Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools

Expert Review of Molecular Diagnostics

Volumn 12, Issue 7, 2012, Pages 767-780

  Ferreri, Carla ^a   Chatgilialoglu, Chryssostomos ^a  

^a CNR   (Italy)

Author keywords

biomarker; fatty acids; lipid signaling; lipidomic profiles; mediator lipidomics; membrane lipidomics; molecular diagnostics; nutraceuticals; trans lipids

Indexed keywords

4 HYDROXYNONENAL; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ARACHIDONIC ACID; BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; FATTY ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN; ISOPROSTANE DERIVATIVE; LIPIDOME; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MONOUNSATURATED FATTY ACID; NUTRACEUTICAL; OLIVE OIL; PHOSPHOLIPASE A2; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; TRANS FATTY ACID;

ALZHEIMER DISEASE; ATHEROGENESIS; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CARDIOVASCULAR DISEASE; CYSTIC FIBROSIS; DISEASE MARKER; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; FAT INTAKE; GAS CHROMATOGRAPHY; HUMAN; ISOMER; ISOMERIZATION; LIPID MEMBRANE; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDOMICS; MOLECULAR DIAGNOSIS; NONHUMAN; OXIDATIVE STRESS; PHOSPHOLIPID MEMBRANE; PREGNANCY; REVIEW; SIGNAL TRANSDUCTION;

BIOLOGICAL MARKERS; FATTY ACIDS; HUMANS; LIPIDS; MEMBRANE LIPIDS; METABOLOMICS;

EID: 84869454145     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.12.73     Document Type: Review

References (93)

1. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purifcation of total lipides from animal tissues. J. Biol. Chem. 226(1), 497-509 (1957).
2. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purifcation. Can. J. Biochem. Physiol. 37(8), 911-917 (1959).
3. Han X, Gross RW. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom. Rev. 24(3), 367-412 (2005). (Pubitemid 40665798)
4. Han X, Gross RW. Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-r elated diseases. Am. J. Physiol. Endocrinol. Metab. 297, E297-E303 (2009).
5. Oresic M, Hänninen VA, Vidal-Puig A. Lipidomics: a new window to biomedical frontiers. Trends Biotechnol. 26(12), 647-652 (2008).
6. Han X. Neurolipidomics: challenges and developments. Front. Biosci. 12, 2601-2615 (2007).
7. Chatgilialoglu C, Ferreri C. Fatty acids and phospholipids. In: Cis-trans Isomerization in Biochemistry. Dugave C (Ed.). Wiley-VCH, Weinheim, Germany, 92-112 (2006).
8. Ferreri C. Trans fatty acids and oxidative transformations by free radicals: the role in health. In: Fatty Acids in Health Promotion and Disease Causation. Watson RR (Ed.). AOCS Press, IL, USA, 379-405 (2009).
9. Kitano H. Systems biology: a brief overview. Science 295(5560), 1662-1664 (2002). (Pubitemid 34202893)
10. Else PL, Hulbert AJ. Membranes as metabolic pacemakers. Clin. Exp. Pharmacol. Physiol. 30(8), 559-564 (2003). (Pubitemid 37011596)
11. Lauritzen L, Hansen HS, Jørgensen MH, Michaelsen KF. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog. Lipid Res. 40(1-2), 1-94 (2001). (Pubitemid 32008650)
12. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. Garland Science, NY, USA (2002).
13. Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem. Rev. 111(10), 6130-6185 (2011).
14. Baburina I, Jackowski S. Cellular responses to excess phospholipid. J. Biol. Chem. 273, 2169-2173 (1998).
15. Fox BG, Lyle KS, Rogge CE. Reactions of the diiron enzyme stearoyl-acyl carrier protein desaturase. Acc. Chem. Res. 37(7), 421-429 (2004).
16. Pala V, Krogh V, Muti P et al. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J. Natl Cancer Inst. 93 (14), 1088-1095 (2001). (Pubitemid 32717541)
17. Puca AA, Novelli V, Viviani C et al. Lipid profle of erythrocyte membranes as possible biomarker of longevity. Rejuven. Res. 11, 63-72 (2008). (Pubitemid 351271623)
18. Stoll LL, Spector AA. Changes in serum infuence the fatty acid composition of established cell lines. In Vitro 20(9), 732-738 (1984). (Pubitemid 15166407)
19. Ulloth JE, Casiano CA, De Leon M. Palmitic and stearic fatty acids induce caspase-dependent and-independent cell death in nerve growth factor differentiated PC12 cells. J. Neurochem. 84(4), 655-668 (2003). (Pubitemid 36176924)
20. Landau Z, Forti E, Alcaly M, Birk RZ. Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells. Apoptosis 11 (5), 717-724 (2006). (Pubitemid 43876841)
21. Andersson C, Al-Turkmani MR, Savaille JE et al. Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. J. Lipid Res. 49(8), 1692-1700 (2008).
22. Cohen G, Riahi Y, Shamni O et al. Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion. Diabetes 60(11), 2830-2842 (2011).
23. Pietiläinen KH, Róg T, Seppänen-Laakso T et al. Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol. 9(6), e1000623 (2011).
24. Hulbert AJ. Explaining longevity of different animals: is membrane fatty acid composition the missing link? Age (Dordr.) 30(2-3), 89-97 (2008).
25. Kim OY, Lim HH, Yang LI, Chae JS, Lee JH. Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study. Nutr. Metab. (Lond.) 8(1), 24 (2011).
26. Litman BJ, Mitchell DC. A role for phospholipid polyunsatu ration in modulating membrane protein function. Lipids 31, S193-S197 (1996).
27. Gawrisch K, Soubias O, Mihailescu M. Insights from biophysical studies on the role of polyunsatu rated fatty acids for function of G-protein coupled membrane receptors. Prostaglandins Leukot. Essent. Fatty Acids 79(3-5), 131-134 (2008).
28. Warensjö E, Ohrvall M, Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr. Metab. Cardiovasc. Dis. 16(2), 128-136 (2006). (Pubitemid 43384710)
29. Jonas A. Lecithin cholesterol acyltransferase. Biochim. Biophys. Acta 1529(1-3), 245-256 (2000).
30. Simonsen NR, Fernandez-Crehuet Navajas J, Martin-Moreno JM et al. Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Am. J. Clin. Nutr. 68(1), 134-141 (1998).
31. Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43(2), 134-176 (2004). (Pubitemid 37492937)
32. Mashima T, Seimiya H, Tsuruo T. De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br. J. Cancer 100(9), 1369-1372 (2009).
