HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis

Journal of Hepatology

Volumn 57, Issue 6, 2012, Pages 1283-1291

  Zhang, Da Wei ^a   Zhao, You Xu ^a   Wei, Ding ^a   Li, Ya Lin ^b   Zhang, Yang ^a   Wu, Jiao ^a   Xu, Jing ^a   Chen, Changsheng ^a   Tang, Hao ^a   Zhang, Wei ^c   Gong, Li ^c   Han, Ying ^d   Chen, Zhi Nan ^a   Bian, Huijie ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b WEINAN NORMAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antibody; EMMPRIN; Liver cirrhosis; Myofibroblasts; TGF 1

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ANTIBODY; ANTIFIBROTIC AGENT; CD147 ANTIGEN; COLLAGEN; GELATINASE A; HAB18 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY THERAPY; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; FIBROGENESIS; GENE EXPRESSION; HEMANGIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION;

ANIMALS; ANTIGENS, CD147; APOPTOSIS; CARBON TETRACHLORIDE; CELL LINE; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MICE; MICE, INBRED BALB C; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84869211561     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.07.042     Document Type: Article

References (30)

1. V. Hernandez-Gea, and S.L. Friedman Pathogenesis of liver fibrosis Annu Rev Pathol 6 2011 425 456
2. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655H 1669H
3. M. Sato, S. Suzuki, and H. Senoo Hepatic stellate cells: unique characteristics in cell biology and phenotype Cell Struct Funct 28 2003 105 112
4. H. Shimada, N.R. Staten, and L.E. Rajagopalan TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells J Hepatol 54 2011 521 528
5. Y. Li, J. Xu, L. Chen, W.D. Zhong, Z. Zhang, and L. Mi HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection Histopathology 54 2009 677 687
6. J. Xu, H.Y. Xu, Q. Zhang, F. Song, J.L. Jiang, and X.M. Yang HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma Mol Cancer Res 5 2007 605 614
7. J. Wu, N.Y. Ru, Y. Zhang, Y. Li, D. Wei, and Z. Ren HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug Oncogene 30 2011 4410 4427
8. B.P. Toole Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function Curr Top Dev Biol 54 2003 371 389
9. E. Huet, B. Vallée, J. Delbé, S. Mourah, V. Prulière-Escabasse, and M. Tremouilleres Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling FASEB J 22 2008 1144 1154
10. T. Tomita, T. Nakase, M. Kaneko, K. Shi, K. Takahi, and T. Ochi Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase in rheumatoid arthritis Arthritis Rheum 46 2002 373 378
11. C.H. Wang, H. Yao, L.N. Chen, J.F. Jia, L. Wang, and J.Y. Dai CD147 induces angiogenesis through vascular endothelial growth factor and hypoxia inducible transcription factor 1α-mediated pathway in rheumatoid arthritis Arthritis Rheum 64 2012 1818 1827
12. M. Kornek, Y. Popov, T.A. Libermann, N.H. Afdhal, and D. Schuppan Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells Hepatology 53 2011 230 242
13. Y.L. Li, J. Wu, D. Wei, D.W. Zhang, H. Feng, and Z.N. Chen Newcastle disease virus represses the activation of human hepatic stellate cells and reverses the development of hepatic fibrosis in mice Liver Int 29 2009 593 602
14. J. Xu, Z.Y. Shen, X.G. Chen, Q. Zhang, H.J. Bian, and P. Zhu A randomized controlled trial of Licartin for preventing hepatoma recurrence after liver transplantation Hepatology 45 2007 269 276
15. Chen ZN, Mi L, Xu J, Song F, Zhang Q, Zhang Z, et al. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys 2006;65:435-44.
16. Z. Zhang, H. Bian, Q. Feng, L. Mi, T. Mo, and A. Kuang Biodistribution and localization of iodine-131-labeled metuximab in patients with hepatocellular carcinoma Cancer Biol Ther 5 2006 318 322
17. R.W. Chadwick, M.F. Copeland, G.P. Carlson, B.A. Trela, and B.M. Most Comparison of in vivo and in vitro methods for assessing the effects of repeated dosing with carbon tetrachloride on the hepatic drug-metabolizing enzyme system Toxicol Lett 44 1988 201 213
18. J.A. Dranoff, and R.G. Wells Portal fibroblasts: underappreciated mediators of biliary fibrosis Hepatology 51 2010 1438 1444
19. E. Novo, C. Busletta, L.V. Bonzo, D. Povero, C. Paternostro, and K. Mareschi Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells J Hepatol 54 2011 964 974
20. T. Kisseleva, H. Uchinami, N. Feirt, O. Quintana-Bustamante, J.C. Segovia, and R.F. Schwabe Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis J Hepatol 45 2006 429 438
21. M. Zeisberg, C. Yang, M. Martino, M.B. Duncan, F. Rieder, and H. Tanjore Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition J Biol Chem 282 2007 23337 23347
22. K. Taura, K. Miura, K. Iwaisako, C.H. Osterreicher, Y. Kodama, and M. Penz-Osterreicher Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice Hepatology 51 2010 1027 1036
23. A.S. Chu, R. Diaz, J.J. Hui, K. Yanger, Y. Zong, and G. Alpini Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis Hepatology 53 2011 1685 1695
24. T. Kisseleva, and D.A. Brenner Anti-fibrogenic strategies and the regression of fibrosis Best Pract Res Clin Gastroenterol 25 2011 305 317
25. E.L. Ellis, and D.A. Mann Clinical evidence for the regression of liver fibrosis J Hepatol 56 2012 1171 1180
26. G. Carpino, S. Morini, S. Ginanni Corradini, A. Franchitto, M. Merli, and M. Siciliano Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation Dig Liver Dis 37 2005 349 356
27. N. Akpolat, S. Yahsi, A. Godekmerdan, M. Yalniz, and K. Demirbag The value of alpha-SMA in the evaluation of hepatic fibrosis severity in hepatitis B infection and cirrhosis development: a histopathological and immunohistochemical study Histopathology 47 2005 276 280
28. N. Nieto A systems biology approach for understanding the collagen regulatory network in alcoholic liver disease Liver Int 32 2012 189 198
29. A. Galli, G. Svegliati-Baroni, E. Ceni, S. Milani, F. Ridolfi, and R. Salzano Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism Hepatology 41 2005 1074 1084
30. C.J. Parsons, B.U. Bradford, C.Q. Pan, E. Cheung, M. Schauer, and A. Knorr Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats Hepatology 40 2004 1106 1115