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Volumn 303, Issue 10, 2012, Pages

Suppression in growth hormone during overeating ameliorates the increase in insulin resistance and cardiovascular disease risk

Author keywords

Lipolysis; Muscle protein fractional synthetic rate; Obesity; Overfeeding; Proteolysis

Indexed keywords

CARBOHYDRATE; FAT; GLUCOSE; GROWTH HORMONE; HUMAN GROWTH HORMONE; INSULIN; PROTEIN;

EID: 84869181627     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00320.2012     Document Type: Article
Times cited : (12)

References (48)
  • 3
    • 0027085687 scopus 로고
    • Regulation of free fatty acid metabolism by insulin in humans: Role of lipolysis and reesterification
    • Campbell PJ, Carlson MG, Hill JO, Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 26: E1063-E1069, 1992.
    • (1992) Am J Physiol , vol.26
    • Campbell, P.J.1    Carlson, M.G.2    Hill, J.O.3    Nurjhan, N.4
  • 5
    • 79957865364 scopus 로고    scopus 로고
    • Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats
    • Chen Q, Li N, Zhu W, Li W, Tang S, Yu W, Gao T, Zhang J, Li J. Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats. J Inflamm (Lond) 8: 13, 2011.
    • (2011) J Inflamm (Lond) , vol.8 , pp. 13
    • Chen, Q.1    Li, N.2    Zhu, W.3    Li, W.4    Tang, S.5    Yu, W.6    Gao, T.7    Zhang, J.8    Li, J.9
  • 7
    • 79952290754 scopus 로고    scopus 로고
    • Rapid suppression of growth hormone concentration by overeating: Potential mediation by hyperinsulinemia
    • Cornford AS, Barkan AL, Horowitz JF. Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia. J Clin Endocrinol Metab 96: 824-830, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 824-830
    • Cornford, A.S.1    Barkan, A.L.2    Horowitz, J.F.3
  • 9
    • 0025915596 scopus 로고
    • Growth hormone alters lipolysis and hormonesensitive lipase activity in 3T3-F442A adipocytes
    • Dietz J, Schwartz J. Growth hormone alters lipolysis and hormonesensitive lipase activity in 3T3-F442A adipocytes. Metabolism 40: 800-806, 1991.
    • (1991) Metabolism , vol.40 , pp. 800-806
    • Dietz, J.1    Schwartz, J.2
  • 11
    • 0029020117 scopus 로고
    • Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects
    • Drent ML, Wever LD, Adèr HJ, van der Veen EA. Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects. Eur J Endocrinol 132: 565-572, 1995.
    • (1995) Eur J Endocrinol , vol.132 , pp. 565-572
    • Drent, M.L.1    Wever, L.D.2    Adèr, H.J.3    van der Veen, E.A.4
  • 12
    • 0022545819 scopus 로고
    • Deliberate overfeeding in women and men: Energy cost and composition of the weight gain
    • Forbes GB, Brown MR, Welle SL, Lipinski BA. Deliberate overfeeding in women and men: energy cost and composition of the weight gain. Br J Nutr 56: 1-9, 1986.
    • (1986) Br J Nutr , vol.56 , pp. 1-9
    • Forbes, G.B.1    Brown, M.R.2    Welle, S.L.3    Lipinski, B.A.4
  • 13
    • 0025818655 scopus 로고
    • Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans
    • Fryburg DA, Gelfand RA, Barrett EJ. Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol Endocrinol Metab 260: E499-E504, 1991.
    • (1991) Am J Physiol Endocrinol Metab , vol.260
    • Fryburg, D.A.1    Gelfand, R.A.2    Barrett, E.J.3
  • 14
    • 77951487050 scopus 로고    scopus 로고
    • Signaling pathways perturbing muscle mass
    • Glass DJ. Signaling pathways perturbing muscle mass. Curr Opin Clin Nutr Metab Care 13: 225-229, 2010.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 225-229
    • Glass, D.J.1
  • 15
    • 24344507668 scopus 로고    scopus 로고
    • Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis
    • Harber MP, Schenk S, Barkan AL, Horowitz JF. Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis. J Clin Endocrinol Metab 90: 5175-5181, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5175-5181
    • Harber, M.P.1    Schenk, S.2    Barkan, A.L.3    Horowitz, J.F.4
  • 18
