Thrombosis and Haemostasis, 82(1), 104-108 (1999) (Pubitemid 29368781)
52. J. K. Hennan, H. Elokdah, M. Leal, A. Ji, G. S. Friedrichs, G. A. Morgan, R. E. Swillo, T. M. Antrilli, A. Hreha and D. L. Crandall: Evaluation of PAI-039 ({1-benzyl-5-(4-(trifluoromethoxy) phenyl)-1H-indol-3-yl} (oxo) acetic acid), a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis. J Pharmacol Exp Ther, 314(2), 710-6 (2005) (Pubitemid 41043853)
53. S. Baxi, D. L. Crandall, T. R. Meier, S. Wrobleski, A. Hawley, D. Farris, H. Elokdah, R. Sigler, R. G. Schaub, T. Wakefield and D. Myers: Dose-dependent thrombus resolution due to oral plaminogen activator inhibitor (PAI) - 1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis. Thromb Haemost, 99(4), 749-58 (2008) (Pubitemid 351694231)
54. G. Lippi, M. Franchini, G. L. Salvagno, M. Montagnana, G. Poli and G. C. Guidi: Correlation between von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity and factor VIII activity in plasma. J Thromb Thrombolysis, 26(2), 150-3 (2008)
55. D. D. Wagner, J. B. Olmsted and V. J. Marder: Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol, 95(1), 355-60 (1982) (Pubitemid 13208536)
56. J. E. Sadler, T. Matsushita, Z. Dong, E. A. Tuley and L. A. Westfield: Molecular mechanism and classification of von Willebrand disease. Thromb Haemost, 74(1), 161-6 (1995)
57. W. Bergmeier, A. K. Chauhan and D. D. Wagner: Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Thromb Haemost, 99(2), 264-70 (2008) (Pubitemid 351230954)
58. A. K. Chauhan, J. Kisucka, C. B. Lamb, W. Bergmeier and D. D. Wagner: von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood, 109(6), 2424-9 (2007) (Pubitemid 46425884)
59. H. M. Tsai, Sussman, II and R. L. Nagel: Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood, 83(8), 2171-9 (1994) (Pubitemid 24112728)
60. M. Furlan, R. Robles and B. Lammle: Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood, 87(10), 4223-34 (1996) (Pubitemid 26152266)
61. Z. M. Ruggeri: Von Willebrand factor, platelets and endothelial cell interactions. J Thromb Haemost, 1(7), 1335-42 (2003)
62. J. M. Cosemans, S. E. Schols, L. Stefanini, S. de Witt, M. A. Feijge, K. Hamulyak, H. Deckmyn, W. Bergmeier and J. W. Heemskerk: Key role of glycoprotein Ib-V-IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood, 117(2), 651-60 (2011)
63. D. Myers, D. Farris, A. Hawley, S. Wrobleski, A. Chapman, L. Stoolman, R. Knibbs, R. Strieter and T. Wakefield: Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. The Journal of Surgical Research, 108(2), 212-221 (2002) (Pubitemid 36062701)
64. D. D. Wagner and P. S. Frenette: The vessel wall and its interactions. Blood, 111(11), 5271-5281 (2008)
65. B. M. Wojcik, S. K. Wrobleski, A. E. Hawley, T. W. Wakefield, D. D. Myers and J. A. Diaz: Interleukin-6: a potential target for post-thrombotic syndrome. Annals of Vascular Surgery, 25(2), 229-239 (2011)
66. C. T. Esmon: Crosstalk between inflammation and thrombosis. Maturitas, 61(1-2), 122-131 (2008)
67. P. Andre, K. S. Prasad, C. V. Denis, M. He, J. M. Papalia, R. O. Hynes, D. R. Phillips and D. D. Wagner: CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med, 8(3), 247-52 (2002) (Pubitemid 34250102)
