-
1
-
-
0028068882
-
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure
-
Davies SP,Hawley SA,Woods A,Carling D,Haystead TA,Hardie DG.Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.Eur J Biochem. 1994;223:351-7.
-
(1994)
Eur J Biochem
, vol.223
, pp. 351-357
-
-
Davies, S.P.1
Hawley, S.A.2
Woods, A.3
Carling, D.4
Haystead, T.A.5
Hardie, D.G.6
-
2
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
Hardie DG.AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.Nat Rev Mol Cell Biol. 2007;8:774-85.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
3
-
-
0030592623
-
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
-
Woods A,Salt I,Scott J,Hardie DG,Carling D.The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro.FEBS Lett. 1996;397:347-51.
-
(1996)
FEBS Lett
, vol.397
, pp. 347-351
-
-
Woods, A.1
Salt, I.2
Scott, J.3
Hardie, D.G.4
Carling, D.5
-
4
-
-
13344285343
-
Mammalian AMP-activated protein kinase subfamily
-
Stapleton D,Mitchelhill KI,Gao G.Mammalian AMP-activated protein kinase subfamily.J Biol Chem. 1996;271:611-4.
-
(1996)
J Biol Chem
, vol.271
, pp. 611-614
-
-
Stapleton, D.1
Mitchelhill, K.I.2
Gao, G.3
-
5
-
-
0032529139
-
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform
-
Salt I,Celler JW,Hawley SA.AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.Biochem J. 1998;334 (Pt 1): 177-87.
-
(1998)
Biochem J
, vol.334
, Issue.Pt 1
, pp. 177-187
-
-
Salt, I.1
Celler, J.W.2
Hawley, S.A.3
-
6
-
-
0037326307
-
Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
-
Viollet B,Andreelli F,Jorgensen SB.Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.Biochem Soc Trans. 2003;31:216-9.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 216-219
-
-
Viollet, B.1
Andreelli, F.2
Jorgensen, S.B.3
-
7
-
-
0037251455
-
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
-
Viollet B,Andreelli F,Jorgensen SB.The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.J Clin Invest. 2003;111:91-8.
-
(2003)
J Clin Invest
, vol.111
, pp. 91-98
-
-
Viollet, B.1
Andreelli, F.2
Jorgensen, S.B.3
-
8
-
-
17844368938
-
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
-
Foretz M,Ancellin N,Andreelli F.Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.Diabetes. 2005;54:1331-9.
-
(2005)
Diabetes
, vol.54
, pp. 1331-1339
-
-
Foretz, M.1
Ancellin, N.2
Andreelli, F.3
-
9
-
-
4344714725
-
Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit
-
Villena JA,Viollet B,Andreelli F,Kahn A,Vaulont S,Sul HS.Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.Diabetes. 2004;53:2242-9.
-
(2004)
Diabetes
, vol.53
, pp. 2242-2249
-
-
Villena, J.A.1
Viollet, B.2
Andreelli, F.3
Kahn, A.4
Vaulont, S.5
Sul, H.S.6
-
10
-
-
63849301000
-
AMPK: lessons from transgenic and knockout animals
-
Viollet B,Athea Y,Mounier R.AMPK: lessons from transgenic and knockout animals.Front Biosci. 2009;14:19-44.
-
(2009)
Front Biosci
, vol.14
, pp. 19-44
-
-
Viollet, B.1
Athea, Y.2
Mounier, R.3
-
11
-
-
34250013613
-
Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice
-
Goirand F,Solar M,Athea Y.Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice.J Physiol. 2007;581:1163-71.
-
(2007)
J Physiol
, vol.581
, pp. 1163-1171
-
-
Goirand, F.1
Solar, M.2
Athea, Y.3
-
12
-
-
79551487613
-
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer
-
Hardie DG.AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.Biochem Soc Trans. 2011;39:1-13.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1-13
-
-
Hardie, D.G.1
-
13
-
-
63849104290
-
AMP-activated protein kinase and cancer
-
Wang W,Guan KL.AMP-activated protein kinase and cancer.Acta Physiol (Oxf). 2009;196:55-63.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 55-63
-
-
Wang, W.1
Guan, K.L.2
-
14
-
-
50049109789
-
AMP-activated protein kinase and human cancer: cancer metabolism revisited
-
Kuhajda FP.AMP-activated protein kinase and human cancer: cancer metabolism revisited.Int J Obes (Lond). 2008;32 (Suppl 4): S36-41.
-
(2008)
Int J Obes (Lond)
, vol.32
, Issue.SUPPL. 4
-
-
Kuhajda, F.P.1
-
15
-
-
55449124298
-
Metformin suppresses intestinal polyp growth in ApcMin/+ mice
-
Tomimoto A,Endo H,Sugiyama M.Metformin suppresses intestinal polyp growth in ApcMin/+ mice.Cancer Sci. 2008;99:2136-41.