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol Endocrinol Metab 277: E1130-E1141, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 19
    • 33947172629 scopus 로고    scopus 로고
    • Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics
    • Krag MB, Gormsen LC, Guo Z, Christiansen JS, Jensen MD, Nielsen S, Jørgensen JO. Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics. Am J Physiol Endocrinol Metab 292: E920-E927, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Krag, M.B.1    Gormsen, L.C.2    Guo, Z.3    Christiansen, J.S.4    Jensen, M.D.5    Nielsen, S.6    Jørgensen, J.O.7
  • 21
    • 79955140406 scopus 로고    scopus 로고
    • High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins
    • Li M, Paran C, Wolins NE, Horowitz JF. High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Am J Physiol Endocrinol Metab 300: E699-E707, 2011.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Li, M.1    Paran, C.2    Wolins, N.E.3    Horowitz, J.F.4
  • 22
    • 0027063655 scopus 로고
    • Regulation of insulin-like growth factor 1 gene expression in skeletal muscle
    • Loughna PT, Mason P, Bates PC. Regulation of insulin-like growth factor 1 gene expression in skeletal muscle. Symp Soc Exp Biol 46: 319-330, 1992.
    • (1992) Symp Soc Exp Biol , vol.46 , pp. 319-330
    • Loughna, P.T.1    Mason, P.2    Bates, P.C.3
  • 23
    • 14844331384 scopus 로고    scopus 로고
    • Measuring very low density lipoprotein-triglyceride kinetics in man in vivo: How different the various methods really are
    • Magkos F, Sidossis LS. Measuring very low density lipoprotein-triglyceride kinetics in man in vivo: how different the various methods really are. Curr Opin Clin Nutr Metab Care 7: 547-555, 2004.
    • (2004) Curr Opin Clin Nutr Metab Care , vol.7 , pp. 547-555
    • Magkos, F.1    Sidossis, L.S.2
  • 24
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 26
    • 0035052108 scopus 로고    scopus 로고
    • Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets
    • Mittendorfer B, Sidossis LS. Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets. Am J Clin Nutr 73: 892-899, 2001.
    • (2001) Am J Clin Nutr , vol.73 , pp. 892-899
    • Mittendorfer, B.1    Sidossis, L.S.2
  • 27
    • 0032741224 scopus 로고    scopus 로고
    • Growth hormone and fluid retention
    • Moller J, Nielsen S, Hansen TK. Growth hormone and fluid retention. Horm Res 51, Suppl 3: 116-120, 1999.
    • (1999) Horm Res , vol.51 , Issue.SUPPL. 3 , pp. 116-120
    • Moller, J.1    Nielsen, S.2    Hansen, T.K.3
  • 28
    • 47549084450 scopus 로고    scopus 로고
    • Growth hormone signaling in vivo in human muscle and adipose tissue: Impact of insulin, substrate background, and growth hormone receptor blockade
    • Nielsen C, Gormsen LC, Jessen N, Pedersen SB, Møller N, Lund S, Jørgensen JO. Growth hormone signaling in vivo in human muscle and adipose tissue: impact of insulin, substrate background, and growth hormone receptor blockade. J Clin Endocrinol Metab 93: 2842-2850, 2008.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2842-2850
    • Nielsen, C.1    Gormsen, L.C.2    Jessen, N.3    Pedersen, S.B.4    Møller, N.5    Lund, S.6    Jørgensen, J.O.7
  • 29
    • 0023026312 scopus 로고
    • Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans
    • Nurjhan N, Campbell PJ, Kennedy FP, Miles JM, Gerich JE. Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans. Diabetes 35: 1326-1331, 1986.
    • (1986) Diabetes , vol.35 , pp. 1326-1331
    • Nurjhan, N.1    Campbell, P.J.2    Kennedy, F.P.3    Miles, J.M.4    Gerich, J.E.5
  • 30
    • 0029881479 scopus 로고    scopus 로고
    • Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GHdeficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity
    • Oscarsson J, Ottosson M, Johansson JO, Wiklund O, Mårin P, Björntorp P, Bengtsson BA. Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GHdeficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity. Metabolism 45: 370-377, 1996.
