Genetic diversity among botulinum neurotoxin-producing clostridial strains

Journal of Bacteriology

Volumn 189, Issue 3, 2007, Pages 818-832

  Hill, K K ^a   Smith, T J ^c   Helma, C H ^a   Ticknor, L O ^a   Foley, B T ^b   Svensson, R T ^a   Brown, J L ^c   Johnson, E A ^d   Smith, L A ^c   Okinaka, R T ^a   Jackson, P J ^e   Marks, J D ^f  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

^e LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN E; HEMAGGLUTININ; RNA 16S;

AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; ARTICLE; BACTERIAL SPORE; BACTERIAL STRAIN; CLOSTRIDIUM; CLOSTRIDIUM BOTULINUM; FATALITY; GENE IDENTIFICATION; GENE SEQUENCE; GENE TRANSFER; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC VARIABILITY; MOLECULAR EVOLUTION; MORPHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARALYSIS; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEROTYPE; SPECIES DIFFERENCE; UNINDEXED SEQUENCE;

BOTULINUM TOXINS; CLOSTRIDIUM BOTULINUM; MOLECULAR SEQUENCE DATA; PHYLOGENY; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; SEROTYPING; VARIATION (GENETICS);

ANIMALIA; CLOSTRIDIUM BOTULINUM;

EID: 33846598840     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01180-06     Document Type: Article

References (50)

