Development of an in vitro activity assay as an alternative to the mouse bioassay for Clostridium botulinum neurotoxin type A

Applied and Environmental Microbiology

Volumn 74, Issue 14, 2008, Pages 4309-4313

  Rasooly, Reuven ^a   Do, Paula M ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ANTIBODIES; CONCENTRATION (PROCESS); ENERGY STORAGE; ENERGY TRANSFER; FLUORESCENCE; LIGHT EMISSION; LUMINESCENCE; MONOCLONAL ANTIBODIES; SENSITIVITY ANALYSIS;

BOTULINUM; CARROT JUICES; CLOSTRIDIUM BOTULINUM NEUROTOXINS; CONCENTRATION (COMPOSITION); FLUORESCENCE RESONANCE ENERGY TRANSFER (FRETS); FLUORESCENT DYES; HEAVY CHAIN (VH); IMMUNOMAGNETIC BEADS; IN VITRO ACTIVITY; IN-VITRO; IN-VIVO; SNAP 25 (SYNAPTOSOMAL ASSOCIATED PROTEIN OF 25 KDA); SPECIALIZED EQUIPMENT; TO MANY; TOXIN ACTIVITY;

BIOASSAY;

BOTULINUM TOXIN A; FLUORESCENT DYE; MONOCLONAL ANTIBODY; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

BACTERIUM; BIOASSAY; DYE; LABORATORY METHOD; PEPTIDE; RODENT; SENSITIVITY ANALYSIS; TOXIN;

ANIMAL TISSUE; ARTICLE; AUTOMATION; BEEF; BIOASSAY; CARROT; CLOSTRIDIUM BOTULINUM; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEAVY CHAIN; IMMUNOMAGNETIC SEPARATION; IN VITRO STUDY; NONHUMAN; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL ASSAY; BOTULINUM TOXIN TYPE A; CATTLE; CLOSTRIDIUM BOTULINUM TYPE A; DAUCUS CAROTA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOOD MICROBIOLOGY; FOOD PRESERVATION; IMMUNOMAGNETIC SEPARATION; MEAT; MICE; NEUROTOXINS; SENSITIVITY AND SPECIFICITY; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TIME FACTORS;

ANIMALIA; CLOSTRIDIUM BOTULINUM; DAUCUS CAROTA;

EID: 47749087132     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.00617-08     Document Type: Article

References (12)

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