Improvement of physicochemical properties of N-4472: Part II: Characterization of N-4472 microemulsion and the enhanced oral absorption

International Journal of Pharmaceutics

Volumn 246, Issue 1-2, 2002, Pages 75-83

  Itoh, K ^a,b   Matsui, S ^b   Tozuka, Y ^a   Oguchi, T ^a   Yamamoto, K ^a  

^a CHIBA UNIVERSITY   (Japan)

^b NISSHIN SEIFUN GROUP INC   (Japan)

Author keywords

Microemulsions; NMR spectroscopy; Oral absorption; Poorly water soluble drug; Solubilization

Indexed keywords

ASCORBIC ACID; DODECYL SULFATE SODIUM; GELUCIRE; N 4472; N [2 (3,5 DI TERT BUTYLHYDROXYPHENETHYL) 4,6 DIFLUOROPHENYL] N' [4 (N BENZYLPIPERIDYL)]UREA; PIPERIDINE DERIVATIVE; RICINOMACROGOL; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; GASTROINTESTINAL TRACT; MALE; MICROEMULSION; MOLECULAR DYNAMICS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ADMINISTRATION, ORAL; ANIMALS; ASCORBIC ACID; CASTOR OIL; DRUG STABILITY; EMULSIONS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PARTICLE SIZE; PIPERIDINES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM DODECYL SULFATE; SOLUBILITY; UREA; WATER;

EID: 0037057347     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00346-0     Document Type: Article

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