Effects of statins on liver cell function and inflammation in septic rats

Journal of Surgical Research

Volumn 178, Issue 2, 2012, Pages 888-897

  Stolf, Aline Maria ^a   Lívero, Francislaine Dos Reis ^a   Dreifuss, Arturo Alejandro ^a   Bastos Pereira, Amanda Leite ^a   Fabosi, Isabella Aviles ^a   Alves De Souza, Carlos Eduardo ^a   Gomes, Liana De Oliveira ^a   Chicorski, Raphaella ^a   Brandt, Anna Paula ^a   Cadena, Silvia Maria Suter ^a   Telles, José Ederaldo Queiroz ^a   Hauser, Aline Borsato ^a   Elferink, Ronald Oude ^b   Zampronio, Aleksander Roberto ^a   Acco, Alexandra ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Atorvastatin; Leukocytes; Liver; Mitochondria; Oxidative stress; Sepsis; Simvastatin

Indexed keywords

ATORVASTATIN; SIMVASTATIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; INFLAMMATION; LAPAROTOMY; LEUKOCYTE COUNT; LIVER FUNCTION; LIVER HISTOLOGY; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT; SEPSIS;

ANIMALS; HEPATOCYTES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SEPSIS; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869087373     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.08.019     Document Type: Article

References (43)

