Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages

Immunobiology

Volumn 217, Issue 12, 2012, Pages 1301-1314

  Czimmerer, Zsolt ^a   Varga, Tamas ^a   Poliska, Szilard ^a   Nemet, Istvan ^a   Szanto, Attila ^a   Nagy, Laszlo ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Alternative macrophage activation markers; ENPP2; MAOA; PPAR ligand; Serotonin

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; 5 METHOXYINDOLEACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING); ARACHIDONATE 15 LIPOXYGENASE; AUTOTAXIN; CORIOLIC ACID; GAMMA INTERFERON; INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD180 GENE; CELL DIFFERENTIATION; CELL METABOLISM; CELL TYPE; COMPUTER MODEL; CONTROLLED STUDY; ENPP2 GENE; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LIPID METABOLISM; MACROPHAGE ACTIVATION; MARKER GENE; MONOCYTE; MS4A4A GENE; PREDICTION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SLA GENE; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD; ARACHIDONATE 15-LIPOXYGENASE; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-4; LIGANDS; LINOLEIC ACIDS; LIPID METABOLISM; LYSOPHOSPHOLIPIDS; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MONOAMINE OXIDASE; PHOSPHORIC DIESTER HYDROLASES; PPAR GAMMA; PROTO-ONCOGENE PROTEINS PP60(C-SRC); REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869084042     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.08.270     Document Type: Article

References (53)

1. Arnold L., Henry A., et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 2007, 204(5):1057-1069.
2. Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 2010, 11(10):889-896.
3. Chaitidis P., Billett E.E., et al. Th2 response of human peripheral monocytes involves isoform-specific induction of monoamine oxidase-A. J. Immunol. 2004, 173(8):4821-4827.
4. Chand H.S., Foster D.C., et al. Structure, function and biology of tissue factor pathway inhibitor-2. Thromb. Haemost. 2005, 94(6):1122-1130.
5. Chen J., Yao Y., et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 2011, 19(4):541-555.
6. Chen J.J., Lin Y.C., et al. Tumor-associated macrophages: the double-edged sword in cancer progression. J. Clin. Oncol. 2005, 23(5):953-964.
7. Crawley J.T., Goulding D.A., et al. Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels. Arterioscler. Thromb. Vasc. Biol. 2002, 22(2):218-224.
8. Curiel T.J., Coukos G., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004, 10(9):942-949.
9. Derecki N.C., Cardani A.N., et al. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J. Exp. Med. 2010, 207(5):1067-1080.
10. Divanovic S., Trompette A., et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 2005, 6(6):571-578.
11. Dragone L.L., Shaw L.A., et al. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunol. Rev. 2009, 232(1):218-228.
12. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3(1):23-35.
13. Gordon S.F., Martinez O. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32(5):593-604.
14. Gordon S.P., Taylor R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 2005, 5(12):953-964.
15. Hart P.H., Vitti G.F., et al. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Proc. Natl. Acad. Sci. U.S.A. 1989, 86(10):3803-3807.
16. Huang J.T., Welch J.S., et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999, 400(6742):378-382.
17. Jezek P., Hlavata L. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int. J. Biochem. Cell Biol. 2005, 37(12):2478-2503.
18. Kim J., Cha Y.N., et al. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 2010, 690(1-2):12-23.
19. Li M., Pascual G., et al. Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 2000, 20(13):4699-4707.
20. Liontos L.M., Dissanayake D., et al. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J. Immunol. 2011, 186(4):1923-1933.
21. Liu S., Murph M., et al. ATX-LPA receptor axis in inflammation and cancer. Cell Cycle 2009, 8(22):3695-3701.
22. Loke P., Gallagher I., et al. Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J. Immunol. 2007, 179(6):3926-3936.
23. Lumeng C.N., Bodzin J.L., et al. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 2007, 117(1):175-184.
24. Martinez F.O., Gordon S., et al. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006, 177(10):7303-7311.
25. Martinez F.O., Sica A., et al. Macrophage activation and polarization. Front. Biosci. 2008, 13:453-461.
26. McIntyre T.M., Pontsler A.V., et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(1):131-136.
27. Mori R., Shaw T.J., et al. Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J. Exp. Med. 2008, 205(1):43-51.
28. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8(12):958-969.
29. Nagy L., Szanto A., et al. Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response. Physiol. Rev. 2012, 92(2):739-789.
30. Nguyen K.D., Qiu Y., et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 2011, 480(7375):104-108.
31. Niiro H., Otsuka T., et al. MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes. Biochem. Biophys. Res. Commun. 1998, 250(2):200-205.
32. Odegaard J.I., Ricardo-Gonzalez R.R., et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447(7148):1116-1120.
33. Qian B.Z., Pollard J.W. Macrophage diversity enhances tumor progression and metastasis. Cell 2010, 141(1):39-51.
34. Ryder M., Ghossein R.A., et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr. Relat. Cancer 2008, 15(4):1069-1074.
35. Sanduja S., Blanco F.F., et al. The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdiscip. Rev. RNA 2011, 2(1):42-57.
36. Stein M., Keshav S., et al. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 1992, 176(1):287-292.
37. Stubbs V.E., Power C., et al. Regulation of eotaxin-3/CCL26 expression in human monocytic cells. Immunology 2010, 130(1):74-82.
38. Szanto A., Balint B.L., et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity 2010, 33(5):699-712.
39. Szatmari I., Gogolak P., et al. Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion. Immunity 2004, 21(1):95-106.
40. Tania M., Khan M.A., et al. Autotaxin: a protein with two faces. Biochem. Biophys. Res. Commun. 2010, 401(4):493-497.
41. Triantafyllopoulou A., Franzke C.W., et al. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(7):3012-3017.
42. Umezu-Goto M., Kishi Y., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 2002, 158(2):227-233.
43. Van Ginderachter J.A., Movahedi K., et al. Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion. Immunobiology 2006, 211(6-8):487-501.
44. Varga T., Czimmerer Z., et al. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim. Biophys. Acta 2011, 1812(8):1007-1022.
45. Vats D., Mukundan L., et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006, 4(1):13-24.
46. Waku T., Shiraki T., et al. The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites. EMBO J. 2010, 29(19):3395-3407.
47. Weisberg S.P., McCann D., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112(12):1796-1808.
48. Welch J.S., Ricote M., et al. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc. Natl. Acad. Sci. U.S.A. 2003, 100(11):6712-6717.
49. Woodward E.A., Kolesnik T.B., et al. The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2. Cytokine 2012, 58(3):415-423.
50. Xu H., Williams M.S., et al. Patterns of expression, membrane localization, and effects of ectopic expression suggest a function for MS4a4B, a CD20 homolog in Th1 T cells. Blood 2006, 107(6):2400-2408.
51. Zabuawala T., Taffany D.A., et al. An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res. 2010, 70(4):1323-1333.
52. Zhang C., Baker D.L., et al. Lysophosphatidic acid induces neointima formation through PPARgamma activation. J. Exp. Med. 2004, 199(6):763-774.
53. Zhu X.D., Zhang J.B., et al. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J. Clin. Oncol. 2008, 26(16):2707-2716.