Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease

PLoS Neglected Tropical Diseases

Volumn 6, Issue 10, 2012, Pages

  Witschel, Matthias ^a   Rottmann, Matthias ^b,c   Kaiser, Marcel ^b,c   Brun, Reto ^b,c  

^a BASF SE   (Germany)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACEQUINOCYL; AGRICULTURAL CHEMICAL; ATOVAQUONE; AZOXYSTROBIN; BITERTANOL; CHLOROTHALONIL; CLIMBAZOLE; CLOTRIMAZOLE; CYAZOFAMID; DIFENOCONAZOLE; DIMOXYSTROBIN; FENCHLORAZO ETHYL; FLOCUMAFEN; FLUACRYPYRIM; FLUOPICOLIDE; IMINOCTADINE; IPCONAZOLE; METCONAZOLE; PRODIAMINE; PYRIDABEN; TEBUCONAZOLE; TETCYCLACIS; TETRAHYDRO 5,5 DIMETHYL 2(1H) PYRIMIDINONE [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 [2 [4 (TRIFLUOROMETHYL)PHENYL]VINYL]ALLYLIDENE]HYDRAZONE; THIOLUTIN; THIRAM; TOLYLFLUANIDE; TRIFLOXYSTROBIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINICONAZOLE; ZOXAMIDE;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOASSAY; CHAGAS DISEASE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IC 50; LEISHMANIA DONOVANI; LEISHMANIASIS; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RAT; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

AGROCHEMICALS; ANIMALS; ANTIPROTOZOAL AGENTS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LEISHMANIA; MALARIA; MICE; PARASITIC SENSITIVITY TESTS; PLASMODIUM; TREATMENT OUTCOME; TROPICAL CLIMATE; TRYPANOSOMA; TRYPANOSOMIASIS, AFRICAN;

EID: 84869001462     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001805     Document Type: Article

References (55)