33. Chajès V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res. 66(10), 5287-5294 (2006). (Pubitemid 43844953)
34. Igal RA. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31(9), 1509-1515 (2010).
35. Scaglia N, Igal RA. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int. J. Oncol. 33(4), 839-850 (2008).
36. Stables MJ, Gilroy DW. Old and new generation lipid mediators in acute infammation and resolution. Prog. Lipid Res. 50(1), 35-51 (2011).
37. Serhan CN. Mediator lipidomics. Prostaglandins Other Lipid Mediat. 77(1-4), 4-14 (2005). (Pubitemid 41133410)
38. Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv. Physiol. Educ. 31(1), 5-16 (2007).
39. Hirata T, Narumiya S. Prostanoid receptors. Chem. Rev. 111(10), 6209-6230 (2011).
40. Horrobin DF. Nutritional and medical importance of y-linolenic acid. Prog. Lipid Res. 31(2), 163-194 (1992).
41. Das UN, Madhavi N, Sravan Kumar G, Padma M, Sangeetha P. Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? Prostaglandins Leukot. Essent. Fatty Acids 58(1), 39-54 (1998). (Pubitemid 28053789)
42. Menendez JA, Vellon L, Colomer R, Lupu R. Effect of y-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. J. Natl Cancer Inst. 97(21), 1611-1615 (2005). (Pubitemid 41670348)
43. Coussens LM, Werb Z. Infammation and cancer. Nature 420(6917), 860-867 (2002).
44. Wang D, Dubois RN. Eicosanoids and cancer. Nat. Rev. Cancer 10(3), 181-193 (2010).
45. Serhan CN, Petasis NA. Resolvins and protectins in infammation resolution. Chem. Rev. 111(10), 5922-5943 (2011).
46. Calder PC. Polyunsaturated fatty acids and infammatory processes: New twists in an old tale. Biochimie 91(6), 791-795 (2009).
47. Morrow DA, de Lemos JA. Benchmarks for the assessment of novel cardiovascular biomarkers. Circulation 115(8), 949-952 (2007). (Pubitemid 46328287)
48. Mamas M, Dunn WB, Neyses L, Goodacre R. The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch. Toxicol. 85(1), 5-17 (2011).
49. Quehenberger O, Armando AM, Brown AH et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J. Lipid Res. 51(11), 3299-3305 (2010).
50. Guerrera IC, Astarita G, Jais JP et al. A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fbrosis patients. PLoS ONE 4(11), e7735 (2009).
51. von Schacky C, Harris WS. Cardiovascular risk and the co-3 index. J. Cardiovasc. Med. (Hagerstown) 8(Suppl. 1), S46-S49 (2007).
52. Iorio EL, Ferreri C. In: Diagnostica molecolare nella Medicina di Laboratorio (vol IX). Balestrieri C, DAmora M, Giornano A, Napoli C, Pavan A (Eds.). Piccin, Padova, Italy, 341-359 (2009).
53. Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chem. Rev. 111(10), 5944-5972 (2011).
54. Negre-Salvayre A, Auge N, Ayala V et al. Pathological aspects of lipid peroxidation. Free Radic. Res. 44(10), 1125-1171 (2010).
55. Romieu I, Barraza-Villarreal A, Escamilla-Nuñez C et al. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J. Allergy Clin. Immunol. 121(4), 903.e6-909.e6 (2008).
56. Guichardant M, Bacot S, Molière P, Lagarde M. Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites. Prostaglandins Leukot. Essent. Fatty Acids 75 (3), 179-182 (2006). (Pubitemid 44308583)
57. Santos AO, Fonseca FA, Fischer SM et al. High circulating autoantibodies against human oxidized low-density lipoprotein are related to stable and lower titers to unstable clinical situation. Clin. Chim. Acta 406(1-2), 113-118 (2009).
58. Holvoet P, Mertens A, Verhamme P et al. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 21(5), 844-848 (2001). (Pubitemid 32448777)
59. Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ 2nd. Isoprostane generation and function. Chem. Rev. 111(10), 5973-5996 (2011).
60. Milne GL, Musiek ES, Morrow JD. F2-isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers 10(Suppl. 1), S10-S23 (2005).
61. Kagan VE, Borisenko GG, Tyurina YY et al. Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic. Biol. Med. 37(12), 1963-1985 (2004). (Pubitemid 39491317)
62. Marchi S, Giorgi C, Suski JM et al. Mitochondria-ROS crosstalk in the control of cell death and aging. J. Signal Transduct. 2012, 329635 (2012).
63. Chatgilialoglu C, Ferreri C. Trans lipids: the free radical path. Acc. Chem. Res. 38(6), 441-448 (2005). (Pubitemid 40994866)
64. Ferreri C, Chatgilialoglu C. Geometrical trans lipid isomers: a new target for lipidomics. Chembiochem 6 (10), 1722-1734 (2005). (Pubitemid 41475260)
65. Ferreri C, Grabovskiy SA, Aoun M et al. Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection in rats fed a deodorized fsh oil diet. Chem. Res. Toxicol. 25(3), 687-694 (2012).
66. Micha R, King IB, Lemaitre RN et al. Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study. Am. J. Clin. Nutr. 91(4), 883-893 (2010).
