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Volumn 303, Issue 10, 2012, Pages

Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and L-arginine uptake

Author keywords

Arginase; Frog urinary bladder; Inducible nitric oxide synthase; L arginine uptake; Lipopolysaccharide; Nitric oxide; Tolllike receptor 4

Indexed keywords

ARGINASE; ARGININE; CITRULLINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRITE; TOLL LIKE RECEPTOR 4;

EID: 84869198401     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00045.2012     Document Type: Article
Times cited : (11)

References (60)
  • 1
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S. Toll-like receptor signaling. J Biol Chem 278: 38105-38108, 2003
    • (2003) J Biol Chem , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 2
    • 4744348388 scopus 로고    scopus 로고
    • Structure and function of arginases
    • Ash DE. Structure and function of arginases. J Nutr 134: 2760S-2764S, 2004
    • (2004) J Nutr , vol.134
    • Ash, D.E.1
  • 3
    • 58349104335 scopus 로고    scopus 로고
    • 2+ regulates bacterial lipopolysaccharide induction of iNOS in human macrophages
    • 2+ regulates bacterial lipopolysaccharide induction of iNOS in human macrophages. Immunobiology 214: 143-152, 2009.
    • (2009) Immunobiology , vol.214 , pp. 143-152
    • Azenabor, A.A.1    Kennedy, P.2    York, J.3
  • 5
    • 0035076194 scopus 로고    scopus 로고
    • Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ-and cell-specific expression of Toll-like receptors within the human urinary tract
    • Bäckhed F, Söderhäll M, Ekman P, Normark S, Richter-Dahlfors A. Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ-and cell-specific expression of Toll-like receptors within the human urinary tract. Cell Microbiol 3: 153-158, 2001.
    • (2001) Cell Microbiol , vol.3 , pp. 153-158
    • Bäckhed, F.1    Söderhäll, M.2    Ekman, P.3    Normark, S.4    Richter-Dahlfors, A.5
  • 6
    • 0033571398 scopus 로고    scopus 로고
    • Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells
    • Baydoun AR, Wileman SM, Wheeler-Jones CP, Marber MS, Mann GE, Pearson JD, Closs EI. Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells. Biochem J 344: 265-272, 1999.
    • (1999) Biochem J , vol.344 , pp. 265-272
    • Baydoun, A.R.1    Wileman, S.M.2    Wheeler-Jones, C.P.3    Marber, M.S.4    Mann, G.E.5    Pearson, J.D.6    Closs, E.I.7
  • 8
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1-5, 2007.
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 10
    • 0037223634 scopus 로고    scopus 로고
    • Arginase 1 overexpression in psoriasis: Limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation
    • Bruch-Gerharz D, Schnorr O, Suschek C, Beck KF, Pfeilschifter J, Ruzicka T, Kolb-Bachofen V. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. Am J Pathol 162: 203-211, 2003.
    • (2003) Am J Pathol , vol.162 , pp. 203-211
    • Bruch-Gerharz, D.1    Schnorr, O.2    Suschek, C.3    Beck, K.F.4    Pfeilschifter, J.5    Ruzicka, T.6    Kolb-Bachofen, V.7
  • 11
    • 33748415333 scopus 로고    scopus 로고
    • Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation
    • Chen Li M, Wang C, Chen M, Marcello MR, Chao J, Chao L, Chai KX. Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation. Am J Physiol Renal Physiol 291: F567-F577, 2006.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Chen Li, M.1    Wang, C.2    Chen, M.3    Marcello, M.R.4    Chao, J.5    Chao, L.6    Chai, K.X.7
  • 12
    • 2942741190 scopus 로고    scopus 로고
    • Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells
    • Chicoine LG, Paffett ML, Young TL, Nelin LD. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 287: L60-L68, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Chicoine, L.G.1    Paffett, M.L.2    Young, T.L.3    Nelin, L.D.4
  • 13
    • 34247245816 scopus 로고    scopus 로고
    • Structure and function of cationic amino acid transporters (CATs)
    • Closs EI, Boissel JP, Habermeier A, Rotmann A. Structure and function of cationic amino acid transporters (CATs). J Membr Biol 213: 67-77, 2006
    • (2006) J Membr Biol , vol.213 , pp. 67-77
    • Closs, E.I.1    Boissel, J.P.2    Habermeier, A.3    Rotmann, A.4
  • 14
    • 0034013014 scopus 로고    scopus 로고
    • Nitric oxide: An inhibitor of NF-κB/Rel system in glial cells
    • Colasanti M, Persichini T. Nitric oxide: an inhibitor of NF-κB/Rel system in glial cells. Brain Res Bull 52: 155-161, 2000.
