Impaired flow-induced arterial remodeling in DOCA-salt hypertensive rats

Hypertension Research

Volumn 35, Issue 11, 2012, Pages 1093-1101

  Lemkens, Pieter ^a   Nelissen, Jelly ^a   Meens, Merlijn J P M T ^a   Fazzi, Gregorio E ^a   Janssen, Ger J M ^a   Debets, Jacques J M ^a   Janssen, Ben J A ^a   Schiffers, Paul M H ^a   De Mey, Jo G R ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

dual NEP ECE inhibition; endothelin 1; resistance artery; salt sensitive hypertension; vascular hypertrophy

Indexed keywords

COLLAGEN; DEOXYCORTICOSTERONE ACETATE; ELASTIN; ENDOTHELIN CONVERTING ENZYME INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL STIFFNESS; ARTERY DIAMETER; ARTICLE; BIOAVAILABILITY; BLOOD FLOW; BODY WEIGHT; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; ENZYME INHIBITION; HISTOLOGY; HYPERPLASIA; HYPERTENSION; HYPERTROPHY; MACROPHAGE; MESENTERIC ARTERY; MONOCYTE; NONHUMAN; RAT; UPREGULATION;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BENZAZEPINES; BLOOD PRESSURE; CELL MOVEMENT; DESOXYCORTICOSTERONE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HYPERTENSION; HYPERTROPHY; MACROPHAGES; MESENTERIC ARTERIES; METALLOENDOPEPTIDASES; MONOCYTES; NEPRILYSIN; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; VASCULAR RESISTANCE;

EID: 84868514203     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2012.94     Document Type: Article

References (50)

