Optimization of a natural product-based class of gamma;-secretase modulators

Journal of Medicinal Chemistry

Volumn 55, Issue 21, 2012, Pages 9270-9282

  Hubbs, Jed L ^a   Fuller, Nathan O ^a   Austin, Wesley F ^a   Shen, Ruichao ^a   Creaser, Steffen P ^a   McKee, Timothy D ^a   Loureiro, Robyn M B ^a   Tate, Barbara ^a   Xia, Weiming ^a   Ives, Jeffrey ^a   Bronk, Brian S ^a  

^a Satori Pharmaceuticals Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; GAMMA SECRETASE MODULATOR; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ADMINISTRATION, ORAL; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BIOLOGICAL AGENTS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CARBAMATES; ETHERS; HUMANS; MICE; MICROSOMES, LIVER; PEPTIDE FRAGMENTS; PERMEABILITY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 84868571940     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300976b     Document Type: Article

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