Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats

Journal of Nutrition

Volumn 128, Issue 12, 1998, Pages 2473-2487

  Ward, G R ^a   Huang, Y S ^b   Bobik, E ^b   Xing, H C ^a   Mutsaers, L ^a   Auestad, N ^b   Montalto, M ^b   Wainwright, P ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Arachidonic acid; Brain development; Docosahexaenoic acid; Rats; Red blood cell

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ARACHIDONIC ACID METABOLISM; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DIETARY INTAKE; ERYTHROCYTE; LIPID ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; RAT;

ANIMALS; ANIMALS, NEWBORN; ARACHIDONIC ACID; BRAIN; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, UNSATURATED; FEMALE; FOOD, FORMULATED; HUMANS; INFANT FOOD; MALE; RATS;

ANIMALIA;

EID: 0032424865     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Altman, J. (1982) Morphological development of the rat cerebellum and some of its mechanisms. Exp. Brain Res. [suppl.] 6: 8-49.
2. Anderson, G. J. & Connor, W. E. (1994) Accretion of (n-3) fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. Am. J. Clin. Nutr. 59: 1338-1346.
3. Auestad, N., Korsak, R. A., Bergstrom, J. D. & Edmond, J. (1989) Milk-substitutes comparable to rat's milk: Their preparation, their preparation, composition and impact on development and metabolism in the artificially reared rat. Brit. J. Nutr. 61: 495-518.
4. Bazan, N. G., Rodriguez de Turco, E. B. & Gordon, W. C. (1994) Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. World Rev. Nutr. Diet 75: 120-123.
5. Birch, E. E., Birch, D. G., Hoffman, D. R. & Uauy, R. (1992) Dietary essential fatty acid supply and visual acuity development. Invest. Ophthalmol. Vis. Sci. 33: 3242-3253.
6. Bligh, E. G. & Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
7. Bourre, J. M., Dumont, O. & Durand, G. (1993) Brain phospholipids as dietary source of (n-3) polyunsaturated fatty acids for nervous tissue in the rat. J. Neurochem. 60: 2018-2028.
8. Bourre, J. M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G. & Durand, G. (1989) The effects of dietary α-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks. J. Nutr. 119: 1880-1892.
9. Carlson, S. E. & Werkman, S. H. (1996) A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. Lipids 31: 85-90.
10. Carlson, S. E., Carver, J. D. & House, S. G. (1986) High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: A comparison of rat neural and red cell membrane phospholipids. J. Nutr. 116: 718-725.
11. Carlson, S. E., Rhodes, P. G., Rao, V. S. & Goldgar, D. E. (1987) Effect of fish-oil supplementation on the (n-3) fatty acid content of red blood cell membranes in preterm infants. Pediatr. Res. 21: 507-510.
12. Carlson, S. E., Werkman, S. H., Rhodes, P. G. & Tolley, E. A. (1993) Visual acuity development in healthy, preterm infants: Effect of marine oil supplementation. Am. J. Clin. Nutr. 58: 35-42.
13. Carlson, S. E., Werkman, S. H. & Tolley, E. A. (1996) Effect of long-chain (n-3) fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Am. J. Clin. Nutr. 63: 687-697.
14. Carnielli, V. P., Wattimena, D. J., Luijendijk, I. H., Boerlage, A., Degenhart, H. J. & Sauer, P. J. (1996) The very low birthweight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. Pediatr. Res. 40: 169-174.
15. Cody, R. P. & Smith, J. K. (1991) Applied Statistics and the SAS Programming Language. Prentice Hall, Englewood cliffs, NJ.
16. Craig-Schmidt, M. C., Stieh, K. E. & Lien, E. L. (1996) Retinal fatty acids of piglets fed docosahexaenoic and arachidonic acids from microbial sources. Lipids 31: 53-59.
17. Dobbing, J. & Sands, J. (1979) Comparative aspects of the brain growth spurt. Early Human Dev. 3: 79-83.
18. Dodge, J. T. & Phillips, G. B. (1967) Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells. J. Lipid Res. 8: 667-675.
19. Farquharson, J., Cockburn, F., Patrick, W. A., Jamieson, E. C. & Logan, R. W. (1992) Infant cerebral cortex phospholipid fatty acid composition and diet. Lancet 340: 810-813.
20. Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
21. Hall, W. G. (1975) Weaning and growth of artificially-reared rats. Science 190: 1313-1315.
22. Innis, S. M. (1991) Essential fatty acids in growth and development. Prog. Lipid Res. 30: 39-103.
23. Innis, S. M. (1993) The colostrum-deprived piglet as a model for study of infant lipid nutrition. J. Nutr. 123: S386-S390.
24. Jensen, R. G., Hagerty, M. M. & McMahon, K. E. (1978) Lipids of human milk and infant formulas: a review. Am. J. Clin. Nutr. 31: 990-1016.
