Methyl siloxanes in environmental matrices around a siloxane production facility, and their distribution and elimination in plasma of exposed population

Environmental Science and Technology

Volumn 46, Issue 21, 2012, Pages 11718-11726

  Xu, Lin ^a   Shi, Yali ^a   Wang, Thanh ^a   Dong, Zhirong ^b   Su, Weiping ^b   Cai, Yaqi ^a  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^b Clinical Laboratory of Yantai Municipal Laiyang Central Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AIR SAMPLES; AVERAGE CONCENTRATION; DUST SAMPLES; ENVIRONMENTAL MATRIXES; EXPOSURE LEVEL; HALF LIVES; HUMAN PLASMA SAMPLES; HUMAN PLASMAS; MANUFACTURING FACILITY; OCCUPATIONAL EXPOSURE; ORDERS OF MAGNITUDE; PLASMA SAMPLES; PRODUCTION FACILITY; PRODUCTION PROCESS; REFERENCE GROUP; TARGET COMPOUND;

PLASMA (HUMAN); PLASMAS;

SILICON COMPOUNDS;

METHYLSILOXANE DERIVATIVE; SILOXANE; UNCLASSIFIED DRUG;

AIR SAMPLING; ATMOSPHERIC POLLUTION; EXPERIMENTAL STUDY; HEALTH RISK; INDOOR AIR; OCCUPATIONAL EXPOSURE; PLASMA; POLLUTION EXPOSURE; PUBLIC HEALTH; RESIDENT POPULATION; SPATIOTEMPORAL ANALYSIS; WORKPLACE;

AIR; AMBIENT AIR; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BODY DISTRIBUTION; CONCENTRATION (PARAMETERS); DUST; FEMALE; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; INDUSTRY; INGESTION; INHALATION; MALE; OCCUPATIONAL EXPOSURE; RESIDENTIAL AREA; SOIL; WORKER; WORKSHOP;

AIR POLLUTANTS; AIR POLLUTION, INDOOR; CHINA; DUST; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MALE; RISK ASSESSMENT; SILOXANES; SOIL POLLUTANTS;

EID: 84868600611     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es3023368     Document Type: Article

References (42)

