A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

Nature Communications

Volumn 3, Issue , 2012, Pages

  Reticker Flynn, Nathan E ^a   Malta, David F Braga ^a,b,c   Winslow, Monte M ^a,d   Lamar, John M ^a   Xu, Mary J ^a   Underhill, Gregory H ^a,e   Hynes, Richard O ^a,f   Jacks, Tyler E ^a,f   Bhatia, Sangeeta N ^a,f,g,h  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Cell2B   (Portugal)

^c Instituto de Biotecnologia e Bioengenharia Lisboa   (Portugal)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of Illinois at Urbana Champaign   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3 INTEGRIN; BETA1 INTEGRIN; FIBRONECTIN; GALECTIN 3; GALECTIN 8; LAMININ;

CELL ORGANELLE; CORRELATION; MATRIX; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL DIFFERENTIATION; CELL INTERACTION; COMBINATORIAL LIBRARY; CORRELATION ANALYSIS; DISEASE MODEL; EXTRACELLULAR MATRIX; GENETIC MODEL; LUNG ADENOCARCINOMA; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN INTERACTION; TUMOR MICROENVIRONMENT;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; EXTRACELLULAR MATRIX; FIBRONECTINS; GALECTIN 3; GALECTINS; LAMININ; LUNG NEOPLASMS; MICE;

EID: 84869042621     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2128     Document Type: Article

References (49)

1. Gupta, G. P. & Massagué, J. Cancer Metastasis: building a framework. Cell 127, 679-695 (2006). (Pubitemid 44781029)
2. Mehlen, P. & Puisieux, A. Metastasis: a question of life or death. Nat. Rev. Cancer 6, 449-458 (2006).
3. Hofman, P. C., Mauer, A. M. & Vokes, E. E. Lung cancer. The Lancet 355, 479-485 (2000). (Pubitemid 30085163)
4. Steeg, P. S. & Teodorescu, D. Metastasis: a therapeutic target for cancer. Nat Clin. Prac. Oncol. 5, 206-219 (2008). (Pubitemid 351493680)
5. Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nat Rev. Cancer 9, 239-252 (2009).
6. Naba, A. et al. The matrisome: in silico defnition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell. Proteomics 11, M111.014647 (2012).
7. Levental, K. R. et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling 139, 891-906 (2009).
8. Oskarsson, T. et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 17, 867-874 (2011).
9. Desgrosellier, J. S. & Cheresh, D. A. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev. Cancer 10, 9-22 (2010).
10. Weaver, V. M. et al. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J. Cell Biol. 137, 231-245 (1997). (Pubitemid 27167310)
11. Dolberg, D. S. & Bissell, M. J. Inability of Rous sarcoma virus to cause sarcomas in the avian embryo. Nature 309, 552-556 (1984). (Pubitemid 14109376)
12. Hendrix, M. J. C. et al. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev. Cancer 7, 246-255 (2007). (Pubitemid 46480969)
13. Olumi, A. F. et al. Carcinoma-associated fbroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011 (1999). (Pubitemid 29472907)
14. Albini, A. et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 47, 3239-3245 (1987). (Pubitemid 17082655)
15. Hotary, K. B. et al. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 114, 33-45 (2003). (Pubitemid 36859839)
16. Malik, G. et al. Plasma fbronectin promotes lung metastasis by contributions to fbrin clots and tumor cell invasion. Cancer Res. 70, 4327-4334 (2010).
17. White, D. E. et al. Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6, 159-170 (2004). (Pubitemid 39485688)
18. Hynes, R. O. The Extracellular Matrix: not just pretty fbrils. Science 326, 1216-1219 (2009).
19. Reuter, J. A. et al. Modeling inducible human tissue neoplasia identifes an extracellular matrix interaction network involved in cancer progression. Cancer Cell 15, 477-488 (2009).
20. Avraamides, C. J., Garmy-Susini, B. & Varner, J. A. Integrins in angiogenesis and lymphangiogenesis. Nat Rev. Cancer 8, 604-617 (2008).
21. Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002). (Pubitemid 35283958)
22. Flaim, C. J., Chien, S. & Bhatia, S. N. An extracellular matrix microarray for probing cellular diferentiation. Nat Meth. 2, 119-125 (2005). (Pubitemid 41131033)
23. Flaim, C. J., Teng, D., Chien, S. & Bhatia, S. N. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 17, 29-40 (2008).
24. LaBarge, M. A. et al. Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol. 1, 70-79 (2009).
25. Mei, Y. et al. Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Small 4, 1600-1604 (2008).
26. Brafman, D. A. et al. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr. Biol. 1, 513-524 (2009).
27. Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001). (Pubitemid 34008190)
28. DuPage, M., Dooley, A. L. & Jacks, T. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protocols 4, 1064-1072 (2009).
29. Winslow, M. M. et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature 473, 101-104 (2011).
30. Carpenter, A. E. et al CellProfler: image analysis sofware for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
31. Jackson, E. L. et al. The diferential efects of mutant p53 alleles on advanced murine lung cancer. Cancer Res. 65, 10280-10288 (2005). (Pubitemid 41743720)
32. Rhodes, D. R. et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6, 1-6 (2004). (Pubitemid 38391943)
33. Liu, F.-T. & Rabinovich, G. A. Galectins as modulators of tumour progression. Nat Rev. Cancer 5, 29-41 (2005). (Pubitemid 40052323)
34. Takenaka, Y., Fukumori, T. & Raz, A. Galectin-3 and metastasis. Glycoconjugate J. 19, 543-549 (2002). (Pubitemid 38316528)
35. Bresalier, R. S. et al. Metastasis of human colon cancer is altered by modifying expression of the β-galactoside-binding protein galectin 3. Gastroenterology 115, 287-296 (1998). (Pubitemid 28363421)
36. Yu, L.-G. The oncofetal Tomsen-Friedenreich carbohydrate antigen in cancer progression. Glycoconjugate J. 24, 411-420 (2007). (Pubitemid 47512574)
37. Nagy, N. et al. Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts signifcantly on human colon cancer cell migration as a suppressor. Gut 50, 392-401 (2002). (Pubitemid 34161058)
38. Zick, Y. et al. Role of galectin-8 as a modulator of cell adhesion and cell growth. Glycoconjugate J. 19, 517-526 (2002). (Pubitemid 38316525)
39. Singhal, H. et al. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. Clin. Cancer Res. 3, 605-611 (1997).
40. McAllister, S. S. et al. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133, 994-1005 (2008). (Pubitemid 351787747)
41. Van't Veer, L. J. et al. Gene expression profling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
42. Beer, D. G. et al. Gene-expression profles predict survival of patients with lung adenocarcinoma. Nat Med. 8, 816-824 (2002).
43. Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
44. Paik, S. et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351, 2817-2826 (2004). (Pubitemid 40051905)
45. Van De Vijver, M. J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002). (Pubitemid 35461656)
46. Hou, J. et al. Gene expression-based classifcation of non-small cell lung carcinomas and survival prediction. PLoS ONE 5, e10312 (2010).
47. Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006). (Pubitemid 43128862)
48. Lamar, J. M. et al. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc. Natl Acad. Sci. USA 109, E2441-E2450 (2012).
49. Stern, P. et al. A system for Cre-regulated RNA interference in vivo. Proc. Natl Acad. Sci. 105, 13895-13900 (2008).