Disulfiram effects on acute cocaine administration

Drug and Alcohol Dependence

Volumn 52, Issue 1, 1998, Pages 27-39

  McCance Katz, Elinore F ^a,b,c,d   Kosten, Thomas R ^b,c,d   Jatlow, Peter ^c,d  

^a Yale New Haven Psychiatric Hospital   (United States)

^b Yale University School of Medicine   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Cocaine; Disulfiram; Drug interaction; Humans; Pharmacotherapy

Indexed keywords

COCAINE; DISULFIRAM;

ADULT; ARTICLE; BEHAVIOR; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DEPENDENCE; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ACUTE DISEASE; ADULT; ALCOHOL DETERRENTS; CHOLINESTERASES; COCAINE-RELATED DISORDERS; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HEART RATE; HUMANS; MALE; TIME FACTORS;

EID: 0032169170     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(98)00050-7     Document Type: Article

References (51)

1. Ambre, J.J., Belknap, S.M., Nelson, J., Ruo, T.I., Shin, S., Atkinson, A.J., 1988. Acute tolerance to cocaine in humans. Clin. Pharmacol. Ther. 44, 1-8.
2. Bailey, D.N., 1993. Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit. Am. J. Clin. Pathol. 99, 123-127.
3. Benowitz, N., 1993. Clinical pharmacology and toxicology of cocaine. Pharmacol. Toxicol. 72, 3-12.
4. Carrol, K.M., Nich, C., Ball, S.A., McCance-Katz, E.F., Rounsaville, B.J., 1998. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addictions, in press.
5. Carroll, K., Ziedonis, D., O'Malley, S., McCance-Katz, E., Gordon, L., Rounsaville, B., 1993. Pharmacologic interventions for abusers of alcohol and cocaine: a pilot study of disulfiram versus naltrexone. J. Drug Addict. 2, 77-79.
6. Chow, M.J., Ambre, J.J., Tsuen, I.R., Atkinson, A.J., Bowsher, D.J., Fischman, M.W., 1985. Kinetics of cocaine distribution, elimination and chronotropic effects. Clin. Pharmacol. Ther. 38, 318-324.
7. Crosby, R., Specker, S., Borden, J., Tarleton, S., Hatsukami, D., 1997. Relapse and coping skills of cocaine using women. NIDA Res. Monogr. 174, 113.
8. Diagnostic and Statistical Manual of Mental Disorders, 1995, 4th ed. American Psychiatric Association.
9. Faiman, M.D., 1979. Biochemical pharmacology of disulfiram. In: Majchowicz, E, Nobel, E.P. (Eds.), Biochemistry and Pharmacology of Ethanol, vol. 2 . Plenum, New York, pp. 325-348.
10. Farre, M., De La Torre, R., Llorente, M., et al., 1993. Alcohol and cocaine interactions in humans. J. Pharmacol. Exp. Ther. 266, 1364-1373.
11. Fischman, M.W., Foltin, R.W., 1992. Self-administration of cocaine by humans: a laboratory perspective. In: 1992 Cocaine: Scientific and Social Dimensions, Ciba Foundation Symp. 166. Wiley, Chichester, pp. 165-180.
12. Fischman, M.W., Schuster, C.R., Javaid, J., Hatano, Y., Davis, J., 1985. Acute tolerance to the cardiovascular and subjective effects of cocaine. J. Pharmacol. Exp. Ther. 235, 677-682.
13. Foltin, R.W., Fischman, M.W., 1988. Ethanol and cocaine interactions in humans: cardiovascular consequences. Pharmacol. Biochem. Behav. 31, 877-883.
14. Foltin, R.W., Fischman, M.W., 1991. Smoked and intravenous cocaine in humans: acute tolerance, cardiovascular and subjective effects of cocaine. J. Pharmacol. Exp. Ther. 257, 247-261.
15. Foltin, R.W., Fischman, M.W., Pedroso, J.J., Pearlson, G.D., 1988. Repeated intanasal cocaine administration: lack of tolerance to pressor effects. Drug Alcohol Depend. 22, 169-177.
16. Fuller, R.K., Roth, H.P., 1979. Disulfiram for the treatment of alcoholism: an evaluation of 128 men. Ann. Intern. Med. 90, 901-904.
17. Fuller, R.K., Branchey, L., Brightwell, D.R., et al., 1986. Disulfiram in the treatment of alcoholism: a Veterans Administration cooperative study. J. Am. Med. Assoc. 256, 1449-1455.
18. Gibaldi, M., Perrier D., 1982. Pharmacokinetics, 2nd ed. Marcel Decker, New York.
19. Goldstein, M., Anagoste, B., Lauber, E., McKereghan, M.R., 1964. Inhibition of dopamine β-hydroxylase by disulfiram. Life Sci. 3, 763-767.
20. Grant, B.F., Harford, T.C., 1990. Current and simultaneous use of alcohol with cocaine: results of a national survey. Drug Alcohol Depend. 25, 97-104.
21. Haley, T.J., 1979. Disulfiram (tetraethylthioperoxydicarbonic diamide): a reappraisal of its toxicity and therapeutic application. Drug Metab. Rev. 9, 319-335.
22. Hameedi, F.A., Rosen, M.I., McCance-Katz, E.F., et al., 1995. Behavioral, physiological and pharmacological interaction of cocaine and disulfiram. Biol. Psychiatr. 37, 560-563.
23. Hatsukami, D.K., Pentel, P.R., Glass, J., et al., 1994. Methodological issues in the administration of multiple doses of smoked cocaine-base in humans. Pharmacol. Biochem. Behav. 47, 531-540.