    • (2000) Brain Res Bull , vol.52 , pp. 155-161
    • Colasanti, M.1    Persichini, T.2
  • 15
    • 0027934360 scopus 로고
    • Determination of arginase activity in macrophages: A micromethod
    • Corraliza IM, Campo ML, Soler G, Modolell M. Determination of arginase activity in macrophages: a micromethod. J Immunol Methods 174: 231-235, 1994.
    • (1994) J Immunol Methods , vol.174 , pp. 231-235
    • Corraliza, I.M.1    Campo, M.L.2    Soler, G.3    Modolell, M.4
  • 16
    • 38449083132 scopus 로고    scopus 로고
    • Diseases of amphibians
    • Densmorez CL, Green DE. Diseases of amphibians. ILAR J 48: 235-254, 2007
    • (2007) ILAR J , vol.48 , pp. 235-254
    • Densmorez, C.L.1    Green, D.E.2
  • 17
    • 33749152085 scopus 로고    scopus 로고
    • Toll-like receptors: From the discovery of NF-κB to new insights into transcriptional regulations in innate immunity
    • Doyle SL, O'Neill LA. Toll-like receptors: from the discovery of NF-κB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 72: 1102-1113, 2006.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1102-1113
    • Doyle, S.L.1    O'Neill, L.A.2
  • 18
    • 34447528959 scopus 로고    scopus 로고
    • Arginase: A critical regulator of nitric oxide synthesis and vascular function
    • Durante W, Johnson FK, Johnson RA. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 34: 906-911, 2007.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 906-911
    • Durante, W.1    Johnson, F.K.2    Johnson, R.A.3
  • 19
    • 0032879041 scopus 로고    scopus 로고
    • Nitric oxide: A useful gas in the detection of lower urinary tract inflammation
    • Ehren I, Hasseini A, Lundberg JO, Wiklund NP. Nitric oxide: a useful gas in the detection of lower urinary tract inflammation. J Urol 162: 327-329, 1999.
    • (1999) J Urol , vol.162 , pp. 327-329
    • Ehren, I.1    Hasseini, A.2    Lundberg, J.O.3    Wiklund, N.P.4
  • 20
    • 4844227764 scopus 로고    scopus 로고
    • Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies
    • Fang FC. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2: 820-832, 2004.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 820-832
    • Fang, F.C.1
  • 21
    • 2442521206 scopus 로고    scopus 로고
    • Nitric oxide inhibits arginine-vasotocin-induced increase of water osmotic permeability in frog urinary bladder
    • Fock EM, Lavrova EA, Bachteeva VT, Chernigovskaya EV, Parnova RG. Nitric oxide inhibits arginine-vasotocin-induced increase of water osmotic permeability in frog urinary bladder. Pflügers Arch 448: 197-203, 2004
    • (2004) Pflügers Arch , vol.448 , pp. 197-203
    • Fock, E.M.1    Lavrova, E.A.2    Bachteeva, V.T.3    Chernigovskaya, E.V.4    Parnova, R.G.5
  • 22
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260, 1998.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 23
    • 0033535039 scopus 로고    scopus 로고
    • Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells
    • Gotoh T, Mori M. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol 144: 427-434, 1999.
