The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling

Biochemical Pharmacology

Volumn 84, Issue 12, 2012, Pages 1643-1650

  Bernhard, Sarah M ^a   Seidel, Kerstin ^a   Schmitz, Jennifer ^a   Klare, Sabrina ^a   Kirsch, Sebastian ^a   Schrezenmeier, Eva ^a   Zaade, Daniela ^a   Meyborg, Heike ^b   Goldin Lang, Petra ^b   Stawowy, Philipp ^b   Zollmann, Frank S ^a   Unger, Thomas ^a   Funke Kaiser, Heiko ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

(Pro)renin receptor; Aliskiren; Beta catenin; Dvl; Furin; Wnt

Indexed keywords

BETA CATENIN; DISHEVELLED PROTEIN; MESSENGER RNA; PROMYELOCYTIC LEUKEMIA PROTEIN; PRORENIN RECEPTOR; PROTEIN; PROTEIN AXIN2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RENIN; UNCLASSIFIED DRUG; WNT3A PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CELL STRAIN HEK293; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPORTER GENE; REPRESSOR GENE; WNT SIGNALING PATHWAY;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENISTEIN; HEK293 CELLS; HEP G2 CELLS; HUMANS; MACROLIDES; MICE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84869207679     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.09.020     Document Type: Article

References (49)

