The role of RANK ligand/osteoprotegerin in rheumatoid arthritis

Therapeutic Advances in Musculoskeletal Disease

Volumn 4, Issue 4, 2012, Pages 225-233

  Geusens, Piet ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

bone erosions; bone loss; osteitis; osteoprotegerin; RANK ligand; rheumatoid arthritis

Indexed keywords

COLONY STIMULATING FACTOR 1; DENOSUMAB; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE EROSION; BONE MARROW; CELL ACTIVATION; CELL DIFFERENTIATION; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG PROTEIN BINDING; ERYTHROCYTE SEDIMENTATION RATE; GENE; GENE EXPRESSION; GENE SILENCING; HIP FRACTURE; HUMAN; NONHUMAN; OSTEITIS; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PATHOGENESIS; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RANKL GENE; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM;

EID: 84868660954     PISSN: 1759720X     EISSN: 17597218     Source Type: Journal    
DOI: 10.1177/1759720X12438080     Document Type: Article

References (76)

1. Anderson D.M. Maraskovsky E. Billingsley W.L. Dougall W.C. Tometsko M.E. Roux E.R. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390: 175–179.
2. Bird P. Conaghan P. Ejbjerg B. McQueen F. Lassere M. Peterfy C. et al. (2005) The development of the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. Ann Rheum Dis 64(Suppl. 1): i8–i10.
3. Boyesen P. Hoff M. Odegard S. Haugeberg G. Syversen S.W. Gaarder P.I. et al. (2009) Antibodies to cyclic citrullinated protein and erythrocyte sedimentation rate predict hand bone loss in patients with rheumatoid arthritis of short duration: a longitudinal study. Arthritis Res Ther 11: R103.
4. Boyle W.J. Simonet W.S. Lacey D.L. (2003) Osteoclast differentiation and activation. Nature 423: 337–342.
5. Braun T. Zwerina J. (2011) Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis. Arthritis Res Ther 13: 235.
6. Bromley M. Woolley D.E. (1984) Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint. Arthritis Rheum 27: 968–975.
7. Bucay N. Sarosi I. Dunstan C.R. Morony S. Tarpley J. Capparelli C. et al. (1998) osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12: 1260–1268.
8. Calvi L.M. Adams G.B. Weibrecht K.W. Weber J.M. Olson D.P. Knight M.C. et al. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841–846.
9. Cohen S.B. Dore R.K. Lane N.E. Ory P.A. Peterfy C.G. Sharp J.T. et al. (2008) Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 58: 1299–1309.
10. Cummings S.R. San Martin J. McClung M.R. Siris E.S. Eastell R. Reid I.R. et al. (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361: 756–765.
11. Dalbeth N. Smith T. Gray S. Doyle A. Antill P. Lobo M. et al. (2009) Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease. Ann Rheum Dis 68: 279–282.
12. Deodhar A. Dore R.K. Mandel D. Schechtman J. Shergy W. Trapp R. et al. (2010) Denosumab-mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patients. Arthritis Care Res (Hoboken) 62: 569–574.
13. Dhore C.R. Cleutjens J.P. Lutgens E. Cleutjens K.B. Geusens P.P. Kitslaar P.J. et al. (2001) Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 21: 1998–2003.
14. Dore R.K. Cohen S.B. Lane N.E. Palmer W. Shergy W. Zhou L. et al. (2010) Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates. Ann Rheum Dis 69: 872–875.
15. Ejbjerg B. Narvestad E. Rostrup E. Szkudlarek M. Jacobsen S. Thomsen H.S. et al. (2004) Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis. Arthritis Rheum 50: 1097–1106.
16. Evans C.H. (2007) John Hunter and the origins of modern orthopaedic research. J Orthop Res 25: 556–560.
17. Fouque-Aubert A. Chapurlat R. Miossec P. Delmas P.D. (2010) A comparative review of the different techniques to assess hand bone damage in rheumatoid arthritis. Joint Bone Spine 77: 212–217.
18. Fujii K. Tsuji M. Tajima M. (1999) Rheumatoid arthritis: A synovial disease? Ann Rheum Dis 58: 727–730.
19. Fuller K. Wong B. Fox S. Choi Y. Chambers T.J. (1998) TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J Exp Med 188: 997–1001.
20. Geusens P. Lems W.F. (2011) Osteoimmunology and osteoporosis. Arthritis Res Ther 13: 242.
