Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation

Journal of Surgical Research

Volumn 178, Issue 2, 2012, Pages 988-995

  De Meyer, Martine ^a   Haufroid, Vincent ^a,b   Elens, Laure ^a   Fusaro, Fabio ^a   Patrono, Damiano ^a   De Pauw, Luc ^a   Kanaan, Nada ^a   Goffin, Eric ^a   Mourad, Michel ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Donor; Genetic polymorphisms; Kidney transplantation; Renal function

Indexed keywords

CREATININE; MULTIDRUG RESISTANCE PROTEIN 1;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BIOTRANSFORMATION; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EXON; FEMALE; FOLLOW UP; GENE FREQUENCY; GENE MUTATION; GENOTYPE; GLOMERULUS FILTRATION RATE; HOMOZYGOSITY; HUMAN; INDEPENDENT VARIABLE; INTRON; KIDNEY BIOPSY; KIDNEY DONOR; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECIPIENT; RENAL PROTECTION; RISK ASSESSMENT; SERUM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGE FACTORS; CALCINEURIN; CYTOCHROME P-450 CYP3A; FEMALE; GENOTYPE; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; TISSUE DONORS;

EID: 84869082325     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.06.070     Document Type: Article

References (38)

1. H. Ekberg, H. Tedesco-Silva, A. Demirbas ELITE-Symphony Study Reduced exposure to calcineurin inhibitors in renal transplantation N Engl J Med 357 2007 2562
2. J. Gloor, and M.D. Stegall Sensitized renal transplant recipients: current protocols and future directions Nat Rev Nephrol 6 2010 297
3. B. Maraha, H. Bonten, and H. van Hooff Infectious complications and antibiotic use in renal transplant recipients during a 1-year follow-up Clin Microbiol Infect 7 2001 619
4. J.R. Chapmann, P. O'Connell, and B.J. Nankivell Chronic renal allograft dysfunction J Am Soc Nephrol 16 2005 3015
5. B.J. Nankivell, R.J. Borrows, and C.L. Fung Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology Transplantation 78 2004 557
6. Y. Dai, K. Iwanaga, and Y.S. Lin In vitro metabolism of cyclosporine A by human kidney CYP3A5 Biochem Pharmacol 68 2004 1889
7. L. Jette, E. Beaulieu, J.M. Leclerc, and R. Beliveau Cyclosporine A treatment induces overexpression of P-glycoprotein in the kidney and other tissues Am J Physiol 270 1996 F756
8. C.E. Staatz, L.K. Goodman, and S.E. Tett Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: part II Clin Pharmacokinet 49 2010 207
9. I.A. Hauser, E. Schaeffeler, and S. Gauer ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation J Am Soc Nephrol 16 2005 1501
10. M.S. Joy, S.L. Hogan, and B.D. Thompson Cytochrome P450 3A5 expression in the kidneys of patients with calcineurin inhibitor nephrotoxicity Nephrol Dial Transplant 22 2007 1963
11. S. Kliewer The nuclear pregnane X receptor regulates xenobiotic detoxification J Nutr 133 2003 2444S
12. J. Lamba, V. Lamba, and E. Schuetz Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics Curr Drug Metab 6 2005 369
13. L. Elens, J.C. Yombi, and D. Lison Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients Pharmacogenomics 10 2009 1589
14. A. Moutabarrik, M. Ishibashi, and M. Fukunaga FK-506 induced kidney tubular cell injury Transplantation 54 1992 1041
15. M.J. Mihatsch, G. Thiel, and B. Ryffel Cyclosporine nephrotoxicity Adv Nephrol Necker Hosp 17 1988 303
16. C.K. Abrass, A.K. Berfield, and C. Stehman-Breen Unique changes in interstitial extracellular matrix composition are associated with rejection and cyclosporine toxicity in human renal allograft biopsies Am J Kidney Dis 33 1999 11
17. M.J. Koziolek, R. Riess, and H. Geiger Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients Kidney Int 60 2001 156
18. S. Hoffmeyer, O. Burk, and O. von Richter Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proc Natl Acad Sci U S A 97 2000 3473
19. E.L. Woodahl, Z. Yang, and T. Bui Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein J Pharmacol Exp Ther 310 2004 1199
20. E.L. Woodahl, M.H. Crouthamel, and T. Bui MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents Cancer Chemother Pharmacol 64 2009 183
21. M. Mourad, P. Wallemacq, and M. De Meyer Biotransformation enzymes and drug transporters pharmacogenetics in relation to immunosuppressive drugs: impact on pharmacokinetics and clinical outcome Transplantation 85 2008 S19
22. L. Elens, A. Capron, and V. Van Kerckhove 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation Pharmacogenet Genomics 17 2007 873
23. S. Crettol, J.P. Venetz, and M. Fontana Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients Pharmacogenet Genomics 18 2008 307
24. A. Capron, M. Mourad, and M. De Meyer CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells in the early phase after renal transplantation Pharmacogenomics 11 2010 703
25. E.L. Woodahl, Z. Yang, and T. Bui MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein expressing epithelial cells AIDS 19 2005 1617
26. M. Naesens, E. Lerut, and H. de Jonge Donor age and renal P-glycoprotein expression associated with chronic histological damage in renal allografts J Am Soc Nephrol 20 2009 2468
27. M.F. Hebert, A.L.S. Dowling, and C. Gierwatowski Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors Pharmacogenetics 13 2003 661
28. R.B. Kim, B.F. Leake, and E.F. Choo Identification of functionally variant ABCB1 alleles among European Americans and African Americans Clin Pharmacol Ther 70 2001 189
29. T. Sakaeda, T. Nakamura, and M. Horinouchi MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects Pharm Res 18 2001 1400
30. Y. Kurata, I. Ieiri, and M. Kimura Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein Clin Pharmacol Ther 72 2002 209
31. D. Anglicheau, N. Pallet, and M. Rabant Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction Kidney Int 70 2006 1019
32. B.D. Haehner, J.C. Gorski, and M. Vandenbranden Bimodal distribution of renal cytochrome P450 3A activity in humans Mol Pharmacol 50 1996 52
33. D.R.J. Kuypers, M. Naesens, and H. de Jonge Tacrolimus dose requirements and CYP3A5 genotype and the development of calcineurin inhibitor-associated nephrotoxicity in renal allograft recipients Ther Drug Monit 32 2010 394
34. M. Epstein Aging and the kidney J Am Soc Nephrol 7 1996 1106
35. F.G. Cosio, W. Qiu, and M.L. Henry Factors related to the donor are major determinants of renal allograft function and survival Transplantation 62 1996 1571
36. G. Remuzzi, P. Cravedi, A. Perna Dual Kidney Transplant Group Long-term outcome of renal transplantation from older donors N Engl J Med 354 2006 343
37. F. Moreso, D. Serón, and S. Gil-Vernet Donor age and delayed graft function as predictors of renal allograft survival in rejection-free patients Nephrol Dial Transplant 14 1999 930
38. P.F. Halloran, A. Melk, and C. Barth Rethinking chronic allograft nephropathy: the concept of accelerated senescence J Am Soc Nephrol 10 1999 167