Clinical utility of genetic variants for cardiovascular risk prediction a futile exercise or insufficient data?

Circulation: Cardiovascular Genetics

Volumn 5, Issue 4, 2012, Pages 387-390

  Di Angelantonio, Emanuele ^a   Butterworth, Adam S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cardiovascular diseases; Editorials; Genetic polymorphisms; Prediction

Indexed keywords

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; FAMILY HISTORY; FRAMINGHAM RISK SCORE; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC MARKER; GENETIC RISK; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

CORONARY ANGIOGRAPHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MYOCARDIAL INFARCTION;

EID: 84868623793     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.112.964148     Document Type: Review

References (30)

1. Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, et al. American College of Cardiology Foundation/American Heart As-scoiation Tasl Force on Practice Guidelines. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010;122:2748-2764.
2. Lloyd-Jones DM. Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation. 2010;121:1768-1777.
3. Wang TJ. Assessing the role of circulating, genetic, and imaging biomark-ers in cardiovascular risk prediction. Circulation. 2011;123:551-565.
4. Lloyd-Jones DM, Nam BH, D'Agostino RB Sr, Levy D, Murabito JM, Wang TJ, et al. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA. 2004;291:2204-2211. (Pubitemid 38608169)
5. Sivapalaratnam S, Boekholdt SM, Trip MD, Sandhu MS, Luben R, Kastelein JJ, et al. Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study. Heart. 2010;96:1985-1989.
6. Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR. C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation. 2008;118:2243-51, 4p following 2251.
7. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet. 2001;29:306-309. (Pubitemid 33096456)
8. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-713.
9. Peden JF, Farrall M. Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum Mol Genet. 2011;20(R2):R198-R205.
10. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. MAGIC; Procardis Consortium. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-948.
11. Voight BF, Scott LJ, Steinthorsdottir V, Morris A P, Dina C, Welch RP, et al. MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42:579-589.
12. Drenos F, Whittaker JC, Humphries SE. The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk. Ann Hum Genet. 2007;71(Pt 5):611-619. (Pubitemid 47087069)
13. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane J P, et al. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2007;166:28-35. (Pubitemid 47234300)
14. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-1249. (Pubitemid 351439225)
15. Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, Miletich JP, et al. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA. 2010;303:631-637.
16. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Shar-ma A, et al. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet. 2010;376:1393-1400.
17. Thanassoulis G, Peloso GM, Pencina MJ, Hoffmann U, Fox CS, Cupples LA, et al. A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study. Circ Cardiovasc Genet. 2012;5:113-121.
18. Vaarhorst AA, Lu Y, Heijmans BT, Dollé ME, Böhringer S, Putter H, et al. Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circ Cardiovasc Genet. 2012;5:202-209.
19. Lluis-Ganella C, Subirana I, Lucas G, Tomás M, Muñoz D, Sentí M, et al. Assessment of the value of a genetic risk score in improving the estimation of coronary risk. Atherosclerosis. 2012;222:456-463.
20. Andreassi MG, Adlerstein D, Carpeggiani C, Shehi E, Fantinato S, Ghezzi E, et al. Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease. Atherosclerosis. 2012
21. Patel RS, Sun Y V, Hartiala J, Veledar E, Su S, Sher S, et al. Association of a Genetic Risk Score with Prevalent and Incident Myocardial Infarction in Subjects Undergoing Coronary Angiography. Circ Cardiovasc Genet. 2012;5:441-449.
22. Clayton DG. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet. 2009;5:e1000540.
23. Zollner S, Pritchard JK. Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am J Hum Genet. 2007;80:605-615. (Pubitemid 46564399)
24. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111:3481-3488. (Pubitemid 40923403)
25. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, et al. Cardiogenics; CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333-338.
26. Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, Cunningham JM, et al. Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet. 2011;43:519-525.
27. Yang J, Weedon MN, Purcell S, Lettre G, Estrada K, Willer CJ, et al. GIANT Consortium. Genomic infation factors under polygenic inheritance. Eur J Hum Genet. 2011;19:807-812.
28. Pepe MS, Thompson ML. Combining diagnostic test results to increase accuracy. Biostatistics. 2000;1:123-140. (Pubitemid 33213526)
29. Aschard H, Chen J, Cornelis MC, Chibnik LB, Karlson EW, Kraft P. Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases. Am J Hum Genet. 2012;90:962-972.
30. Knowles JW, Assimes TL, Kiernan M, Pavlovic A, Goldstein BA, Yank V, et al. Randomized trial of personal genomics for preventive cardiology: design and challenges. Circ Cardiovasc Genet. 2012;5:368-376.