1. J. Ludwig, S. Kerscher, U. Brandt, K. Pfeiffer, F. Getlawi, and D.K. Apps Identification and characterization of a novel 9.2 kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules J Biol Chem 273 1998 10939 10947
2. G. Nguyen, F. Delarue, C. Burckle, L. Bouzhir, T. Giller, and J.D. Sraer Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin J Clin Invest 109 2002 1417 1427
3. J.H. Schefe, M. Menk, J. Reinemund, K. Effertz, R.M. Hobbs, and P.P. Pandolfi A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein Circ Res 99 2006 1355 1366
4. J.H. Schefe, C. Neumann, M. Goebel, J. Danser, S. Kirsch, and R. Gust Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren J Hypertens 26 2008 1787 1794
5. C. Cousin, D. Bracquart, A. Contrepas, P. Corvol, L. Muller, and G. Nguyen Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma Hypertension 53 2009 1077 1082
6. A. Yoshikawa, Y. Aizaki, K. Kusano, F. Kishi, T. Susumu, and S. Iida The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space Hypertens Res 34 2011 599 605
7. H. Funke-Kaiser, F.S. Zollmann, J.H. Schefe, and T. Unger Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage Hypertens Res 33 2010 98 104
8. +-ATPase signaling pathway in cancer Curr Protein Pept Sci 13 2012 152 163
9. G. Sihn, A. Rousselle, L. Vilianovitch, C. Burckle, and M. Bader Physiology of the (pro)renin receptor: Wnt of change Kidney Int 78 2010 246 256
10. P. Liang, C.A. Jones, B.W. Bisgrove, L. Song, S.T. Glenn, and H.J. Yost Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish Physiol Genomics 16 2004 314 322
11. A. Amsterdam, R.M. Nissen, Z. Sun, E.C. Swindell, S. Farrington, and N. Hopkins Identification of 315 genes essential for early zebrafish development Proc Natl Acad Sci U S A 101 2004 12792 12797
12. +-ATPase assembly in murine cardiomyocytes Circ Res 107 2010 30 34
13. F. Riediger, I. Quack, F. Qadri, B. Hartleben, J.K. Park, and S.A. Potthoff Prorenin receptor is essential for podocyte autophagy and survival J Am Soc Nephrol 22 2011 2193 2202
14. Y. Oshima, K. Kinouchi, A. Ichihara, M. Sakoda, A. Kurauchi-Mito, and K. Bokuda Prorenin receptor is essential for normal podocyte structure and function J Am Soc Nephrol 22 2011 2203 2212
15. M. Krop, X. Lu, A.H. Danser, and M.E. Meima The (pro)renin receptor. A decade of research: what have we learned? Pflugers Arch April 2012 [Epub ahead of print]
16. T.L. Reudelhuber The interaction between prorenin, renin and the (pro)renin receptor: time to rethink the role in hypertension Curr Opin Nephrol Hypertens 21 2012 137 141
17. W.W. Batenburg, and A.H. Danser (Pro)renin and its receptors: pathophysiological implications Clin Sci (Lond) 123 2012 121 133
18. +-ATPase-mediated acidification for Wnt signaling Science 327 2010 459 463
19. T. Buechling, K. Bartscherer, B. Ohkawara, V. Chaudhary, K. Spirohn, and C. Niehrs Wnt/Frizzled signaling requires dPRR, the drosophila homolog of the prorenin receptor Curr Biol 20 2010 1263 1268
20. Nguyen G. Renin (Pro)renin and receptor: an update Clin Sci (Lond) 120 2010 169 178
21. J.E. Darnell Transcription factors as targets for cancer therapy Nature Rev Cancer 2 2002 740 749
22. A.J. Chien, W.H. Conrad, and R.T. Moon A Wnt survival guide: from flies to human disease J Invest Dermatol 129 2009 1614 1627
23. A. Ichihara, M. Hayashi, Y. Kaneshiro, F. Suzuki, T. Nakagawa, and Y. Tada Inhibition of diabetic nephropathy by a decoy peptide corresponding to the handle region for nonproteolytic activation of prorenin J Clin Invest 114 2004 1128 1135
24. A. Ichihara, Y. Kaneshiro, T. Takemitsu, M. Sakoda, F. Suzuki, and T. Nakagawa Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension Hypertension 47 2006 894 900
25. H. Mahmud, H.H. Sillje, M.V. Cannon, W.H. van Gilst, and R.A. de Boer Regulation of the (pro)renin-renin receptor in cardiac remodelling J Cell Mol Med 16 2011 722 729
26. K. Takahashi, H. Yamamoto, T. Hirose, K. Hiraishi, I. Shoji, and A. Shibasaki Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy Peptides 31 2010 1405 1408
27. L.C. Matavelli, J. Huang, and H.M. Siragy (Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation Clin Exp Pharmacol Physiol 37 2010 277 282
28. P. Balakumar, and G. Jagadeesh Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders Hypertens Res 34 2011 1161 1170
29. C. Dai, D.B. Stolz, L.P. Kiss, S.P. Monga, L.B. Holzman, and Y. Liu Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria J Am Soc Nephrol 20 2009 1997 2008
30. P.M. McSheehy, H. Troy, L.R. Kelland, I.R. Judson, M.O. Leach, and J.R. Griffiths Increased tumour extracellular pH induced by bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics Eur J Cancer 39 2003 532 540
31. T. Senbonmatsu, T. Saito, E.J. Landon, O. Watanabe, E. Price Jr., and R.L. Roberts A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy EMBO J 22 2003 6471 6482
32. M.J. Brown, and Aliskiren Circulation 118 2008 773 784
33. K. Seidel, S. Kirsch, K. Lucht, D. Zaade, J. Reinemund, and J. Schmitz The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke Brain Pathol 21 2010 31 43
34. M.T. Veeman, D.C. Slusarski, A. Kaykas, S.H. Louie, and R.T. Moon Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements Curr Biol 13 2003 680 685
35. D.H. Kho, J.A. Bae, J.H. Lee, H.J. Cho, S.H. Cho, and J.H. Lee KITENIN recruits Dishevelled/PKC delta to form a functional complex and controls the migration and invasiveness of colorectal cancer cells Gut 58 2009 509 519
36. F. Hubé, G. Velasco, J. Rollin, D. Furling, and C. Francastel Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation Nucleic Acids Res 39 2011 513 525
37. M.J. Larriba, P. Ordonez-Moran, I. Chicote, G. Martin-Fernandez, I. Puig, and A. Munoz Vitamin D receptor deficiency enhances Wnt/beta-catenin signaling and tumor burden in colon cancer PloS ONE 6 2011 e23524
38. H. Funke-Kaiser, J. Lemmer, C.V. Langsdorff, A. Thomas, S.D. Kovacevic, and M. Strasdat Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5 FASEB J 17 2003 1487 1489
39. N. Barker, and H. Clevers Mining the Wnt pathway for cancer therapeutics Nature Rev 5 2006 997 1014
40. A. de La Coste, B. Romagnolo, P. Billuart, C.A. Renard, M.A. Buendia, and O. Soubrane Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas Proc Natl Acad Sci U S A 95 1998 8847 8851
41. S.S. Molloy, E.D. Anderson, F. Jean, and G. Thomas Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis Trends Cell Biol 9 1999 28 35
42. G. Baravalle, D. Schober, M. Huber, N. Bayer, R.F. Murphy, and R. Fuchs Transferrin recycling and dextran transport to lysosomes is differentially affected by bafilomycin, nocodazole, and low temperature Cell Tissue Res 320 2005 99 113
43. K. Kurashima, M. Numata, A. Yachie, Y. Sai, N. Ishizaka, and M. Fujimura The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils Lab Invest 75 1996 689 698
44. S. Feldt, W.W. Batenburg, I. Mazak, U. Maschke, M. Wellner, and H. Kvakan Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide Hypertension 51 2008 682 688
45. D.L. Feldman, L. Jin, H. Xuan, A. Contrepas, Y. Zhou, and R.L. Webb Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats Hypertension 52 2008 130 136
46. A. Steege, M. Fahling, A. Paliege, A. Bondke, K.M. Kirschner, and P. Martinka Wilms' tumor protein (-KTS) modulates renin gene transcription Kidney Int 74 2008 458 466
47. J.C. Curtin, and M.V. Lorenzi Drug discovery approaches to target Wnt signaling in cancer stem cells Oncotarget 1 2010 563 577
48. K. Willert, J.D. Brown, E. Danenberg, A.W. Duncan, I.L. Weissman, and T. Reya Wnt proteins are lipid-modified and can act as stem cell growth factors Nature 423 2003 448 452
49. J. Albers, J. Schulze, F.T. Beil, M. Gebauer, A. Baranowsky, and J. Keller Control of bone formation by the serpentine receptor Frizzled-9 J Cell Biol 192 2011 1057 1072