Influence of manufacturing factors on physical stability and solubility of solid dispersions containing a low glass transition temperature drug

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 11, 2012, Pages 1366-1371

  Sakurai, Atsushi ^a,b   Sako, Kazuhiro ^a   Maitani, Yoshie ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

Hot melt extrusion; Low glass transition temperature drug; Particle size; Solubility; Stability; Water content

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 3 METHOXY 1,5 BIS(4 METHOXYPHENYL) 1H 1,2,4 TRIAZOLE; HYDROXYPROPYLMETHYLCELLULOSE; POVIDONE; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG MANUFACTURE; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; GLASS TRANSITION TEMPERATURE; HUMIDITY; INVERSE GAS CHROMATOGRAPHY; MELTING POINT; MOISTURE; MOLECULAR WEIGHT; PARTICLE SIZE; SOLID STATE; SPRAY DRYING; WATER ABSORPTION; WATER CONTENT; WATER VAPOR; WETTABILITY; X RAY DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; METHYLCELLULOSE; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POVIDONE; SOLUBILITY; TRANSITION TEMPERATURE; WATER;

EID: 84868539449     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00354     Document Type: Article

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