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Volumn 86, Issue 19, 2012, Pages 10792-10804

Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DIHYDROLIPOAMIDE DEHYDROGENASE; LIVE VACCINE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; TYROSINE;

EID: 84869007034     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01227-12     Document Type: Article
Times cited : (47)

References (38)
  • 1
    • 77749273997 scopus 로고    scopus 로고
    • Respiratory syncytial virus activity-United States
    • Anonymous, July 2008-December 2009
    • Anonymous. 2010. Respiratory syncytial virus activity-United States, July 2008-December 2009. MMWR Morb. Mortal. Wkly. Rep. 59:230-233.
    • (2010) MMWR Morb. Mortal. Wkly. Rep. , vol.59 , pp. 230-233
  • 2
    • 10444255610 scopus 로고    scopus 로고
    • Evaluation of combined live, attenuated respira-tory syncytial virus and parainfluenza 3 virus vaccines in infants and young children
    • Belshe RB, et al. 2004. Evaluation of combined live, attenuated respira-tory syncytial virus and parainfluenza 3 virus vaccines in infants and young children. J. Infect. Dis. 190:2096-2103.
    • (2004) J. Infect. Dis. , vol.190 , pp. 2096-2103
    • Belshe, R.B.1
  • 3
    • 0032888955 scopus 로고    scopus 로고
    • Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter
    • Buchholz UJ, Finke S, Conzelmann KK. 1999. Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J. Virol. 73:251-259.
    • (1999) J. Virol. , vol.73 , pp. 251-259
    • Buchholz, U.J.1    Finke, S.2    Conzelmann, K.K.3
  • 4
    • 0035198506 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor expressed by recom- binant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells
    • Bukreyev A, Belyakov IM, Berzofsky JA, Murphy BR, Collins PL. 2001. Granulocyte-macrophage colony-stimulating factor expressed by recom- binant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells. J. Virol. 75:12128-12140.
    • (2001) J. Virol , vol.75 , pp. 12128-12140
    • Bukreyev, A.1    Belyakov, I.M.2    Berzofsky, J.A.3    Murphy, B.R.4    Collins, P.L.5
  • 5
    • 0030782367 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse
    • Bukreyev A, Whitehead SS, Murphy BR, Collins PL. 1997. Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J. Virol. 71:8973-8982.
    • (1997) J. Virol. , vol.71 , pp. 8973-8982
    • Bukreyev, A.1    Whitehead, S.S.2    Murphy, B.R.3    Collins, P.L.4
  • 6
    • 0029584042 scopus 로고
    • Production of infectious human respiratory syn-cytial virus from cloned cDNA confirms an essential role for the transcrip- tion elongation factor from the 5= proximal open reading frame of the M2mRNA in gene expression and provides a capability for vaccine develop-ment
    • U. S. A.
    • Collins PL, et al. 1995. Production of infectious human respiratory syn-cytial virus from cloned cDNA confirms an essential role for the transcrip-tion elongation factor from the 5= proximal open reading frame of the M2mRNA in gene expression and provides a capability for vaccine develop- ment. Proc. Natl. Acad. Sci. U. S. A. 92:11563-11567.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 11563-11567
    • Collins, P.L.1
  • 7
    • 24144497074 scopus 로고    scopus 로고
    • New generation live vaccines against human respiratory syncytial virus designed by reverse genetics
    • Collins PL, Murphy BR. 2005. New generation live vaccines against human respiratory syncytial virus designed by reverse genetics. Proc. Am. Thorac. Soc. 2:166-173.
    • (2005) Proc. Am. Thorac. Soc. , vol.2 , pp. 166-173
    • Collins, P.L.1    Murphy, B.R.2
  • 8
    • 0026581303 scopus 로고
    • Cotton rats previously immunized with a chime-ric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immuniza-tion with vaccinia-RSV recombinants or RSV
    • Connors M, et al. 1992. Cotton rats previously immunized with a chime-ric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immuniza-tion with vaccinia-RSV recombinants or RSV. Vaccine 10:475-484.
