Noradrenergic α 1 receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: A randomized trial

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Newton, Thomas F ^a   de La Garza II, Richard ^a   Brown, Gregory ^a   Kosten, Thomas R ^a   Mahoney III, James J ^a   Haile, Colin N ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; COCAINE; DOXAZOSIN; PLACEBO; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG TOLERABILITY; ELECTROCARDIOGRAM; FEMALE; HEART RATE; HUMAN; LABORATORY TEST; MALE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TABLET FORMULATION; ADOLESCENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; MIDDLE AGED; TREATMENT OUTCOME;

ADOLESCENT; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADULT; BLOOD PRESSURE; COCAINE; COCAINE-RELATED DISORDERS; DOXAZOSIN; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84863393762     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030854     Document Type: Article

References (31)

1. Wise RA, Rompre PP, (1989) Brain dopamine and reward. Annu Rev Psychol 40: 191-225.
2. Woolverton WL, Balster RL, (1981) Effects of antipsychotic compounds in rhesus monkeys given a choice between cocaine and food. Drug Alcohol Depend 8: 69-78.
3. Soares BG, Lima MS, Reisser AA, Farrell M, (2001) Dopamine agonists for cocaine dependence (Cochrane Review). Cochrane Database Syst Rev 4.
4. Grabowski J, Rhoades H, Stotts A, Cowan K, Kopecky C, et al. (2004) Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials. Neuropsychopharmacology 29: 969-981.
5. Mooney ME, Herin DV, Schmitz JM, Moukaddam N, Green CE, et al. (2009) Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 101: 34-41.
6. Jasinski DR, (1991) History of abuse liability testing in humans. British Journal of Addiction 86: 1559-1562.
7. Weinshenker D, Schroeder JP, (2007) There and back again: a tale of norepinephrine and drug addiction. Neuropsychopharmacology 32: 1433-1451.
8. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, et al. (2002) Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. J Neurosci 22: 2873-2884.
9. Darracq L, Blanc G, Glowinski J, Tassin J-P, (1998) Importance of the Noradrenaline-Dopamine Coupling in the Locomotor Activating Effects of D-Amphetamine. J Neurosci 18: 2729-2739.
10. Drouin C, Blanc G, Villegier AS, Glowinski J, Tassin JP, (2002) Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine, and GBR 12783: influence of preexposure conditions and pharmacological characteristics. Synapse 43: 51-61.
11. Snoddy AM, Tessel RE, (1985) Prazosin: effect on psychomotor-stimulant cues and locomotor activity in mice. Eur J Pharmacol 116: 221-228.
12. Zhang XY, Kosten TA, (2005) Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biol Psychiatry 57: 1202-1204.
13. Jaillon P, (1980) Clinical pharmacokinetics of prazosin. Clin Pharmacokinet 5: 365-376.
14. Elliott HL, Meredith PA, Sumner DJ, McLean K, Reid JL, (1982) A pharmacodynamic and pharmacokinetic assessment of a new alpha-adrenoceptor antagonist, doxazosin (UK33274) in normotensive subjects. Br J Clin Pharmacol 13: 699-703.
15. Prys-Roberts C, Farndon JR, (2002) Efficacy and safety of doxazosin for perioperative management of patients with pheochromocytoma. World J Surg 26: 1037-1042.
16. Guo TZ, Tinklenberg J, Oliker R, Maze M, (1991) Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology 75: 252-256.
17. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, et al. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 (Suppl 20): 22-33; quiz 34-57.
18. Beck AT, Steer RA, Ball R, Ranieri W, (1996) Comparison of Beck Depression Inventories-IA and-II in psychiatric outpatients. J Pers Assess 67: 588-597.
19. Newton TF, De La Garza R 2nd, Kalechstein AD, Nestor L, (2005) Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Pharmacol Biochem Behav 82: 90-97.
20. Chiou WL, (1978) Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm 6: 539-546.
21. Kirby RS, Andersen M, Gratzke P, Dahlstrand C, Hoye K, (2001) A combined analysis of double-blind trials of the efficacy and tolerability of doxazosin-gastrointestinal therapeutic system, doxazosin standard and placebo in patients with benign prostatic hyperplasia. BJU Int 87: 192-200.
22. Cohen J, (1988) Statistical Power Analysis for the Behavioral Science Hillsdale, N.J. L. Erlbaum Associates.
23. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J, (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) 168: 3-20.
24. Woolverton WL, (1987) Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Pharmacol Biochem Behav 26: 835-839.
25. Fischman MW, (1989) Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. NIDA Res Monogr 92: 211-230.
26. Fischman MW, Foltin RW, (1991) Utility of subjective-effects measurements in assessing abuse liability of drugs in humans. Br J Addict 86: 1563-1570.
27. Haney M, Spealman R, (2008) Controversies in translational research: drug self-administration. Psychopharmacology (Berl) 199: 403-419.
28. Rothman RB, Blough BE, Baumann MH, (2002) Appetite suppressants as agonist substitution therapies for stimulant dependence. Ann N Y Acad Sci 965: 109-126.
29. Morrison JH, Molliver ME, Grzanna R, Coyle JT, (1981) The intra-cortical trajectory of the coeruleo-cortical projection in the rat: a tangentially organized cortical afferent. Neuroscience 6: 139-158.
30. Schroeder JP, Cooper DA, Schank JR, Lyle MA, Gaval-Cruz M, et al. (2010) Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine beta-hydroxylase. Neuropsychopharmacology 35: 2440-2449.
31. Waeber B, Feihl F, Ruilope LM, (2009) Fixed-dose combinations as initial therapy for hypertension: a review of approved agents and a guide to patient selection. Drugs 69: 1761-1776.