메뉴 건너뛰기




Volumn 73, Issue 4, 1999, Pages 3438-3442

Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT VACCINE; VIRUS VACCINE;

EID: 0032978732     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.4.3438-3442.1999     Document Type: Article
Times cited : (199)

References (35)
  • 1
    • 0031907721 scopus 로고    scopus 로고
    • The NS1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and RNA replication
    • Atreya, P. L., M. E. Peeples, and P. L. Collins. 1998. The NS1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and RNA replication. J. Virol. 72:1452-1461.
    • (1998) J. Virol. , vol.72 , pp. 1452-1461
    • Atreya, P.L.1    Peeples, M.E.2    Collins, P.L.3
  • 2
    • 0029034843 scopus 로고
    • Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine
    • Bouchard, M. J., D. H. Lam, and V. R. Racaniello. 1995. Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine. J. Virol. 69:4972-4978.
    • (1995) J. Virol. , vol.69 , pp. 4972-4978
    • Bouchard, M.J.1    Lam, D.H.2    Racaniello, V.R.3
  • 3
    • 0030782367 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse
    • Bukreyev, A., S. S. Whitehead, B. R. Murphy, and P. L. Collins. 1997 Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J. Virol. 71:8973-8982.
    • (1997) J. Virol. , vol.71 , pp. 8973-8982
    • Bukreyev, A.1    Whitehead, S.S.2    Murphy, B.R.3    Collins, P.L.4
  • 4
    • 0013887462 scopus 로고
    • An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test
    • Coates, H. V., D. W. Ailing, and R. M. Chanock. 1966. An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test. Am. J. Epidemiol. 83:299-313.
    • (1966) Am. J. Epidemiol. , vol.83 , pp. 299-313
    • Coates, H.V.1    Ailing, D.W.2    Chanock, R.M.3
  • 5
    • 0029584042 scopus 로고
    • Production of infectious human respiratory syncytial virus from cloned cDNa confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development
    • Collins, P. L., M. G. Hill, E. Camargo, H. Grosfeld, R. M. Chanock, and B. R. Murphy. 1995. Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. Proc. Natl. Acad. Sci. USA 92:11563-11567.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11563-11567
    • Collins, P.L.1    Hill, M.G.2    Camargo, E.3    Grosfeld, H.4    Chanock, R.M.5    Murphy, B.R.6
  • 6
    • 0000089226 scopus 로고    scopus 로고
    • Respiratory syncytial virus
    • B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Lippincott-Raven, Philadelphia, Pa
    • Collins, P. L., K. McIntosh, and R. M. Chanock. 1996. Respiratory syncytial virus, p. 1313-1352. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven, Philadelphia, Pa.
    • (1996) Fields Virology, 3rd Ed. , vol.2 , pp. 1313-1352
    • Collins, P.L.1    McIntosh, K.2    Chanock, R.M.3
  • 7
    • 0025348180 scopus 로고
    • Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus
    • Collins, P. L., R. H. Purcell, W. T. London, L. A. Lawrence, R. M. Chanock, and B. R. Murphy. 1990. Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus. Vaccine 8:164-168.
    • (1990) Vaccine , vol.8 , pp. 164-168
    • Collins, P.L.1    Purcell, R.H.2    London, W.T.3    Lawrence, L.A.4    Chanock, R.M.5    Murphy, B.R.6
  • 8
    • 0028177120 scopus 로고
    • A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees
    • Crowe, J. E., Jr., P. T. Bui, A. R. Davis, R. M. Chanock, and B. R. Murphy. 1994. A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees. Vaccine 12:783-790.
    • (1994) Vaccine , vol.12 , pp. 783-790
    • Crowe J.E., Jr.1    Bui, P.T.2    Davis, A.R.3    Chanock, R.M.4    Murphy, B.R.5
  • 9
    • 0028232335 scopus 로고
    • Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis
    • Crowe, J. E., Jr., P. T. Bui, W. T. London, A. R. Davis, P. P. Hung, R. M. Chanock, and B. R. Murphy. 1994. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis. Vaccine 12:691-699.
