Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model

Calcified Tissue International

Volumn 82, Issue 2, 2008, Pages 108-115

  Rissanen, Jukka P ^a   Suominen, Mari I ^a   Peng, Zhiqi ^a   Halleen, Jussi M ^a  

^a Pharmatest Services Ltd   (Finland)

Author keywords

CTX; Osteoclast activity; Osteoclast number; Ovariectomy; Resorption index; TRACP 5b

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN TYPE 1; ESTRADIOL; ESTROGEN; TARTRATE RESISTANT ACID PHOSPHATASE 5B; TELOPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CARBOXY TERMINAL SEQUENCE; CD34 SELECTION; CELL ACTIVITY; CELL COUNT; CELL CULTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; COW; CULTURE MEDIUM; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; METAPHYSIS; MORPHOMETRICS; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STEM CELL; TIBIA; TRABECULAR BONE;

ACID PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; BONE RESORPTION; CATTLE; CELL COUNT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ESTRADIOL; FEMALE; HUMANS; ISOENZYMES; OSTEOCLASTS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 39249083918     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-007-9091-4     Document Type: Article

References (38)

1. Yaziji H, Janckila AJ, Lear SC, Martin AW, Yam LT (1995) Immunohistochemical detection of tartrate-resistant acid phosphatase in non-hematopoietic human tissues. Am J Clin Pathol 104:397-402
2. Hayman AR, Macary P, Lehner PJ, Cox TM (2001) Tartrate-resistant acid phosphatase (Acp 5): Identification in diverse human tissues and dendritic cells. J Histochem Cytochem 49:675-684
3. Lam WK, Eastlund DT, Li CY, Yam LT (1978) Biochemical properties of tartrate-resistant acid phosphatase in serum of adults and children. Clin Chem 24:1105-1108
4. Janckila AJ, Parthasarathy RN, Parthasarathy LK, et al. (2005) Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells. J Leukoc Biol 77:209-218
5. Lam KW, Li CY, Yam LT, Desnick RJ (1981) Comparison of the tartrate-resistant acid phosphatase in Gaucher's disease and leukemic reticuloendotheliosis. Clin Biochem 14:177-181
6. Janckila AJ, Takahashi K, Sun SZ, Yam LT (2001) Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity. Clin Chem 47:74-80
7. Janckila AJ, Parthasarathy RN, Parthasarathy LK, Seelan RS, Yam LT (2002) Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells. Clin Chim Acta 326:113-122
8. Halleen JM, Tiitinen SL, Ylipahkala H, Fagerlund KM, Väänä nen HK (2006) Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption (review). Clin Lab 52:499-509
9. Stepan JJ, Silinkova-Malkova E, Havranek T, et al. (1993) Relationship of plasma tartrate resistant acid phosphatase to the bone isoenzyme of serum alkaline phosphatase in hyperparathyroidism. Clin Chim Acta 133:189-200
10. Alatalo SL, Halleen JM, Hentunen TA, Mönkkönen J, Väänänen HK (2000) Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium. Clin Chem 46:1751-1754
11. Chu P, Chao TY, Lin YF, Janckila AJ, Yam LT (2003) Correlation between histomorphometric parameters of bone resorption and serum type 5b tartrate-resistant acid phosphatase in uremic patients on maintenance hemodialysis. Am J Kidney Dis 41:1052-1059
12. Alatalo SL, Penq Z, Janckila AJ, et al. (2003) A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum. J Bone Miner Res 18:134-139
13. Alatalo SL, Ivaska KK, Waguespack SG, Econs MJ, Väänänen HK, Halleen JM (2004) Osteoclast-derived serum tartrate-resistant acid phosphatase 5b in Albers-Schonberg disease (type II autosomal dominant osteopetrosis). Clin Chem 50:883-890
14. Quinn JM, Elliott J, Gillespie MT, Martin TJ (1998) A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 139:4424-4427
15. Massey HM, Flanagan AM (1999) Human osteoclasts derive from CD34-positive monocytes. Br J Haematol 106:167-170
