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Volumn 77, Issue 11, 2012, Pages 1028-1038

Easy derivatisation of group 10 N-heterocyclic carbene complexes and in vitro evaluation of an anticancer oestradiol conjugate

Author keywords

Antitumor agents; Carbenes; Cycloaddition; Nitrogen heterocycles; Platinum

Indexed keywords


EID: 84869044843     PISSN: None     EISSN: 21926506     Source Type: Journal    
DOI: 10.1002/cplu.201200092     Document Type: Article
Times cited : (35)

References (93)
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    • The 1H NMR spectrum of complex 3 shows a similar signal pattern to that of complexes reported in the literature: a) R. Jothibasu, K.-W. Huang, H.V. Huynh, Organometallics 2010, 29, 3746
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    • During the reaction, less than 5% of the cis isomers was formed, which was easily removed by chromatography on silica gel because they were more polar than the trans isomers
    • During the reaction, less than 5% of the cis isomers was formed, which was easily removed by chromatography on silica gel because they were more polar than the trans isomers.
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    • In contrast to platinum, the monocarbenic complexes of palladium were experimentally demonstrated to be not robust enough to further support the TMS-deprotection conditions
    • In contrast to platinum, the monocarbenic complexes of palladium were experimentally demonstrated to be not robust enough to further support the TMS-deprotection conditions.
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    • Attempts to use other sources of amines as solvent/ligand such as cyclohexylamine to synthesise Pt-cyclohexylamine complex 6 directly from 2 led to the partial deprotection of the TMS group and afforded a mixture of polynuclear complexes. E. Chardon, G. L. Puleo, G. Dahm, G. Guichard, S. Bellemin-Laponnaz, unpublished results
    • Attempts to use other sources of amines as solvent/ligand such as cyclohexylamine to synthesise Pt-cyclohexylamine complex 6 directly from 2 led to the partial deprotection of the TMS group and afforded a mixture of polynuclear complexes. E. Chardon, G. L. Puleo, G. Dahm, G. Guichard, S. Bellemin-Laponnaz, unpublished results.
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    • Ref. [31 f]
    • g) Ref. [31 f]
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    • CCDC-856303 (4) and CCDC-856304 (6) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The
    • CCDC-856303 (4) and CCDC-856304 (6) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data- request/cif.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.