1. R.S. Hotchkiss, and I.E. Karl The pathophysiology and treatment of sepsis N Engl J Med 348 2003 138
2. D. Salvemini, and S. Cuzzocrea Oxidative stress in septic shock and disseminated intravascular coagulation Free Radic Biol Med 33 2002 1173
3. A.L. Beal, and F.B. Cerra Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction JAMA 271 1994 226
4. J.F. Dhainaut, N. Marin, A. Mignon, and C. Vinsonneau Hepatic response to sepsis: interaction between coagulation and inflammatory processes Crit Care Med 29 2001 S42
5. M.H. Shishehbor, M.L. Brennan, and R.J. Aviles Statins promote potent systemic antioxidant effects through specific inflammatory pathways Circulation 108 2003 426
6. M.W. Merx, E.A. Liehn, and J. Graf Statin treatment after onset of sepsis in a murine model improves survival Circulation 112 2005 117
7. C.C. McGown, and Z.L.S. Brookes Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide Br J Anaesth 98 2007 163
8. M.E. Falagas, G.C. Makris, D.K. Matthaiou, and P.I. Rafailidis Statins for infection and sepsis: a systematic review of the clinical evidence J Antimicrob Chemother 61 2008 774
9. P.J. McGuigan, C.M. O'Kane, and D.F. McAuley Benefits of statins in the critically ill: promising but not proven Crit Care Med 39 2011 1599
10. J.E. Slotta, M.W. Laschke, M.K. Schilling, M.D. Menger, B. Jeppsson, and H. Thorlacius Simvastatin attenuates hepatic sensitization to lipopolysaccharide after partial hepatectomy J Surg Res 162 2010 184
11. N. Matsuda, Y. Hayashi, Y. Takahashi, and Y. Hattori Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-Kinase/Akt pathway: reversal effect of fluvastatin therapy J Pharmacol Exp Ther 319 2006 1348
12. M.W. Russo, M. Scobey, and H.L. Bonkovsky Drug-induced liver injury associated with statins Semin Liver Dis 29 2009 412
13. D.C. Angus, W.T. Linde-Zwirble, and J. Lidicker Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303
14. J.R. Pachaly, and H.F.V. Brito Interspecific allometric scaling M.E. Fowler, P.R. Cubas, Biology, medicine and surgery of South American wild animals 2001 Iowa University Ames (IA) 475 481
15. H. Aebi Catalase in vitro Methods Enzymol 105 1984 121
16. R. Gao, Z. Yuan, Z. Zhao, and X. Gao Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity Bioelectrochem Bioenerg 45 1998 41
17. W.H. Habig, M.J. Papst, and W.B. Jakoby Glutathione S-transferases: the first enzymatic step in mercapturic acid formation J Biol Chem 249 1974 7130
18. 2+ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method Lipids 26 1991 853
19. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 1968 192
20. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Anal Biochem 72 1976 248
21. D.O. Voss, A.P. Campelo, and M. Bacila The respiratory chain and the oxidative phosphorylation of rat brain mitochondria Biochem Biophys Res Commun 4 1961 48
22. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement whit the Folin phenol reagent J Biol Chem 193 1951 265
23. T.P. Singer, and M. Gutman The DPNH dehydrogenase of the mitochondrial respiratory chain Adv Enzymol Relat Areas Mol Biol 34 1971 79
24. E. Gnaiger Polarographic oxygen sensors, the oxygraph, and high-resolution respirometry to assess mitochondrial function J. Dykens, Y. Will, Drug-induced mitochondrial dysfunction 2008 John Wiley & Sons, Inc Hoboken, NJ 327 352
25. E. Otero-Aton, A. Gonzales-Quintela, A. Lopez-Soto, S. Lopez-Ben, I. Ltova, and L.F. Perez Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels Eur Surg Res 33 2001 77
26. D.A. Brealey, M. Singer, and M. Terblanche Potential metabolic consequences of statins in sepsis Crit Care Med 39 2011 1514
27. P. Fraunberger, E. Gröne, H.E. Gröne, and A.K. Walli Simvastatin reduces endotoxin-induced nuclear factor b activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol Shock 32 2009 159
28. K.R. Feingold, I. Staprans, and R.A. Memon Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance J Lipid Res 33 1992 1765
29. M.G.B. Oliveira, R.S. Santos, and L.D. Lima Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis Crit Care 13 2009 R74
30. T.V. Avila, A.L. Bastos Pereira, and A. De Oliveira Christoff Hepatic effects of flunixin-meglumin in LPS-induced sepsis Fundam Clin Pharmacol 24 2010 759
31. S. Yamashiro, H. Kamohara, J.M. Wang, D. Yang, W.H. Gong, and T. Yoshimura Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses J Leukoc Biol 69 2001 698
32. R.C. Bone, R.A. Balk, and F.B. Cerra American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Chest 101 1992 1644
33. F. Venet, F. Davin, and C. Guignant Early assessment of leukocyte alterations at diagnosis of septic shock Shock 34 2010 358
34. S. Zhang, M. Rahman, S. Zhang, Z. Qi, and H. Thorlacius Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis J Leukoc Biol 89 2011 735
35. D. Torres-Dueñas, C.F. Benjamim, S.H. Ferreira, and F.Q. Cunha Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatment Shock 25 2006 267
36. J.C. Alves-Filho, F. Sônego, and F.O. Souto Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection Nat Med 16 2010 708
37. J.C. Alves-Filho, C. Benjamim, B.M. Tavares-Murta, and F.Q. Cunha Failure of neutrophil migration toward infectious focus in severe sepsis: a critical event for the outcome of this syndrome Mem Inst Oswaldo Cruz 100 2005 223
38. D. Rittirsch, L.M. Hoesel, and P.A. Ward The disconnect between animal models of sepsis and human sepsis J Leukoc Biol 81 2007 137
39. H.F. Galley Oxidative stress and mitochondrial dysfunction in sepsis Br J Anaesth 107 2011 57
40. D.A. Brealey, I. Hargreaves, S. Heales, J. Land, R. Smolenski, and M. Singer Recovery from organ failure is associated with improved mitochondrial function in septic patients Intensive Care Med 29 2003 S134
41. C.M. Tsao, S.J. Chen, and M.C. Shih Effects of terbutaline on circulatory failure and organ dysfunction induced by peritonitis in rats Intensive Care Med 36 2010 1571
42. M. Spite, L.V. Norling, and L. Summers Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis Nature 461 2009 1287
43. A.P. Delaney, A. Dan, J. McCaffrey, and S. Finfer The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis Crit Care Med 39 2011 386