메뉴 건너뛰기




Volumn 1832, Issue 1, 2013, Pages 96-104

CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: Involving activation of PI3K/Akt signaling

Author keywords

Apoptosis; Myocardial I R; PI3K Akt signaling; TLR9

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P85; TOLL LIKE RECEPTOR 9;

EID: 84868516625     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.08.008     Document Type: Article
Times cited : (61)

References (37)
  • 1
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A., Ulevitch R.J. Toll-like receptors in the induction of the innate immune response. Nature 2000, 406:782-787.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 3
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 4
    • 58149500135 scopus 로고    scopus 로고
    • Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart
    • Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H12.
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.296
    • Chao, W.1
  • 6
    • 77749291737 scopus 로고    scopus 로고
    • Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways
    • Dong J.W., Vallejo J.G., Tzeng H.P., Thomas J.A., Mann D.L. Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. Am. J. Physiol. Heart Circ. Physiol. 2010, 298:H1079-H1087.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298
    • Dong, J.W.1    Vallejo, J.G.2    Tzeng, H.P.3    Thomas, J.A.4    Mann, D.L.5
  • 7
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio Y., Nguyen T., Wencker D., Kitsis R.N., Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000, 101:660-667.
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 8
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T., Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003, 24:358-363.
    • (2003) Trends Immunol. , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 12
    • 34249787873 scopus 로고    scopus 로고
    • Protection against myocardial ischemia/reperfusion injury in TLR4 deficient mice is mediated through a phosphoinositide 3-kinase dependent mechanism
    • Hua F., Ha T., Ma J., Li Y., Kelley J., Gao X., Browder I.W., Kao R.L., Williams D.L., Li C. Protection against myocardial ischemia/reperfusion injury in TLR4 deficient mice is mediated through a phosphoinositide 3-kinase dependent mechanism. J. Immunol. 2007, 178:7317-7324.
    • (2007) J. Immunol. , vol.178 , pp. 7317-7324
    • Hua, F.1    Ha, T.2    Ma, J.3    Li, Y.4    Kelley, J.5    Gao, X.6    Browder, I.W.7    Kao, R.L.8    Williams, D.L.9    Li, C.10
  • 15
    • 9444260363 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes
    • Jozsef L., Khreiss T., Filep J.G. CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes. FASEB J. 2004, 18:1776-1778.
    • (2004) FASEB J. , vol.18 , pp. 1776-1778
    • Jozsef, L.1    Khreiss, T.2    Filep, J.G.3
  • 17
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 2006, 5:471-484.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 18
    • 41349106548 scopus 로고    scopus 로고
    • TLR9 as a key receptor for the recognition of DNA
    • Kumagai Y., Takeuchi O., Akira S. TLR9 as a key receptor for the recognition of DNA. Adv. Drug Deliv. Rev. 2008, 60:795-804.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 795-804
    • Kumagai, Y.1    Takeuchi, O.2    Akira, S.3
  • 19
    • 1142309739 scopus 로고    scopus 로고
    • Modulating Toll-like receptor mediated signaling by (1->3)-b-D-glucan rapidly induces cardioprotection
    • Li C., Ha T., Kelley J., Gao X., Qiu Y., Kao R.L., Browder W., Williams D.L. Modulating Toll-like receptor mediated signaling by (1->3)-b-D-glucan rapidly induces cardioprotection. Cardiovasc. Res. 2003, 61:538-547.
    • (2003) Cardiovasc. Res. , vol.61 , pp. 538-547
    • Li, C.1    Ha, T.2    Kelley, J.3    Gao, X.4    Qiu, Y.5    Kao, R.L.6    Browder, W.7    Williams, D.L.8
  • 20
    • 78149275614 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
    • Lim E.J., Park D.W., Lee J.G., Lee C.H., Bae Y.S., Hwang Y.C., Jeong J.W., Chin B.R., Baek S.H. Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Exp. Mol. Med. 2010, 42:712-720.
