The Impact of Disulfiram Treatment on the Reinforcing Effects of Cocaine: A Randomized Clinical Trial

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Haile, Colin N ^a   de la Garza II, Richard ^a   Mahoney III, James J ^a   Nielsen, David A ^a   Kosten, Thomas R ^a   Newton, Thomas F ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DISULFIRAM; PLACEBO; SODIUM CHLORIDE;

ADULT; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DECISION MAKING; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONEY; RANDOMIZED CONTROLLED TRIAL; REINFORCEMENT; SYSTOLIC BLOOD PRESSURE;

ADULT; CHOICE BEHAVIOR; COCAINE; COCAINE-RELATED DISORDERS; CROSS-OVER STUDIES; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HEART RATE; HUMANS; MALE; TREATMENT OUTCOME;

EID: 84869018929     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047702     Document Type: Article

References (49)

1. SAMHSA (2010) Substance Abuse and Mental Health Services Administration. Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings. Available: http://www.oas.samhsa.gov/NSDUH/2k9NSDUH/2k9ResultsP.pdf.
2. Haile CN, Mahoney JJ, Newton TF, De La Garza R, (2012) Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: Focus on dopamine, norepinephrine and glutamate. Pharmacol Ther 134: 260-277 doi:10.1016/j.pharmthera.2012.01.010.
3. Major LF, Lerner P, Ballenger JC, Brown GL, Goodwin FK, et al. (1979) Dopamine-beta-hydroxylase in the cerebrospinal fluid: relationship to disulfiram-induced psychosis. Biol Psychiatry 14: 337-344.
4. Hoeldtke RD, Stetson PL, (1980) An in vivo tritium release assay of human dopamine beta-hydroxylase. J Clin Endocrinol Metab 51: 810-815.
5. Goldstein M, Anagnoste B, Lauber E, Mckeregham MR, (1964) Inhibition of dopamine-beta-hydroxylase by disulfiram. Life Sci 3: 763-767.
6. Lippmann W, Lloyd K, (1969) Dopamine--hydroxylase inhibition by dimethyldithiocarbamate and related compounds. Biochem Pharmacol 18: 2507-2516.
7. Rosen GF, Lobo RA, (1987) Further evidence against dopamine deficiency as the cause of inappropriate gonadotropin secretion in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 65: 891-895.
8. Paradisi R, Grossi G, Pintore A, Venturoli S, Porcu E, et al. (1991) Evidence for a pathological reduction in brain dopamine metabolism in idiopathic hyperprolactinemia. Acta Endocrinol 125: 246-252.
9. Johansson B, (1992) A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand Suppl 369: 15-26.
10. Hald J, Jacobsen E, (1948) A drug sensitizing the organism to ethyl alcohol. Lancet 2: 1001-1004.
11. Wright C, Moore RD, (1990) Disulfiram treatment of alcoholism. Am J Med 88: 647-55.
12. Zemaitis MA, Greene FE, (1976) Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamate. Biochem Pharmacol 25: 453-459.
13. Nousiainen U, Törrönen R, (1984) Differentiation of microsomal and cytosolic carboxylesterases in the rat liver by in vivo and in vitro inhibition. Gen Pharmacol 15: 223-227.
14. Savolainen K, Hervonen H, (1985) Dithiocarbamate fungicides decrease histochemical reactivity of cholinesterases in the gut wall of the rat. Arch Toxicol Suppl. 8: 272-276.
15. Stewart DJ, Inaba T, Lucassen M, Kalow W, (1979) Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther 25: 464-468.
16. Benowitz NL, (1993) Clinical pharmacology and toxicology of cocaine. Pharmacol Toxicol 72: 3-12.
17. McCance-Katz EF, Kosten TR, Jatlow P, (1998) Disulfiram effects on acute cocaine administration. Drug Alcohol Depend 52: 27-39.
18. McCance-Katz EF, Kosten TR, Jatlow P, (1998) Chronic disulfiram treatment effects on intranasal cocaine administration: initial results. Biol Psychiatry 43: 540-3.
19. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ, (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237: 1219-1223.
20. Volkow ND, Fowler JS, Wang GJ, (1999) Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol (Oxford) 13: 337-345.
21. Weinshenker D, Schroeder JP, (2007) There and back again: a tale of norepinephrine and drug addiction. Neuropsychopharmacology 32: 1433-1451 doi:10.1038/sj.npp.1301263.
22. Newton TF, De La Garza R, Brown G, Kosten TR, Mahoney JJ 3rd, et al. (2012) Noradrenergic α(1) Receptor Antagonist Treatment Attenuates Positive Subjective Effects of Cocaine in Humans: A Randomized Trial. PLoS ONE 7: e30854 doi:10.1371/journal.pone.0030854.
23. Baker JR, Jatlow P, McCance-Katz EF, (2007) Disulfiram effects on responses to intravenous cocaine administration. Drug Alcohol Depend 87: 202-9.
