A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes

Virology

Volumn 247, Issue 2, 1998, Pages 232-239

  Whitehead, Stephen S ^a   Firestone, Cai Yen ^a   Collins, Peter L ^a   Murphy, Brian R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; HUMAN; HUMAN CELL; IMMUNOGENICITY; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SEQUENCE ANALYSIS; TEMPERATURE SENSITIVITY; TRANSCRIPTION INITIATION; VACCINE PRODUCTION; VIRUS MUTATION;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS; RNA VIRUSES; SYNCYTIAL VIRUS;

EID: 0032145583     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9248     Document Type: Article

References (46)

1. Bouchard M. J., Lam D.-H., Racaniello V. R. Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine. J. Virol. 69:1995;4972-4978.
2. Bukreyev A., Whitehead S. S., Murphy B. R., Collins P. L. Recombinant respiratory syncytial virus (RSV) from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J. Virol. 71:1997;8973-8982.
3. Collins P. L., Hill M. G., Camargo E., Grosfeld H., Chanock R. M., Murphy B. R. Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. Proc. Natl. Acad. Sci. USA. 92:1995;11563-11567.
4. Collins, P. L. McIntosh, K. Chanock, R. M. 1996, Respiratory syncytial virus, In, Fields Virology, 2, 1313, 1352, Lippincott-Raven, Philadelphia.
5. Connors M., Crowe J. E. Jr., Firestone C.-Y., Murphy B. R., Collins P. L. A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes. Virology. 208:1995;478-484.
6. Crowe J. E. Jr., Bui P. T., Davis A. R., Chanock R. M., Murphy B. R. A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees. Vaccine. 12:1994a;783-790.
7. Crowe J. E. Jr., Bui P. T., London W. T., Davis A. R., Hung P. P., Chanock R. M., Murphy B. R. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. Vaccine. 12:1994b;691-699.
8. Crowe J. E. Jr., Bui P. T., Siber G. R., Elkins W. R., Chanock R. M., Murphy B. R. Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization. Vaccine. 13:1995;847-855.
9. Crowe J. E. Jr., Collins P. L., London W. T., Chanock R. M., Murphy B. R. A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV. Vaccine. 11:1993;1395-1404.
10. Crowe J. E. Jr., Firestone C.-Y., Whitehead S. S., Collins P. L., Murphy B. R. Acquisition of thets. Virus Genes. 13:1996;269-273.
11. Dildine S. L., Stark K. R., Haller A. A., Semler B. L. Poliovirus translation initiation: Differential effects of directed and selected mutations in the 5′ noncoding region of viral RNAs. Virology. 182:1991;742-752.
12. Falsey A. R., Cunningham C. K., Barker W. H., Kouides R. W., Yuen J. B., Menegus M., Weiner L. B., Bonville C. A., Betts R. F. Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J. Infect. Dis. 172:1995;389-394.
13. Firestone C.-Y., Whitehead S. S., Collins P. L., Murphy B. R., Crowe J. E. Jr. Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cptscpts. Virology. 225:1996;419-422.
14. Friedewald W. T., Forsyth B. R., Smith C. B., Gharpure M. A., Chanock R. M. Low-temperature-grown RS virus in adult volunteers. J. Am. Med. Assoc. 203:1968;690-694.
15. Garcin D., Pelet T., Calain P., Roux L., Curran J., Kolakofsky D. A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: Generation of a novel copy-back nondefective interfering virus. EMBO J. 14:1995;6087-6094.
16. Gutierrez A. L., Denova-Ocampo M., Racaniello V. R., del Angel R. M. Attenuating mutations in the poliovirus 5′ untranslated region alter its interaction with polypyrimidine tract-binding protein. J. Virol. 71:1997;3826-3833.
17. Hall C. B., Powell K. R., MacDonald N. E., Gala C. L., Menegus M. E., Suffin S. C., Cohen H. J. Respiratory syncytial viral infection in children with compromised immune function. N. Engl. J. Med. 315:1986;77-81.
18. Hall S. L., Stokes A., Tierney E. L., London W. T., Belshe R. B., Newman F. C., Murphy B. R. Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys. Virus Res. 22:1992;173-184.
19. Harrington R. D., Hooton T. M., Hackman R. C., Storch G. A., Osborne B., Gleaves C. A., Benson A., Meyers J. D. An outbreak of respiratory syncytial virus in a bone marrow transplant center. J. Infect. Dis. 165:1992;987-993.
20. Jacobson S. J., Konings D. A., Sarnow P. Biochemical and genetic evidence for a pseudoknot structure at the 3′ terminus of the poliovirus RNA genome and its role in viral RNA amplification. J. Virol. 67:1993;2961-2971.
21. Juhasz K., Whitehead S. S., Bui P. T., Biggs J. M., Crowe J. E. Jr., Boulanger C. A., Collins P. L., Murphy B. R. The temperature-sensitive (tscpcpts. J. Virol. 71:1997;5814-5819.
22. Karron R. A., Wright P. F., Crowe J. E. Jr., Clements M. L., Thompson J., Makhene M., Casey R., Murphy B. R. Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus (RSV) vaccines in chimpanzees, adults, infants and children. J. Infect. Dis. 176:1997;1428-1436.
