WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

Biochemical Journal

Volumn 435, Issue 1, 2011, Pages 113-125

  Goodfellow, Sarah J ^a   Rebello, Michelle R ^b   Toska, Eneda ^b   Zeef, Leo A H ^a   Rudd, Sean G ^a,c   Medler, Kathryn F ^b   Roberts, Stefan G E ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Brain acid soluble protein 1 (BASP1); K562 cell; Wilms' tumour; Wilms' tumour 1 (WT1)

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA2 INTEGRIN; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMPHIREGULIN; ANGIOPOIETIN 1; BETA3 INTEGRIN; BRAIN ACID SOLUBLE PROTEIN 1; CALCIUM; ENTACTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HEMIN; MESSENGER RNA; MYC PROTEIN; PROTEIN BAX; PROTEIN P21; PURINERGIC P2X5 RECEPTOR; RENIN; SYNAPSIN I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; VITAMIN D RECEPTOR; WT1 PROTEIN;

ARTICLE; BINDING SITE; BLOOD CELL; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; MEGAKARYOCYTE; MYELOID LEUKEMIA; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNAPSE; TRANSCRIPTION REGULATION; UPREGULATION;

CELL DIFFERENTIATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MEMBRANE PROTEINS; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; NEURITES; NEUROGENESIS; NEURONS; NUCLEAR REPROGRAMMING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYNAPSES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTIONAL ACTIVATION; WT1 PROTEINS;

EID: 79952830159     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101734     Document Type: Article

References (43)