    • (1999) J Cell Biol , vol.144 , pp. 427-434
    • Gotoh, T.1    Mori, M.2
  • 25
  • 26
    • 0034763928 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase abrogates lipopolysaccharides-induced up-regulation of L-arginine uptake in rat alveolar macrophages
    • Hammermann R, Stichnote C, Closs EI, Nawrath H, Racke K. Inhibition of nitric oxide synthase abrogates lipopolysaccharides-induced up-regulation of L-arginine uptake in rat alveolar macrophages. Br J Pharmacol 133: 379-386, 2001.
    • (2001) Br J Pharmacol , vol.133 , pp. 379-386
    • Hammermann, R.1    Stichnote, C.2    Closs, E.I.3    Nawrath, H.4    Racke, K.5
  • 27
    • 27944453911 scopus 로고    scopus 로고
    • Immunocytochemical studies on translocation of phosphorylated aquaporin-h2 protein in granular cells of the frog urinary bladder before and after stimulation with vasotocin
    • Hasegawa T, Suzuki M, Tanaka S. Immunocytochemical studies on translocation of phosphorylated aquaporin-h2 protein in granular cells of the frog urinary bladder before and after stimulation with vasotocin. Cell Tissue Res 322: 407-415, 2005.
    • (2005) Cell Tissue Res , vol.322 , pp. 407-415
    • Hasegawa, T.1    Suzuki, M.2    Tanaka, S.3
  • 28
    • 0030975894 scopus 로고    scopus 로고
    • Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D, L-indospicine, effects on L-arginine utilization by nitric oxide synthase
    • Hey C, Boucher JL, Vadon-Le Goff S, Ketterer G, Wessler I, Racké K. Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D, L-indospicine, effects on L-arginine utilization by nitric oxide synthase. Br J Pharmacol 121: 395-400, 1997.
    • (1997) Br J Pharmacol , vol.121 , pp. 395-400
    • Hey, C.1    Boucher, J.L.2    Vadon-le Goff, S.3    Ketterer, G.4    Wessler, I.5    Racké, K.6
  • 32
    • 67449124245 scopus 로고    scopus 로고
    • Lipopolysaccharide E. coli inhibits the arginine-vasotocin-induced increase of osmotic water permeability in the frog urinary bladder [in Russian]
    • Lavrova EA, Nikolaeva SD, Fock EM, Bachteeva VT, Parnova RG. Lipopolysaccharide E. coli inhibits the arginine-vasotocin-induced increase of osmotic water permeability in the frog urinary bladder [in Russian]. Russ J Physiol 95: 215-224, 2009.
    • (2009) Russ J Physiol , vol.95 , pp. 215-224
    • Lavrova, E.A.1    Nikolaeva, S.D.2    Fock, E.M.3    Bachteeva, V.T.4    Parnova, R.G.5
  • 33
    • 84864877098 scopus 로고    scopus 로고
    • Colonization of frog urinary bladder mucosal epithelium by gram-negative bacteria as a cause of decreased effect of arginine-vasotocin on osmotic water permeability
    • (in Russian)
    • Lavrova EA, Gretchenko LS, Parnova RG, Fok EM. Colonization of frog urinary bladder mucosal epithelium by gram-negative bacteria as a cause of decreased effect of arginine-vasotocin on osmotic water permeability. Russ J Physiol 98: 506-513, 2012 (in Russian).
    • (2012) Russ J Physiol , vol.98 , pp. 506-513
    • Lavrova, E.A.1    Gretchenko, L.S.2    Parnova, R.G.3    Fok, E.M.4
  • 34
    • 0343920708 scopus 로고    scopus 로고
    • Lipopolysaccharides of Brucella abortus and Brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
    • López-Urrutia L, Alonso A, Nieto ML, Bayón Y, Orduña A, Sánchez Crespo M. Lipopolysaccharides of Brucella abortus and Brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages. Infect Immun 68: 1740-1745, 2000.