    • (1992) Vaccine , vol.10 , pp. 475-484
    • Connors, M.1
  • 9
    • 0035888291 scopus 로고    scopus 로고
    • Respiratory syncytial virus vaccine development
    • Crowe JE, Jr. 2001. Respiratory syncytial virus vaccine development. Vaccine 20(Suppl 1):S32-S37.
    • (2001) Vaccine , vol.20 , Issue.SUPPL. 1
    • Crowe, J.E.Jr.1
  • 10
    • 0028177120 scopus 로고
    • A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpan-zees
    • Crowe JE, Jr, Bui PT, Davis AR, Chanock RM, Murphy BR. 1994. A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpan-zees. Vaccine 12:783-790.
    • (1994) Vaccine. , vol.12 , pp. 783-790
    • Crowe Jr., J.E.1    Bui, P.T.2    Davis, A.R.3    Chanock, R.M.4    Murphy, B.R.5
  • 11
    • 0028232335 scopus 로고
    • Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis
    • Crowe JE, Jr, et al. 1994. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. Vaccine 12:691-699.
    • (1994) Vaccine. , vol.12 , pp. 691-699
    • Crowe Jr., J.E.1
  • 12
    • 0029041616 scopus 로고
    • Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immu-nogenic, and protective in seronegative chimpanzees, even when RSV an-tibodies are infused shortly before immunization
    • Crowe JE, Jr, et al. 1995. Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immu-nogenic, and protective in seronegative chimpanzees, even when RSV an-tibodies are infused shortly before immunization. Vaccine 13:847-855.
    • (1995) Vaccine. , vol.13 , pp. 847-855
    • Crowe Jr., J.E.1
  • 13
    • 0027421444 scopus 로고
    • A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mu-tant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV
    • Crowe JE, Jr, Collins PL, London WT, Chanock RM, Murphy BR. 1993. A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mu-tant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV. Vaccine 11:1395-1404.
    • (1993) Vaccine. , vol.11 , pp. 1395-1404
    • Crowe Jr., J.E.1    Collins, P.L.2    London, W.T.3    Chanock, R.M.4    Murphy, B.R.5
  • 14
    • 0030445267 scopus 로고    scopus 로고
    • Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene
    • Crowe JE, Jr, Firestone CY, Whitehead SS, Collins PL, Murphy BR. 1996. Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene. Virus Genes 13:269-273.
    • (1996) Virus Genes. , vol.13 , pp. 269-273
    • Crowe Jr., J.E.1    Firestone, C.Y.2    Whitehead, S.S.3    Collins, P.L.4    Murphy, B.R.5
  • 17
    • 0014504703 scopus 로고
    • Temperature-sensitive mutants of respiratory syncytial virus
    • Gharpure MA, Wright PF, Chanock RM. 1969. Temperature-sensitive mutants of respiratory syncytial virus. J. Virol. 3:414-421.
    • (1969) J. Virol. , vol.3 , pp. 414-421
    • Gharpure, M.A.1    Wright, P.F.2    Chanock, R.M.3
  • 18
    • 20144370691 scopus 로고    scopus 로고
    • Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants
    • Karron RA, et al. 2005. Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J. Infect. Dis. 191:1093-1104.
    • (2005) J. Infect. Dis. , vol.191 , pp. 1093-1104
    • Karron, R.A.1
  • 19
    • 0030657620 scopus 로고    scopus 로고
    • Evaluation of two live, cold-passaged, tempera-ture-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children
    • Karron RA, et al. 1997. Evaluation of two live, cold-passaged, tempera-ture-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children. J. Infect. Dis. 176:1428-1436.
