Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity

Arthritis and Rheumatism

Volumn 64, Issue 10, 2012, Pages 3478-3485

  Wang, Min ^a   Xie, Hehuang ^a   Shrestha, Sheela ^a   Sredni, Simone ^a   Morgan, Gabrielle A ^a   Pachman, Lauren M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALX4 PROTEIN; BISULFITE; HOMEODOMAIN PROTEIN; HOXB1 PROTEIN; HOXC11 PROTEIN; HOXD3 PROTEIN; HOXD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMX2; UNCLASSIFIED DRUG; WT1 PROTEIN;

ARTICLE; CELL CYCLE REGULATION; CELL RENEWAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LOCATION; GENOME; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JUVENILE DERMATOMYOSITIS; MALE; MUSCLE BIOPSY; MYOSITIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; PYROSEQUENCING; SCHOOL CHILD;

CHILD; CHILD, PRESCHOOL; DERMATOMYOSITIS; FEMALE; GENES, HOMEOBOX; HUMANS; INFLAMMATION; MALE; METHYLATION; MUSCLE, SKELETAL; WT1 PROTEINS;

EID: 84869046236     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34573     Document Type: Article

References (50)

1. Christen-Zaech S, Seshadri R, Sundberg J, Paller AS, Pachman LM. Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis. Arthritis Rheum 2008; 58: 571-6. (Pubitemid 351294893)
2. Feldman BM, Rider LG, Reed AM, Pachman LM. Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood. Lancet 2008; 371: 2201-12. (Pubitemid 351890413)
3. Schwartz T, Sanner H, Husebye T, Flato B, Sjaastad I. Cardiac dysfunction in juvenile dermatomyositis: a case-control study. Ann Rheum Dis 2011; 70: 766-71.
4. Huber AM, Lang B, LeBlanc CM, Birdi N, Bolaria RK, Malleson P, et al. Medium- and long-term functional outcomes in a multicenter cohort of children with juvenile dermatomyositis. Arthritis Rheum 2000; 43: 541-9. (Pubitemid 30394944)
5. Eimer MJ, Brickman WJ, Seshadri R, Ramsey-Goldman R, McPherson DD, Smulevitz B, et al. Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis. J Pediatr 2011; 159: 795-801.
6. Shrestha S, Wershil B, Sarwark JF, Niewold TB, Philipp T, Pachman LM. Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells. Arthritis Rheum 2010; 62: 2813-22.
7. Aziz A, Sebastian S, Dilworth FJ. The origin and fate of muscle satellite cells. Stem Cell Rev 2012; 8: 609-22.
8. De Bari C, Dell'Accio F, Vandenabeele F, Vermeesch JR, Raymackers JM, Luyten FP. Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. J Cell Biol 2003; 160: 909-18. (Pubitemid 36350845)
9. Farthing CR, Ficz G, Ng RK, Chan CF, Andrews S, Dean W, et al. Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet 2008;4:e1000116.
10. Patel DR, Richardson BC. Epigenetic mechanisms in lupus. Curr Opin Rheumatol 2010; 22: 478-82.
11. Xie H, Wang M, Bonaldo MD, Rajaram V, Stellpflug W, Smith C, et al. Epigenomic analysis of Alu repeats in human ependymomas. Proc Natl Acad Sci U S A 2010; 107: 6952-7.
12. Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med 1975; 292: 403-7.
13. Lovell DJ, Lindsley CB, Rennebohm RM, Ballinger SH, Bowyer SL, Giannini EH, et al, in cooperation with the Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies. II. The Childhood Myositis Assessment Scale (CMAS): a quantitative tool for the evaluation of muscle function. Arthritis Rheum 1999; 42: 2213-9. (Pubitemid 30263608)
14. Pachman LM, Abbott K, Sinacore JM, Amoruso L, Dyer A, Lipton R, et al. Duration of illness is an important variable for untreated children with juvenile dermatomyositis. J Pediatr 2006; 148:247-53. (Pubitemid 43286768)
15. Chen YW, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM. Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. BMC Immunol 2008;9:43.
16. Rachidi M, Lopes C, Charron G, Delezoide AL, Paly E, Bloch B, et al. Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome. Int J Dev Neurosci 2005;23: 475-84. (Pubitemid 40981872)
17. Farrall AL, Whitelaw ML. The HIF1-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene 2009;28: 3671-80.
18. He LC, Xu HZ, Gu ZM, Liu CX, Chen GQ, Wang YF, et al. Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction. Biochem Biophys Res Commun 2011; 406: 430-4.
19. Arnaud L, Saison C, Helias V, Lucien N, Steschenko D, Giarratana MC, et al. A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia. Am J Hum Genet 2010; 87: 721-7.
20. Bauer DE, Orkin SH. Update on fetal hemoglobin gene regulation in hemoglobinopathies. Curr Opin Pediatr 2011; 23: 1-8.
21. Goodfellow SJ, Rebello MR, Toska E, Zeef LA, Rudd SG, Medler KF, et al. WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line. Biochem J 2011; 435: 113-25.
22. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN, et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007; 21: 1258-66. (Pubitemid 46831815)