-
(2008)
Cancer Sci
, vol.99
, pp. 2136-2141
-
-
Tomimoto, A.1
Endo, H.2
Sugiyama, M.3
-
16
-
-
84855562731
-
Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft
-
Liu J,Li M,Song B,et al.Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft.Urol Oncol. 2011;:.
-
(2011)
Urol Oncol
-
-
Liu, J.1
Li, M.2
Song, B.3
-
19
-
-
34249069215
-
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis
-
Isakovic A,Harhaji L,Stevanovic D.Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.Cell Mol Life Sci. 2007;64:1290-302.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 1290-1302
-
-
Isakovic, A.1
Harhaji, L.2
Stevanovic, D.3
-
20
-
-
78549283186
-
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
-
Green AS,Chapuis N,Maciel TT.The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.Blood. 2010;116:4262-73.
-
(2010)
Blood
, vol.116
, pp. 4262-4273
-
-
Green, A.S.1
Chapuis, N.2
Maciel, T.T.3
-
21
-
-
47249088612
-
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
-
Gotlieb WH,Saumet J,Beauchamp MC.In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.Gynecol Oncol. 2008;110:246-50.
-
(2008)
Gynecol Oncol
, vol.110
, pp. 246-250
-
-
Gotlieb, W.H.1
Saumet, J.2
Beauchamp, M.C.3
-
22
-
-
33750492981
-
5'-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway
-
Garcia-Gil M,Bertini F,Pesi R,Voccoli V,Tozzi MG,Camici M.5'-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.Nucleosides Nucleotides Nucleic Acids. 2006;25:1265-70.
-
(2006)
Nucleosides Nucleotides Nucleic Acids
, vol.25
, pp. 1265-1270
-
-
Garcia-Gil, M.1
Bertini, F.2
Pesi, R.3
Voccoli, V.4
Tozzi, M.G.5
Camici, M.6
-
24
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker SL,Majumdar SR,Veugelers P,Johnson JA.Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.Diabetes Care. 2006;29:254-8.
-
(2006)
Diabetes Care
, vol.29
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
25
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM,Donnelly LA,Emslie-Smith AM,Alessi DR,Morris AD.Metformin and reduced risk of cancer in diabetic patients.BMJ. 2005;330:1304-5.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
26
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ,Kosmatka M,Bardeesy N.The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.Proc Natl Acad Sci U S A. 2004;101:3329-35.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
-
27
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne DE,Reimann H,Nezu J.Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.Nat Genet. 1998;18:38-43.
-
(1998)
Nat Genet
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
-
28
-
-
0036636173
-
LKB1: a master tumour suppressor of the small intestine and beyond
-
Yoo LI,Chung DC,Yuan J.LKB1: a master tumour suppressor of the small intestine and beyond.Nat Rev Cancer. 2002;2:529-35.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 529-535
-
-
Yoo, L.I.1
Chung, D.C.2
Yuan, J.3
-
29
-
-
39149083762
-
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
-
Gurumurthy S,Hezel AF,Sahin E,Berger JH,Bosenberg MW,Bardeesy N.LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.Cancer Res. 2008;68:55-63.
-
(2008)
Cancer Res
, vol.68
, pp. 55-63
-
-
Gurumurthy, S.1
Hezel, A.F.2
Sahin, E.3
Berger, J.H.4
Bosenberg, M.W.5
Bardeesy, N.6
-
30
-
-
70349883650
-
Histological evaluation of AMPK signalling in primary breast cancer
-
Hadad SM,Baker L,Quinlan PR.Histological evaluation of AMPK signalling in primary breast cancer.BMC Cancer. 2009;9:307.
-
(2009)
BMC Cancer
, vol.9
, pp. 307
-
-
Hadad, S.M.1
Baker, L.2
Quinlan, P.R.3
-
31
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line
-
Imamura K,Ogura T,Kishimoto A,Kaminishi M,Esumi H.Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.Biochem Biophys Res Commun. 2001;287:562-7.
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
32
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones RG,Plas DR,Kubek S.AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.Mol Cell. 2005;18:283-93.
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
-
33
-
-
42949152052
-
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress
-
Okoshi R,Ozaki T,Yamamoto H.Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress.J Biol Chem. 2008;283:3979-87.
-
(2008)
J Biol Chem
, vol.283
, pp. 3979-3987
-
-
Okoshi, R.1
Ozaki, T.2
Yamamoto, H.3
-
34
-
-
84863281299
-
Inhibition of AMP-activated protein kinase alpha (AMPKalpha) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1
-
Wang S,Song P,Zou MH.Inhibition of AMP-activated protein kinase alpha (AMPKalpha) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.J Biol Chem. 2012;287:8001-12.
