Analysis of colorectal adenocarcinoma tissue by desorption electrospray ionization mass spectrometric imaging

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 8, 2012, Pages 2315-2325

  Gerbig, Stefanie ^a   Golf, Ottmar ^a   Balog, Julia ^b   Denes, Julia ^a   Baranyai, Zsolt ^c   Zarand, Attila ^c   Raso, Erzsebet ^d   Timar, Jozsef ^d   Takats, Zoltan ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Medimass Ltd   (Hungary)

^c UZSOKI HOSPITAL   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Colorectal adenocarcinoma; Desorption electrospray ionization; KRAS mutation; Mass spectrometry imaging; Multivariate statistical analysis; Phospholipid profile

Indexed keywords

ALTERNATIVE APPROACH; CERAMIDES; COLORECTAL ADENOCARCINOMA; CONNECTIVE TISSUES; DATA POINTS; DATA SETS; DESORPTION ELECTROSPRAY IONIZATION; EX-VIVO; FROZEN SECTIONS; HIGH RESOLUTION; HISTOLOGICAL FEATURES; HISTOLOGICAL TISSUE; HISTOLOGICAL TYPE; IDENTIFICATION METHOD; IMAGING DATA; IMAGING MASS SPECTROMETRY; INDIVIDUAL SECTIONS; ION DESORPTION; KRAS MUTATION; LINEAR DISCRIMINANT ANALYSIS; LIVER METASTASIS; MASS SPECTROMETRIC DATA; MOLECULAR CONSTITUENTS; MS/MS FRAGMENTATION; MULTIVARIATE STATISTICAL ANALYSIS; ORBITRAP; PHOSPHATIDIC ACIDS; PLASMALOGENS; SAMPLE SETS; SEMI-AUTOMATED; SMOOTH MUSCLES; SPATIAL RESOLUTION; SPHINGOLIPIDS; TISSUE TYPES; WILD TYPES;

AMIDES; AMINO ACIDS; AUTOMATION; COLLAGEN; DESORPTION; ELECTROSPRAY IONIZATION; GLYCEROL; MASS SPECTROMETERS; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; MUSCULOSKELETAL SYSTEM; PHOSPHOLIPIDS; PIXELS; PRINCIPAL COMPONENT ANALYSIS; SECONDARY ION MASS SPECTROMETRY; SEPARATION;

TISSUE;

KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHOLIPID; RAS PROTEIN;

ADENOCARCINOMA; ARTICLE; CHEMISTRY; COLON; COLORECTAL TUMOR; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; LIVER; LIVER TUMOR; METABOLISM; METASTASIS; METHODOLOGY; MUTATION; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; RECTUM;

ADENOCARCINOMA; COLON; COLORECTAL NEOPLASMS; HUMANS; LIVER; LIVER NEOPLASMS; MUTATION; PHOSPHOLIPIDS; PRINCIPAL COMPONENT ANALYSIS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RECTUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84863723868     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-5841-x     Document Type: Article

References (59)

1. Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 69(23):4751-4760
2. Stoeckli M, Farmer TB, Caprioli RM (1999) Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument. J Am Soc Mass Spectrom 10 (1):67-71
3. Makarov A (2000) Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis. Anal Chem 72 (6):1156-1162
4. Rompp A, Guenther S, Takats Z, Spengler B (2011) Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level. Anal Bioanal Chem 401 (1):65-73
5. Chaurand P, Schriver KE, Caprioli RM (2007) Instrument design and characterization for high resolution MALDI-MS imaging of tissue sections. J Mass Spectrom 42(4):476-489
6. Spengler B, Hubert M (2002) Scanning microprobe matrixassisted laser desorption ionization (SMALDI) mass spectrometry: instrumentation for sub-micrometer resolved LDI and MALDI surface analysis. J Am Soc Mass Spectrom 13(6):735-748
7. Morrison G, Gay I, Chandra S (1994) Ion microscopy in biology. Scanning Microsc Suppl 8:359-370
8. Pacholski ML, Cannon DM, Ewing AG, Winograd N (1998) Static time-of-flight secondary ion mass spectrometry imaging of freezefractured, frozen-hydrated biological membranes. Rapid Commun Mass Spectrom 12(18):1232-1235
9. Touboul D, Halgand F, Brunelle A, Kersting R, Tallarek E, Hagenhoff B, Laprevote O (2004) Tissue molecular ion imaging by gold cluster ion bombardment. Anal Chem 76(6):1550-1559
10. Altelaar AFM, Klinkert I, Jalink K, de Lange RPJ, Adan RAH, Heeren RMA, Piersma SR (2006) Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry. Anal Chem 78(3):734-742
11. Touboul D, Kollmer F, Niehuis E, Brunelle A, Laprevote O (2005) Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source. J Am Soc Mass Spectrom 16(10):1608-1618
12. Brunelle A, Touboul D, Laprevote O (2005) Biological tissue imaging with time-of-flight secondary ion mass spectrometry and cluster ion sources. J Mass Spectrom 40(8):985-999
13. Weibel D, Wong S, Lockyer N, Blenkinsopp P, Hill R, Vickerman JC (2003) A C-60 primary ion beam system for time of flight secondary ion mass spectrometry: its development and secondary ion yield characteristics. Anal Chem 75(7):1754-1764
14. Takats Z, Wiseman JM, Gologan B, Cooks RG (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306(5695):471-473
15. Haddad R, Sparrapan R, Eberlin MN (2006) Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry. Rapid Commun Mass Spectrom 20(19):2901-2905
16. Haddad R, Sparrapan R, Kotiaho T, Eberlin MN (2008) Easy ambient sonic-spray ionization-membrane interface mass spectrometry for direct analysis of solution constituents. Anal Chem 80(3):898-903
17. Shiea J, Huang MZ, Hsu HJ, Lee CY, Yuan CH, Beech I, Sunner J (2005) Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids. Rapid Commun Mass Spectrom 19(24):3701-3704
18. Nemes P, Barton AA, Vertes A (2009) Three-dimensional imaging of metabolites in tissues under ambient conditions by laser ablation electrospray ionization mass spectrometry. Anal Chem 81 (16):6668-6675
19. Cody RB, Laramee JA, Durst HD (2005) Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal Chem 77(8):2297-2302
20. Williams JP, Scrivens JH (2005) Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples. Rapid Commun Mass Spectrom 19 (24):3643-3650
21. McEwen CN, McKay RG, Larsen BS (2005) Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments. Anal Chem 77(23):7826-7831
22. Harper JD, Charipar NA, Mulligan CC, Zhang XR, Cooks RG, Ouyang Z (2008) Low-temperature plasma probe for ambient desorption ionization. Anal Chem 80(23):9097-9104
23. Wiseman J, Puolitaival S, Takats Z, Cooks R, Caprioli R (2005) Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization. Angew Chem Int Ed 44 (43):7094-7097
24. Nemes P, Woods AS, Vertes A (2010) Simultaneous imaging of small metabolites and lipids in rat brain tissues at atmospheric pressure by laser ablation electrospray ionization mass spectrometry. Anal Chem 82(3):982-988
25. Liu Y, Ma X, Lin Z, He M, Han G, Yang C, Xing Z, Zhang S, Zhang X (2010) Imaging mass spectrometry with a low-temperature plasma probe for the analysis of works of art. Angew Chem Int Ed 49 (26):4435-4437
26. Takats Z, Wiseman J, Cooks R (2005) Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J Mass Spectrom 40(10):1261-1275
27. Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM (1990) Electrospray ionization - principles and practice. Mass Spectrom Rev 9(1):37-70
28. Wiseman JM, Ifa DR, Song QY, Cooks RG (2006) Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. Angew Chem Int Ed 45(43):7188-7192
29. Manicke NE, Dill AL, Ifa DR, Cooks RG (2010) High-resolution tissue imaging on an orbitrap mass spectrometer by desorption electrospray ionization mass spectrometry. J Mass Spectrom 45 (2):223-226
30. Thunig J, Hansen SH, Janfelt C (2011) Analysis of secondary plant metabolites by indirect desorption electrospray ionization imaging mass spectrometry. Anal Chem 83(9):3256-3259
31. Kertesz V, Van Berkel GJ (2008) Improved imaging resolution in desorption electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 22(17):2639-2644
32. Masterson TA, Dill AL, Eberlin LS, Mattarozzi M, Cheng L, Beck SDW, Bianchi F, Cooks RG (2011) Distinctive glycerophospholipid profiles of human seminoma and adjacent normal tissues by desorption electrospray ionization imaging mass spectrometry. J Am Soc Mass Spectrom 22(8):1326-1333