23. Kim H. W., Arrobio J. O., Pyles G., Brandt C. D., Camargo E., Chanock R. M., Parrott R. H. Clinical and immunological response of infants and children to administration of low-temperature adapted respiratory syncytial virus. Pediatrics. 48:1971;745-755.
24. Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J. Mol. Biol. 196:1987;947-950.
25. Kunkel T. A., Roberts J. D., Zakour R. A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:1987;367-382.
26. Kuo L., Fearns R., Collins P. L. Analysis of the gene start and gene end signals of human respiratory syncytial virus: Quasi-templated initiation at position 1 of the encoded mRNA. J. Virol. 71:1997;4944-4953.
27. La Via W. V., Marks M. I., Stutman H. R. Respiratory syncytial virus puzzle: Clinical features, pathophysiology, treatment, and prevention. J. Pediatr. 121:1992;503-510.
28. Lawson C. M., Subbarao E. K., Murphy B. R. Nucleotide sequence changes in the polymerase basic protein 2 gene of temperature-sensitive mutants of influenza A virus [published Erratum appears inVirology,195. Virology. 191:1992;506-510.
29. Milner M. E., de la Monte S. M., Hutchins G. M. Fatal respiratory syncytial virus infection in severe combined immunodeficiency syndrome. Am. J. Dis. Child. 139:1985;1111-1114.
30. Murphy B. R., Markoff L. J., Hosier N. T., Massicot J. G., Chanock R. M. Production and level of genetic stability of an influenza A virus temperature-sensitive mutant containing two genes with ts mutations. Infect. Immun. 37:1982;235-242.
31. Murphy B. R., Park E. J., Gottlieb P., Subbarao K. An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters. Vaccine. 15:1997;1372-1378.
32. Murphy B. R., Sotnikov A. V., Lawrence L. A., Banks S. M., Prince G. A. Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization. Vaccine. 8:1990;497-502.
33. Murphy B. R., Wood F. T., Massicot J. G., Spring S. B., Chanock R. M. Temperature-sensitive mutants of influenza virus. XV. The genetic and biological characterization of a recombinant influenza virus containing two ts lesions produced by mating two complementing, single lesion ts mutants. Virology. 88:1978;231-243.
34. Racaniello V. R., Meriam C. Poliovirus temperature-sensitive mutant containing a single nucleotide deletion in the 5′-noncoding region of the viral RNA. Virology. 155:1986;498-507.
35. Ramig R. F., Fields B. N. Revertants of temperature-sensitive mutants of reovirus: evidence for frequent extragenic suppression. Virology. 92:1979;155-167.
36. Rinehart J. E., Gomez R. M., Roos R. P. Molecular determinants for virulence in coxsackievirus B1 infection. J. Virol. 71:1997;3986-3991.
37. Shimizu K., Mullinix M. G., Chanock R. M., Murphy B. R. Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. II. Genetic analysis and demonstration of intrasegmental complementation. Virology. 117:1982;45-61.
38. Skiadopoulos M. H., Durbin A. P., Tatem J. M., Wu S., Paschalis M., Tao T., Collins P. L., Murphy B. R. Three amino acid substitutions in the L protein of the human parainfluenza type 3cp45. J. Virol. 72:1998;1762-1768.
39. Snyder M. H., Betts R. F., DeBorde D., Tierney E. L., Clements M. L., Herrington D., Sears S. D., Dolin R., Maassab H. F., Murphy B. R. Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. J. Virol. 62:1988;488-495.
40. Spring S. B., Nusinoff S. R., Mills J., Richman D. D., Tierney E. L., Murphy B. R., Chanock R. M. Temperature-sensitive mutants of influenza virus. VI. Transfer of TS lesions from the Asian subtype of influenza A virus (H2N2) to the Hong Kong subtype (H3N2). Virology. 66:1975;522-532.
41. Subbarao E. K., Park E. J., Lawson C. M., Chen A. Y., Murphy B. R. Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine. J. Virol. 69:1995;5969-5977.
42. Tatem J. M., Weeks-Levy C., Georgiu A., DiMichele S. J., Gorgacz E. J., Racaniello V. R., Cano F. R., Mento S. J. A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating. J. Virol. 66:1992;3194-3197.
43. Tolpin M. D., Massicot J. G., Mullinix M. G., Kim H. W., Parrott R. H., Chanock R. M., Murphy B. R. Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-tsin vivo. Virology. 112:1981;505-517.
44. Westrop G. D., Wareham K. A., Evans D. M. A., Dunn G., Minor P. D., Magrath D. I., Taffs F., Marsden S., Skinner M. A., Schild G. C., Almond J. W. Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine. J. Virol. 63:1989;1338-1344.
45. Whitehead S. S., Juhasz K., Firestone C. Y., Collins P. L., Murphy B. R. Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees. J. Virol. 72:1998;4467-4471.
46. Wyatt L. S., Moss B., Rozenblatt S. Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells. Virology. 210:1995;202-205.