Electrochemical oxidation of troglitazone: Identification and characterization of the major reactive metabolite in liver microsomes

Chemical Research in Toxicology

Volumn 21, Issue 10, 2008, Pages 2035-2041

  Madsen, Kim G ^a   Gron̈berg, Gunnar ^b   Skonberg, Christian ^a   Jurva, Ulrik ^c   Hansen, Steen H ^a   Olsen, Jørgen ^d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

^c DMPK and Physical Chemistry   (Sweden)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CARBON; CHROMAN DERIVATIVE; CIGLITAZONE; GLUTATHIONE; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ACETYLCYSTEINE; ANIMALS; CHROMANS; ELECTROCHEMISTRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; THIAZOLIDINEDIONES;

RATTUS;

EID: 55949091420     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx8002214     Document Type: Article

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