33. Basile F, Sibray T, Belisle JT, Bowen RA (2011) Analysis of lipids from crude lung tissue extracts by desorption electrospray ionization mass spectrometry and pattern recognition. Anal Biochem 408 (2):289-296
34. Wiseman JM, Ifa DR, Zhu YX, Kissinger CB, Manicke NE, Kissinger PT, Cooks RG (2008) Desorption electrospray ionization mass spectrometry: imaging drugs and metabolites in tissues. Proc Natl Acad Sci USA 105(47):18120-18125
35. Podo F (1999) Tumour phospholipid metabolism. NMR Biomed 12(7):413-439
36. Chaurand P, Schwartz SA, Billheimer D, Xu BGJ, Crecelius A, Caprioli RM (2004) Integrating histology and imaging mass spectrometry. Anal Chem 76(4):1145-1155
37. Jackson SN, Wang HYJ, Woods AS (2005) Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS. Anal Chem 77 (14):4523-4527
38. Gemoll T, Roblick UJ, Habermann JK (2011) MALDI mass spectrometry imaging in oncology (Review). Mol Med Rep 4(6):1045-1051
39. Thiel V, Sjovall P (2011) Using time-of-flight secondary ion mass spectrometry to study biomarkers. Annu Rev Earth Planet Sci 39:125-156
40. Eberlin LS, Dill AL, Costa AB, Ifa DR, Cheng L, Masterson T, Koch M, Ratliff TL, Cooks RG (2010) Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry. Anal Chem 82(9):3430-3434
41. Eberlin LS, Dill AL, Golby AJ, Ligon KL, Wiseman JM, Cooks RG, Agar NYR (2010) Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. Angew Chem Int Ed 49(34):5953-5956
42. Manicke NE, Nefliu M, Wu C, Woods JW, Reiser V, Hendrickson RC, Cooks RG (2009) Imaging of lipids in atheroma by desorption electrospray ionization mass spectrometry. Anal Chem 81 (21):8702-8707
43. Dill AL, Eberlin LS, Costa AB, Zheng C, Ifa DR, Cheng LA, Masterson TA, Koch MO, Vitek O, Cooks RG (2011) Multivariate statistical identification of human bladder carcinomas using ambient ionization imaging mass spectrometry. Chem-Eur J 17 (10):2897-2902
44. Dill AL, Eberlin LS, Zheng C, Costa AB, Ifa DR, Cheng LA, Masterson TA, Koch MO, Vitek O, Cooks RG (2010) Multivariate statistical differentiation of renal cell carcinomas based on lipidomic analysis by ambient ionization imaging mass spectrometry. Anal Bioanal Chem 398(7-8):2969-2978
45. Cooks RG, Manicke NE, Dill AL, Ifa DR, Eberlin LS, Costa AB, Wang H, Huang G, Zheng O (2011) New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring. Faraday Discuss 149:247-267
46. Merchant TE, Kasimos JN, Vroom T, de Bree E, Iwata JL, de Graaf PW, Glonek T (2002) Malignant breast tumor phospholipid profiles using P-31 magnetic resonance. Cancer Lett 176(2):159-167
47. Daly PF, Lyon RC, Faustino PJ, Cohen JS (1987) Phospholipidmetabolism in cancer-cells monitored by P-31 NMR-spectroscopy. J Biol Chem 262(31):14875-14878
48. Schaefer K-C, Denes J, Albrecht K, Szaniszlo T, Balog J, Skoumal R, Katona M, Toth M, Balogh L, Takats Z (2009) In vivo, in situ tissue analysis using rapid evaporative ionization mass spectrometry. Angew Chem Int Ed 48(44):8240-8242
49. Balog J, Szaniszlo T, Schaefer KC, Denes J, Lopata A, Godorhazy L, Szalay D, Balogh L, Sasi-Szabo L, Toth M, Takats Z (2010) Identification of biological tissues by rapid evaporative ionization mass spectrometry. Anal Chem 82(17):7343-7350
50. Schaefer KC, Szaniszlo T, Guenther S, Balog J, Denes J, Keseru M, Dezso B, Toth M, Spengler B, Takats Z (2011) In situ, real-time identification of biological tissues by ultraviolet and infrared laser desorption ionization mass spectrometry. Anal Chem 83(5):1632-1640
51. Merchant TE, Kasimos JB, Degraaf PW, Minsky BD, Gierke LW, Glonek T (1991) Phospholipid profile of human colorectal cancer using P-31 magnetic-resonance spectroscopy. Int J Colorectal Dis 6:121-126
52. Dueck D-A, Chan M, Tran K, Wong JT, Jay FT, Littman C, Stimpson R, Choy PC (1996) The modulation of choline phosphoglyceride metabolism in human colon cancer. Mol Cell Biochem 162(2):97-103
53. Dobrzynska I, Szachowicz-Petelska B, Sulkowski S, Figaszewski Z (2005) Changes in electric charge and phospholipids composition in human colorectal cancer cells. Mol Cell Biochem 276(1-2):113-119
54. Dill AL, Eberlin LS, Costa AB, Ifa DR, Cooks RG (2011) Data quality in tissue analysis using desorption electrospray ionization. Anal Bioanal Chem 401(6):1949-1961
55. Malumbres M, Barbacid M (2003) Timeline - RAS oncogenes: the first 30 years. Nat Rev Cancer 3(6):459-465
56. Ogino S, Meyerhardt JA, Irahara N, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Schaefer P, Whittom R, Hantel A, Benson AB III, Goldberg RM, Bertagnolli MM, Fuchs CS, Canadian Canc Soc Res I (2009) KRAS Mutation in Stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin Cancer Res 15(23):7322-7329
57. Normanno N, Tejpar S, Morgillo F, De Luca A, Van Cutsem E, Ciardiello F (2009) Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat Rev Clin Oncol 6(9):519-527
58. Siddiqui AD, Piperdi B (2010) KRAS Mutation in Colon Cancer: A Marker of Resistance to EGFR-I Therapy. Ann Surg Oncol 17 (4):1168-1176
59. Sjolander A, Yamamoto K, Huber BE, Lapetina EG (1991) Association of P21RAS with phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 88(18):7908-7912