24. Hearn, W.L., Flynn, D.D., Hime, G.W., et al., 1991. Cocaethylene: a unique cocaine metabolite displays high affinity for the dopamine transporter. J. Neurochem. 56, 698-701.
25. Helander, A., Carlsson, S., 1990. Use of leukocyte aldehyde dehydrogenase activity to monitor inhibitory effect of disulfiram treatment. Alcohol. Clin. Exp. Res. 14, 48-52.
26. Higgins, S.T., Rush, C.R., Bickel, W.K., Hughes, J.R., Lynn, M., Capeless, M.A., 1995. Acute behavioral and cardiac effects of cocaine and alcohol combinations in humans. Psychopharmacology 111, 285-294.
27. Higgins, S.T., Roll, J.M., Bickel, W.K., 1996. Alcohol pretreatment increases preference for cocaine over monetary reinforcement. Psychopharmacology 123, 1-8.
28. Honjo, T., Netter, K.J., 1969. Inhibition of drug demethylation by disulfiram in vivo and in vitro. Biochem. Pharmacol. 18, 2681-2683.
29. Inaba, T., Stewart, D.J., Kalow, W., 1978. Metabolism of cocaine man. Clin. Pharmacol. Ther. 23, 547-552.
30. Jatlow, P., 1988. Cocaine: analysis, pharmacokinetics, and metabolic disposition. Yale J. Biol. Med. 61, 105-113.
31. Jatlow, P., Elsworth, J.D., Bradberry, C.W., et al., 1991. Cocaethylene: a neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion. Life Sci. 48, 1787-1794.
32. Javaid, J.I., Mahmous, N.M., Fischman, M.W., Schuster, C.R., Davis, J.M., 1983. Kinetics of cocaine in humans after intravenous and intranasal administration. Biopharm. Drug Dispos. 4, 9-18.
33. Jeffcoat, A.R., Perez-Reyes, M., Hill, J.M., Sadler, B.M., Cook, C.E., 1989. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. Drug Metab. Dispos. 17, 153-159.
34. Kalow, W., Genst, K., 1957. A method for the detection of atypical forms of human serum cholinesterase: determination of dibucaine numbers. Can. J. Biochem. 35, 339-346.
35. Katz, J.L., Terry, P., Witkin, J.M., 1992. Comparative behavioral pharmacology and toxicology of cocaine and it's ethanol-derived metabolite, cocaine ethylester (cocaethylene). Life Sci. 50, 1351-1361.
36. Kumor, K., Sherer, M., Thomson, L., Cone, E., Mahaffey, J., Jaffe, J., 1988. Lack of cardiovascular tolerance during intravenous cocaine infusions in human volunteers. Life Sci. 42, 2063-2071.
37. McCance, E.F., Price, L.H., Kosten, T.R., Jatlow, P.I., 1995. Cocaethylene: pharmacology, physiology, and behavioral effects in humans. J. Pharm. Exp. Ther. 274, 215-223.
38. McCance-Katz, E.F., Price, L.H., McDougle, C.J., Kosten, T.R., Black, J.E., Jatlow, P.I., 1993. Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. Psychopharmacology 111, 39-46.
39. McCance-Katz, E.F., Kosten, T.R., Jatlow, P., 1998. Chronic disulfiram treatment effects on intranasal cocaine administration: initial results. Biol. Psychiatry. 43, 540-543.
40. Mussachio, J., Kopin, I.J., Snyder, S., 1964. Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites. Life Sci. 3, 769-775.
41. Perez-Reyes, M., Jeffcoat, A.R., 1992. Ethanol/cocaine interaction: cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects. Life Sci. 51, 553-563.
42. Perez-Reyes, M., Jeffcoat, A.R., Myers, M., Sihler, K., Cook, C.E., 1994. Comparison in humans of the potency and pharmacokinetics of intravenously injected cocaethylene and cocaine. Psychopharmacology 116, 428-432.
43. Sauter, A.M., Boss, D., von Wartburg, J.P., 1977. Reevaluation of the disulfiram-alcohol reaction in man. J. Stud. Alcohol 38, 1680-1695.
44. Stewart, D.J., Inaba, T., Lucassen, M., Kalow, W., 1979. Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin. Pharmacol. Ther. 25, 464-468.
45. Van Dyke, C., Jatlow, P., Ungerer, J., Barash, P., Byck, R., 1976. Cocaine: plasma concentrations after intranasal application in man. Science 191, 859-861.
46. Van Etten, M.L., Higgins, S.T., Budney, A.J., Bickel, W.K., Hughes, J.R., Foerg, F., 1994. Disulfiram therapy in patients abusing cocaine and alcohol. NIDA Res. Monogr. 141, 443.
47. Weiss, R.D., Mirin, S.M., Griffin, M.L., Michael, J.L., 1988. Psychopathology in cocaine abusers-changing trends. J. Nerv. Ment. Dis. 176, 719-725.
48. Wilkinson, P., Van Dyke, C., Jatlow, P., Barash, P., Byck, R., 1988. Intranasal and oral cocaine kinetics. Clin. Pharmacol. Ther. 27, 386-394.
49. WinNonlin 1.0™, 1995. Scientific Consulting, Apex, NC.
50. Woodward, J.J., Mansbach, R., Carroll, F.I., Balster, R.L., 1991. Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies. Eur. J. Pharmacol. 197, 235-236.
51. Wright, C., Moore, R.D., 1990. Disulfiram treatment of alcoholism. Am. J. Med. 88, 647-655.