68. P. K. Henke, L. A. De Brunye, R. M. Strieter, J. S. Bromberg, M. Prince, A. M. Kadell, M. Sarkar, F. Londy and T. W. Wakefield: Viral IL-10 gene transfer decreases inflammation and cell adhesion molecule expression in a rat model of venous thrombosis. Journal of Immunology (Baltimore, Md.: 1950), 164(4), 2131-2141 (2000) (Pubitemid 30108772)
69. K. G. Mann, C. van't Veer, K. Cawthern and S. Butenas: The role of the tissue factor pathway in initiation of coagulation. Blood Coagul Fibrinolysis, 9 Suppl 1, S3-7 (1998) (Pubitemid 28511559)
70. Y. Nemerson: Tissue factor and hemostasis. Blood, 71(1), 1-8 (1988) (Pubitemid 18050383)
71. T. J. Girard, L. A. Warren, W. F. Novotny, K. M. Likert, S. G. Brown, J. P. Miletich and G. J. Broze: Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature, 338(6215), 518-520 (1989) (Pubitemid 19107996)
72. N. Mackman: Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol, 24(6), 1015-22 (2004) (Pubitemid 38737825)
73. P. L. Giesen, U. Rauch, B. Bohrmann, D. Kling, M. Roque, J. T. Fallon, J. J. Badimon, J. Himber, M. A. Riederer and Y. Nemerson: Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A, 96(5), 2311-5 (1999) (Pubitemid 29117911)
74. U. Rauch and Y. Nemerson: Tissue factor, the blood, and the arterial wall. Trends Cardiovasc Med, 10(4), 139-43 (2000) (Pubitemid 32178189)
75. N. S. Key, A. Slungaard, L. Dandelet, S. C. Nelson, C. Moertel, L. A. Styles, F. A. Kuypers and R. R. Bach: Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease. Blood, 91(11), 4216-23 (1998) (Pubitemid 28261985)
76. R. Nieuwland, R. J. Berckmans, R. C. Rotteveel-Eijkman, K. N. Maquelin, K. J. Roozendaal, P. G. Jansen, K. ten Have, L. Eijsman, C. E. Hack and A. Sturk: Cellderived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation, 96(10), 3534-41 (1997) (Pubitemid 27513430)
77. K. Joop, R. J. Berckmans, R. Nieuwland, J. Berkhout, F. P. Romijn, C. E. Hack and A. Sturk: Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost, 85(5), 810-20 (2001) (Pubitemid 32421813)
78. Z. Mallat, B. Hugel, J. Ohan, G. Leseche, J. M. Freyssinet and A. Tedgui: Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation, 99(3), 348-53 (1999) (Pubitemid 29051259)
79. M. Diamant, R. Nieuwland, R. F. Pablo, A. Sturk, J. W. Smit and J. K. Radder: Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus. Circulation, 106(19), 2442-7 (2002) (Pubitemid 35278799)
80. S. M. Day, J. L. Reeve, B. Pedersen, D. M. Farris, D. D. Myers, M. Im, T. W. Wakefield, N. Mackman and W. P. Fay: Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood, 105(1), 192-8 (2005) (Pubitemid 40053082)
81. C. T. Esmon: Role of coagulation inhibitors in inflammation. Thromb Haemost, 86(1), 51-6 (2001) (Pubitemid 32663936)
82. E. F. Grabowski and F. P. Lam: Endothelial cell function, including tissue factor expression, under flow conditions. Thromb Haemost, 74(1), 123-8 (1995)
83. M. Ernofsson and A. Siegbahn: Platelet-derived growth factor-BB and monocyte chemotactic protein-1 induce human peripheral blood monocytes to express tissue factor. Thromb Res, 83(4), 307-20 (1996) (Pubitemid 26284128)
84. R. Pawlinski and N. Mackman: Cellular sources of tissue factor in endotoxemia and sepsis. Thrombosis Research, 125(Supplement 1), S70-S73-S70-S73 (2010)
85. N. Mackman, R. E. Tilley and N. S. Key: Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis. Arterioscler Thromb Vasc Biol, 27(8), 1687-1693 (2007) (Pubitemid 47207163)