21. Geusens P. Miller C.G. (2008) Study design and end points for rheumatoid arthritis trials. In: Ed. Reid M. Miller C.G. (Eds), Clinical Trials in Rheumatoid Arthritis and Osteoarthritis. London: Springer-Verlag.
22. Geusens P.P. Landewe R.B. Garnero P. Chen D. Dunstan C.R. Lems W.F. et al. (2006) The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis Rheum 54: 1772–1777.
23. Goldring S.R. Schett G. (2011) The role of the immune system in bone loss of inflammatory arthritis. In: Ed. Lorenzo J. Choi Y. Horowitz M. Takayanagi H. (Eds), Osteoimmunology. London: Academic Press/Elsevier.
24. Gravallese E.M. Harada Y. Wang J.T. Gorn A.H. Thornhill T.S. Goldring S.R. (1998) Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 152: 943–951.
25. Haavardsholm E.A. Boyesen P. Ostergaard M. Schildvold A. Kvien T.K. (2008) Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression. Ann Rheum Dis 67: 794–800.
26. Haugeberg G. Green M.J. Quinn M.A. Marzo-Ortega H. Proudman S. Karim Z. et al. (2006) Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis. Ann Rheum Dis 65: 736–740.
27. Heidet L. Gubler M.C. (2009) The renal lesions of Alport syndrome. J Am Soc Nephrol 20: 1210–1215.
28. Hoff M. Haugeberg G. Odegard S. Syversen S. Landewe R. van der Heijde D. et al. (2009) Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up. Ann Rheum Dis 68: 324–329.
29. Jarad G. Miner J.H. (2009) Update on the glomerular filtration barrier. Curr Opin Nephrol Hypertens 18: 226–232.
30. Jimenez-Boj E. Nobauer-Huhmann I. Hanslik-Schnabel B. Dorotka R. Wanivenhaus A.H. Kainberger F. et al. (2007) Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. Arthritis Rheum 56: 1118–1124.
31. Koch A.E. (2003) Angiogenesis as a target in rheumatoid arthritis. Ann Rheum Dis 62(Suppl. 2): ii60–ii67.
32. Kong Y.Y. Yoshida H. Sarosi I. Tan H.L. Timms E. Capparelli C. et al. (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397: 315–323.
33. Lacey D.L. Timms E. Tan H.L. Kelley M.J. Dunstan C.R. Burgess T. et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165–176.
34. Larochelle C. Alvarez J.I. Prat A. (2011) How do immune cells overcome the blood–brain barrier in multiple sclerosis? FEBS Lett 585: 3770–3780.
35. Lorenzo J. Choi Y. Horowitz M. Takayanagi H. (Eds) (2011) Osteoimmunology. London: Academic Press/Elsevier.
36. Lorenzo J. Horowitz M. Choi Y. (2008) Osteoimmunology: interactions of the bone and immune system. Endocr Rev 29: 403–440.
37. McGonagle D. (2010) The history of erosions in rheumatoid arthritis: are erosions history? Arthritis Rheum 62: 312–315.
38. McGonagle D. Tan A.L. Moller Dohn U. Ostergaard M. Benjamin M. (2009) Microanatomic studies to define predictive factors for the topography of periarticular erosion formation in inflammatory arthritis. Arthritis Rheum 60: 1042–1051.
39. McInnes I.B. Schett G. (2011) The Pathogenesis of Rheumatoid Arthritis. N Engl J Med 365: 2205–2219.
40. McQueen F.M. Benton N. Perry D. Crabbe J. Robinson E. Yeoman S. et al. (2003) Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis. Arthritis Rheum 48: 1814–1827.
41. McQueen F.M. Dalbeth N. (2009) Predicting joint damage in rheumatoid arthritis using MRI scanning. Arthritis Res Ther 11: 124.
42. McQueen F.M. Gao A. Ostergaard M. King A. Shalley G. Robinson E. et al. (2007) High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone. Ann Rheum Dis 66: 1581–1587.
43. Mundwiler M.L. Maranian P. Brown D.H. Silverman J.M. Wallace D. Khanna D. et al. (2009) The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study. Arthritis Res Ther 11 (3): R94.
44. Muto A. Mizoguchi T. Udagawa N. Ito S. Kawahara I. Abiko Y. et al. (2011) Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res 26: 2978–2990.
45. Nakashima T. Hayashi M. Fukunaga T. Kurata K. Oh-Hora M. Feng J.Q. et al. (2011) Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 17: 1231–1234.
46. Nemeth K. Schoppet M. Al-Fakhri N. Helas S. Jessberger R. Hofbauer L.C. et al. (2011) The role of osteoclast-associated receptor in osteoimmunology. J Immunol 186: 13–18.
