Inactivation of the Dlc1 gene cooperates with downregulation of p15 INK4b and p16Ink4a, leadingto neoplastic transformation and poor prognosis in human cancer

Cancer Research

Volumn 72, Issue 22, 2012, Pages 5900-5911

  Qian, Xiaolan ^a   Durkin, Marian E ^a   Wang, Dunrui ^b   Tripathi, Brajendra K ^a   Olson, Lyra ^a   Yang, Xu Yu ^a   Vass, William C ^a   Popescu, Nicholas C ^a   Lowy, Douglas R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b W2MOTIF LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN ROCK; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PROGNOSIS; COLON CANCER; CONTROLLED STUDY; DELETED IN LIVER CANCER 1 GENE; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; FEMALE; FIBROBLAST; GENE DISRUPTION; GENE EXPRESSION; GENE IDENTIFICATION; GENE INACTIVATION; GENETIC SUSCEPTIBILITY; HUMAN; LUNG CANCER; MALE; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOWN-REGULATION; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, P16; GENES, RAS; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; NEOPLASMS; PROGNOSIS; RHO-ASSOCIATED KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84869238685     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2368     Document Type: Article

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