23. Nagaraju K, Casciola-Rosen L, Lundberg I, Rawat R, Cutting S, Thapliyal R, et al. Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis Rheum 2005; 52: 1824-35. (Pubitemid 40852891)
24. Sallum AM, Kiss MH, Silva CA, Wakamatsu A, Sachetti S, Lotufo S, et al. MHC class I and II expression in juvenile dermatomyositis skeletal muscle. Clin Exp Rheumatol 2009; 27: 519-26.
25. Baechler EC, Bilgic H, Reed AM. Type I interferon pathway in adult and juvenile dermatomyositis. Arthritis Res Ther 2011;13: 249.
26. Lassar AB, Paterson BM, Weintraub H. Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell 1986; 47: 649-56. (Pubitemid 17011408)
27. Lee WJ, Kim HJ. Inhibition of DNA methylation is involved in transdifferentiation of myoblasts into smooth muscle cells. Mol Cells 2007; 24: 441-4.
28. Cunninghame Graham DS, Morris DL, Bhangale TR, Criswell LA, Syvanen AC, Ronnblom L, et al. Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet 2011;7:e1002341.
29. Toth K, Galamb O, Spisak S, Wichmann B, Sipos F, Valcz G, et al. The influence of methylated septin 9 gene on RNA and protein level in colorectal cancer. Pathol Oncol Res 2011; 17: 503-9.
30. Da L, Li D, Yokoyama KK, Li T, Zhao M. Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene. Biochem J 2006; 393: 779-88. (Pubitemid 43163818)
31. Lee N, Maurange C, Ringrose L, Paro R. Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 2005; 438: 234-7. (Pubitemid 41599876)
32. Sustar A, Bonvin M, Schubiger M, Schubiger G. Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs. Dev Biol 2011; 356: 576-87.
33. Fjose A, McGinnis WJ, Gehring WJ. Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature 1985; 313: 284-9. (Pubitemid 15151983)
34. Capovilla M, Kambris Z, Botas J. Direct regulation of the muscleidentity gene apterous by a Hox protein in the somatic mesoderm. Development 2001; 128: 1221-30. (Pubitemid 32409645)
35. Goff DJ, Tabin CJ. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 1997; 124: 627-36. (Pubitemid 27092428)
36. Houghton L, Rosenthal N. Regulation of a muscle-specific transgene by persistent expression of Hox genes in postnatal murine limb muscle. Dev Dyn 1999; 216: 385-97.
37. Costa BM, Smith JS, Chen Y, Chen J, Phillips HS, Aldape KD, et al. Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res 2010; 70: 453-62.
38. Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana- Pereira M, et al. MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature. Cancer Res 2010; 70: 9243-52.
39. Branciamore S, Chen ZX, Riggs AD, Rodin SN. CpG island clusters and pro-epigenetic selection for CpGs in protein-coding exons of HOX and other transcription factors. Proc Natl Acad Sci U S A 2010; 107: 15485-90.
40. Haber DA, Buckler AJ, Glaser T, Call KM, Pelletier J, Sohn RL, et al. An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell 1990;61: 1257-69.
41. Huff V. Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer 2011; 11: 111-21.
42. Schumacher V, Schneider S, Figge A, Wildhardt G, Harms D, Schmidt D, et al. Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromalpredominant histology. Proc Natl Acad Sci U S A 1997; 94: 3972-7. (Pubitemid 27180483)
43. Miyagawa K, Kent J, Moore A, Charlieu JP, Little MH, Williamson KA, et al. Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour. Nat Genet 1998; 18: 15-7.
44. Tiffin N, Williams RD, Robertson D, Hill S, Shipley J, Pritchard- Jones K. WT1 expression does not disrupt myogenic differentiation in C2C12 murine myoblasts or in human rhabdomyosarcoma. Exp Cell Res 2003; 287: 155-65. (Pubitemid 36683210)
45. Wagner KD, Wagner N, Bondke A, Nafz B, Flemming B, Theres H, et al. The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction. FASEB J 2002; 16:1117-9.
46. Smart N, Bollini S, Dube KN, Vieira JM, Zhou B, Davidson S, et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011; 474: 640-4.
47. Martinez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, et al. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and Ecadherin. Nat Genet 2010; 42: 89-93.
48. Rider LG, Pachman LM, Miller FW, Bollar H. Myositis and you: a guide to juvenile dermatomyositis for patients, families, and healthcare providers. Alexandria (VA): Myositis Association; 2007.
49. Nakanishi K, Sudo T, Morishima N. Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development. J Cell Biol 2005; 169: 555-60. (Pubitemid 41002848)
50. Wang M, Xie H, Stellpflug W, Rajaram V, Bonaldo MD, Goldman S, et al. BTECH: a platform to integrate genomic, transcriptomic and epigenomic alterations in brain tumors. Neuroinformatics 2011; 9: 59-67.