24. Hameedi FA, Rosen MI, McCance-Katz EF, McMahon TJ, Price LH, et al. (1995) Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans. Biol Psychiatry 37: 560-563 doi:10.1016/0006-3223(94)00361-6.
25. Higgins ST, Budney AJ, Bickel WK, Hughes JR, Foerg F, (1993) Disulfiram therapy in patients abusing cocaine and alcohol. Am J Psychiatry 150: 675-6.
26. Carroll KM, Power ME, Bryant K, Rounsaville B, (1993) One-year follow-up status of treatment-seeking cocaine abusers. Psychopathology and dependence severity as predictors of outcome. J Nerv Ment Dis 181: 71-9.
27. Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ, (1998) Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 93: 713-727.
28. Carroll KM, Nich C, Ball SA, McCance E, Frankforter TL, et al. (2000) One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment. Addiction 95: 1335-1349.
29. George TP, Chawarski MC, Pakes J, Carroll KM, Kosten TR, et al. (2000) Disulfiram versus placebo for cocaine dependence in buprenorphine maintained subjects: a preliminary trial. Biol Psychiatry 47: 1080-6.
30. Carroll KM, Fenton LR, Ball SA, Nich C, Frankforter TL, et al. (2004) Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Arch Gen Psychiatry 61: 264-272 doi:10.1001/archpsyc.61.3.264.
31. Grassi MC, Cioce AM, Giudici FD, Antonilli L, Nencini P, (2007) Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study. Pharmacol Res 55: 117-121 doi:10.1016/j.phrs.2006.11.005.
32. Oliveto A, Poling J, Mancino MJ, Feldman Z, Cubells JF, et al. (2011) Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. Drug Alcohol Depend 113: 184-191 doi:10.1016/j.drugalcdep.2010.07.022.
33. Pettinati HM, Kampman KM, Lynch KG, Xie H, Dackis C, et al. (2008) A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. Addict Behav 33: 651-667 doi:10.1016/j.addbeh.2007.11.011.
34. Higgins ST, Roll JM, Bickel WK, (1996) Alcohol pretreatment increases preference for cocaine over monetary reinforcement. Psychopharmacology (Berl.) 123: 1-8.
35. Hart CL, Haney M, Foltin RW, Fischman MW, (2000) Alternative reinforcers differentially modify cocaine self-administration by humans. Behav Pharmacol 11: 87-91.
36. Stoops WW, Lile JA, Rush CR, (2010) Monetary alternative reinforcers more effectively decrease intranasal cocaine choice than food alternative reinforcers. Pharmacol Biochem Behav 95: 187-191 doi:10.1016/j.pbb.2010.01.003.
37. Higgins ST, Bickel WK, Hughes JR, (1994) Influence of an alternative reinforcer on human cocaine self-administration. Life Sci 55: 179-187.
38. Walsh SL, Haberny KA, Bigelow GE, (2000) Modulation of intravenous cocaine effects by chronic oral cocaine in humans. Psychopharmacology (Berl.) 150: 361-373.
39. Faul F, Erdfelder E, Lang AG, Buchner A, (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175-191.
40. Sofuoglu M, Poling J, Waters A, Sewell A, Hill K, et al. (2008) Disulfiram enhances subjective effects of dextroamphetamine in humans. Pharmacol Biochem Behav 90: 394-398 doi:10.1016/j.pbb.2008.03.021.
41. Schroeder JP, Cooper DA, Schank JR, Lyle MA, Gaval-Cruz M, et al. (2010) Disulfiram Attenuates Drug-Primed Reinstatement of Cocaine Seeking via Inhibition of Dopamine beta-Hydroxylase. Neuropsychopharmacology. Available: http://www.ncbi.nlm.nih.gov/pubmed/20736996. Accessed 15 Oct 2010.
42. Schroeder JP, Cooper DA, Schank JR, Lyle MA, Gaval-Cruz M, et al. (2010) Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase. Neuropsychopharmacology 35: 2440-2449 doi:10.1038/npp.2010.127.
43. Pani PP, Trogu E, Vacca R, Amato L, Vecchi S, et al. (2010) Disulfiram for the treatment of cocaine dependence. Cochrane Database Syst Rev pp. CD007024 doi:10.1002/14651858.CD007024.pub2.
44. Gaval-Cruz M, Weinshenker D, (2009) mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv 9: 175-187 doi:10.1124/mi.9.4.6.
45. Yao L, Fan P, Arolfo M, Jiang Z, Olive MF, et al. (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat Med 16: 1024-1028 doi:10.1038/nm.2200.
46. Haile CN, During MJ, Jatlow PI, Kosten TR, Kosten TA, (2003) Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. Biol Psychiatry 54: 915-921.
47. Schank JR, Ventura R, Puglisi-Allegra S, Alcaro A, Cole CD, et al. (2006) Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology 31: 2221-30.
48. Hart CL, Haney M, Collins ED, Rubin E, Foltin RW, (2007) Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug Alcohol Depend 86: 274-277 doi:10.1016/j.drugalcdep.2006.05.028.
49. Haney M, Rubin E, Foltin RW, (2011) Aripiprazole maintenance increases smoked cocaine self-administration in humans. Psychopharmacology (Berl.) 216: 379-387 doi:10.1007/s00213-011-2231-6.