86. B. Østerud and E. Bjørklid: Sources of tissue factor. Seminars in Thrombosis and Hemostasis, 32(1), 11-23 (2006)
87. U. Rauch, D. Bonderman, B. Bohrmann, J. J. Badimon, J. Himber, M. A. Riederer and Y. Nemerson: Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood, 96(1), 170-5 (2000) (Pubitemid 30456467)
88. B. Furie, B. C. Furie and R. Flaumenhaft: A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion. Thromb Haemost, 86(1), 214-21 (2001) (Pubitemid 32666187)
89. M. S. Goel and S. L. Diamond: Neutrophil enhancement of fibrin deposition under flow through platelet-dependent and -independent mechanisms. Arterioscler Thromb Vasc Biol, 21(12), 2093-8 (2001) (Pubitemid 34219767)
90. P. S. Frenette, C. V. Denis, L. Weiss, K. Jurk, S. Subbarao, B. Kehrel, J. H. Hartwig, D. Vestweber and D. D. Wagner: P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med, 191(8), 1413-22 (2000) (Pubitemid 30227127)
91. V. E. Armstead, A. G. Minchenko, R. Scalla and A. M. Lefer: Pulmonary tissue factor mRNA expression during murine traumatic shock: effect of P-selectin blockade. Shock, 15(4), 323-6 (2001) (Pubitemid 33596727)
92. C. Vidal, C. Spaulding, F. Picard, F. Schaison, J. Melle, S. Weber and M. Fontenay-Roupie: Flow cytometry detection of platelet procoagulation activity and microparticles in patients with unstable angina treated by percutaneous coronary angioplasty and stent implantation. Thromb Haemost, 86(3), 784-90 (2001) (Pubitemid 32834186)
93. N. A. Swords, P. B. Tracy and K. G. Mann: Intact platelet membranes, not platelet-released microvesicles, support the procoagulant activity of adherent platelets. Arterioscler Thromb, 13(11), 1613-22 (1993) (Pubitemid 23328480)
94. D. Kirchhofer, T. B. Tschopp, B. Steiner and H. R. Baumgartner: Role of collagen-adherent platelets in mediating fibrin formation in flowing whole blood. Blood, 86(10), 3815-22 (1995)
95. A. Celi, G. Pellegrini, R. Lorenzet, A. De Blasi, N. Ready, B. C. Furie and B. Furie: P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A, 91(19), 8767-71 (1994)
96. J. M. Walenga, W. P. Jeske and H. L. Messmore: Mechanisms of venous and arterial thrombosis in heparininduced thrombocytopenia. J Thromb Thrombolysis, 10 Suppl 1, 13-20 (2000)
97. M. Mesri and D. C. Altieri: Endothelial cell activation by leukocyte microparticles. J Immunol, 161(8), 4382-7 (1998) (Pubitemid 28469024)
98. M. Mesri and D. C. Altieri: Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. J Biol Chem, 274(33), 23111-8 (1999)
99. C. M. Boulanger, A. Scoazec, T. Ebrahimian, P. Henry, E. Mathieu, A. Tedgui and Z. Mallat: Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation, 104(22), 2649-52 (2001) (Pubitemid 33108128)
100. F. Sabatier, V. Roux, F. Anfosso, L. Camoin, J. Sampol and F. Dignat-George: Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. Blood, 99(11), 3962-70 (2002) (Pubitemid 35332035)
101. E. Biro, K. N. Sturk-Maquelin, G. M. Vogel, D. G. Meuleman, M. J. Smit, C. E. Hack, A. Sturk and R. Nieuwland: Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost, 1(12), 2561-8 (2003)
102. E. Ramacciotti, A. E. Hawley, D. M. Farris, N. E. Ballard, S. K. Wrobleski, D. D. Myers, Jr., P. K. Henke and T. W. Wakefield: Leukocyte-and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis. Thromb Haemost, 101(4), 748-54 (2009)