    • (1996) Metabolism , vol.45 , pp. 370-377
    • Oscarsson, J.1    Ottosson, M.2    Johansson, J.O.3    Wiklund, O.4    Mårin, P.5    Björntorp, P.6    Bengtsson, B.A.7
  • 32
    • 0037387194 scopus 로고    scopus 로고
    • Claims for the anabolic effects of growth hormone: A case of the emperor's new clothes?
    • Rennie MJ. Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes? Br J Sports Med 37: 100-105, 2003.
    • (2003) Br J Sports Med , vol.37 , pp. 100-105
    • Rennie, M.J.1
  • 34
    • 0034235093 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients
    • Richelsen B, Pedersen SB, Kristensen K, Børglum JD, Nørrelund H, Christiansen JS, Jørgensen JO. Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. Metabolism 49: 906-911, 2000.
    • (2000) Metabolism , vol.49 , pp. 906-911
    • Richelsen, B.1    Pedersen, S.B.2    Kristensen, K.3    Børglum, J.D.4    Nørrelund, H.5    Christiansen, J.S.6    Jørgensen, J.O.7
  • 35
    • 4544293878 scopus 로고    scopus 로고
    • IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
    • Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 287: E591-E601, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Sacheck, J.M.1    Ohtsuka, A.2    McLary, S.C.3    Goldberg, A.L.4
  • 36
    • 0025766522 scopus 로고
    • Exogenous human growth hormone reduces body fat in obese women
    • Skaggs SR, Crist DM. Exogenous human growth hormone reduces body fat in obese women. Horm Res 35: 19-24, 1991.
    • (1991) Horm Res , vol.35 , pp. 19-24
    • Skaggs, S.R.1    Crist, D.M.2
  • 37
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82: 420-430, 1959.
    • (1959) Ann NY Acad Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 39
    • 68549132319 scopus 로고    scopus 로고
    • The pattern of growth hormone delivery to peripheral tissues determines insulin-like growth factor-1 and lipolytic responses in obese subjects
    • Surya S, Horowitz JF, Goldenberg N, Sakharova A, Harber M, Cornford AS, Symons K, Barkan AL. The pattern of growth hormone delivery to peripheral tissues determines insulin-like growth factor-1 and lipolytic responses in obese subjects. J Clin Endocrinol Metab 94: 2828-2834, 2009.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2828-2834
    • Surya, S.1    Horowitz, J.F.2    Goldenberg, N.3    Sakharova, A.4    Harber, M.5    Cornford, A.S.6    Symons, K.7    Barkan, A.L.8
  • 40
    • 0036389493 scopus 로고    scopus 로고
    • The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity
    • Takahashi S, Satozawa N. The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity. Horm Res 58: 157-164, 2002.
    • (2002) Horm Res , vol.58 , pp. 157-164
    • Takahashi, S.1    Satozawa, N.2
  • 45
    • 73949131768 scopus 로고    scopus 로고
    • Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors
    • West DW, Burd NA, Tang JE, Moore DR, Staples AW, Holwerda AM, Baker SK, Phillips SM. Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol 108: 60-67, 2010.
    • (2010) J Appl Physiol , vol.108 , pp. 60-67
    • West, D.W.1    Burd, N.A.2    Tang, J.E.3    Moore, D.R.4    Staples, A.W.5    Holwerda, A.M.6    Baker, S.K.7    Phillips, S.M.8
  • 47
    • 0029808383 scopus 로고    scopus 로고
    • Effects of growth hormone on serum lipids and lipoproteins: Possible significance of increased peripheral conversion of thyroxine to triiodothyronine
    • Wolthers T, Lemming L, Grøfte T, Møller N, Christiansen JS, Klausen IC, Jørgensen JO. Effects of growth hormone on serum lipids and lipoproteins: possible significance of increased peripheral conversion of thyroxine to triiodothyronine. Metabolism 45: 1016-1020, 1996.
    • (1996) Metabolism , vol.45 , pp. 1016-1020
    • Wolthers, T.1    Lemming, L.2    Grøfte, T.3    Møller, N.4    Christiansen, J.S.5    Klausen, I.C.6    Jørgensen, J.O.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.