Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7223-7226

  Brumfield, Stephanie ^a   Korakas, Peter ^a   Silverman, Lisa S ^a   Tulshian, Deen ^a   Matasi, Julius J ^a   Qiang, Li ^a   Bennett, Chad E ^a   Burnett, Duane A ^a   Greenlee, William J ^a   Knutson, Chad E ^a   Wu, Wen Lian ^a   Sasikumar, T K ^a   Domalski, Martin ^a   Bertorelli, Rosalia ^a   Grilli, Mariagrazia ^a   Lozza, Gianluca ^a   Reggiani, Angelo ^a   Li, Cheng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; PYRIDOTHIENOPYRIMIDINONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PAIN; DRUG ACTIVITY; DRUG EXPOSURE; DRUG METABOLISM; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IN VIVO STUDY; NERVE LIGATION; NONHUMAN; RAT; SPINAL NERVE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CHRONIC PAIN; DISEASE MODELS, ANIMAL; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; PYRIMIDINONES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84869081295     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.048     Document Type: Article

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