103. N. M. Abdullah, M. Kachman, A. Walker, A. E. Hawley, S. K. Wrobleski, D. D. Myers, J. R. Strahler, P. C. Andrews, G. C. Michailidis, E. Ramacciotti, P. K. Henke and T. W. Wakefield: Microparticle surface protein are associated with experimental venous thrombosis: a preliminary study. Clin Appl Thromb Hemost, 15(2), 201-8 (2009)
104. M. W. Mosesson: Fibrinogen gamma chain functions. J Thromb Haemost, 1(2), 231-8 (2003)
105. K. Yokoyama, H. P. Erickson, Y. Ikeda and Y. Takada: Identification of amino acid sequences in fibrinogen gamma - chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3. J Biol Chem, 275(22), 16891-8 (2000) (Pubitemid 30398926)
106. S. Johansson and M. Hook: Substrate adhesion of rat hepatocytes: on the mechanism of attachment to fibronectin. J Cell Biol, 98(3), 810-7 (1984) (Pubitemid 14166510)
107. A. L. Main, T. S. Harvey, M. Baron, J. Boyd and I. D. Campbell: The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell, 71(4), 671-8 (1992)
108. E. Ramacciotti, A. E. Hawley, S. K. Wrobleski, D. D. Myers, Jr., J. R. Strahler, P. C. Andrews, K. E. Guire, P. K. Henke and T. W. Wakefield: Proteomics of microparticles after deep venous thrombosis. Thromb Res, 125(6), e269-74
109. I. Iurisci, A. Cumashi, A. A. Sherman, Y. E. Tsvetkov, N. Tinari, E. Piccolo, M. D'Egidio, V. Adamo, C. Natoli, G. A. Rabinovich, S. Iacobelli and N. E. Nifantiev: Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis. Anticancer Res, 29(1), 403-10 (2009)
110. J. A. Diaz, E. Ramacciotti and T. W. Wakefield: Do galectins play a role in venous thrombosis? a review. Thromb s, 125(5), 373-6 (2010)
111. R. J. Berckmans, R. Neiuwland, A. N. Boing, F. P. Romijn, C. E. Hack and A. Sturk: Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost, 85(4), 639-46 (2001) (Pubitemid 32293699)
112. L. L. Horstman, W. Jy, J. J. Jimenez, C. Bidot and Y. S. Ahn: New horizons in the analysis of circulating cellderived microparticles. Keio J Med, 53(4), 210-30 (2004) (Pubitemid 40139594)
113. W. Jy, L. L. Horstman, J. J. Jimenez, Y. S. Ahn, E. Biro, R. Nieuwland, A. Sturk, F. Dignat-George, F. Sabatier, L. Camoin-Jau, J. Sampol, B. Hugel, F. Zobairi, J. M. Freyssinet, S. Nomura, A. S. Shet, N. S. Key and R. P. Hebbel: Measuring circulating cell-derived microparticles. J Thromb Haemost, 2(10), 1842-51 (2004) (Pubitemid 40197488)
114. D. T. Giacobbe and M. J. Murray: Vascular disease and inflammation. Anesthesiol Clin North America, 22(2), 183-97, v (2004) (Pubitemid 38739145)
115. P. Libby, P. M. Ridker and A. Maseri: Inflammation and atherosclerosis. Circulation, 105(9), 1135-43 (2002) (Pubitemid 34212626)
116. M. R. Varma, A. J. Varga, B. S. Knipp, P. Sukheepod, G. R. Upchurch, S. L. Kunkel, T. W. Wakefield and P. K. Henke: Neutropenia impairs venous thrombosis resolution in the rat. J Vasc Surg, 38(5), 1090-8 (2003) (Pubitemid 37409647)
117. T. W. Wakefield, R. M. Strieter, C. A. Wilke, A. M. Kadell, S. K. Wrobleski, M. D. Burdick, R. Schmidt, S. L. Kunkel and L. J. Greenfield: Venous Thrombosis Associated Inflammation and Attenuation With Neutralizing Antibodies to Cytokines and Adhesion Molecules. Arterioscler Thromb Vasc Biol, 15(2), 258-268 (1995)