1. Silicones Environmental, Health and Safety Council of North America (SEHSC). Available from: http://www.sehsc.com/d5.asp. 2011
2. Horii, Y.; Kannan, K. Survey of organosilicones compounds, including cyclic and linear siloxanes, in personal-care and household products Arch. Environ. Contam. Toxicol. 2008, 55, 701-710
3. Lu, Y.; Yuan, T.; Wang, W. H.; Kannan, K. Concentrations and assessment of exposure to siloxanes and synthetic musks in personal care products from China Environ. Pollut. 2011, 159, 3522-3528
4. Warner, N. A.; Evenset, A.; Christensen, G.; Gabrielsen, G. W.; Borgå, K.; Leknes, H. Volatile siloxanes in the European arctic: assessment of sources and spatial distribution Environ. Sci. Technol. 2010, 44 (19) 7705-7710
5. Sanchez-Brunete, C.; Miguel, E.; Albero, B.; Tadeo, A. J. Determination of cyclic and linear siloxanes in soil samples by ultrasonic-assisted extraction and gas chromatography-mass spectrometry J. Chromatogr. A 2010, 1217 (45) 7024-7030
6. Boehmer, T.; Gerhards, R. Decamethylcyclopentasiloxane (D5), A Compilation of Environmental Data. Essen: Degussa Goldschmidt AG; Brussels: Centre Européen des Silicones 2003, not supplied.
7. Zhang, Z. F.; Qi, H.; Ren, N. Q.; Li, Y. F.; Gao, D. W.; Kannan, K. Survey of cyclic and linear siloxanes in sediment from the songhua river and in sewage sludge from wastewater treatment plants, northeastern China Arch. Environ. Contam. Toxicol. 2011, 60, 204-211
8. Kierkegaard, A.; Egmond, R. V.; Mclachlan, M. S. Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humer Esturary Environ. Sci. Technol. 2011, 45, 5936-5942
9. Liebierman, M. W.; Lykissa, E. D.; Barrios, R.; Qu, C. N.; Kala, G.; Kala, S. V. Cyclosiloxanes produce fatal liver and lung damage in mice Environ. Health Perspect. 1999, 107, 161-165
10. He, B.; Rhodes-Brower, S.; Miller, M. R. Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ER alpha Toxicol. Appl. Pharmacol. 2003, 192, 254-261
11. OEHHA. Toxicity data review: Decamethylcyclopentasiloxane (D5). Available from: http://www.arb.ca.gov/toxics/dryclean/oehhad5review.pdf. 2007.
12. Brooke, D. N.; Crookes, M. J.; Gray, D.; Robertson, S. Environmental Risk Assessment Report: Decamethylcyclopentasiloxane; Environment Agency of England and Wales: Bristol, 2009.
13. Brooke, D. N.; Crookes, M. J.; Gray, D.; Robertson, S. Environmental Risk Assessment Report: Octamethylcyclotetrasiloxane; Environment Agency of England and Wales: Bristol, 2009.
14. Shields, H.; Fleisher, D. M.; Weschler, C. J. Comparisons among VOCs measured in three types of U.S. commercial buildings with different occupant densities Indoor Air 1996, 6, 2-17
15. Kaj, L.; Andersson, J.; Palm Cousins, A.; Schmidbauer, N.; Brorström-Lundén, E. Results from the Swedish National Screening Programme 2004, Subreport 4: Siloxanes; IVL: Stockholm, 2005.
16. Utell, M. J.; Gelein, R.; Yu, C. P.; Kenaga, C.; Geigel, E.; Torres, A.; Chalupa, D.; Gibb, F. R.; Speers, D. M.; Mast, R. W.; Morrow, P. E. Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor Toxicol. Sci. 1998, 44, 206-213
17. Reddy, M. B.; Dobrev, I. D.; McNett, D. A.; Tobin, J. M.; Utell, M. J.; Morrow, P. E.; Domoradzki, J. Y.; Plotzke, K. P.; Andersen, M. E. Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans Toxicol. Sci. 2008, 105 (2) 275-285
18. Mclachlan, M. S.; Kierkegaard, A.; Hansen, K. M.; Egmond, R. V.; Christensen, J. H.; Skjøth, C. A. Concentrations and fate of decamethylcyclopentasiloxane (D5) in the atmosphere Environ. Sci. Technol. 2010, 44 (14) 5365-5370
19. Kaj, L.; Schlabach, M.; Andersson, J.; Palm Cousins, A.; Schmidbauer, N.; Brorström-Lundén, E. Siloxanes in the Nordic Environment; Nordic Council of Ministers: Copenhagen, 2005.
20. Kochetkov, A.; Smith, J. S.; Ravikrishna, R.; Valsaraj, K. T.; Thibodeaux, L. J. Air-water partition constants for volatile methyl siloxanes Environ. Toxicol. Chem. 2001, 20 (10) 2184-2188
21. Lu, Y.; Yuan, T.; Yun, S. H.; Wang, W. H.; Wu, Q.; Kannan, K. Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures Environ. Sci. Technol. 2010, 44, 6081-6087