-
(2012)
J Biol Chem
, vol.287
, pp. 8001-8012
-
-
Wang, S.1
Song, P.2
Zou, M.H.3
-
35
-
-
0037079003
-
Rules for making human tumor cells
-
Hahn WC,Weinberg RA.Rules for making human tumor cells.N Engl J Med. 2002;347:1593-603.
-
(2002)
N Engl J Med
, vol.347
, pp. 1593-1603
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
37
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC,Counter CM,Lundberg AS,Beijersbergen RL,Brooks MW,Weinberg RA.Creation of human tumour cells with defined genetic elements.Nature. 1999;400:464-8.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
38
-
-
0021769478
-
Cancer: mutant ras proteins and cell transformation
-
Newbold R.Cancer: mutant ras proteins and cell transformation.Nature. 1984;310:628-9.
-
(1984)
Nature
, vol.310
, pp. 628-629
-
-
Newbold, R.1
-
39
-
-
0020521611
-
Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene
-
Newbold RF,Overell RW.Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene.Nature. 1983;304:648-51.
-
(1983)
Nature
, vol.304
, pp. 648-651
-
-
Newbold, R.F.1
Overell, R.W.2
-
40
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M,Lin AW,McCurrach ME,Beach D,Lowe SW.Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.Cell. 1997;88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
41
-
-
77949462458
-
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
-
Luo Z,Zang M,Guo W.AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.Future Oncol. 2010;6:457-70.
-
(2010)
Future Oncol
, vol.6
, pp. 457-470
-
-
Luo, Z.1
Zang, M.2
Guo, W.3
-
42
-
-
66149129259
-
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
-
Zhou J,Huang W,Tao R.Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.Oncogene. 2009;28:1993-2002.
-
(2009)
Oncogene
, vol.28
, pp. 1993-2002
-
-
Zhou, J.1
Huang, W.2
Tao, R.3
-
43
-
-
0031052020
-
Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase
-
Sprenkle AB,Davies SP,Carling D,Hardie DG,Sturgill TW.Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.FEBS Lett. 1997;403:254-8.
-
(1997)
FEBS Lett
, vol.403
, pp. 254-258
-
-
Sprenkle, A.B.1
Davies, S.P.2
Carling, D.3
Hardie, D.G.4
Sturgill, T.W.5
-
44
-
-
70350359685
-
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity
-
Costanzo-Garvey DL,Pfluger PT,Dougherty MK.KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.Cell Metab. 2009;10:366-78.
-
(2009)
Cell Metab
, vol.10
, pp. 366-378
-
-
Costanzo-Garvey, D.L.1
Pfluger, P.T.2
Dougherty, M.K.3
-
45
-
-
33745840203
-
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
Laderoute KR,Amin K,Calaoagan JM.5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.Mol Cell Biol. 2006;26:5336-47.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
-
46
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K,Ouyang H,Zhu T.TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Cell. 2006;126:955-68.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
-
47
-
-
0035487104
-
The INK4a/ARF network in tumour suppression
-
Sherr CJ.The INK4a/ARF network in tumour suppression.Nat Rev Mol Cell Biol. 2001;2:731-7.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
48
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D,Weinberg RA.Hallmarks of cancer: the next generation.Cell. 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
49
-
-
37349070024
-
An E2F1-dependent gene expression program that determines the balance between proliferation and cell death
-
Hallstrom TC,Mori S,Nevins JR.An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.Cancer Cell. 2008;13:11-22.
-
(2008)
Cancer Cell
, vol.13
, pp. 11-22
-
-
Hallstrom, T.C.1
Mori, S.2
Nevins, J.R.3
-
50
-
-
84861142867
-
AMPKalpha modulation in cancer progression: multilayer integrative transcriptome analysis in Asian gastric cancer
-
Kim YH,Liang H,Liu X.AMPKalpha modulation in cancer progression: multilayer integrative transcriptome analysis in Asian gastric cancer.Cancer Res. 2012;72:2512-21.
-
(2012)
Cancer Res
, vol.72
, pp. 2512-2521
-
-
Kim, Y.H.1
Liang, H.2
Liu, X.3
-
51
-
-
58149156184
-
Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model
-
Phoenix KN,Vumbaca F,Claffey KP.Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.Breast Cancer Res Treat. 2009;113:101-11.
-
(2009)
Breast Cancer Res Treat
, vol.113
, pp. 101-111
-
-
Phoenix, K.N.1
Vumbaca, F.2
Claffey, K.P.3
|