118. J. Lin, M. C. Proctor, M. Varma, L. J. Greenfield, G. R. Upchurch, Jr. and P. K. Henke: Factors associated with recurrent venous thromboembolism in patients with malignant disease. J Vasc Surg, 37(5), 976-83 (2003) (Pubitemid 36538919)
119. M. R. Varma, A. J. Varga, B. S. Knipp, P. Sukheepod, G. R. Upchurch, S. L. Kunkel, T. W. Wakefield and P. K. Henke: Neutropenia impairs venous thrombosis resolution in the rat. Journal of Vascular Surgery: Official Publication, the Society for Vascular Surgery (and) International Society for Cardiovascular Surgery, North American Chapter, 38(5), 1090-1098 (2003) (Pubitemid 37409647)
120. P. K. Henke, A. Varga, S. De, C. B. Deatrick, J. Eliason, D. A. Arenberg, P. Sukheepod, P. Thanaporn, S. L. Kunkel, G. R. Upchurch and T. W. Wakefield: Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(6), 1130-1137 (2004) (Pubitemid 38737842)
121. P. Saha, J. Humphries, B. Modarai, K. Mattock, M. Waltham, C. E. Evans, A. Ahmad, A. S. Patel, S. Premaratne, O. T. A. Lyons and A. Smith: Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(3), 506-512 (2011)
122. J. Humphries, C. L. McGuinness, A. Smith, M. Waltham, R. Poston and K. G. Burnand: Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi. J Vasc Surg, 30(5), 894-9 (1999)
123. A. D. Northeast, K. S. Soo, L. G. Bobrow, P. J. Gaffney and K. G. Burnand: The tissue plasminogen activator and urokinase response in vivo during natural resolution of venous thrombus. J Vasc Surg, 22(5), 573-9 (1995)
124. K. S. Soo, A. D. Northeast, L. C. Happerfield, K. G. Burnand and L. G. Bobrow: Tissue plasminogen activator production by monocytes in venous thrombolysis. J Pathol, 178(2), 190-4 (1996) (Pubitemid 26057971)
125. I. Singh, K. G. Burnand, M. Collins, A. Luttun, D. Collen, B. Boelhouwer and A. Smith: Failure of thrombus to resolve in urokinase-type plasminogen activator geneknockout mice: rescue by normal bone marrow-derived cells. Circulation, 107(6), 869-75 (2003) (Pubitemid 36241046)
126. V. Brinkmann, U. Reichard, C. Goosmann, B. Fauler, Y. Uhlemann, D. S. Weiss, Y. Weinrauch and A. Zychlinsky: Neutrophil extracellular traps kill bacteria. Science, 303(5663), 1532-5 (2004) (Pubitemid 38314426)
127. T. A. Fuchs, U. Abed, C. Goosmann, R. Hurwitz, I. Schulze, V. Wahn, Y. Weinrauch, V. Brinkmann and A. Zychlinsky: Novel cell death program leads to neutrophil extracellular traps. J Cell Biol, 176(2), 231-41 (2007) (Pubitemid 46143263)
128. V. Papayannopoulos and A. Zychlinsky: NETs: a new strategy for using old weapons. Trends Immunol, 30(11), 513-21 (2009)
129. F. Wartha and B. Henriques-Normark: ETosis: a novel cell death pathway. Sci Signal, 1(21), pe25 (2008)
130. K. Kessenbrock, M. Krumbholz, U. Schonermarck, W. Back, W. L. Gross, Z. Werb, H. J. Grone, V. Brinkmann and D. E. Jenne: Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med, 15(6), 623-5 (2009)
131. S. R. Clark, A. C. Ma, S. A. Tavener, B. McDonald, Z. Goodarzi, M. M. Kelly, K. D. Patel, S. Chakrabarti, E. McAvoy, G. D. Sinclair, E. M. Keys, E. Allen-Vercoe, R. Devinney, C. J. Doig, F. H. Green and P. Kubes: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med, 13(4), 463-9 (2007) (Pubitemid 46559832)
132. T. A. Fuchs, A. Brill, D. Duerschmied, D. Schatzberg, M. Monestier, D. D. Myers, Jr., S. K. Wrobleski, T. W. Wakefield, J. H. Hartwig and D. D. Wagner: Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A, 107(36), 15880-5 (2010)