25. Jimenez, J., Boza, J., Suarez, M. D. & Gil, A. (1997) The effect of a formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids on plasma phospholipid, liver microsomal, retinal and brain fatty acid composition in neonatal piglets. J. Nutr. Biochem. 8: 217-223.
26. Jorgensen, M. H., Hernell, O., Lund, P., Holmer, G., Michaelsen, K. F. (1996) Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four mos of life. Lipids 31: 99-105.
27. Jumpsen, J. J., Lein, E. L., Goh, Y. K. & Clandinin, M. T. (1997a) During neuronal and glial cell development diet (n-6) to (n-3) fatty acid ratio alters the fatty acid composition of phosphatidylinositol and phosphatidylserine. Biochim. Biophys. Acta 1347: 40-50.
28. Jumpsen, J. J., Lein, E. L., Goh, Y. K. & Clandinin, M. T. (1997b) Small changes of dietary (n-6) and (n-3)/fatty acid content ratio alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. J. Nutr. 127: 724-731.
29. Lamptey, M. S. & Walker, B. L. (1976) A possible essential role for dietary linolenic acid in the development of the young rat. J. Nutr. 106: 86-93.
30. Lucas, A. (1997) Long-chain polyunsaturated fatty acids, infant feeding and cognitive development. In: Developing Brain and Behaviour (Dobbing, J., ed.), pp. 3-27. Academic Press, Ltd., London, UK.
31. Makrides, M., Neuman, M. A., Byard, R. W., Simmer, K., and Gibson, R. A. (1994) Fatty acid composition of brain, retina, and erythrocytes in breast-and formula-fed infants. Am. J. Clin. Nutr. 60: 189-194.
32. Makrides, M., Neumann, M. A. & Gibson, R. A. (1996) Is dietary docosahexaenoic acid essential for term infants? Lipids 31: 115-119.
33. Messer, M., Thoman, E. B., Terrasa, A. G. & Dallman, P. R. (1969) Artificial feeding of infant rats by continuous gastric infusion. J. Nutr. 98: 404-410.
34. Mills, D. E., Ward, R. P. & Huang, Y.S. (1990) Fatty acid composition of milk from genetically normotensive and hypertensive rats. J. Nutr. 120: 431-435.
35. Moore, S. A., Yoder, E., Murphy, S., Dutton, G. R. & Spector, A. A. (1991) Astrocytes, not neurons, produce docosahexaenoic acid and arachidonic acid. J. Neurochem. 56: 518-524.
36. Morrison, W. R. & Smith, L. M. (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5: 600-608.
37. Neuringer, M., Connor, W. E., Lin, D. S., Barstad, L. & Lin, D. (1986) Biochemical and functional effects of prenatal and postnatal w-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc. Natl. Acad. Sci. USA 83: 4021-4025.
38. Neuringer, M., Connor, W. E., van Petten, C. & Barstad, L. (1984) Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest. 73: 272-276.
39. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J. Nutr. 123: 1939-1951.
40. Reisbick, S., Neuringer, M., Gohl, E. & Wald, R. (1997) Visual attention in infant monkeys: effects of dietary fatty acids and age. Dev. Psychol. 33: 387-395.
41. Sastry, P. S. (1985) Lipids of nervous tissue: Composition and metabolism. Prog. Lipid Res. 24: 69-176.
42. Wainwright, P. E. (1992) Do essential fatty acids play a role in brain and behavioral development? Neurosci. Biobehav. Rev. 16: 193-205.
43. Wainwright, P. E. & Ward, G. R. (1997) Early nutrition and behaviour: A conceptual framework for critical analysis of research. In: Developing Brain and Behaviour (Dobbing, J., ed.), pp. 387-414. Academic Press, Ltd., London, UK.
44. Wainwright, P. E., Huang, Y.S., Bulman-Fleming, B., Dalby, D., Mills, D. E., Redden, P. & McCutcheon, D. (1992) The effects of dietary n-3/n-6 ratio on brain development in the mouse: a dose-response study with long-chain (n-3) fatty acids. Lipids 27: 98-103.
45. Wainwright, P. E., King, H. C., Mutsaers, L., McCutcheon, D. & Kyle, D. (1997) Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6)(n-3) ratio and very high levels of docosahexaenoic acid J. Nutr. 127: 184-193.
46. Ward, G., Woods, J. Reyzer, M. & Salem, N. Jr. (1996) Artificial rearing of infant rats on milk formula deficient in (n-3) essential fatty acids: A rapid method for the production of experimental n-3-deficiency, Lipids 31: 71-77.
47. Weisinger, H. S., Vingrys, A. J. & Sinclair, A. J. (1996) The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. Lipids 31: 65-70.
48. Winters, B. L., Yeh, S. M. & Yeh, Y. Y. (1994) Linolenio acid provides a source of docosahexaenoic acid for artificially reared rat pups. J. Nutr. 124: 1654-1659.
49. Woods, J., Ward, G. & Salem, N. Jr. (1996) Is docosahexaenoic acid necessary in infant formula: Evaluation of high linolenate diets in the neonatal rat? Pediatr. Res. 40: 687-694.