1. Rivera, M. N. and Haber, D. A. (2005) Wilms' tumour: connecting tumorigenesis and organ development in the kidney. Nat. Rev. Cancer 5, 699-712
2. Yang, L., Han, Y., Suarez Saiz, F. and Minden, M. D. (2007) A tumor suppressor and oncogene: the WT1 story. Leukemia 21, 868-876
3. Hohenstein, P. and Hastie, N. D. (2006) The many facets of the Wilms' tumour gene, WT1. Hum. Mol. Genet. 15, R196-R201
4. Wagner, K. D., Wagner, N., Vidal, V. P., Schley, G., Wilhelm, D., Schedl, A., Englert, C. and Scholz, H. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 21, 1398-1405 (Pubitemid 34246518)
5. Wagner, N., Wagner, K. D., Hammes, A., Kirschner, K. M., Vidal, V. P., Schedl, A. and Scholz, H. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development 132, 1327-1336 (Pubitemid 40528792)
6. Armstrong, J. F., Pritchard-Jones, K., Bickmore, W. A., Hastie, N. D. and Bard, J. B. (1993) The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech. Dev. 40, 85-97
7. Roberts, S. G. E. (2005) Transcriptional regulation by WT1 in development. Curr. Opin. Genet. Dev. 15, 542-547
8. McKay, L. M., Carpenter, B. and Roberts, S. G. E. (1999) Regulation of the Wilms' tumour suppressor protein transcriptional activation domain. Oncogene 18, 6546-6554
9. Carpenter, B., Hill, K. J., Charalambous, M., Wagner, K. J., Lahiri, D., James, D. I., Anderson, J. S., Schumacher, V., Royer-Pokora, B., Mann, M. et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumour suppressor protein WT1. Mol. Cell. Biol. 24, 537-549
10. Hartkamp, J., Carpenter, B. and Roberts, S. G. E. (2010) The Wilms' tumour suppressor protein WT1 is processed by the serine protease HtrA2/Omi. Mol. Cell 37, 159-171
11. Mosevitsky, M. I. (2005) Nerve ending 'signal' proteins GAP-43, MARCKS, and BASP1. Int. Rev. Cytol. 245, 245-325
12. Ohsawa, S., Watanabe, T., Katada, T., Nishina, H. and Miura, M. (2008) Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. Biochem. Biophys. Res. Commun. 371, 639-643
13. Green, L. M., Wagner, K. J., Campbell, H. A., Addison, K. and Roberts, S. G. E. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res. 37, 431-440
14. Hartl, M., Nist, A., Khan, M. I., Valovka, T. and Bister, K. (2009) Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1). Proc. Natl. Acad. Sci. U.S.A. 106, 5604-5609
15. Moribe, T., Iizuka, N., Miura, T., Stark, M., Tamatsukuri, S., Ishitsuka, H., Hamamoto, Y., Sakamoto, K., Tamesa, T. and Oka, M. (2008) Identification of novel aberrant methylation of BASP1 and SRD5A2 for early diagnosis of hepatocellular carcinoma by genome-wide search. Int. J. Oncol. 33, 949-958
16. Yeoh, E. J., Ross, M. E., Shurtleff, S. A., Williams, W. K., Patel, D., Mahfouz, R., Behm, F. G., Raimondi, S. C., Relling, M. V., Patel, A. et al. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1, 133-143 (Pubitemid 41039160)
17. Wang, J., Coombes, K. R., Highsmith, W. E., Keating, M. J. and Abruzzo, L. V. (2004) Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies. Bioinformatics 20, 3166-3178
18. Ariyaratana, S. and Loeb, D. M. (2007) The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis. Expert Rev. Mol. Med. 9, 1-17
19. Rosenfeld, C., Cheever, M. A. and Gaiger, A. (2003) WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies. Leukemia 17, 1301-1312 (Pubitemid 36857337)
20. Nelson, J. D., Denisenko, O. and Bomsztyk, K. (2006) Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat. Protoc. 1, 179-185
21. Steege, A., Fähling, M., Paliege, A., Bondke, A., Kirschner, K.M., Martinka, P., Kaps, C., Patzak, A., Persson, P. B., Thiele, B. J. et al. (2008) Wilms' tumor protein (-KTS) modulates renin gene transcription. Kidney Int. 74, 458-466
22. Lee, T. H. and Pelletier, J. (2001) Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter. Physiol. Genomics 7, 187-200
23. Wagner, N., Michiels, J. F., Schedl, A. and Wagner, K. D. (2008) The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo. Oncogene 27, 3662-3672
24. Lee, S. B., Huang, K., Palmer, R., Truong, V. B., Herzlinger, D., Kolquist, K. A., Wong, J., Paulding, C., Yoon, S. K., Gerald, W. et al. (1999) The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell 98, 663-673 (Pubitemid 29418957)
25. Kim, H. S., Kim, M. S., Hancock, A. L., Harper, J. C., Park, J. Y., Poy, G., Perantoni, A. O., Cam, M., Malik, K. and Lee, S. B. (2007) Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development. J. Biol. Chem. 282, 16278-16287
26. Li, C. and Wong, W. H. (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. U.S.A. 98, 31-6
27. Wu, Z., Irizarry, R. A., Gentleman, R., Martinez-Murillo, F. and Spencer, F. (2004) A model-based background adjustment for oligonucleotide expression arrays. J. Am. Stat. Assoc. 99, 909-917
28. Smyth, G. K. (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, Article3
29. Storey, J. D. and Tibshirani, R. (2003) Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. U.S.A. 100, 9440-9445
30. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450
31. Tsiftsoglou, A. S., Pappas, I. S. and Vizirianakis, I. S. (2003) Mechanisms involved in the induced differentiation of leukemia cells. Pharmacol. Ther. 100, 257-90
32. Huo, X. F., Yu, J., Peng, H., Du, Z. W., Liu, X. L., Ma, Y. N., Zhang, X., Zhang, Y., Zhao, H. L. and Zhang, J. W. (2006) Differential expression changes in K562 cells during the hemin-induced erythroid differentiation and the phorbol myristate acetate (PMA)-induced megakaryocytic differentiation. Mol. Cell. Biochem. 292, 155-167
33. Daniels, R. H., Hall, P. S. and Bokoch, G. M. (1998) Membrane targeting of p21- activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J. 17, 754-764
34. Kim, T. A., Lim, J., Ota, S., Raja, S., Rogers, R., Rivnay, B., Avraham, H. and Avraham, S. (1998) NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J. Cell Biol. 141, 553-566 (Pubitemid 28217904)
35. Fox, M. A., Ho, M. S., Smyth, N. and Sanes, J. R. (2008) A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction. Neural Dev. 25, 3-24
36. North, R. A. (2002) Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067
37. Fornasiero, E. F., Bonanomi, D., Benfenati, F. and Valtorta, F. (2009) The role of synapsins in neuronal development. Cell. Mol. Life Sci. 67, 1383-1396
38. Lindner, I., Kharfan-Dabaja, M. A., Ayala, E., Kolonias, D., Carlson, L. M., Beazer-Barclay, Y., Scherf, U., Hnatyszyn, J. H. and Lee, KP. (2003) Induced dendritic cell differentiation of chronic myeloid leukemia blasts is associated with down-regulation of BCR-ABL. J. Immunol. 171, 1780-1791 (Pubitemid 36966460)
39. Korshunova, I., Caroni, P., Kolkova, K., Berezin, V., Bock, E. and Walmod, P. S. (2008) Characterization of BASP1-mediated neurite outgrowth. J. Neurosci. Res. 86, 2201-2213
40. Wagner, N., Wagner, K. D., Schley, G., Coupland, S. E., Heimann, H., Grantyn, R. and Scholz, H. (2002) The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells. Cell Growth Differ. 13, 297-305 (Pubitemid 34791203)
41. Kobayashi, N., Gao, S. Y., Chen, J., Saito, K., Miyawaki, K., Li, C. Y., Pan, L., Saito, S., Terashita, T. and Matsuda, S. (2004) Process formation of the renal glomerular podocyte: is there common molecular machinery for processes of podocytes and neurons? Anat. Sci. Int. 79, 1-10
42. Udtha, M., Lee, S. J., Alam, R., Coombes, K. and Huff, V. (2003) Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors. Oncogene 22, 3821-3826 (Pubitemid 36760745)
43. Kim, M. K., McGarry, T. J., O'Broin, P., Flatow, J. M., Golden, A. A. and Licht, J. D. (2009) An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1. Proc. Natl. Acad. Sci. U.S.A. 106, 11154-11159