1. Martinez-Lemus LA, Hill MA, Meininger GA. The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology 2009; 24: 45-57.
2. Bellien J, Iacob M, Gutierrez L, Isabelle M, Lahary A, Thuillez C, Joannides R. Crucial role of NO and endothelium-derived hyperpolarizing factor in human sustained conduit artery flow-mediated dilatation. Hypertension 2006; 48: 1088-1094. (Pubitemid 44772712)
3. Sun D, Huang A, Yan EH, Wu Z, Yan C, Kaminski PM, Oury TD, Wolin MS, Kaley G. Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am J Physiol Heart Circ Physiol 2004; 286: H2249-H2256. (Pubitemid 38685240)
4. Hilgers RH, Schiffers PM, Aartsen WM, Fazzi GE, Smits JF, De Mey JG. Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice. Arterioscler Thromb Vasc Biol 2004; 24: 892-897. (Pubitemid 38620868)
5. Li JS, Lariviere R, Schiffrin EL. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. Hypertension 1994; 24: 183-188. (Pubitemid 24239426)
6. Jaeckel M, Simon G. Altered structure and reduced distensibility of arteries in Dahl salt-sensitive rats. J Hypertens 2003; 21: 311-319. (Pubitemid 36269702)
7. Folkow B. Physiological aspects of primary hypertension. Physiol Rev 1982; 62: 347-504.
8. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 1993; 21: 391-397. (Pubitemid 23095149)
9. Buus CL, Pourageaud F, Fazzi GE, Janssen G, Mulvany MJ, De Mey JG. Smooth muscle cell changes during flow-related remodeling of rat mesenteric resistance arteries. Circ Res 2001; 89: 180-186. (Pubitemid 34135827)
10. Briones AM, Arribas SM, Salaices M. Role of extracellular matrix in vascular remodeling of hypertension. Curr Opin Nephrol Hypertens 2010; 19: 187-194.
11. Rizzoni D, Muiesan ML, Porteri E, De Ciuceis C, Boari GE, Salvetti M, Paini A, Rosei EA. Vascular remodeling, macro-and microvessels: therapeutic implications. Blood Press 2009; 18: 242-246.
12. Rizzoni D, Porteri E, Piccoli A, Castellano M, Bettoni G, Muiesan ML, Pasini G, Guelfi D, Mulvany MJ, Agabiti Rosei E. Effects of losartan and enalapril on small artery structure in hypertensive rats. Hypertension 1998; 32: 305-310. (Pubitemid 28376489)
13. Schiffrin EL, Park JB, Intengan HD, Touyz RM. Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan. Circulation 2000; 101: 1653-1659. (Pubitemid 30196624)
14. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415. (Pubitemid 18090241)
15. Donckier JE, Michel L, Van Beneden R, Delos M, Havaux X. Increased expression of endothelin-1 and its mitogenic receptor ETA in human papillary thyroid carcinoma. Clin Endocrinol 2003; 59: 354-360. (Pubitemid 37046989)
16. Ammarguellat F, Larouche I, Schiffrin EL. Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation 2001; 103: 319-324. (Pubitemid 32095422)
17. Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM. Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension 2010; 56: 942-949.
18. Boldrini L, Pistolesi S, Gisfredi S, Ursino S, Ali G, Pieracci N, Basolo F, Parenti G, Fontanini G. Expression of endothelin 1 and its angiogenic role in meningiomas. Virchows Arch 2006; 449: 546-553. (Pubitemid 44722323)
19. Schiffrin EL. Vascular endothelin in hypertension. Vascul Pharmacol 2005; 43: 19-29. (Pubitemid 40828829)
20. Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension 1995; 25(Part 2): 769-773.
21. Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM. Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats. Clin Exp Pharmacol Physiol Suppl 1995; 22: S188-S190. (Pubitemid 26064483)
22. Sawamura T, Kimura S, Shinmi O, Sugita Y, Yanagisawa M, Goto K, Masaki T. Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme. Biochem Biophys Res Commun 1990; 168: 1230-1236. (Pubitemid 20176011)
23. Nakano A, Kishi F, Minami K, Wakabayashi H, Nakaya Y, Kido H. Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acidlength endothelins by chymase from human mast cells. J Immunol 1997; 159: 1987-1992. (Pubitemid 127484189)
24. Fernandez-Patron C, Radomski MW, Davidge ST. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 1999; 85: 906-911. (Pubitemid 29534165)
25. Nelissen J, Lemkens P, Sann H, Bindl M, Bassissi F, Jasserand D, De Mey JG, Janssen BJ. Pharmacokinetic and pharmacodynamic properties of SOL1: a novel dual inhibitor of neutral endopeptidase and endothelin converting enzyme. Life Sci (e-pub ahead of print 17 February 2012).
26. Kalk P, Sharkovska Y, Kashina E, von Websky K, Relle K, Pfab T, Alter M, Guillaume P, Provost D, Hoffmann K, Fischer Y, Hocher B. Endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 prevents hypertensive cardiac remodeling in a blood pressure-independent manner. Hypertension 2011; 57: 755-763.
