Combination of electrochemistry and nuclear magnetic resonance spectroscopy for metabolism studies

Analytical Chemistry

Volumn 84, Issue 20, 2012, Pages 8777-8782

  Simon, Hannah ^a   Melles, Daniel ^a   Jacquoilleot, Sandrine ^b   Sanderson, Paul ^b   Zazzeroni, Raniero ^b   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DISCOVERY; DRUG METABOLISMS; HEPATOTOXICITY; HUMAN LIVER; INSTRUMENTAL METHODS; OXIDATIVE FUNCTIONS; PARACETAMOL; PHASE I; REACTIVE INTERMEDIATE; REACTIVE METABOLITES; STRAIGHTFORWARD TECHNIQUES; STRUCTURE ELUCIDATION; THERAPEUTIC DOSE; TOXIC SIDE EFFECTS;

BIOACTIVITY; BIOMOLECULES; DRUG PRODUCTS; ELECTROCHEMISTRY; METABOLISM; METABOLITES; PHYSIOLOGY;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANALGESIC AGENT; BENZOQUINONE DERIVATIVE; IMINE; N ACETYL 4 BENZOQUINONEIMINE; N-ACETYL-4-BENZOQUINONEIMINE; PARACETAMOL;

ARTICLE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; ECONOMICS; ELECTROCHEMICAL ANALYSIS; ENZYMOLOGY; EQUIPMENT DESIGN; HUMAN; INSTRUMENTATION; LIVER; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; BENZOQUINONES; DRUG EVALUATION, PRECLINICAL; ELECTROCHEMICAL TECHNIQUES; EQUIPMENT DESIGN; HUMANS; IMINES; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION;

EID: 84869425626     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac302152a     Document Type: Article

References (26)

1. Davidson, D. G.; Eastham, W. N. Br. Med. J. 1966, 2, 497-499.
2. Dahlin, D. C.; Miwa, G. T.; Lu, A. Y. H.; Nelson, S. D. Proc. Natl. Acad. Sci. U. S. A. 1984, 81, 1327-1331.
3. Mitchell, J. R.; Jollow, D. J.; Potter, W. Z.; Gillette, J. R.; Brodie, B. B. J. Pharmacol. Exp. Ther. 1973, 187, 211-217.
4. Jollow, D. J.; Mitchell, J. R.; Potter, W. Z.; Davis, D. C.; Gillette, J. R.; Brodie, B. B. J. Pharmacol. Exp. Ther. 1973, 187, 195-202.
5. Thummel, K. E.; Lee, C. A.; Kunze, K. L.; Nelson, S. D.; Slattery, J. T. Biochem. Pharmacol. 1993, 45, 1563-1569.
6. Jurva, U.; Wikström, H. V.; Weidolf, L.; Bruins, A. P. Rapid Commun. Mass Spectrom. 2003, 17, 800-810.
7. Faber, H.; Melles, D.; Brauckmann, C.; Wehe, C.; Wentker, K.; Karst, U. Anal. Bioanal. Chem. 2012, 403, 345-354.
8. Lohmann, W.; Karst, U. Anal. Bioanal. Chem. 2006, 386, 1701-1708.
9. Lohmann, W.; Hayen, H.; Karst, U. Anal. Chem. 2008, 80, 9714-9719.
10. Richards, J. A.; Evans, D. H. Anal. Chem. 1975, 47, 964-966.
11. Mincey, D. W.; Popovich, M. J.; Faustino, P. J.; Hurst, M. M.; Caruso, J. A. Anal. Chem. 1990, 62, 1197-1200.
12. Sandifer, M. E.; Zhao, M.; Kim, S. H.; Scherson, D. A. Anal. Chem. 1993, 65, 2093-2095.
13. Mairanovsky, V. G.; Yusefovich, L. Y.; Filippova, T. M. J. Magn. Reson. 1983, 54, 19-35.
14. Prenzler, P. D.; Bramley, R.; Downing, S. R.; Heath, G. A. Electrochem. Commun. 2000, 2, 516-521.
15. Webster, R. D. Anal. Chem. 2004, 76, 1603-1610.
16. Zhang, X.; Zwanziger, J. W. J. Magn. Reson. 2011, 208, 136-147.
17. Klod, S.; Ziegs, F.; Dunsch, L. Anal. Chem. 2009, 81, 10262-10267.
18. Albert, K.; Dreher, E. L.; Straub, H.; Rieker, A. Magn. Reson. Chem. 1987, 25, 919-922.
19. Madsen, K. G.; Skonberg, C.; Jurva, U.; Cornett, C.; Hansen, S. H.; Johansen, T. N.; Olsen, J. Chem. Res. Toxicol. 2008, 21, 1107-19.
20. Thevis, M.; Lohmann, W.; Schrader, Y.; Kohler, M.; Bornatsch, W.; Karst, U.; Schanzer, W. Eur. J. Mass Spectrom. 2008, 14, 163-170.
21. Johansson, T.; Jurva, U.; Grönberg, G.; Weidolf, L.; Masimirembwa, C. Drug Metab. Dispos. 2009, 37, 571-9.
22. Tahara, K.; Yano, Y.; Kanagawa, K.; Abe, Y.; Yamada, J.; Iijima, S.; Mochizuki, M.; Nishikawa, T. Chem. Pharm. Bull. 2007, 55, 1207-1212.
23. Jurva, U.; Holmen, A.; Grönberg, G.; Masimirembwa, C.; Weidolf, L. Chem. Res. Toxicol. 2008, 21, 928-35.
24. Madsen, K. G.; Olsen, J.; Skonberg, C.; Hansen, S. H.; Jurva, U. Chem. Res. Toxicol. 2007, 20, 821-831.
25. Madsen, K. G.; Grönberg, G.; Skonberg, C.; Jurva, U.; Hansen, S. H.; Olsen, J. Chem. Res. Toxicol. 2008, 21, 2035-41.
26. Getek, T. A.; Korfmacher, W. A.; McRae, T. A.; Hinson, J. A. J. Chromatogr. 1989, 474, 245-256.