Novel strategies to improve co-fermentation of pentoses with d-glucose by recombinant yeast strains in lignocellulosic hydrolysates

Bioengineered

Volumn 3, Issue 6, 2012, Pages 347-351

  Oreb, Mislav ^a   Dietz, Heiko ^a   Farwick, Alexander ^a   Boles, Eckhard ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Bioethanol; Co fermentation of pentoses with glucose; Substrate channeling; Sugar transport

Indexed keywords

GLUCOSE; LIGNOCELLULOSIC HYDROLYSATE; PENTOSE; STARCH HYDROLYSATE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME MECHANISM; FERMENTATION; GENETIC ENGINEERING; NONHUMAN; YEAST;

EID: 84868565867     PISSN: 19491018     EISSN: 19491026     Source Type: Journal    
DOI: 10.4161/bioe.21444     Document Type: Article

References (21)

1. Weber C, Farwick A, Benisch F, Brat D, Dietz H, Subtil T, et al. Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels. Appl Microbiol Biotechnol 2010; 87:1303-15. PMID:20535464; http://dx.doi.org/10.1007/ s00253-010-2707-z.
2. Van Vleet JH, Jeffries TW. Yeast metabolic engineering for hemicellulosic ethanol production. Curr Opin Biotechnol 2009; 20:300-6. PMID:19545992; http://dx.doi.org/10.1016/j.copbio.2009.06.001
3. Young E, Lee SM, Alper H. Optimizing pentose utilization in yeast: the need for novel tools and approaches. Biotechnol Biofuels 2010; 3:24. PMID:21080929; http://dx.doi.org/10.1186/1754-6834-3-24
4. Kuhad RC, Gupta R, Khasa YP, Singh A, Zhang YHP. Bioethanol production from pentose sugars: Current status and future prospects. Renew Sustain Energy Rev 2011; 15:4950-62. http://dx.doi. org/10.1016/j.rser.2011.07.058
5. Brat D, Boles E, Wiedemann B. Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae. Appl Environ Microbiol 2009; 75:2304-11. PMID:19218403; http://dx.doi.org/10.1128/ AEM.02522-08
6. Becker J, Boles E. A modified Saccharomyces cerevisiae strain that consumes L-Arabinose and produces ethanol. Appl Environ Microbiol 2003; 69:4144-50. PMID:12839792; http://dx.doi.org/10.1128/AEM.69.7.4144-4150.2003
7. Wiedemann B, Boles E. Codon-optimized bacterial genes improve L-Arabinose fermentation in recombinant Saccharomyces cerevisiae. Appl Environ Microbiol 2008; 74:2043-50. PMID:18263741; http://dx.doi.org/10.1128/AEM.02395-07
8. Kuyper M, Hartog MM, Toirkens MJ, Almering MJ, Winkler AA, van Dijken JP, et al. Metabolic engineering of a xylose-isomerase-expressing Saccharomyces cerevisiae strain for rapid anaerobic xylose fermentation. FEMS Yeast Res 2005; 5:399-409. PMID:15691745; http://dx.doi.org/10.1016/j. femsyr.2004.09.010
9. Hamacher T, Becker J, Gárdonyi M, Hahn-Hägerdal B, Boles E. Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization. Microbiology 2002; 148:2783-8. PMID:12213924
10. Subtil T, Boles E. Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae. Biotechnol Biofuels 2012; 5:14. PMID:22424089; http://dx.doi. org/10.1186/1754-6834-5-14
11. Leandro MJ, Fonseca C, Gonçalves P. Hexose and pentose transport in ascomycetous yeasts: an overview. FEMS Yeast Res 2009; 9:511-25. PMID:19459982; http://dx.doi.org/10.1111/j.1567- 1364.2009.00509.x.
12. Young E, Poucher A, Comer A, Bailey A, Alper H. Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host. Appl Environ Microbiol 2011; 77:3311-9. PMID:21421781; http://dx.doi.org/10.1128/ AEM.02651-10
13. Subtil T, Boles E. Improving L-arabinose utilization of pentose fermenting Saccharomyces cerevisiae cells by heterologous expression of L-arabinose transporting sugar transporters. Biotechnol Biofuels 2011; 4:38. PMID:21992610; http://dx.doi. org/10.1186/1754-6834-4-38
14. Kasahara T, Shimogawara K, Kasahara M. Crucial effects of amino acid side chain length in transmembrane segment 5 on substrate affinity in yeast glucose transporter Hxt7. Biochemistry 2011; 50:8674-81. PMID:21892826; http://dx.doi.org/10.1021/ bi200958s.
15. Senac T, Hahn-Hägerdal B. Intermediary Metabolite Concentrations in Xylulose- and Glucose-Fermenting Saccharomyces cerevisiae Cells. Appl Environ Microbiol 1990; 56:120-6. PMID:16348083
16. Wisselink HW, Cipollina C, Oud B, Crimi B, Heijnen JJ, Pronk JT, et al. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Metab Eng 2010; 12:537-51. PMID:20816840; http://dx.doi.org/10.1016/j.ymben.2010.08.003
17. Walfridsson M, Hallborn J, Penttilä M, Keränen S, Hahn-Hägerdal B. Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 1995; 61:4184-90. PMID:8534086
18. Wahlbom CF, Cordero Otero RR, van Zyl WH, Hahn-Hägerdal B, Jönsson LJ. Molecular analysis of a Saccharomyces cerevisiae mutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism, and the pentose phosphate pathway. Appl Environ Microbiol 2003; 69:740-6. PMID:12570990; http:// dx.doi.org/10.1128/AEM.69.2.740-746.2003
19. Karhumaa K, Påhlman AK, Hahn-Hägerdal B, Levander F, Gorwa-Grauslund MF. Proteome analysis of the xylose-fermenting mutant yeast strain TMB 3400. Yeast 2009; 26:371-82. PMID:19504622; http://dx.doi.org/10.1002/yea.1673
20. Wright J, Bellissimi E, de Hulster E, Wagner A, Pronk JT, van Maris AJ. Batch and continuous culturebased selection strategies for acetic acid tolerance in xylose-fermenting Saccharomyces cerevisiae. FEMS Yeast Res 2011; 11:299-306. PMID:21251209; http://dx.doi.org/10.1111/j.1567-1364.2011.00719.x.
21. Petersson A, Almeida JR, Modig T, Karhumaa K, Hahn-Hägerdal B, Gorwa-Grauslund MF, et al. A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast 2006; 23:455-64. PMID:16652391; http://dx.doi.org/10.1002/ yea.1370.