Black soybean anthocyanins inhibit adipocyte differentiation in 3T3-L1 cells

Nutrition Research

Volumn 32, Issue 10, 2012, Pages 770-777

  Kim, Hye Kyeong ^a   Kim, Jin Nam ^a   Han, Sung Nim ^b   Nam, Jae Hwan ^a   Na, Ha Na ^a   Ha, Tae Joung ^c  

^a The Catholic University of Korea   (South Korea)

^b Seoul National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

3T3 L1 cells; Antiobesity; Black soybean anthocyanins; Lipolysis

Indexed keywords

ANTHOCYANIN; CYANIDINE 3 O GLUCOSIDE; DELPHINIDIN 3 O GLUCOSIDE; GLUCOSIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PETUNIDINE 3 O GLUCOSIDE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; SOYBEAN;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; ANTHOCYANINS; ANTI-OBESITY AGENTS; CELL PROLIFERATION; EPINEPHRINE; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; LIPOLYSIS; MICE; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; PPAR GAMMA; SEEDS; SOYBEANS;

GLYCINE MAX; MUS;

EID: 84869085163     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2012.06.008     Document Type: Article

References (36)

1. Li S.Z. Black soybeans. Ben-Cao-Gang- Mu (An Outline Treatise of Medical Herbs written in 1500's AD) 1999, 1344-1349. People's Hygiene Publishing Company. Y.J. Wang (Ed.).
2. Duenas M., Hernadez T., Estrella I. Assessment of in vitro antioxidant activity of the seed coat and the cotyledon of legumes in relation to their phenolic contents. Food Chem 2006, 98:95-103.
3. He J., Giusti M.M. Anthocyanins: natural colorants with health-promoting properties. Annu Rev Food Sci Technol 2010, 1:163-187.
4. Tsuda T. Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Mol Nutr Food Res 2012, 56:159-170.
5. Tsuda T., Horio Y., Uchida K., Aoki H., Osawa T. Dietary cyanidine 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003, 133:2125-2130.
6. Titta L., Trinei M., Stendardo M., Berniakovich I., Petroni K., Toneli C., et al. Blood orange juice inhibits fat accumulation in mice. Int J Obes 2010, 34:578-588.
7. Matsui T., Ueda T., Oki T., Sugita K., Terahara N., Matsumoto K. Alpha-glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity. J Agric Food Chem 2001, 49:1948-1951.
8. Kwon S.H., Ahn I.S., Kim S.O., Kong C.S., Chung H.Y., Do M.S., et al. Anti-obesity and hypolipidemic effects of black soybean anthocyanins. J Med Food 2007, 10:552-556.
9. Kim S.L., Kim H.B., Chi H.Y., Park N.K., Son J.R., Yun H.T., et al. Variation of anthocyanins and isoflavones between yellow-cotyledon and green-cotyledon seeds of black soybean. Food Sci Biotechnol 2005, 14:778-782.
10. Nizamutdinova I.T., Jin Y.C., Chung J.I., Shin S.C., Lee S.J., Seo H.G., et al. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res 2009, 53:1419-1429.
11. Spiegelman B.M., Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell 1996, 87:377-389.
12. Ntambi J.M., Kim Y.C. Adipocyte differentiation and gene expression. J Nutr 2000, 130:S3122-S3126.
13. Lila M.A. From beans to berries and beyond: teamwork between plant chemicals for protection of optimal human health. Ann NY Acad Sci 2007, 1114:372-380.
14. Ailhaud G., Grimaldi P., Négrel R. Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 1992, 12:207-233.
15. Lee J.H., Kang N.S., Shin S.O., Shin S.H., Lim S.G., Suh D.Y., et al. Characterization of anthocyanins in the black soybean (Glycine max L.) by HPLC-DAD-ESI/MS analysis. Food Chem 2009, 112:226-231.
16. Hemati N., Ross S.E., Erickson R.L., Groblewski G.E., MacDougal O.A. Signaling pathways through insulin regulates CCAAT/enhancer binding protein alpha (C/EBP alpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression. J Biol Chem 1997, 272:25913-25919.
17. Wise L.S., Green H. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J Biol Chem 1979, 254:273-275.
18. Tang Q.Q., Otto T.C., Lane M.D. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA 2003, 100:44-49.
19. Zimmermann-Belsing T., Feldt-Rasmusen U. Obesity: the new worldwide epidemic threat to general health and our complete lack of effective treatment. Endocrinology 2004, 145:1501-1502.
20. Liu J., Zhang W., Jing H., Popovich D.G. Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. J Food Sci 2010, 75:H103-H107.
21. Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000, 16:145-171.
22. Grimaldi P.A. The roles of PPARs in adipocyte differentiation. Prog Lipid Res 2001, 40:269-281.
23. Suzuki R., Tanaka M., Takahashi M., Hussain A., Yuan B., Toyoda H., et al. Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. Nutr Metab 2011, 8:14.
24. Tsuda T., Ueno Y., Aoki H., Koda T., Horio F., Takahashi N., et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 2004, 316:149-157.
25. Takikawa M., Inoue S., Horio F., Tsuda T. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 2010, 140:527-533.
26. Hwang J.T., Park I.J., Lee Y.K., Lee S.K., Baik H.W., Ha J., et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophy Res Commun 2005, 338:694-699.
27. Scazzocchio B., Vari R., Filesi C., D'Archivo M., Santangelo C., Giovannini C., et al. Cyanidin-3-O-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes. Diabetes 2011, 60:2234-2244.
28. Frayn K.N., Karpe F., Fielding B.A., Macdonald I.A., Coppack S.W. Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord 2003, 27:875-888.
29. Morimoto C., Tsujita T., Okuda H. Antilipolytic actions of basal and hormone-induced lipolysis in rat adipocytes. J Lipid Res 1998, 39:957-962.
30. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease. Nature 2006, 444:875-880.
31. Pilz S., Schamagl H., Tiran B., Seehorst U., Wellnitz B., Boehm B.O., et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 2006, 91:2542-2547.
32. Jayaprakasam B., Olson L.K., Schutzki R.E., Tai M.H., Nair M.G. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and urosolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 2006, 54:243-248.
33. 2-terminal kinase activation. Biochem Pharm 2008, 75:1393-1401.
34. Kim H.K., Nelson-Dooley C., Della-Fera M.A., Yang J.Y., Zhang W., Duan J., et al. Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr 2006, 136:409-414.
35. Kim J.M., Kim J.S., Yoo H., Choung M.G., Sung M.K. Effects of black soybean [Glycine max (L.) Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo. J Agric Food Chem 2008, 56:8427-8433.
36. Chen P.N., Chu S.C., Chiou H.L., Chiang C.L., Yang S.F., Hsieh Y.S. Cyanidine 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. Nutr Cancer 2005, 53:232-243.