27. Ceiler DL, De Mey JG. Chronic N(G)-nitro-L-arginine methyl ester treatment does not prevent flow-induced remodeling in mesenteric feed arteries and arcading arterioles. Arterioscler Thromb Vasc Biol 2000; 20: 2057-2063.
28. Ceiler DL, Nelissen-Vrancken HJ, Smits JF, De Mey JG. Pressure but not angiotensin IIinduced increases in wall mass or tone influences static and dynamic aortic mechanics. J Hypertens 1999; 17: 1109-1116. (Pubitemid 29389558)
29. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985; 54: 589-599. (Pubitemid 15132717)
30. Pourageaud F, De Mey JG. Structural properties of rat mesenteric small arteries after 4-wk exposure to elevated or reduced blood flow. Am J Physiol 1997; 273(Part 2): H1699-H1706.
31. Unthank JL, Nixon JC, Burkhart HM, Fath SW, Dalsing MC. Early collateral and microvascular adaptations to intestinal artery occlusion in rat. Am J Physiol 1996; 271(Part 2): H914-H923.
32. Hynynen MM, Khalil RA. The vascular endothelin system in hypertension-recent patents and discoveries. Recent Pat Cardiovasc Drug Discov 2006; 1: 95-108.
33. Dhaun N, Goddard J, Kohan DE, Pollock DM, Schiffrin EL, Webb DJ. Role of endothelin-1 in clinical hypertension: 20 years on. Hypertension 2008; 52: 452-459.
34. Shimamoto H, Iriuchijima J. Hemodynamic characteristics of conscious deoxycorticosterone acetate hypertensive rats. Jpn J Physiol 1987; 37: 243-254. (Pubitemid 17087734)
35. Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 2004; 110: 2233-2240. (Pubitemid 39372507)
36. Fukuda G, Khan ZA, Barbin YP, Farhangkhoee H, Tilton RG, Chakrabarti S. Endothelinmediated remodeling in aortas of diabetic rats. Diabetes Metab Res Rev 2005; 21: 367-375. (Pubitemid 40945959)
37. Rossi GP, Sacchetto A, Rizzoni D, Bova S, Porteri E, Mazzocchi G, Belloni AS, Bahcelioglu M, Nussdorfer GG, Pessina AC. Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic (mREN2)27 rats via adrenocortical steroid-independent mechanisms. Arterioscler Thromb Vasc Biol 2000; 20: 949-956. (Pubitemid 30207567)
38. Rossi GP, Bova S, Sacchetto A, Rizzoni D, Agabiti-Rosei E, Neri G, Nussdorfer GG, Pessina AC. Comparative effects of the dual ACE-NEP inhibitor MDL-100,240 and ramipril on hypertension and cardiovascular disease in endogenous angiotensin IIdependent hypertension. Am J Hypertens 2002; 15(2 Part 1): 181-188. (Pubitemid 34161095)
39. Rossi GP, Cavallin M, Rizzoni D, Bova S, Mazzocchi G, Agabiti-Rosei E, Nussdorfer GG, Pessina AC. Dual ACE and NEP inhibitor MDL-100,240 prevents and regresses severe angiotensin II-dependent hypertension partially through bradykinin type 2 receptor. J Hypertens 2002; 20: 1451-1459. (Pubitemid 34925692)
40. Rizzoni D, Rossi GP, Porteri E, Sticchi D, Rodella L, Rezzani R, Sleiman I, De Ciuceis C, Paiardi S, Bianchi R, Nussdorfer GG, Agabiti-Rosei E. Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP. J Hypertens 2004; 22: 759-766. (Pubitemid 38543568)
41. Tulis DA, Unthank JL, Prewitt RL. Flow-induced arterial remodeling in rat mesenteric vasculature. Am J Physiol 1998; 274(3 Part 2): H874-H882.
42. Tuttle JL, Nachreiner RD, Bhuller AS, Condict KW, Connors BA, Herring BP, Dalsing MC, Unthank JL. Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression. Am J Physiol Heart Circ Physiol 2001; 281: H1380-H1389.
43. Miyashiro JK, Poppa V, Berk BC. Flow-induced vascular remodeling in the rat carotid artery diminishes with age. Circ Res 1997; 81: 311-319. (Pubitemid 27362517)
44. Ibrahim J, Miyashiro JK, Berk BC. Shear stress is differentially regulated among inbred rat strains. Circ Res 2003; 92: 1001-1009. (Pubitemid 36588499)
45. Glagov S, Vito R, Giddens DP, Zarins CK. Micro-architecture and composition of artery walls: relationship to location, diameter and the distribution of mechanical stress. J Hypertens Suppl 1992; 10: S101-S104.
46. Hilgers RH, De Mey JG. Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1. Br J Pharmacol 2009; 156: 1239-1247.
47. Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998; 101: 731-736. (Pubitemid 28096068)
48. Tronc F, Wassef M, Esposito B, Henrion D, Glagov S, Tedgui A. Role of NO in flowinduced remodeling of the rabbit common carotid artery. Arterioscler Thromb Vasc Biol 1996; 16: 1256-1262. (Pubitemid 26339713)
49. Shimokawa H, Yasutake H, Fujii K, Owada MK, Nakaike R, Fukumoto Y, Takayanagi T, Nagao T, Egashira K, Fujishima M, Takeshita A. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J Cardiovasc Pharmacol 1996; 28: 703-711. (Pubitemid 26397030)
50. Mulvany MJ. Small artery remodeling and significance in the development of hypertension. News Physiol Sci 2002; 17: 105-109.