47. O'Brien C.A. (2010) Control of RANKL gene expression. Bone 46: 911–919.
48. Okamoto K. Takayanagi H. (2011) Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther 13: 219.
49. Ooi J.D. Holdsworth S.R. Kitching A.R. (2008) Advances in the pathogenesis of Goodpasture's disease: from epitopes to autoantibodies to effector T cells. J Autoimmun 31: 295–300.
50. Osako M.K. Nakagami H. Koibuchi N. Shimizu H. Nakagami F. Koriyama H. et al. (2010) Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res 107: 466–475.
51. Parfitt A.M. (1976) The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases. II. PTH and bone cells: bone turnover and plasma calcium regulation. Metabolism 25: 909–955.
52. Parfitt A.M. (1982) The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis Relat Res 4: 1–6.
53. Pettit A.R. Ji H. von Stechow D. Muller R. Goldring S.R. Choi Y. et al. (2001) TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159: 1689–1699.
54. Pettit A.R. Walsh N.C. Manning C. Goldring S.R. Gravallese E.M. (2006) RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology (Oxford) 45: 1068–1076.
55. Raggatt L.J. Partridge N.C. (2010) Cellular and molecular mechanisms of bone remodeling. J Biol Chem 285: 25103–25108.
56. Raisz L.G. (1981) What marrow does to bone. N Engl J Med 304: 1485–1486.
57. Redzic Z. (2011) Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS 8: 3.
58. Ritchlin C.T. Haas-Smith S.A. Li P. Hicks D.G. Schwarz E.M. (2003) Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 111: 821–831.
59. Schett G. (2009) Bone marrow edema. Ann N Y Acad Sci 1154: 35–40.
60. Schett G. Firestein G.S. (2010) Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis. Ann Rheum Dis 69: 787–789.
61. Schett G. Hayer S. Zwerina J. Redlich K. Smolen J.S. (2005) Mechanisms of Disease: the link between RANKL and arthritic bone disease. Nat Clin Pract Rheumatol 1: 47–54.
62. Scott D.L. Wolfe F. Huizinga T.W. (2010) Rheumatoid arthritis. Lancet 376: 1094–1108.
63. Sharp J.T. Tsuji W. Ory P. Harper-Barek C. Wang H. Newmark R. (2010) Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis. Arthritis Care Res (Hoboken) 62: 537–544.
64. Simonet W.S. Lacey D.L. Dunstan C.R. Kelley M. Chang M.S. Luthy R. et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89: 309–319.
65. Skapenko A. Prots I. Schulze-Koops H. (2009) Prognostic factors in rheumatoid arthritis in the era of biologic agents. Nat Rev Rheumatol 5: 491–496.
66. Smolen J.S. Aletaha D. Bijlsma J.W. Breedveld F.C. Boumpas D. Burmester G. et al. (2010) Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 69: 631–637.
67. Stach C.M. Bauerle M. Englbrecht M. Kronke G. Engelke K. Manger B. et al. (2010) Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum 62: 330–339.
68. Stolina M. Adamu S. Ominsky M. Dwyer D. Asuncion F. Geng Z. et al. (2005) RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res 20: 1756–1765.
69. Takayanagi H. (2009) Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol 5: 667–676.
70. Theumann N.H. Pfirrmann C.W. Drape J.L. Trudell D.J. Resnick D. (2002) MR imaging of the metacarpophalangeal joints of the fingers: part I. Conventional MR imaging and MR arthrographic findings in cadavers. Radiology 222: 437–445.
71. Tsuda E. Goto M. Mochizuki S. Yano K. Kobayashi F. Morinaga T. et al. (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234: 137–142.
72. van Tuyl L.H. Voskuyl A.E. Boers M. Geusens P. Landewe R.B. Dijkmans B.A. et al. (2010) Baseline RANKL:OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis. Ann Rheum Dis 69: 1623–1628.
73. Warde N. (2011) The odyssey of osteoclast precursors. Nat Rev Rheumatol 7: 557.
74. Weichselbaum A. (1878) The finer changes of cartilage with fungus synovitis and caries of the joint ends [in German]. Archiv Pathol Anat Physiol Klin Med 73: 461–475.
75. Yeo L. Toellner K.M. Salmon M. Filer A. Buckley C.D. Raza K. et al. (2011) Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis. Ann Rheum Dis 70: 2022–2028.
76. Yin T. Li L. (2006) The stem cell niches in bone. J Clin Invest 116: 1195–1201.