1. Arnon, S. A., R. Schecter, T. V. Inglesby, D. A. Henderson, J. G. Bartlett, M. S. Ascher, E. Eitzen, A. D. Fine, J. Hauer, M. Layton, S. Lillibridge, M. T. Osterholm, T. O'Toole, G. Parker, T. M. Perl, P. K. Russell, D. L. Swerdlow, and K. Tonat. 2001. Botulinum toxin as a biological weapon: medical and public health management. JAMA 285:1059-1070.
2. Aureli, P., L. Fenicia, B. Pasolini, M. Gianfranceschi, L. M. McCroskey, and C. L. Hatheway. 1986. Two cases of type E infant botulism caused by neurotoxigenic Clostridium butyricum in Italy. J. Infect. Dis. 154:207-211.
3. Balding, P., E. R. Gold, D. A. Boroff, and T. A. Roberts. 1973. Observations on receptor specific proteins. II. Haemagglutination and haemagglutination-inhibition reactions of Clostridium botulinum types A, C, D and E haemagglutinins. Immunology 25:773-782.
4. Barash, J. R., and S. S. Arnon. 2004. Dual toxin-producing strain of Clostridium botulinum type Bf isolated from a California patient with infant botulism. J. Clin. Microbiol. 42:1713-1715.
5. Bozheyeva, G., Y. Kunakbayev, and D. Yeleukenov. 1999. Former soviet biological weapons facilities in Kazakhstan: past, present, and future. Center for Nonproliferation Studies, Monterey Institute of International Studies, Monterey, CA.
6. Centers for Disease Control and Prevention. 1998. Botulism in the United States, 1899-1998. Handbook for epidemiologists, clinicians, and laboratory workers. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. http://www.bt.cdc.gov/agent/botulism/index.asp.
7. Christensen, D. R., L. J. Hartman, B. M. Loveless, M. S. Frye, M. A. Shipley, D. L. Bridge, M. J. Richards, R. S. Kaplan, J. Garrison, C. D. Baldwin, D. A. Kulesh, and D. A. Norwood. 2006. Detection of biological threat agents by real-time PCR: comparison of assay performance on the R.A.P.I.D., the LightCycler, and the Smart Cycler platforms. Clin. Chem. 52:141-145.
8. Collins, M. D., and A. K. East. 1998. Phylogeny and taxonomy of the food-borne pathogen Clostridium botulinum and its neurotoxins. J Appl. Microbiol. 84:5-17.
9. Dineen, S. S., M. Bradshaw, and E. A. Johnson. 2003. Neurotoxin gene clusters in Clostridium botulinum type A strains: sequence comparison and evolutionary implications. Curr. Microbiol. 46:345-352.
10. East, A. K., M. Bhandari, S. Hielm, and M. D. Collins. 1998. Analysis of the botulinum neurotoxin type F gene clusters in proteolytic and nonproteolytic Clostridium botulinum and Clostridium barati. Curr. Microbiol. 37:262-268.
11. East, A. K., M. Bhandari, J. M. Stacey, K. D. Campbell, and M. D. Collins. 1996. Organization and phylogenetic interrelationships of genes encoding components of the botulinum toxin complex in proteolytic Clostridium botulinum types A, B, and F: evidence of chimeric sequences in the gene encoding the nontoxic nonhemagglutinin component. Int. J. Syst. Bacteriol. 46:1105-1112.
12. East, A. K., J. M. Stacey, and M. D. Collins. 1994. Cloning and sequencing of a hemagglutinin component of the botulinum neurotoxin complex encoded by the Clostridium botulinum types A and B. Syst. Appl. Microbiol. 17:306-312.
13. Gibson, A. M., N. K. Modi, T. A. Roberts, P. Hambleton, and J. Melling. 1988. Evaluation of a monoclonal antibody-based immunoassay for detecting type B Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system. J. Appl. Bacteriol. 64:285-291.
14. Gimenez, D. F., and A. S. Ciccarelli. 1970. Another type of Clostridium botulinum. Zentralbl. Bakeriol. 1 Abt. Orig. A Med. Mikrobiol. Infecktionskr. Parasitl. 215:221-224.
15. Gimenez, D. F., and J. A. Gimenez. 1993. Serological subtypes of botulinal neurotoxins, p. 421-431. In B. R. DasGupta (ed.), Botulinum and tetanus neurotoxins. Plenum Press, New York, NY.
16. Hall, J. D., L. M. McCroskey, B. J. Pincomb, and C. L. Hatheway. 1985. Isolation of an organism resembling Clostridium barati which produces type F botulinal toxin from an infant with botulism. J. Clin. Microbiol. 21:654-655.
17. Hatheway, C. L. 1995. Botulism: the present status of the disease. Curr. Top. Microbiol. Immunol. 195:55-75.
18. Hatheway, C. L. 1990. Toxigenic clostridia. Clin. Microbiol. Rev. 3:66-98.
19. Hatheway, C. L., and J. L. Ferreira. 1996. Detection and identification of Clostridium botulinum neurotoxins. Adv. Exp. Med. Biol. 391:481-498.
20. Hutson, R. A., M. D. Collins, A. K. East, and D. E. Thompson. 1994. Nucleotide sequence of the gene coding for non-proteolytic Clostridium botulinum type B neurotoxin: comparison with other clostridial neurotoxins. Curr. Microbiol. 28:101-110.
21. Hutson, R. A., D. E. Thompson, and M. D. Collins. 1993. Genetic interrelationships of saccharolytic Clostridium botulinum types B, E and F and related clostridia as revealed by small-subunit rRNA gene sequences. FEMS Microbiol. Lett. 108:103-110.
22. Hutson, R. A., D. E. Thompson, P. A. Lawson, R. P. Schocken-Itturino, E. C. Bottger, and M. D. Collins. 1993. Genetic interrelationships of proteolytic Clostridium botulinum types A, B, and F and other members of the Clostridium botulinum complex as revealed by small-subunit rRNA gene sequences. Antonie Leeuwenhoek 64:273-283.
23. Ihara, H., T. Kohda, F. Morimoto, K. Tsukamoto, T. Karasawa, S. Nakamura, M. Mukamoto, and S. Kozaki. 2003. Sequence of the gene for Clostridium botulinum type B neurotoxin associated with infant botulism, expression of the C-terminal half of heavy chain and its binding activity. Biochim. Biophys. Acta 1625:19-26.
24. Kaufman, L., and P. J. Rousseeuw. 1990. Finding groups in data: an introduction to cluster analysis. John Wiley & Sons, Inc., New York, NY.