    • (2000) Infect Immun , vol.68 , pp. 1740-1745
    • López-Urrutia, L.1    Alonso, A.2    Nieto, M.L.3    Bayón, Y.4    Orduña, A.5    Sánchez Crespo, M.6
  • 35
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 42: 145-151, 2008.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 37
    • 0026700522 scopus 로고
    • Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes
    • Malawista SE, Montgomery RR, van Blaricom G. Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes. J Clin Invest 90: 631-636, 1992.
    • (1992) J Clin Invest , vol.90 , pp. 631-636
    • Malawista, S.E.1    Montgomery, R.R.2    van Blaricom, G.3
  • 38
    • 28644440380 scopus 로고    scopus 로고
    • Regulation of amino acid arginine transport by lipopolysaccharide and nitric oxide in intestinal epithelial IEC-6 cells
    • Meng Q, Choudry HA, Souba WW, Karinch AM, Huang J, Lin C, Vary TC, Pan M. Regulation of amino acid arginine transport by lipopolysaccharide and nitric oxide in intestinal epithelial IEC-6 cells. J Gastrointest Surg 9: 1276-85, 2005.
    • (2005) J Gastrointest Surg , vol.9 , pp. 1276-1285
    • Meng, Q.1    Choudry, H.A.2    Souba, W.W.3    Karinch, A.M.4    Huang, J.5    Lin, C.6    Vary, T.C.7    Pan, M.8
  • 39
    • 34249818191 scopus 로고    scopus 로고
    • Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling
    • Mori M. Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J Nutr 137: 1616S-1620S, 2007.
    • (2007) J Nutr , vol.137
    • Mori, M.1
  • 40
    • 0017119987 scopus 로고
    • Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharide
    • Morrison DC, Jacobs DM. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharide. Immunochemistry 13: 813-818, 1976.
    • (1976) Immunochemistry , vol.13 , pp. 813-818
    • Morrison, D.C.1    Jacobs, D.M.2
  • 42
    • 0032956542 scopus 로고    scopus 로고
    • Inverse relationship between severity of experimental pyelonephritis and nitric oxide production in C3H/HeJ mice
    • Nowicki B, Singhal J, Fang L, Nowicki S, Yallampalli C. Inverse relationship between severity of experimental pyelonephritis and nitric oxide production in C3H/HeJ mice. Infect Immun 67: 2421-2427, 1999.
    • (1999) Infect Immun , vol.67 , pp. 2421-2427
    • Nowicki, B.1    Singhal, J.2    Fang, L.3    Nowicki, S.4    Yallampalli, C.5
  • 43
    • 0028084722 scopus 로고
    • Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production
    • Nussler AK, Billiar TR, Liu ZZ, Morris SM Jr. Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production. J Biol Chem 269: 1257-1261, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 1257-1261
    • Nussler, A.K.1    Billiar, T.R.2    Liu, Z.Z.3    Morris Jr., S.M.4
  • 44
    • 0031751209 scopus 로고    scopus 로고
    • Molecular biology of mammalian plasma membrane amino acid transporters
    • Palacin M, Estevez R, Bertran J, Zorzano A. Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78: 969-1054, 1998.
    • (1998) Physiol Rev , vol.78 , pp. 969-1054
    • Palacin, M.1    Estevez, R.2    Bertran, J.3    Zorzano, A.4
  • 45
    • 4744370253 scopus 로고    scopus 로고
    • Signal transduction by the lipolysaccharide receptor, Toll-like receptor-4
    • Pallson-McDermott EM, O'Neill LA. Signal transduction by the lipolysaccharide receptor, Toll-like receptor-4. Immunology 113: 153-162, 2004
    • (2004) Immunology , vol.113 , pp. 153-162
    • Pallson-McDermott, E.M.1    O'Neill, L.A.2
  • 46
    • 0035092537 scopus 로고    scopus 로고
    • Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
    • Poljakovic M, Svensson ML, Svanborg C, Johansson K, Larsson B, Persson K. Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney. Kidney Int 59: 893-904, 2001.
