Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: A preliminary study

Schizophrenia Research

Volumn 58, Issue 1, 2002, Pages 11-20

  Vawter, Marquis P ^a,b   Crook, Jeremy M ^c   Hyde, Thomas M ^c   Kleinman, Joel E ^c   Weinberger, Daniel R ^c   Becker, Kevin G ^d   Freed, William J ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Gene expression; Genomics; Microarray; Postmortem; Prefrontal cortex; Schizophrenia

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; HISTIDINE DERIVATIVE; NUCLEOTIDE BINDING PROTEIN; UBIQUITIN CONJUGATING ENZYME;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENOME ANALYSIS; HUMAN; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SYNAPSE;

ADULT; AGED; AUTOPSY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREFRONTAL CORTEX; RNA, MESSENGER; SCHIZOPHRENIA; STATISTICS, NONPARAMETRIC;

EID: 0036843296     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(01)00377-2     Document Type: Article

References (27)

1. Baron M. Genetics of schizophrenia and the new millennium: progress and pitfalls. Am. J. Hum. Genet. 68:2001;299-312.
2. Barrett T., Cheadle C., Wong W.H., Teichberg D., Donovan D.M., Freed W.J., Becker K.G., Vawter M.P. Assembly and use of a broadly applicable neural cDNA microarray. Restor. Neurol. Neurosci. 18:2001;127-135.
3. Becher B., Barker P.A., Owens T., Antel J.P. CD95-CD95L: can the brain learn from the immune system? Trends Neurosci. 21:1998;114-117.
4. Brenner C., Bieganowski P., Pace H.C., Huebner K. The histidine triad superfamily of nucleotide-binding proteins. J. Cell. Physiol. 181:1999;179-187.
5. Eastwood S.L., McDonald B., Burnet P.W., Beckwith J.P., Kerwin R.W., Harrison P.J. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Mol. Brain Res. 29:1995;211-223.
6. Eastwood S.L., Porter R.H., Harrison P.J. The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain. Neurosci. Lett. 212:1996;163-166.
7. Eastwood S.L., Kerwin R.W., Harrison P.J. Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol. Psychiatry. 41:1997;636-643.
8. Freed W.J. An hypothesis regarding the antipsychotic effect of neuroleptic drugs. Pharmacol. Biochem. Behav. 32:1989;337-345.
9. Freed W.J., Dillon-Carter O., Kleinman J.E. Properties of [3H]AMPA binding in postmortem human brain from psychotic subjects and controls: increases in caudate nucleus associated with suicide. Exp. Neurol. 121:1993;48-56.
10. Gamble S.C., Dunn M.J., Wheeler C.H., Joiner M.C., Adu-Poku A., Arrand J.E. Expression of proteins coincident with inducible radioprotection in human lung epithelial cells. Cancer Res. 60:2000;2146-2151.
11. Gao X.M., Sakai K., Roberts R.C., Conley R.R., Dean B., Tamminga C.A. Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am. J. Psychiatry. 157:2000;1141-1149.
12. Gilmour J., Liang N., Lowenstein J.M. Isolation, cloning and characterization of a low-molecular-mass purine nucleoside-and nucleotide-binding protein. Biochem. J. 326:1997;1-7.
13. Hakak Y., Walker J.R., Li C., Wong W.H., David K.L., Buxbaum J.D., Haroutunian V., Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 98:2001;4746-4751.
14. Harrison P.J. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 122:1999;593-624.
15. Healy D.J., Haroutunian V., Powchik P., Davidson M., Davis K.L., Watson S.J., Meador-Woodruff J.H. AMPA receptor binding and subunit mRNA expression in prefrontal cortex and striatum of elderly schizophrenics. Neuropsychopharmacology. 19:1998;278-286.
16. Kelso G.F., Porteous C.M., Coulter C.V., Hughes G., Porteous W.K., Ledgerwood E.C., Smith R.A., Murphy M.P. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J. Biol. Chem. 276:2001;4588-4596.
17. Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G., Farahani R., McLean M., Ideda J.E., MacKenzie A., Korneluk R.G. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature. 379:1996;349-353.
18. Meador-Woodruff J.H., Healy D.J. Glutamate receptor expression in schizophrenic brain. Brain Res. Rev. 31:2000;288-294.
19. Mielke K., Herdegen T. JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog. Neurobiol. 61:2000;45-60.
20. Mirnics K., Middleton F.A., Marquez A., Lewis D.A., Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron. 28:2000;53-67.
21. Mirnics K., Middleton F.A., Stanwood G.D., Lewis D.A., Levitt P. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol. Psychiatry. 6:2001;293-301.
22. Spurney C.F., Baca S.M., Murray A.M., Jaskiw G.E., Kleinman J.E., Hyde T.M. Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats. Synapse. 34:1999;266-276.
23. Stillman B.A., Tonkinson J.L. Expression microarray hybridization kinetics depend on length of the immobilized DNA but are independent of immobilization substrate. Anal. Biochem. 295:2001;149-157.
24. Straub R.E., MacLean C.J., O'Neill F.A., Walsh D., Kendler K.S. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol. Psychiatry. 2:1997;148-155.
25. Tan Z., Qu W., Tu W., Liu W., Baudry M., Schreiber S.S. p53 accumulation due to down-regulation of ubiquitin: relevance for neuronal apoptosis. Cell Death Differ. 7:2000;675-681.
26. Vawter M.P., Barrett T., Cheadle C., Sokolov B., Wood W., Donovan D.M., Webster M., Freed W.J., Becker K.G. Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Res. Bull. 55:2001;641-650.
27. Whitney L.W., Becker K.G., Tresser N.J., Caballero-Ramos C.I., Munson P.J., Prabhu V.V., Trent J.M., McFarland H.F., Biddison W.E. Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 46:1999;425-428.