The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk

Annals of Human Genetics

Volumn 71, Issue 5, 2007, Pages 611-619

  Drenos, F ^a   Whittaker, J C ^b   Humphries, S E ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

10year risk; ACE; APOB; APOE; Candidate genes; CETP; Coronary heart disease; ITGA2B; LPL; Meta analysis; MTHFR; NOS3; Odds ratio; PON 1; Risk; SERPINE1

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APOLIPOPROTEIN B; APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE 1; CHOLESTEROL ESTER TRANSFER PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRINOGEN RECEPTOR; LIPOPROTEIN LIPASE; SERINE PROTEINASE INHIBITOR;

ACCURACY; AGE; ALLELE; ARTICLE; CARDIOVASCULAR RISK; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

CORONARY DISEASE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT;

EID: 34447624686     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2007.00359.x     Document Type: Article

References (24)

1. Assmann, G., Cullen, P. & Schulte, H. (2002) Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Munster (PROCAM) Study. Circulation 105, 310-315.
2. Boekholdt, S. M., Bijsterveld, N. R., Moons, A. H. M., Levi, M., Buller, H. R. & Peters, R. J. G. (2001) Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction. Circulation 104, 3063-3068.
3. Boekholdt, S. M., Sacks, F. M., Jukema, J. W., Shepherd, J., Freeman, D. J., McMahon, A. D., Cambien, F., Nicaud, V., de Grooth, G. J., Talmud, P. J., Humphries, S. E., Miller, G. J., Eiriksdottir, G., Gudnason, V., Kauma, H., Kakko, S., Savolainen, M. J., Arca, M., Montali, A., Liu, S., Lanz, H. J., Zwinderman, A. H., Kuivenhoven, J. A. & Kastelein, J. J. P. (2005) Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment -Individual patient meta-analysis of 13,677 subjects. Circulation 111, 278-287.
4. Casas, J. P., Bautista, L. E., Humphries, S. E. & Hingorani, A. D. (2004) Endothelial nitric oxide synthase genotype and ischemic heart disease -Meta-analysis of 26 studies involving 23028 subjects. Circulation 109, 1359-1365.
5. Casas, J. P., Cooper, J., Miller, G. J., Hingorani, A. D. & Humphries, S. E. (2006) Investigating the genetic determinants of cardiovascular disease using candidate genes and meta-analysis of association studies. Ann Hum Genet 70, 145-169.
6. Chiodini, B. D., Barlera, S., Franzosi, M. G., Beceiro, V. L., Introna, M. & Tognoni, G. (2003) APO B gene polymorphisms and coronary artery disease: A meta-analysis. Atherosclerosis 167, 355-366.
7. Cooper, J. A., Miller, G. J. & Humphries, S. E. (2005) A comparison of the PROCAM and Framingham point-scoring systems for estimation of individual risk of coronary heart disease in the Second Northwick Park Heart Study. Atherosclerosis 181, 93-100.
8. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Garcia-Gonzalez, M. J. & Ferrer-Hita, J. (2005) Is homocysteine an independent risk factor for cardiovascular disease? Med Clin 125 798-799.
9. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 2486-2497.
10. Humphries, S. E., Ridker, P. M. & Talmud, P. J. (2004) Genetic testing for cardiovascular disease susceptibility: A useful clinical management tool or possible misinformation? Arteriosclerosis Thrombosis and Vascular Biology 24, 628-636.
11. Humphries, S. E., Talmud, P. J., Hawe, E., Bolla, M., Day, I. N. M. & Miller, G. J. (2001) Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: A prospective study. Lancet 358, 115-119.
12. Janssens, A., Aulchenko, Y. S., Elefante, S., Borsboom, G., Steyerberg, E. W. & van Duijin, C. M. (2006) Predictive testing for complex diseases using multiple genes: Fact or fiction? Genet Med 8, 395-400.
13. Keavney, B., Parish, S., Palmer, A., Clark, S., Youngman, L., Danesh, J., McKenzie, C., Delepine, M., Lathrop, M. & Peto, R. (2003) Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E [epsilon]2/[epsilon]3/ [epsilon]4 genotype. Lancet 361, 396-398.
14. Lloyd-Jones, D. M., Leip, E. P., Larson, M. G., D'Agostino, R. B., Beiser, A., Wilson, P. W. F., Wolf, P. A. & Levy, D. (2006) Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation 113, 791-798.
15. Loew, M., Hoffmann, M. M., Hahmann, H., Marz, W., Rothenbacher, D. & Brenner, H. (2005) Smoking, apolipoprotein E genotype, and early onset of coronary heart disease. Euro J Cardiovasc Prev Rehabil 12, 268-270.
16. Morgan, T. M., Coffey, C. S. & Krumholz, H. M. (2003) Overestimation of genetic risks owing to small sample sizes in cardiovascular studies. Clin Genet 64, 7-17.
17. Prepared by: British Cardiac Society, B. H. S., Diabetes UK, HEART UK, Primary Care Cardiovascular Society, The Stroke Association (2005) JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice 2005. Heart 91, v1-52.
18. Sistrom, C. L. & Garvan, C. W. (2004) Proportions, odds, and risk. Radiology 230, 12-19.
19. Song, Y. Q. & Liu, S. M. (2003) APOE genotypes and risk of coronary heart disease: A meta-analysis of population studies. Circulation 108, 726-726.
20. Song, Y. Q., Stampfer, M. J. & Liu, S. M. (2004) Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease. Ann Internal Med 141, 137-147.
21. Talmud, P. J., Stephens, J. W., Hawe, E., Demissie, S., Cupples, L. A., Hurel, S. J., Humphries, S. E. & Ordovas, J. M. (2005) The significant increase in cardiovascular disease risk in APOE epsilon 4 carriers is evident only in men who smoke: Potential relationship between reduced antioxidant status and ApoE4. Ann Hum Genet 69, 613-622.
22. Wilson, P. W. F., D'Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H. & Kannel, W. B. (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97, 1837-1847.
23. Wittrup, H. H., Tybjaerg-Hansen, A. & Nordestgaard, B. G. (1999) Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease - A meta-analysis. Circulation 99, 2901-2907.
24. Yang, Q. H., Khoury, M. J., Friedman, J. M., Little, J. & Flanders, W. D. (2005) How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol 34, 1129-1137.