22. Abdallah, M. A. E.; Harrad, S. Personal exposure to HBCDs and its degradation products via ingestion of indoor dust Environ. Int. 2009, 35, 870-876
23. Flassbeck, D.; Pfleiderer, B.; Grümping, R.; Hirner, A. V. Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS Anal. Chem. 2001, 73, 606-611
24. Liu, J. Y.; Li, J. G.; Luan, Y.; Zhao, Y. F.; Wu, Y. N. Geographical distribution of perfluorinated compounds in human blood from Liaoning Province, China Environ. Sci. Technol. 2009, 43, 4044-4048
25. Qin, Y. Y.; Leung, C. K. M.; Lin, C. K.; Leung, A. O. W.; Wang, H. S.; Giesy, J. P.; Wong, M. H. Halogenated POPs and PAHs in blood plasma of Hong Kong residents Environ. Sci. Technol. 2011, 45, 1630-1637
26. Andersen, M. E.; Reddy, M. B.; Plotzke, K. P. Are highly lipophilic volatile organic compounds expected to bioaccumulate on repeated exposures? Toxicol. Ltrs. 2008, 179, 85-92
27. Seals, R.; Bartell, S. M.; Steenland, K. Accumulation and clearance of perfluorooctanoic acid (PFOA) in current and former residents of an exposed community Environ. Health Perspect. 2011, 119 (1) 119-124
28. Stahlhut, R.; Welshons, W.; Swan, S.; Bisphenol, A. Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both Environ Health Perspect. 2009, 117, 784-789
29. Haskell, M. J.; Lembcke, J. L.; Salazar, M.; Green, M. H.; Peerson, J. M.; Brown, K. H. Population-based plasma kinetics of an oral dose of [2H4]retinyl acetate among preschool-aged, Peruvian children1-3 Am. J. Clin. Nutr. 2003, 77 (3) 681-686
30. Karlsson, M. O.; Molnar, V.; Freijs, A.; Nygren, P.; Bergh, J.; Larsson, R. Pharmacokinetic models for the saturable distribution of paclitaxel Drug Metab. Dispos. 1999, 27 (10) 1220-1223
31. Meeks, R. The Dow Corning Siloxane Research Program: An overview and update Med. Dev. Diag. Ind. 1999, 20, 112
32. Available at: www.mddionline.com/article/dow-corning-siloxane-research- program-overview-and-update
33. Reddy, M. B.; Dobrev, I. D.; Plotzke, K. P.; Andersen, M. E.; Reitz, R. H.; Morrow, P.; Utell, M. A physiologically based pharmacokinetic model for inhalation of octamethylcyclotetrasiloxane (D4) in human during rest and exercise Toxicol. Sci. 2003, 72, 3-18
34. Andersen, M. E.; Sarangapani, R.; Reitz, R. H.; Gallavan, R. H.; Doberv, I. D.; Plotzke, K. P. Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats Toxicol. Sci. 2001, 60, 214-231
35. Reddy, M. B.; Dobrev, I. D.; McNett, D. A.; Tobin, J. M.; Utell, M. J.; Morrow, P. E.; Domoradzki, J. Y.; Plotzke, K. P.; Andersen, M. E. Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans Toxicol. Sci. 2008, 105 (2) 275-285
36. Luu, H. M. D.; Hutter, J. C. Bioavailability of octamethylcyclotetrasiloxane (D4) after exposure to silicones by inhalation and implantation Environ Health Perspect. 2011, 109 (11) 1095-1102
37. Reddy, M. B.; Looney, R. J.; Utell, M. J.; Plotzke, K. P.; Andersen, M. E. Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) Toxicol. Sci. 2007, 99 (2) 422-431
38. Varaprath, S.; Mcmahon, J. M.; Plotzke, K. P. Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in fischer 344 rat urine-a comparison of a linear and a cyclic siloxane Drug Metab. Dispos. 2003, 31 (2) 206-214
39. Olsen, G. W.; Burris, J. M.; Ehresman, D. J.; Froehlich, J. W.; Seacat, A. M.; Butenhoff, J. L.; Zobel, L. R. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers Environ. Health Perspect. 2007, 115 (9) 1298-1304
40. Thuresson, K.; Höglund, P.; Hagmar, L.; Siödin, A.; Bergman, A.; Jakobsson, K. Apparent half-lives of hepta- to decabrominated diphenyl ethers in human serum as determined in occupationally exposed workers Environ. Health Perspect. 2006, 114 (2) 176-181
41. Flassbeck, D.; Pfleiderer, B.; Klemens, P.; Heumann, K. G.; Eltze, E.; Hirner, A. V. Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants Anal. Bioanal. Chem. 2003, 375, 356-362
42. Kala, S. V.; Lykissa, E. D.; Neely, M. W.; Lieberman, M. W. Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice Am. J. Pathol. 1998, 152 (3) 645-649