Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity

Journal of Virology

Volumn 73, Issue 2, 1999, Pages 871-877

  Whitehead, Stephen S ^a   Firestone, Cai Yen ^a   Karron, Ruth A ^b   Crowe Jr , James E ^a,c   Elkins, William R ^a   Collins, Peter L ^a   Murphy, Brian R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GLYCINE CLEAVAGE SYSTEM; RESPIRATORY SYNCYTIAL VIRUS CPTS 248 404 VACCINE; RESPIRATORY SYNCYTIAL VIRUS CPTS 530 1030 VACCINE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIMPANZEE; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; HUMAN; INTRANASAL DRUG ADMINISTRATION; INTRATRACHEAL DRUG ADMINISTRATION; MISSENSE MUTATION; NONHUMAN; PHASE 1 CLINICAL TRIAL; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; TEMPERATURE SENSITIVITY; VERO CELL; VIRUS GENE; VIRUS MUTANT; VIRUS RECOMBINANT;

EID: 0032932708     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.2.871-877.1999     Document Type: Article

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