Computational approaches to the understanding of ADMET properties and problems

Drug Discovery Today

Volumn 8, Issue 14, 2003, Pages 621-623

  Modi, Sandeep ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

ADMET; Bioinformatics; Biotechnology; CNS; Computational; Drug Discovery; Drug metabolism; In silico

Indexed keywords

NEW DRUG;

DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; MEMBRANE TRANSPORT; MODEL; REVIEW; STATISTICAL ANALYSIS; TOXICITY;

EID: 0038350683     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02739-9     Document Type: Letter

References (4)

1. Kennedy T. Managing the drug discovery/development interface. Drug Discov. Today. 2:1997;436-444.
2. Cruciani G., et al. VolSurf: a new tool for the pharmacokinetic optimization of lead compounds. Eur. J. Pharm. Sci. 11:(Suppl.2):2000;S29-S39.
3. Agoram B., et al. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv. Drug Del. Rev. 90:2001;S42-S67.
4. Noris D.A., et al. Development of predictive pharmacokinetics simulation models for drug discovery. J. Control. Release. 65:2000;55-62.