    • (1997) J. Infect. Dis. , vol.176 , pp. 1428-1436
    • Karron, R.A.1
  • 20
    • 0015146196 scopus 로고
    • Clinical and immunological response of infants and children to administration of low-temperature adapted respiratory syncy-tial virus
    • Kim HW, et al. 1971. Clinical and immunological response of infants and children to administration of low-temperature adapted respiratory syncy-tial virus. Pediatrics 48:745-755.
    • (1971) Pediatrics. , vol.48 , pp. 745-755
    • Kim, H.W.1
  • 21
    • 28844438758 scopus 로고    scopus 로고
    • Genetic stability determinants of temperature sensi-tive, live attenuated respiratory syncytial virus vaccine candidates
    • Lin YH, et al. 2006. Genetic stability determinants of temperature sensi-tive, live attenuated respiratory syncytial virus vaccine candidates. Virus Res. 115:9-15.
    • (2006) Virus Res. , vol.115 , pp. 9-15
    • Lin, Y.H.1
  • 22
    • 68949194431 scopus 로고    scopus 로고
    • Codon stabilization analysis of the "248" temper-ature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates
    • Luongo C, et al. 2009. Codon stabilization analysis of the "248" temper-ature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates. Vaccine 27:5667-5676.
    • (2009) Vaccine. , vol.27 , pp. 5667-5676
    • Luongo, C.1
  • 23
    • 0842282802 scopus 로고    scopus 로고
    • Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro
    • McAuliffe JM, et al. 2004. Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro. J. Virol. 78:2029-2036.
    • (2004) J. Virol. , vol.78 , pp. 2029-2036
    • Mcauliffe, J.M.1
  • 24
    • 77951101124 scopus 로고    scopus 로고
    • Review of palivizumab in the prophylaxis of respiratory syncytial virus (RSV) in high-risk infants
    • Mejias A, Ramilo O. 2008. Review of palivizumab in the prophylaxis of respiratory syncytial virus (RSV) in high-risk infants. Biologics 2:433-439.
    • (2008) Biologics. , vol.2 , pp. 433-439
    • Mejias, A.1    Ramilo, O.2
  • 25
    • 0025052448 scopus 로고
    • Enhanced pulmonary histopathology is observed in cotton rats immu-nized with formalin-inactivated respiratory syncytial virus (RSV) or puri-fied F glycoprotein and challenged with RSV 3-6 months after immuni-zation
    • Murphy BR, Sotnikov AV, Lawrence LA, Banks SM, Prince GA. 1990. Enhanced pulmonary histopathology is observed in cotton rats immu-nized with formalin-inactivated respiratory syncytial virus (RSV) or puri-fied F glycoprotein and challenged with RSV 3-6 months after immuni-zation. Vaccine 8:497-502.
    • (1990) Vaccine , vol.8 , pp. 497-502
    • Murphy, B.R.1    Sotnikov, A.V.2    Lawrence, L.A.3    Banks, S.M.4    Prince, G.A.5
  • 26
    • 77951653074 scopus 로고    scopus 로고
    • Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis
    • Nair H, et al. 2010. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375:1545-1555.
    • (2010) Lancet. , vol.375 , pp. 1545-1555
    • Nair, H.1
  • 27
    • 34548643897 scopus 로고    scopus 로고
    • Effects of serine-to-cysteine mutations on beta-lactamase folding
    • Santos J, Risso VA, Sica MP, Ermacora MR. 2007. Effects of serine-to-cysteine mutations on beta-lactamase folding. Biophys. J. 93:1707-1718.
    • (2007) Biophys. J. , vol.93 , pp. 1707-1718
    • Santos, J.1    Risso, V.A.2    Sica, M.P.3    Ermacora, M.R.4
  • 28
    • 0033803734 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immuno-genic in chimpanzees
    • Teng MN, et al. 2000. Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immuno-genic in chimpanzees. J. Virol. 74:9317-9321.