    • (2010) Exp. Mol. Med. , vol.42 , pp. 712-720
    • Lim, E.J.1    Park, D.W.2    Lee, J.G.3    Lee, C.H.4    Bae, Y.S.5    Hwang, Y.C.6    Jeong, J.W.7    Chin, B.R.8    Baek, S.H.9
  • 21
    • 80054925307 scopus 로고    scopus 로고
    • The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction
    • Mathur S., Walley K.R., Boyd J.H. The Toll-like receptor 9 ligand CPG-C attenuates acute inflammatory cardiac dysfunction. Shock 2011, 36:478-483.
    • (2011) Shock , vol.36 , pp. 478-483
    • Mathur, S.1    Walley, K.R.2    Boyd, J.H.3
  • 22
    • 0033534088 scopus 로고    scopus 로고
    • Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
    • Matsui T., Ling L., del Monte F., Fukui Y., Franke T.F., Hajjar R.J., Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 1999, 100:2373-2379.
    • (1999) Circulation , vol.100 , pp. 2373-2379
    • Matsui, T.1    Ling, L.2    del Monte, F.3    Fukui, Y.4    Franke, T.F.5    Hajjar, R.J.6    Rosenzweig, A.7
  • 25
    • 0037352702 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    • Ojaniemi M., Glumoff V., Harju K., Liljeroos M., Vuori K., Hallman M. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 2003, 33:597-605.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 597-605
    • Ojaniemi, M.1    Glumoff, V.2    Harju, K.3    Liljeroos, M.4    Vuori, K.5    Hallman, M.6
  • 26
    • 1242336786 scopus 로고    scopus 로고
    • Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice
    • Oyama J., Blais C., Liu X., Pu M., Kobzik L., Kelly R.A., Bourcier T. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004, 109:784-789.
    • (2004) Circulation , vol.109 , pp. 784-789
    • Oyama, J.1    Blais, C.2    Liu, X.3    Pu, M.4    Kobzik, L.5    Kelly, R.A.6    Bourcier, T.7
  • 33
    • 61749098024 scopus 로고    scopus 로고
    • Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
    • Vollmer J., Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv. Drug Deliv. Rev. 2009, 61:195-204.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 195-204
    • Vollmer, J.1    Krieg, A.M.2
  • 34
    • 0034668119 scopus 로고    scopus 로고
    • Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response
    • Weighardt H., Feterowski C., Veit M., Rump M., Wagner H., Holzmann B. Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response. J. Immunol. 2000, 165:4537-4543.
    • (2000) J. Immunol. , vol.165 , pp. 4537-4543
    • Weighardt, H.1    Feterowski, C.2    Veit, M.3    Rump, M.4    Wagner, H.5    Holzmann, B.6
  • 35
    • 33646784031 scopus 로고    scopus 로고
    • Modulation of the phosphoinositide-3-kinase signaling pathway alters host resistance to sepsis, inflammation, and ischemia/reperfusion injury
    • Williams D.L., Ozment-Skelton T., Li C. Modulation of the phosphoinositide-3-kinase signaling pathway alters host resistance to sepsis, inflammation, and ischemia/reperfusion injury. Shock 2006, 25:432-439.
    • (2006) Shock , vol.25 , pp. 432-439
    • Williams, D.L.1    Ozment-Skelton, T.2    Li, C.3
  • 36
    • 82555176456 scopus 로고    scopus 로고
    • Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions
    • Yang L., Guo W., Zhang Q., Li H., Liu X., Yang Y., Zuo J., Liu W. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. J. Mol. Biol. 2011, 414:654-666.
    • (2011) J. Mol. Biol. , vol.414 , pp. 654-666
    • Yang, L.1    Guo, W.2    Zhang, Q.3    Li, H.4    Liu, X.5    Yang, Y.6    Zuo, J.7    Liu, W.8
  • 37
    • 84863980947 scopus 로고    scopus 로고
    • The TLR9 agonist, CpG-ODN 1826, ameliorates cardiac dysfunction after trauma-hemorrhage
    • Zhang X., Gao M., Ha T., Kalbfleisch J.H., Browder W., Williams D.L., Li C., Kao R.L. The TLR9 agonist, CpG-ODN 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock 2012, 38:146-152.
    • (2012) Shock , vol.38 , pp. 146-152
    • Zhang, X.1    Gao, M.2    Ha, T.3    Kalbfleisch, J.H.4    Browder, W.5    Williams, D.L.6    Li, C.7    Kao, R.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.