Comparative effects of the dual ACE-NEP inhibitor MDL-100, 240 and ramipril on hypertension and cardiovascular disease in endogenous angiotensin II-dependent hypertension

American Journal of Hypertension

Volumn 15, Issue 2, 2002, Pages 181-188

  Rossi, Gian Paolo ^a   Bova, Sergio ^a   Sacchetto, Alfredo ^a   Rizzoni, Damiano ^b   Agabiti Rosei, Enrico ^b   Neri, Giuliano ^a   Nussdorfer, Gastone G ^a   Pessina, Achille C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Angiotensin; Endothelin; Hypertension; Receptor antagonists; Target organ damage

Indexed keywords

7 (2 ACETYLTHIO 3 PHENYLPROPIONAMIDO) 1,2,3,4,6,7,8,12B OCTAHYDRO 6 OXOPYRIDO[2,1 A][2]BENZAZEPINE 4 CARBOXYLIC ACID; ALDOSTERONE; ANGIOTENSIN; ATRIAL NATRIURETIC FACTOR; CREATININE; CYCLIC GMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENKEPHALINASE INHIBITOR; PHENYLEPHRINE; PLACEBO; POTASSIUM CHLORIDE; RAMIPRIL; RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY DIAMETER; ARTERY DILATATION; ARTERY TONE; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HEART LEFT VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; MESENTERIC ARTERY; NONHUMAN; ORGAN WEIGHT; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; TARGET ORGAN; TRANSGENIC ANIMAL;

ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AORTA; BENZAZEPINES; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR DISEASES; HYPERTENSION; MALE; NEPRILYSIN; ORGAN SIZE; PYRIDINES; RAMIPRIL; RATS; VASOCONSTRICTION;

EID: 0036179428     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(01)02278-6     Document Type: Article

References (29)

1. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia
2. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: A novel autocrine function
3. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
4. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
5. Increased adrenal renin in transgenic hypertensive rats, TGR(m-REN2)27, and its regulation by cAMP, angiotensin II, and calcium
6. Increased vascular angiotensin formation in female rats harboring the mouse Ren-2 gene
7. The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27
8. Transgenic rats: New animal models in hypertension research
9. Sexual dimorphism of blood pressure: Possible role of the renin-angiotensin system
10. Transgenic rats carrying the mouse renin gene - Morphological characterization of a low-renin hypertension model
11. Blockade of angiotensin II type 1 receptor and not of endothelin receptor prevents hypertension and cardiovascular disease in transgenic TGR(mRen2)27 rats via adrenocortical steroid-independent mechanisms
12. Disproportional arterial hypertrophy in hypertensive mRen-2 transgenic rats
13. Suppression of atherosclerotic changes in cholesterol-fed rabbits treated with an oral inhibitor of neutral endopeptidase 24.11 (EC 3.4.24.11)
14. Vasopeptidase inhibition: A new concept in blood pressure management
15. Renin-angiotensin-aldosterone system and myocardial fibrosis
16. Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure
17. Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure
18. Effects of omapatrilat in low, normal, and high renin experimental hypertension
19. Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril
20. Comparative effects of the dual metallopeptidase inhibitor, MDL 100, 240 and of enalaprilat on regional and on cardiac haemodynamics in conscious, hypertensive, transgenic ((mRen-2)27) rats
21. Nitric oxide and prostaglandins in the prolonged effects of losartan and ramipril in hypertension
22. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth musle cell layers
23. Effects of the dual metallopeptidase inhibitor, MDL 100, 240, on regional haemodynamic responses to vasoactive peptides in conscious rats
24. Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats
25. Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme in rats with hypertension and diabetes mellitus
26. Chronic inhibition of endopeptidase 24.11 in essential hypertension: Evidence for enhanced atrial natriuretic peptide and angiotensin II
27. Effects of a dual inhibitor of angiotensin converting enzyme and neutral endopeptidase, MDL 100, 240, on endocrine and renal functions in healthy volunteers
28. Structure and function of small arteries
29. Structure and mechanical properties of resistance arteries in hypertension: Role of adhesion molecules and extracellular matrix determinants