16. Nicholson GC, Malakellis M, Collier FM, et al. (2000) Induction of osteoclasts from CD34-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor kappaB ligand (RANKL). Clin Sci (Lond) 99:133-140
17. Boyde A, Ali NN, Jones SJ (1984) Resorption of dentine by isolated osteoclasts in vitro. Br Dent J 156:216-220
18. Chambers TJ, Revell PA, Fuller K, Athanasou NA (1984) Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 66:383-399
19. Selander K, Lehenkari P, Väänänen HK (1994) The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 55:368-375
20. Christgau S, Rosenquist C, Alexandersen P, et al. (1998) Clinical evaluation of the Serum CrossLaps One Step ELISA, a new assay measuring the serum concentration of bone-derived degradation products of type I collagen C-telopeptides. Clin Chem 44:2290-2300
21. Bagger YZ, Foged NT, Andersen L, Lou H, Qvist P (1999) CrossLaps for culture: An improved enzyme-linked immunosorbent assay (ELISA) for measuring bone resorption in vitro. J Bone Miner Res 14 (Suppl. 1):S370 (abstract)
22. Parfitt AM, Drezner MK, Glorieux FH et al. (1987) Bone histomorphometry: Standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610
23. Gurkan L, Ekeland A, Gautvik KM, Langeland N, Ronningen H, Solheim LF (1986) Bone changes after castration in rats. A model for osteoporosis. Acta Orthop Scand 57:67-70
24. Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-191
25. Vanderscueren D, Van Herck E, Suiker AM, Visser WJ, Schot LP, Bouillon R (1992) Bone and mineral metabolism in aged male rats: Short and long term effects of androgen deficiency. Endocrinology 130:2906-2916
26. Erben RG, Eberle J, Stahr K, Goldberg M (2000) Androgen deficiency induces high turnover osteopenia in aged male rats: A sequential histomorphometric study. J Bone Miner Res 15:1085-1098
27. Halleen JM, Alatalo SL, Suominen H, Cheng S, Janckila AJ, Väänänen HK (2000) Tartrate-resistant acid phosphatase 5b: A novel serum marker of bone resorption. J Bone Miner Res 15:1337-1345
28. Hannon RA, Clowes JA, Eagleton AC, Al Hadari AA, Eastell R, Blumsohn A (2004) Clinical performance of immunoreactive tartrate resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone 34:187-194
29. Henriksen DB, Alexandersen P, Bjarnason NH, et al. (2003) Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res 18:2180-2189
30. Halleen JM, Alatalo SL, Janckila AJ, Woitge HW, Seibel MJ, Väänänen HK (2001) Serum tartrate-resistant acid phosphatase is a specific and sensitive marker of bone resorption. Clin Chem 47:597-600
31. Shevde NK, Bendixen AC, Dienger KM, Pike JW (2000) Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression. Proc Natl Acad Sci USA 97:7829-7834
32. Srivastava S, Toraldo G, Weitzmann MN, Cenci S, Ross FP, Pacifici R (2001) Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J Biol Chem 276:8836-8840
33. Ramalho AC, Couttet P, Baudoin C, et al. (2002) Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures. Eur Cytokine Netw 13:39-45
34. Sorensen MG, Henriksen K, Dziegiel MH, Tanko LB, Karsdal MA (2006) Estrogen directly attenuates human osteoclastogenesis, but has no effect on resorption by mature osteoclasts. DNA Cell Biol 25:475-483
35. Kameda T, Mano H, Yuasa T, et al. (1997) Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med 186:489-495
36. Rissanen JP, Suutari S, Ylönen S, Baugh M, Long C, Halleen JM (2005) The ratio of osteoclast activity/osteoclast number (CTX/TRACP 5b) improves the interpretation of the effects of anti-resorptive treatment in human osteoclast cultures. J Bone Miner Res 20(Suppl 1):S256
37. Karsdal MA, Martin TJ, Bollerslev J, Christiansen C, Henriksen K (2007) Are nonresorbing osteoclasts sources of bone anabolic activity? J Bone Miner Res 22:487-494
38. Henriksen K, Tanko LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA (2007) Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos Int 18:681-685