Accumulation and clearance of perfluorooctanoic acid (PFOA) in current and former residents of an exposed community

Environmental Health Perspectives

Volumn 119, Issue 1, 2011, Pages 119-124

  Seals, Ryan ^a   Bartell, Scott M ^b   Steenland, Kyle ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C8; Half life; Pfa; Pfoa; Serum levels; Water contamination

Indexed keywords

PERFLUOROOCTANOIC ACID;

ADULT; ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PLASMA CLEARANCE; PLASMA HALF LIFE; POLLUTION MONITORING; PRIORITY JOURNAL; RESIDENTIAL AREA; UNITED STATES; WATER CONTAMINATION;

ADULT; AGED; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; FLUOROCARBONS; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OCTANOIC ACIDS; OHIO; QUESTIONNAIRES; RESIDENCE CHARACTERISTICS; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY; WEST VIRGINIA; YOUNG ADULT;

EID: 78751475781     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002346     Document Type: Article

References (20)

1. Bartell SM, Calafat AM, Lyu C, Kato K, Ryan PB, Steenland K. 2009. Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia. Environ Health Perspect 118(2):222-228.
2. Brede E, Wilhelm M, Göen T, Müller J, Rauchfuss K, Kraft M, et al. 2010. Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany. Int J Hyg Environ Health 213:217-223.
3. Calafat A, Wong L, Kuklenyik Z, Reidy J, Needham L. 2007. Polyfluoroalkyl chemicals in the US population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ Health Perspect 115:1596-1602.
4. DeWitt J, Shnyra A, Badr M, Loveless S, Hoban D, Frame S, et al. 2009. Immunotoxicity of perfluorooctanoic acid and perfluo-rooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha. Crit Rev Toxicol 39:76-94.
5. Frisbee S, Brooks AP Jr., Maher A, Flensborg P, Arnold S, Fletcher T, et al. 2009. The C8 Health Project: design, methods, and participants. Environ Health Perspect 117:1873-1882.
6. Harada K, Inoue K, Morikawa A, Yoshinaga T, Saito N, Koizumi A. 2005. Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specifc excretion. Environ Res 99:253-261.
7. Hines E, White S, Stanko J, Gibbs-Flournoy E, Lau C, Fenton S. 2009. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol 304:97-105.
8. Houde M, Martin J, Letcher R, Solomon K, Muir D. 2006. Biological monitoring of polyfluoroalkyl substances: a review. Environ Sci Technol 40:3463-3473.
9. Kennedy G Jr, Butenhoff J, Olsen G, O'Connor J, Seacat A, Perkins R, et al. 2004. The toxicology of perfluorooctanoate. Crit Rev Toxicol 34:351-384.
10. Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J. 2007. Perfluoroalkyl acids: a review of monitoring and toxicological fndings. Toxicol Sci 99:366-394.
11. Lundin J, Alexander B, Olsen G, Church T. 2009. Ammonium perfluorooctanoate production and occupational mortality. Epidemiology 20:921-928.
12. Michalek J, Tripathi R, Kulkarni P, Gupta P, Selvavel K. 1998. Correction for bias introduced by truncation in pharmaco kinetic studies of environmental contaminants. Environmetrics 9(2):165-174.
13. Olsen G, Burris J, Ehresman D, Froehlich J, Seacat A, Butenhoff J, et al. 2007. Half-life of serum elimination of perfluoro octanesulfonate, perfluorohexanesulfonate, and perfluoro octanoate in retired fluorochemical production workers. Environ Health Perspect 115:1298-1305.
14. Olsen G, Zobel L. 2007. Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers. Int Arch Occup Environ Health 81:231-246.
15. Paustenbach D, Panko J, Scott P, Unice K. 2007. A methodology for estimating human exposure to perfluorooctanoic acid (PFOA): a retrospective exposure assessment of a community (1951-2003). J Toxicol Environ Health Part A 70:28-57.
16. Rosen M, Lau C, Corton J. 2009. Does exposure to perfluoroalkyl acids present a risk to human health? Toxicol Sci 111:1-3.
17. Stahlhut R, Welshons W, Swan S. 2009. Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ Health Perspect 117:784-789.
18. Steenland K, Deddens JA. 2004. A practical guide to dose-response analyses and risk assessment in occupational epidemiology. Epidemiology 15:63-70.
19. Steenland K, Jin C, MacNeil J, Lally C, Ducatman A, Vieira V, et al. 2009. Predictors of PFOA levels in a community surrounding a chemical plant. Environ Health Perspect 117:1083-1088.
20. Tan YM, Clewell HJ III, Andersen ME. 2008. Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis. Toxicol Lett 177:38-47.