    • (1994) Vaccine , vol.12 , pp. 691-699
    • Crowe J.E., Jr.1    Bui, P.T.2    London, W.T.3    Davis, A.R.4    Hung, P.P.5    Chanock, R.M.6    Murphy, B.R.7
  • 10
    • 0030445267 scopus 로고    scopus 로고
    • Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene
    • Crowe, J. E., Jr., C. Y. Firestone, S. S. Whitehead, P. L. Collins, and B. R. Murphy. 1996. Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene. Virus Genes 13:269-273.
    • (1996) Virus Genes , vol.13 , pp. 269-273
    • Crowe J.E., Jr.1    Firestone, C.Y.2    Whitehead, S.S.3    Collins, P.L.4    Murphy, B.R.5
  • 13
    • 0026573923 scopus 로고
    • Viral respiratory infections in the institutionalized elderly: Clinical and epidemiologic findings
    • Falsey, A. R., J. J. Treanor, R. F. Betts, and E. E. Walsh. 1992. Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings. J. Am. Geriatr. Soc. 40:115-119.
    • (1992) J. Am. Geriatr. Soc. , vol.40 , pp. 115-119
    • Falsey, A.R.1    Treanor, J.J.2    Betts, R.F.3    Walsh, E.E.4
  • 14
    • 0030588949 scopus 로고    scopus 로고
    • Nucleotide sequence analysis of the respiratory syncytial virus subgroup a cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate
    • Firestone, C. Y., S. S. Whitehead, P. L. Collins, B. R. Murphy, and J. E. Crowe, Jr. 1996. Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate. Virology 225:419-422.
    • (1996) Virology , vol.225 , pp. 419-422
    • Firestone, C.Y.1    Whitehead, S.S.2    Collins, P.L.3    Murphy, B.R.4    Crowe J.E., Jr.5
  • 18
    • 0026552470 scopus 로고
    • Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys
    • Hall, S. L., A. Stokes, E. L. Tierney, W. T. London, R. B. Belshe, F. C. Newman, and B. R. Murphy. 1992. Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys. Virus Res. 22:173-184.
    • (1992) Virus Res. , vol.22 , pp. 173-184
    • Hall, S.L.1    Stokes, A.2    Tierney, E.L.3    London, W.T.4    Belshe, R.B.5    Newman, F.C.6    Murphy, B.R.7
  • 20
    • 0033577312 scopus 로고    scopus 로고
    • The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations
    • in press
    • Juhasz, K., S. S. Whitehead, C. A. Boulanger, C. Y. Firestone, P. L. Collins, and B. R. Murphy. The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations. Vaccine, in press.
    • Vaccine
    • Juhasz, K.1    Whitehead, S.S.2    Boulanger, C.A.3    Firestone, C.Y.4    Collins, P.L.5    Murphy, B.R.6
  • 21
    • 0030788294 scopus 로고    scopus 로고
    • The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein
    • Juhasz, K., S. S. Whitehead, P. T. Bui, J. M. Biggs, C. A. Boulanger, P. L. Collins, and B. R. Murphy. 1997. The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein. J. Virol. 71:5814-5819.
    • (1997) J. Virol. , vol.71 , pp. 5814-5819
    • Juhasz, K.1    Whitehead, S.S.2    Bui, P.T.3    Biggs, J.M.4    Boulanger, C.A.5    Collins, P.L.6    Murphy, B.R.7
  • 22
    • 0026722698 scopus 로고
    • Respiratory syncytial virus puzzle: Clinical features, pathophysiology, treatment, and prevention
    • La Via, W. V., M. I. Marks, and H. R. Stutman. 1992. Respiratory syncytial virus puzzle: clinical features, pathophysiology, treatment, and prevention. J. Pediatr. 121:503-510.