133. S. M. Stevens, C. Gregory Elliott, S. C. Woller, L. Li, S. T. Bennett, M. Egger and G. L. Snow: The use of a fixed high sensitivity to evaluate five D-dimer assays' ability to rule out deep venous thrombosis: a novel approach. Br J Haematol, 131(3), 341-7 (2005) (Pubitemid 43899666)
134. P. S. Wells, D. R. Anderson, M. Rodger, M. Forgie, C. Kearon, J. Dreyer, G. Kovacs, M. Mitchell, B. Lewandowski and M. J. Kovacs: Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med, 349(13), 1227-35 (2003) (Pubitemid 37152032)
135. H. S. Khaira and J. Mann: Plasma D-dimer measurement in patients with suspected DVT-a means of avoiding unnecessary venography. Eur J Vasc Endovasc Surg, 15(3), 235-8 (1998) (Pubitemid 28163674)
136. J. E. Rectenwald, D. D. Myers, Jr., A. E. Hawley, C. Longo, P. K. Henke, K. E. Guire, A. H. Schmaier and T. W. Wakefield: D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study. Thromb Haemost, 94(6), 1312-7 (2005) (Pubitemid 41819632)
137. R. S. Bobrow: Excess factor VIII: a common cause of hypercoagulability. The Journal of the American Board of Family Practice/American Board of Family Practice, 18(2), 147-149 (2005) (Pubitemid 41664020)
138. N. L. Smith, K. M. Rice, E. G. Bovill, M. Cushman, J. C. Bis, B. McKnight, T. Lumley, N. L. Glazer, A. van Hylckama Vlieg, W. Tang, A. Dehghan, D. P. Strachan, C. J. O'Donnell, J. I. Rotter, S. R. Heckbert, B. M. Psaty and F. R. Rosendaal: Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis. Blood (2010)
139. J. G. Wang, D. Manly, D. Kirchhofer, R. Pawlinski and N. Mackman: Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice. Journal of Thrombosis and Haemostasis: JTH, 7(7), 1092-1098 (2009)
140. A. S. C. Yong, G. J. Pennings, M. Chang, A. Hamzah, T. Chung, M. Qi, D. Brieger, M. Behnia, S. A. Krilis, M. K. C. Ng, H. C. Lowe and L. Kritharides: Intracoronary shear-related up-regulation of platelet P-selectin and
141. D. M. Barnes, T. W. Wakefield and J. E. Rectenwald: Novel Biomarkers Associated with Deep Venous Thrombosis: A Comprehensive Review. Biomark Insights, 3, 93-100 (2008)
142. R. K. Andrews and M. C. Berndt: Microparticles facilitate neutrophil/platelet crosstalk. Blood, 112(6), 2174-2175 (2008)
143. R. K. Popuri and S. Vedantham: The role of thrombolysis in the clinical management of deep vein thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(3), 479-484 (2011)
144. M. W. Mewissen, G. R. Seabrook, M. H. Meissner, J. Cynamon, N. Labropoulos and S. H. Haughton: Catheterdirected Thrombolysis for Lower Extremity Deep Venous Thrombosis: Report of a National Multicenter Registry1. Radiology, 211(1), 39-49 (1999) (Pubitemid 29161732)
145. A. J. Comerota, R. C. Throm, S. D. Mathias, S. Haughton and M. Mewissen: Catheter-directed thrombolysis for iliofemoral deep venous thrombosis improves health-related quality of life. Journal of Vascular Surgery: Official Publication, the Society for Vascular Surgery (and) International Society for Cardiovascular Surgery, North American Chapter, 32(1), 130-137 (2000) (Pubitemid 30461161)