1. WHO-website. Available: http://www.who.int/malaria/world_malaria_report_2011/en/. Accessed 2012 Aug 31.
2. Murray CJL, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, et al. (2011) Global malaria mortality between 1980 and 2010: a systematic analysis. The Lancet 379: 413-431.
3. Noedl H, Chanthap L, Se Y, Socheat D, Peou S, et al. (2007) Artemisinin resistance in Cambodia? Trop. Med. Int. Health 12: 69.
4. Plouffe D, Brinker A, McNamara C, Henson K, Kato N, et al. (2008) In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A 105: 9059-9064.
5. Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, et al. (2010) Thousands of chemical starting points for antimalarial lead identification. Nature 465: 305-310.
6. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, et al. (2010) Chemical genetics of Plasmodium falciparum. Nature 465: 311-315.
7. Nwaka S, Besson D, Ramitez B, Maes L, Matheeussen A, et al. (2011) Integrated dataset of screening hits against multiple neglected disease pathogens. PLoS Negl Trop Dis 5: e1412.
8. Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, et al. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science 329: 1175-1180.
9. MMV-website. Available: http://www.mmv.org/research-development/science-portfolio. Accessed 2012 Aug 31.
10. Yeung BS, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, et al. (2010) Spirotetrahydro-carbolines (Spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J of Med Chem 53: 5155-5164.
11. Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, et al. (2011) First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med 365: 1926-1927.
12. Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, et al. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc Natl Acad Sci U S A 108: 4400-4405.
13. Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, et al. (2011) A research agenda to underpin malaria eradication. PLoS Med Jan 25;8: e1000406.
14. Fèvre EM, Wissmann BV, Welburn SC, Lutumba P, (2008) The burden of human african trypanosomiasis. PLoS Negl Trop Dis 2: e333 doi:10.1371/journal.pntd.0000333.
15. Simarro PP, Diarra A, Ruiz Postigo JA, Franco JR, Jannin G, (2011) The human african trypanosomiasis control and surveillance programme of the world health organisation 2000-2009: The Way Forward. PLOS Negl Trop Dis 5: e1007 doi: 10.1371/journal.pntd.0001007.
16. Priotto G, Kasparian S, Mutombo W, Ngouama D, Gorashina S, Arnold U, et al. (2009) Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet 374: 56-64.
17. Astelbauer F, Walochnik J, (2011) Antiprotozoal compounds: state of the art and new developments. International Journal of Antimicrobial Agents 38: 118-124.
18. DNDi-website. Available: www.dndi.org/diseases/chagas/current-treatment.html. Accessed 2012 Aug 31.
19. Castro JA, Montalto de Mecca M, Bartel LC, (2006) Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis). Human & Experimental Toxicology 25: 471-479.
20. WHO-website. Available: http://apps.who.int/ghodata/?vid=110001 http://www.who.int/tdr/publications/disease_watch/leish/en/. Accessed 2012 Feb 8.
21. WHO-website. Available: http://www.who.int/leishmaniasis/en/. Accessed 2012 Aug 31.
22. WHO-website. Available: www.dndi.org/diseases/vl/current-treatment.html. Accessed 2012 Aug 31.
23. Swanton CJ, Mashhadi HR, Solomon KR, Afifi MM, Duke SO, (2011) Similarities between the discovery and regulation of pharmaceuticals and pesticides: in support of a better understanding of the risks and benefits of each. Pest Management Science 67: 790-797.
24. Friedrich A, Olejniczak K, (2011) Evaluation of carcinogenicity studies of medicinal products for human use authorised via the European centralised procedure (1995-2009). Regulatory Toxicology and Pharmacology 60: 225-248.
25. Nosten F, McGready R, d'Alessandro U, Bonell A, Verhoeff F, et al. (2006) Antimalarial drugs in pregnancy: a review. Current Drug Safety 1: 1-15.
26. Bajsa J, Singh K, Nanayakkara D, Duke SO, Rimando AM, et al. (2007) A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds. Biological & Pharmaceutical Bulletin 30: 1740-1744.
27. Baltz T, Baltz D, Giroud D, Crockett J, (1985) Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO Journal 4: 1273-1277.
28. Räz B, Iten M, Grether-Buhler Y, Kaminsky R, Brun R, (1997) The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Trop 68: 139-147.
29. Huber W, Koella JC, (1993) A comparison of the three methods of estimating EC50 in studies of drug resistance of malaria parasites. Acta Trop 55: 257-261.
30. Buckner FS, Verlinde CL, La Flamme AC, Van Voorhis WC, (1996) Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase,. Antimicrobial agents and chemotherapy 40: 2592-2597.
31. Cunningham I, (1977) New culture medium for maintenance of tsetse tissues and growth of trypanosomatids. J Protozool 24: 325-329.
32. Mikus J, Steverding D, (2000) A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue. Parasitology International 48: 265-269.
33. Franke-Fayard B, Trueman H, Ramesar J, Mendoza J, van der Keur M, et al. (2004) A Plasmodium berghei reference line that constituively expresses GFP at a high level throughout the complete life cycle. Mol Biochem Parasitol 137: 23-33.
34. Scory S, Caffrey CR, Stierhof YD, Ruppel A, Steverding D, (1999) Trypanosoma rangeli: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-Phe-Ala-CHN2. Exp Parasitol 91: 327-333.
35. Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, et al. (2008) RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis 2: e298.
36. Hedges S, Blair DJ, Kumar S, (2006) TimeTree: A public knowledge-based of divergence times among organisms. Bioinformatics 22: 2971-2972.
37. Tree of Life-website. Available: http://tolweb.org/tree/phylogeny.html. Accessed 2012 Aug 31.
38. Clark RL, Lerman SA, Cox EM, Gristwood WE, White TEK, (2008) Developmental toxicity of artesunate in the rat: comparison to other artemisinins, comparison of embryotoxicity and kinetics by oral and intravenous routes, and relationship to maternal reticulocyte count. Birth Defects Research, Part B: Developmental and Reproductive Toxicology 83: 397-406.
39. Clark RL, Gristwood WE, Lewsley R, Wilson R, Harrell AW, (2010) Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity. Birth Defects Research, Part B: Developmental and Reproductive Toxicology 89: 364-375.
40. Crouzette J, Vicaut E, Palombo S, Girre C, Fournier PE, (1983) Experimental assessment of the protective activity of diazepam on the acute toxicity of chloroquine. Journal of Toxicology, Clinical Toxicology 20: 271-279.
41. LD50 data have been retrieved from the E-Pesticide Manual, V5.2, BCPC Publications 2011.
42. Van Nieuwenhuyse P, Van Leeuwen T, Khajehali J, Vanholme B, Tirry L, (2009) Mutations in the mitochondrial cytochrome b of Tetranychus urticae Koch (Acari: Tetranychidae) confer cross-resistance between bifenazate and acequinocyl. Pest Management Science 65: 404-412.
43. Alzeer J, Chollet J, Heinze-Krauss I, Hubschwerlen C, Matile H, (2000) Phenyl-methoxyacrylates: a new antimalarial pharmacophore. Journal of Medicinal Chemistry 43: 560-568.
44. ChEMBL-website. Available: https://www.ebi.ac.uk/chemblntd. Accessed 2012 Aug 31.
45. Hollingshaus JG, (1987) Inhibition of mitochondrial electron transport by hydramethylnon: a new amidinohydrazone insecticide. Pesticide Biochemistry and Physiology 27: 61-70.
46. Arafa RK, Wenzler T, Brun R, Chai Y, Wilson DW, (2011) Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European Journal of Medicinal Chemistry 46: 5852-5860.
47. Fennell BJ, Naughton JA, Dempsey E, Bell A, (2006) Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: Tubulin as a specific antimalarial target. Molecular & Biochemical Parasitology 145: 226-238.
48. Rademacher W, Jung J, Hildebrandt E, Graebe JE, (1983) Influence of the bioregulator tetcyclacis (BAS 106 W) on gibberellin biosynthesis and the hormonal status of plants. Proceedings- Plant Growth Regulation Society of America 10: 36-41.
49. Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, et al. (2010) Structural insights into inhibition of sterol 14a-demethylase in the human pathogen trypanosoma cruzi. Journal of Biological Chemistry 285: 25582-25590.
50. Castro JA, Montalto de Mecca M, Bartel LC, (2006) Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis. Human & Experimental Toxicology 25: 471-479.
51. De Toranzo EGD, Masana M, Castro JA, (1984) Administration of benznidazole, a chemotherapeutic agent against Chagas' disease, to pregnant rats. Covalent binding of reactive metabolites to fetal and maternal proteins. Archives Internationales de Pharmacodynamie et de Therapie 272: 17-23.
52. Ogata M, Matsumoto H, Shimizu S, Kida S, Shiro M, Tawara K, (1987) Synthesis and antifungal activity of new 1-vinylimidazoles. Journal of Medicinal Chemistry 30: 1348-1354.
53. Seneca H, Kane JH, Rockenbach J, (1952) Bactericidal, protozoicidal, and fungicidal properties of thiolutin. Antibiotics and Chemotherapy (Washington, D. C.) 2: 357-360.
54. Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ Jr (2006) A clinical drug library screen identifies astemizole as an antimalarial agent. Nature Chemical Biology 2: 415-416.
55. Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, et al. (2006) Searching for new antimalarial therapeutics amongst known drugs. Chemical Biology & Drug Design 67: 409-416.