    • (1992) J. Pediatr. , vol.121 , pp. 503-510
    • La Via, W.V.1    Marks, M.I.2    Stutman, H.R.3
  • 23
    • 0015096514 scopus 로고
    • Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness
    • Mills, J., J. E. Van Kirk, P. F. Wright, and R. M. Chanock. 1971. Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. J. Immunol. 107:123-130.
    • (1971) J. Immunol. , vol.107 , pp. 123-130
    • Mills, J.1    Van Kirk, J.E.2    Wright, P.F.3    Chanock, R.M.4
  • 25
    • 0028296935 scopus 로고
    • An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines
    • Murphy, B. R., S. L. Hall, A. B. Kulkarni, J. E. Crowe, Jr., P. L. Collins, M. Connors, R. A. Karron, and R. M. Chanock. 1994. An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines. Virus Res. 32:13-36.
    • (1994) Virus Res. , vol.32 , pp. 13-36
    • Murphy, B.R.1    Hall, S.L.2    Kulkarni, A.B.3    Crowe J.E., Jr.4    Collins, P.L.5    Connors, M.6    Karron, R.A.7    Chanock, R.M.8
  • 26
    • 0030920478 scopus 로고    scopus 로고
    • An influenza a live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters
    • Murphy, B. R., E. J. Park, P. Gottlieb, and K. Subbarao. 1997 An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters. Vaccine 15:1372-1378.
    • (1997) Vaccine , vol.15 , pp. 1372-1378
    • Murphy, B.R.1    Park, E.J.2    Gottlieb, P.3    Subbarao, K.4
  • 29
    • 0032889254 scopus 로고    scopus 로고
    • Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce the NS2 protein
    • Teng, M. N., and P. L. Collins. 1998. Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce the NS2 protein. J. Virol. 73:466-473.
    • (1998) J. Virol. , vol.73 , pp. 466-473
    • Teng, M.N.1    Collins, P.L.2
  • 30
    • 0019458558 scopus 로고
    • Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-ts-1A2 recombinant during growth in vivo
    • Tolpin, M. D., J. G. Massicot, M. G. Mullinix, H. W. Kim, R. H. Parrott, R. M. Chanock, and B. R. Murphy. 1981. Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-ts-1A2 recombinant during growth in vivo. Virology 112:505-517.
    • (1981) Virology , vol.112 , pp. 505-517
    • Tolpin, M.D.1    Massicot, J.G.2    Mullinix, M.G.3    Kim, H.W.4    Parrott, R.H.5    Chanock, R.M.6    Murphy, B.R.7
  • 31
    • 0029610014 scopus 로고
    • Respiratory syncytial virus and parainfluenza virus infections in the immunocompromised host
    • Wendt, C. H., and M. I. Hertz. 1995. Respiratory syncytial virus and parainfluenza virus infections in the immunocompromised host. Semin. Respir. Infect. 10:224-231.
    • (1995) Semin. Respir. Infect. , vol.10 , pp. 224-231
    • Wendt, C.H.1    Hertz, M.I.2
  • 33
    • 0032145583 scopus 로고    scopus 로고
    • A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes
    • Whitehead, S. S., C. Y. Firestone, P. L. Collins, and B. R. Murphy. 1998. A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes. Virology 247:232-239.
    • (1998) Virology , vol.247 , pp. 232-239
    • Whitehead, S.S.1    Firestone, C.Y.2    Collins, P.L.3    Murphy, B.R.4
  • 34
    • 0031977449 scopus 로고    scopus 로고
    • Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees
    • Whitehead, S. S., K. Juhasz, C. V. Firestone, P. L. Collins, and B. R. Murphy. 1998. Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees. J. Virol. 72:4467-4471.
    • (1998) J. Virol. , vol.72 , pp. 4467-4471
    • Whitehead, S.S.1    Juhasz, K.2    Firestone, C.V.3    Collins, P.L.4    Murphy, B.R.5
  • 35
    • 0344403673 scopus 로고    scopus 로고
    • Personal communication
    • Wright, P. F. Personal communication.
    • Wright, P.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.