146. H. Sillesen, S. Just, M. Jørgensen and N. Baekgaard: Catheter directed thrombolysis for treatment of iliofemoral deep venous thrombosis is durable, preserves venous valve function and may prevent chronic venous insufficiency. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, 30(5), 556-562 (2005) (Pubitemid 41472430)
147. S. Konstantinides, A. Geibel, M. Olschewski, F. Heinrich, K. Grosser, K. Rauber, S. Iversen, M. Redecker, J. Kienast, H. Just and W. Kasper: Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation, 96(3), 882-888 (1997) (Pubitemid 27329623)
148. D. T. Eitzman, R. J. Westrick, E. G. Nabel and D. Ginsburg: Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood, 95(2), 577-80 (2000) (Pubitemid 30041672)
149. D. D. Myers, A. E. Hawley, D. M. Farris, S. K. Wrobleski, P. Thanaporn, R. G. Schaub, D. D. Wagner, A. Kumar and T. W. Wakefield: P-selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg, 38(5), 1075-89 (2003) (Pubitemid 37409646)
150. D. D. Myers, S. K. Wrobleski, P. K. Henke and T. W. Wakefield: Coagulation Biology. In: Surgical research. Ed W. W. Souba and D. W. Wilmore. Academic Press, San Diego, CA (2001)
151. B. C. Cooley, L. Szema, C. Y. Chen, J. P. Schwab and G. Schmeling: A murine model of deep vein thrombosis: characterization and validation in transgenic mice. Thromb Haemost, 94(3), 498-503 (2005) (Pubitemid 41300842)
152. I. Singh, A. Smith, B. Vanzieleghem, D. Collen, K. Burnand, J. M. Saint-Remy and M. Jacquemin: Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model. Blood, 99(9), 3235-40 (2002) (Pubitemid 34525303)
153. S. S. Pierangeli, J. H. Barker, D. Stikovac, D. Ackerman, G. Anderson, J. Barquinero, R. Acland and E. N. Harris: Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thromb Haemost, 71(5), 670-4 (1994)
154. S. S. Pierangeli, X. W. Liu, J. H. Barker, G. Anderson and E. N. Harris: Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome. Thromb Haemost, 74(5), 1361-7 (1995)
155. S. M. Day, J. L. Reeve, D. D. Myers and W. P. Fay: Murine thrombosis models. Thromb Haemost, 92(3), 486-94 (2004) (Pubitemid 39248005)
156. R. Moore, A. Hawley, R. Sigler, D. Farris, S. Wrobleski, E. Ramacciotti and D. Myers: Tissue inhibitor of metalloproteinase-1 is an early marker of acute endothelial dysfunction in a rodent model of venous oxidative injury. Ann Vasc Surg, 23(4), 498-505 (2009)
157. P. K. Henke, A. Varga, S. De, C. B. Deatrick, J. Eliason, D. A. Arenberg, P. Sukheepod, P. Thanaporn, S. L. Kunkel, G. R. Upchurch, Jr. and T. W. Wakefield: Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol, 24(6), 1130-7 (2004) (Pubitemid 38737842)
158. K. G. Burnand, P. J. Gaffney, C. L. McGuinness, J. Humphries, J. W. Quarmby and A. Smith: The role of the monocyte in the generation and dissolution of arterial and venous thrombi. Cardiovasc Surg, 6(2), 119-25 (1998) (Pubitemid 28202240)
159. S. S. Pierangeli, S. W. Liu, G. Anderson, J. H. Barker and E. N. Harris: Thrombogenic properties of murine anticardiolipin antibodies induced by beta 2 glycoprotein 1 and human immunoglobulin G antiphospholipid antibodies. Circulation, 94(7), 1746-51 (1996) (Pubitemid 26320284)
160. J. A. Diaz, A. E. Hawley, C. M. Alvarado, A. M. Berguer, N. K. Baker, S. K. Wrobleski, T. W. Wakefield, B. R. Lucchesi and D. D. Myers, Jr.: Thrombogenesis with continuous blood flow in the inferior vena cava. A novel mouse model. Thromb Haemost, 104(2), 366-75 (2010)