    • (2001) Kidney Int , vol.59 , pp. 893-904
    • Poljakovic, M.1    Svensson, M.L.2    Svanborg, C.3    Johansson, K.4    Larsson, B.5    Persson, K.6
  • 47
    • 0005641915 scopus 로고    scopus 로고
    • Protozoa, and metazoan infecting amphibians
    • In:, edited by Wright KM and Whitaker BR. Malabar, FL: Krieger
    • Poynton SL, Whitaker BR. Protozoa, and metazoan infecting amphibians. In: Amphibian Medicine and Captive Husbandry, edited by Wright KM and Whitaker BR. Malabar, FL: Krieger, p. 193-221, 2001.
    • (2001) Amphibian Medicine and Captive Husbandry , pp. 193-221
    • Poynton, S.L.1    Whitaker, B.R.2
  • 48
    • 0031932328 scopus 로고    scopus 로고
    • Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder
    • Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J Pharmacol Exp Ther 284: 1203-1208, 1998.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 1203-1208
    • Olsson, L.E.1    Wheeler, M.A.2    Sessa, W.C.3    Weiss, R.M.4
  • 51
  • 53
    • 40849087796 scopus 로고    scopus 로고
    • TLR-mediated immune responses in the urinary tract
    • Song J, Abraham SN. TLR-mediated immune responses in the urinary tract. Curr Opin Microbiol 11: 66-73, 2008.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 66-73
    • Song, J.1    Abraham, S.N.2
  • 54
    • 34247574895 scopus 로고    scopus 로고
    • A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells
    • Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, Abraham SN. A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathog 3: 541-552, 2007
    • (2007) PLoS Pathog , vol.3 , pp. 541-552
    • Song, J.1    Duncan, M.J.2    Li, G.3    Chan, C.4    Grady, R.5    Stapleton, A.6    Abraham, S.N.7
  • 55
    • 0031013624 scopus 로고    scopus 로고
    • Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide
    • Sonoki T, Nagasaki A, Gotoh T, Takiguchi M, Takeya M, Matsuzaki H, Mori M. Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide. J Biol Chem 272: 3689-3693, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 3689-3693
    • Sonoki, T.1    Nagasaki, A.2    Gotoh, T.3    Takiguchi, M.4    Takeya, M.5    Matsuzaki, H.6    Mori, M.7
  • 56
    • 77952862001 scopus 로고    scopus 로고
    • The effect of nitric oxide on adherence of P-fimbriated uropathogenic Escherichia coli to human renal epithelial cells
    • Svensson L, Save S, Persson K. The effect of nitric oxide on adherence of P-fimbriated uropathogenic Escherichia coli to human renal epithelial cells. BJU Int 105: 1726-1731, 2009.
    • (2009) BJU Int , vol.105 , pp. 1726-1731
    • Svensson, L.1    Save, S.2    Persson, K.3
  • 57
    • 1942545081 scopus 로고    scopus 로고
    • Cytokine function of heat shock proteins
    • Tsan MF, Gao B. Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286: C739-C744, 2004.
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Tsan, M.F.1    Gao, B.2
  • 60
    • 0036793564 scopus 로고    scopus 로고
    • Early activation of the p42/ p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: A novel calcium-insensitive mechanism
    • Wyatt AW, Steinert JR, Wheeler-Jones CP, Morgan AJ, Sugden D, Pearson JD, Sobrevia L, Mann GE. Early activation of the p42/ p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J 16: 1584-1594, 2002.
    • (2002) FASEB J , vol.16 , pp. 1584-1594
    • Wyatt, A.W.1    Steinert, J.R.2    Wheeler-Jones, C.P.3    Morgan, A.J.4    Sugden, D.5    Pearson, J.D.6    Sobrevia, L.7    Mann, G.E.8


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