    • (2000) J. Virol. , vol.74 , pp. 9317-9321
    • Teng, M.N.1
  • 29
    • 0032978732 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus bear-ing a deletion of either the NS2 or SH gene is attenuated in chimpanzees
    • Whitehead SS, et al. 1999. Recombinant respiratory syncytial virus bear- ing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. J. Virol. 73:3438-3442.
    • (1999) J. Virol. , vol.73 , pp. 3438-3442
    • Whitehead, S.S.1
  • 30
    • 0032145583 scopus 로고    scopus 로고
    • A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major de-terminant of the temperature-sensitive and attenuation phenotypes
    • Whitehead SS, Firestone CY, Collins PL, Murphy BR. 1998. A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major de-terminant of the temperature-sensitive and attenuation phenotypes. Vi-rology 247:232-239.
    • (1998) Vi-rology , vol.247 , pp. 232-239
    • Whitehead, S.S.1    Firestone, C.Y.2    Collins, P.L.3    Murphy, B.R.4
  • 31
    • 0032932708 scopus 로고    scopus 로고
    • Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitiv- ity
    • Whitehead SS, et al. 1999. Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitiv- ity. J. Virol. 73:871-877.
    • (1999) J. Virol. , vol.73 , pp. 871-877
    • Whitehead, S.S.1
  • 32
    • 0031977449 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees
    • Whitehead SS, Juhasz K, Firestone CY, Collins PL, Murphy BR. 1998. Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees. J. Virol. 72:4467-4471.
    • (1998) J. Virol. , vol.72 , pp. 4467-4471
    • Whitehead, S.S.1    Juhasz, K.2    Firestone, C.Y.3    Collins, P.L.4    Murphy, B.R.5
  • 33
    • 33646538804 scopus 로고    scopus 로고
    • An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development
    • Witko SE, et al. 2006. An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development. J. Virol. Methods 135:91-101.
    • (2006) J. Virol. Methods , vol.135 , pp. 91-101
    • Witko, S.E.1
  • 34
    • 34748850172 scopus 로고    scopus 로고
    • The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenu-ated, respiratory syncytial virus vaccines
    • Wright PF, et al. 2007. The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenu-ated, respiratory syncytial virus vaccines. Vaccine 25:7372-7378.
    • (2007) Vaccine , vol.25 , pp. 7372-7378
    • Wright, P.F.1
  • 35
    • 0033791293 scopus 로고    scopus 로고
    • Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy
    • Wright PF, et al. 2000. Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J. Infect. Dis. 182:1331-1342.
    • (2000) J. Infect. Dis. , vol.182 , pp. 1331-1342
    • Wright, P.F.1
  • 36
    • 32044433987 scopus 로고    scopus 로고
    • The interferon antagonist NS2 protein of respira-tory syncytial virus is an important virulence determinant for humans
    • Wright PF, et al. 2006. The interferon antagonist NS2 protein of respira-tory syncytial virus is an important virulence determinant for humans. J. Infect. Dis. 193:573-581.
    • (2006) J. Infect. Dis. , vol.193 , pp. 573-581
    • Wright, P.F.1
  • 37
    • 84886607831 scopus 로고
    • Evaluation of a live, attenuated respiratory syn-cytial virus vaccine in infants
    • Wright PF, et al. 1976. Evaluation of a live, attenuated respiratory syn-cytial virus vaccine in infants. J. Pediatr. 88:931-936.
    • (1976) J. Pediatr. , vol.88 , pp. 931-936
    • Wright, P.F.1
  • 38
    • 34047143155 scopus 로고    scopus 로고
    • Development of motavizumab, an ultra-potent anti-body for the prevention of respiratory syncytial virus infection in the up-per and lower respiratory tract
    • Wu H, et al. 2007. Development of motavizumab, an ultra-potent anti-body for the prevention of respiratory syncytial virus infection in the up-per and lower respiratory tract. J. Mol. Biol. 368:652-665.
    • (2007) J. Mol. Biol. , vol.368 , pp. 652-665
    • Wu, H.1


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