67. Craig-Schmidt MC. World-wide consumption of trans fatty acids. Atheroscler. Suppl. 7(2), 1-4 (2006). (Pubitemid 43831741)
68. Mos J. Labeling of trans fatty acid content in food, regulations and limits-the FDA view. Atherosclerosis Suppl. 7, 57-59 (2006).
69. Mozaffarian D, Aro A, Willett WC. Health effects of trans-fatty acids: experimental and observational evidence. Eur. J. Clin. Nutr. 63(Suppl. 2), S5-21 (2009).
70. Gebauer SK, Chardigny JM, Jakobsen MU et al. Effects of ruminant trans fatty acids on cardiovascular disease and cancer: a comprehensive review of epidemiological, clinical, and mechanistic studies. Adv. Nutr. 2(4), 332-354 (2011).
71. Enke U, Jaudszus A, Schleussner E, Seyfarth L, Jahreis G, Kuhnt K. Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acids. Lipids Health Dis. 10, 247 (2011).
72. Chatgilialoglu C, Ferreri C, Lykakis IN, Wardman P. Tran s-fatty acids and radical stress: what are the real culprits? Bioorg Med. Chem. 14(18), 6144-6148 (2006). (Pubitemid 44224079)
73. Ferreri C, Kratzsch S, Brede O, Marciniak B, Chatgilialoglu C. Trans lipid formation induced by thiols in human monocytic leukemia cells. Free Radic. Biol. Med. 38(9), 1180-1187 (2005). (Pubitemid 40445534)
74. Zambonin L, Ferreri C, Cabrini L, Prata C, Chatgilialoglu C, Landi L. Occurrence of trans fatty acids in rats fed a trans-free diet: a free radical-mediated formation? Free Radic. Biol. Med. 40(9), 1549-1556 (2006).
75. Ferreri C, Angelini F, Chatgilialoglu C et al. Trans fatty acids and atopic eczema/dermatitis syndrome: the relationship with a free radical cis-trans isomerization of membrane lipids. Lipids 40(7), 661-667 (2005). (Pubitemid 41266304)
76. Melchiorre M, Torreggiani A, Chatgilialoglu C, Ferreri C. Lipid markers of 'geometrical' radical stress: synthesis of monotrans cholesteryl ester isomers and detection in human plasma. J. Am. Chem. Soc. 133(38), 15184-15190 (2011).
77. Masood MA, Salem N Jr. High-throughput analysis of plasma fatty acid methyl esters employing robotic transesterifcation and fast gas chromatography. Lipids 43(2), 171-180 (2008).
78. Glaser C, Demmelmair H, Koletzko B. High-throughput analysis of fatty acid composition of plasma glycerophospholipids. J. Lipid Res. 51(1), 216-221 (2010).
79. Kramer JK, Fellner V, Dugan ME, Sauer FD, Mossoba MM, Yurawecz MP. Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids. Lipids 32(11), 1219-1228 (1997). (Pubitemid 27508115)
80. Ichihara K, Fukubayashi Y. Preparation of fatty acid methyl esters for gas-liquid chromatography. J. Lipid Res. 51(3), 635-640 (2010).
81. Baur LA, O'Connor J, Pan DA, Wu BJ, O'Connor MJ, Storlien LH. Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding. Lipids 35(1), 77-82 (2000). (Pubitemid 30084633)
82. Quraishi R, Lakshmy R, Prabhakaran D, Mukhopadhyay AR, Jailkhani B. Use of flter paper stored dried blood for measurement of triglycerides. Lipids Health Dis. 5, 20 (2006)
83. Marangoni F, Colombo C, Galli C. A method for the direct evaluation of the fatty acid status in a drop of blood from a fngertip in humans: applicability to nutritional and epidemiological studies. Anal. Biochem. 326(2), 267-272 (2004). (Pubitemid 38293388)
84. Mohandas N, Gallagher PG. Red cell membrane: past, present, and future. Blood 112(10), 3939-3948 (2008).
85. McLaughlin J, Engel WK. Lipid composition of erythrocytes. Findings in Duchennes muscular dystrophy and myotonic atrophy Arch. Neurol. 36(6), 351-354 (1979). (Pubitemid 9150281)
86. Simopoulos AP. The importance of the Cü-6/cü-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood) 233(6), 674-688 (2008).
87. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am. J. Clin. Nutr. 91(3), 502-509 (2010).
88. Lemaitre RN, King IB, Sotoodehnia N et al. Endogenous red blood cell membrane fatty acids and sudden cardiac arrest. Metab. Clin. Exp. 59(7), 1029-1034 (2010).
89. Quinn JF, Raman R, Thomas RG et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 304(17), 1903-1911 (2010).
90. Umhau JC. Docosahexaenoic acid supplementation and Alzheimer disease. JAMA 305(7), 672; author reply 673 (2011).
91. Farwanah H, Kolter T. Lipidomics of glycosphingolipids. Metabolites 2, 134-164 (2012).
92. Bird SS, Marur VR, Sniatynski MJ, Greenberg HK, Kristal BS. Lipidomics profling by high-resolution LC-MS and high-energy collisional dissociation fragmentation: focus on characterization of mitochondrial cardiolipins and monolysocardiolipins. Anal. Chem. 83(3), 940-949 (2011).
93. Murphy RC, Hankin JA, Barkley RM. Imaging of lipid species by MALDI mass spectrometry. J. Lipid Res. 50, S317-S322 (2009).