25. Keto-Timonen, R., M. Nevas, and H. Korkeala. 2005. Efficient DNA finger-printing of Clostridium botulinum types A, B, E, and F by amplified fragment length polymorphism analysis. Appl. Environ. Microbiol. 71:1148-1154.
26. Kirma, N., J. L. Ferreira, and B. R. Baumstark. 2004. Characterization of six type A strains of Clostridium botulinum that contain type B toxin gene sequences. FEMS Microbiol. Lett. 231:159-164.
27. Kozaki, S., Y. Kamata, T. Nishiki, H. Kakinuma, H. Maruyama, H. Takahashi, T. Karasawa, K. Yamakawa, and S. Nakamura. 1998. Characterization of Clostridium botulinum type B neurotoxin associated with infant botulism in Japan. Infect. Immun. 66:4811-4816.
28. Kozaki, S., S. Nakaue, and Y. Kamata. 1995. Immunological characterization of the neurotoxin produced by Clostridium botulinum type A associated with infant botulism in Japan. Microbiol. Immunol. 39:767-774.
29. Leighton, G. 1923. Botulism and food preservation (the Loch Maree tragedy). Collins & Sons, Glasgow, United Kingdom.
30. McCroskey, L. M., C. L. Hatheway, L. Fenicia, B. Pasolini, and P. Aureli. 1986. Characterization of an organism that produces type E botulinal toxin but which resembles Clostridium butyricum from the feces of an infant with type E botulism. J. Clin. Microbiol. 23:201-202.
31. Moriishi, K., M. Koura, N. Abe, N. Fujii, Y. Fujinaga, K. Inoue, and K. Oguma. 1996. Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms. Biochim. Biophys. Acta 1307: 123-126.
32. Moriishi, K., M. Koura, N. Fujii, Y. Fujinaga, K. Inoue, B. Syuto, and K. Oguma. 1996. Molecular cloning of the gene encoding the mosaic neurotoxin, composed of parts of botulinum neurotoxin types C1 and D, and PCR detection of this gene from Clostridium botulinum type C organisms. Appl. Environ. Microbiol. 62:662-667.
33. Mullaney, B. P., M. G. Pallavincini, and J. D. Marks. 2001. Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display. Infect. Immun. 69:6511-6514.
34. Popoff, M., and J.-C. Marvaud. 1999. Structural and genomic features of clostridial neurotoxins, p. 202-228. In J. E. Alouf and J. H. Freer (ed.), The comprehensive sourcebook of bacterial protein toxins. Academic Press, London, United Kingdom.
35. Poulet, S., D. Hauser, M. Quanz, H. Niemann, and M. R. Popoff. 1992. Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain Beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755). Biochem. Biophys. Res. Commun. 183:107-113.
36. Raffestin, S., J. C. Marvaud, R. Cerrato, B. Dupuy, and M. R. Popoff. 2004. Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani. Anaerobe 10:93-100.
37. Santos-Buelga, J. A., M. D. Collins, and A. K. East. 1998. Characterization of the genes encoding the botulinum neurotoxin complex in a strain of Clostridium botulinum producing type B and F neurotoxins. Curr. Microbiol. 37:312-318.
38. Smith, L. D. S. 1977. Botulinum: the organism, its toxins, the disease. Charles C. Thomas, Springfield, IL.
39. Smith, T. J., J. Lou, I. Geren, C. M. Forsyth, R. Tsai, S. L. LaPorte, W. H. Tepp, M. Bradshaw, E. A. Johnson, L. A. Smith, and J. D. Marks. 2005. Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect. Immun. 73:5450-5457.
40. Sonnabend, O., W. Sonnabend, R. Heinzle, T. Sigrist, R. Dirnhofer, and V. Krech. 1981. Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths. J. Infect. Dis. 143:22-27.
41. Sonnabend, O. A., W. F. Sonnabend, U. Krech, G. Molz, and T. Sigrist. 1985. Continuous microbiological and pathological study of 70 sudden and unexpected infant deaths: toxigenic intestinal Clostridium botulinum infection in 9 cases of sudden infant death syndrome. Lancet i:237-241.
42. Stackebrandt, E., I. Kramer, J. Swiderski, and H. Hippe. 1999. Phylogenetic basis for a taxonomic dissection of the genus Clostridium. FEMS Immunol. Med. Microbiol. 24:253-258.
43. Suen, J. C., C. L. Hatheway, A. G. Steigerwalt, and D. J. Brenner. 1988. Clostridium argentinense, sp. nov.: a genetically homogeneous group composed of all strains of Clostridium botulinum toxin type G and some non-toxigenic strains previously identified as Clostridium subterminale or Clostridium hastiforme. Int. J. Syst. Bacteriol. 38:375-381.
44. Ticknor, L. O., A. B. Kolstø, K. K. Hill, P. Keim, M. T. Laker, M. Tonks, and P. J. Jackson. 2001. Fluorescent amplified fragment length polymorphism analysis of Norwegian Bacillus cereus and Bacillus thuringiensis soil isolates. Appl. Environ. Microbiol. 67:4863-4873.
45. United Nations Security Council. 1995. Tenth report of the Executive Committee of the Special Commission established by the Secretary-General pursuant to paragraph 9(b) (I) of Security Council resolution 687 (1991), and paragraph 3 of resolution 699 (1991) on the activities of the Special Commission. United Nations Security Council, New York, NY.
46. Wang, X., T. Maegawa, T. Karasawa, S. Kozaki, K. Tsukamoto, Y. Gyobu, K. Yamakawa, K. Oguma, Y. Sakaguchi, and S. Nakamura. 2000. Genetic analysis of type E botulinum toxin-producing Clostridium butyricum strains. Appl. Environ. Microbiol. 66:4992-4997.
47. Ward, B. Q., B. J. Carroll, E. S. Garrett, and G. B. Reese. 1967. Survey of the U.S. Atlantic coast and estuaries from Key Largo to Staten Island for the presence of Clostridium botulinum. Appl. Microbiol. 15:964-965.
48. Whelan, S. M., M. J. Elmore, N. J. Bodsworth, J. K. Brehm, T. Atkinson, and N. P. Minton. 1992. Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence. Appl. Environ Microbiol. 58:2345-2354.
49. Willems, A., A. K. East, P. A. Lawson, and M. D. Collins. 1993. Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. Res. Microbiol. 144:547-556.
50. Zhang, L., W.-J. Lin, S. Li, and K. R. Aoki. 2003. Complete DNA sequences of the botulinum neurotoxin complex of Clostridium botulinum type A-Hall (Allergan) strain. Gene 315:21-32.